Reports (MDPI)最新文献

{"title":"Oral Pemphigus in Children and Adolescents: A Narrative Review of Published Case Reports.","authors":"Filippos Fytros, Panagiota Dimitropoulou, Christina Charisi, Dorothea Pliaka, Nikolaos Spantidakis, Konstantinos Poulopoulos, Maria Fasoula, Efstratios Karagiannidis, Athanasios Poulopoulos, Vasileios Zisis","doi":"10.3390/reports9030297","DOIUrl":"10.3390/reports9030297","url":null,"abstract":"<p><p><b>Background:</b> Pemphigus is a rare group of autoimmune blistering diseases characterized by autoantibody-mediated loss of keratinocyte adhesion, resulting in intraepithelial blister formation involving the skin and mucous membranes. Pemphigus Vulgaris (PV) is the most common type of pemphigus, which usually presents in adulthood and has a prevalence rate of about 2.83 cases per million person years worldwide. The prevalence rate in children and adolescents is relatively uncommon; however, it accounts for about 1.4 to 3.7 percent of all cases of pemphigus vulgaris reported worldwide. The involvement of oral cavity is clinically significant since it can present prior to the disease or as its predominant feature. Hence, this narrative review seeks to review literature on pemphigus with involvement of oral cavity in children and adolescents. <b>Objective:</b> The objective of this study was to review the current literature regarding epidemiology, pathogenesis, clinical presentation, diagnosis, histopathological characteristics, treatment, and outcomes of pemphigus with oral involvement in children and adolescents. <b>Materials and Methods:</b> A literature search was conducted using the PubMed/MEDLINE, Scopus, and Cochrane Library databases to identify relevant studies published between 2015 and 2026. The search strategy included terms related to pemphigus, pediatric patients, and oral manifestations. Articles involving patients younger than 18 years of age with oral involvement were screened according to predefined inclusion criteria. Following database screening, duplicate removal, and full-text assessment, 25 studies comprising a total of 51 patients with documented oral or orofacial involvement were included in the final review. <b>Results:</b> Pemphigus vulgaris was the predominant subtype, with oral lesions representing the initial or sole manifestation in the majority of patients. The gingiva, mucosa, tongue, lip, and palate were the most common affected areas in the mouth. The lesions in these areas usually appeared as painful erosion, ulcers, and desquamative gingivitis. Histopathology with the presence of acantholysis in the suprabasal area and direct immunofluorescence was the most definitive test for diagnosis. Systemic corticosteroids were the mainstay of treatment in conjunction with steroid sparing agents in some cases, with good results in difficult cases using rituximab. Overall, most patients achieved partial or complete clinical remission following appropriate treatment, although relapses were occasionally reported. <b>Conclusions:</b> Pemphigus in children and adolescents is rarely encountered; however, it should be included as a differential diagnosis of erosive/ulcerative lesions. Early identification, diagnosis, and treatment through a collaborative approach from dental practitioners are critical. Further research is required at multiple centers to gain a better understanding of the disease and to develop evidence-bas","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Adult Ileo-Ileo-Colic Intussusception Caused by an Ileal Lipoma with Spontaneous Ileal Rupture and Rectal Hemorrhage: A Case Report with a Hypothesis-Generating Discussion of Mesenteric Anatomical Variability.","authors":"Salvatore Pezzino, Mariacarla Castorina, Stefano Puleo, Sergio Castorina","doi":"10.3390/reports9030293","DOIUrl":"10.3390/reports9030293","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Adult intussusception is rare, accounting for approximately 5% of all intussusceptions and 1-5% of adult bowel obstructions, whereas the ileo-ileo-colic subtype is exceptionally uncommon. We report a rare case of ileo-ileo-colic intussusception caused by an ileal lipoma and complicated by spontaneous ileal rupture and rectal hemorrhage, emphasizing the diagnostic challenge and proposing the hypothesis that mesenteric anatomical variability may have contributed to its pathophysiology. <b>Case Presentation:</b> A 61-year-old man presented with progressive abdominal distension, right lower quadrant pain and mass, and signs of bowel obstruction. Contrast-enhanced abdominal CT showed an ileo-ileo-colic intussusception extending into the ascending colon, with a typical target sign and marked ischemic changes involving the ileal loops. Emergency laparotomy confirmed a complex ileo-ileo-colic intussusception extending into the right colon, with an ileal lipoma acting as the lead point. The intussuscepted bowel had undergone spontaneous rupture with active bleeding, explaining the rectal hemorrhage. The patient underwent right hemicolectomy with ileocecal resection and side-to-side ileocolic anastomosis. Histopathological examination confirmed a submucosal ileal lipoma associated with transmucosal ischemic necrosis. Recovery was uneventful, and no recurrence or late complications were observed at 6- and 12-month follow-up. <b>Conclusions:</b> This case highlights an exceptionally rare and severe presentation of adult intussusception. Early CT diagnosis and prompt surgical resection are essential when ischemia, necrosis, or failed reduction are present. Mesenteric anatomical variability is proposed as a plausible contributing factor to the extensive telescoping and vascular compromise observed in this patient, a hypothesis that warrants further anatomical investigation.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacubitril/Valsartan in Patients with HFrEF Undergoing Maintenance Hemodialysis, Evidence of Cardiac Reverse Remodeling During 12-Month Follow-Up: Case Series.","authors":"Sonila Mocka, Danilo Baccino, Ledio Shurdi, Stefano Cornara, Stefano Ferraro","doi":"10.3390/reports9030291","DOIUrl":"10.3390/reports9030291","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Heart failure with reduced ejection fraction (HFrEF) is highly prevalent among patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (MHD) and is associated with poor clinical outcomes. Sacubitril/valsartan (SV) is a cornerstone therapy for HFrEF; however, its use in dialysis patients remains limited due to safety concerns and lack of robust evidence. This case series describes the clinical response and safety of SV in patients with HFrEF receiving MHD; <b>Case Presentation:</b> Four male patients with HFrEF undergoing MHD were treated with SV and followed for 12 months. Baseline evaluation showed a left ventricular ejection fraction (LVEF) of 35.5%, left ventricular end-systolic volume (LVESV) of 118.5 mL, left ventricular end-diastolic volume (LVEDV) of 185.7 mL, pulmonary artery systolic pressure (PASP) of 52.7 mmHg, and NT-proBNP levels above 35,000 pg/mL in all patients. After 12 months of SV therapy, LVEF improved to 53.7%, corresponding to a 51.4% relative increase from baseline. Reverse cardiac remodeling was observed, with LVESV decreasing to 58.2 mL and LVEDV to 110 mL, together with reductions in left ventricular dimensions. PASP decreased to 32 mmHg, and NT-proBNP levels declined to 7261.7 pg/mL. Blood pressure improved, serum potassium remained stable at 4.95 mmol/L, and no severe hyperkalemia, intradialytic hypotension, post-dialysis hypotension, or heart failure-related hospitalization occurred; <b>Conclusions:</b> In this case series, SV was associated with improved cardiac function, reverse remodeling, pulmonary pressure reduction, and an acceptable safety profile in patients with HFrEF undergoing MHD. These findings suggest a potential therapeutic role for SV in selected dialysis patients and support further investigation.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Alcoholic Wernicke-Korsakoff Syndrome After a Whipple Procedure: Delayed Recognition, Neuropsychological Findings, and Rehabilitation Follow-Up: A Case Report.","authors":"Ülkü Figen Demir, Fatmanur Karakuş Dilbaz, Nur Banu Memur, Cahit Keskinkılıç, Aylin Hasanefendioğlu Bayrak, Muharrem Battal","doi":"10.3390/reports9030290","DOIUrl":"10.3390/reports9030290","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Wernicke encephalopathy (WE) is a potentially reversible neurological emergency caused by thiamine deficiency. Although classically associated with alcohol use, it may also occur after gastrointestinal surgery and prolonged nutritional compromise, where diagnosis can be obscured by postoperative delirium or metabolic encephalopathy. <b>Case Presentation</b>: A 58-year-old woman with no history of alcohol use underwent a Whipple procedure for pancreatic head adenocarcinoma. Her postoperative course included an anastomotic leak, prolonged open-abdomen management, severely restricted oral intake, and long-term total parenteral nutrition. Approximately 1.5 months after surgery, she developed fluctuating confusion, visual hallucinations, marked recent-memory impairment, diplopia, nystagmus, and gait ataxia, initially interpreted as postoperative delirium/metabolic encephalopathy. Approximately two years later, persistent anterograde amnesia, cerebellar and oculomotor findings, and neuropsychological deficits in attention, memory, and executive functions led to clinical suspicion of previous WE. Re-evaluation of the acute MRI showed bilateral medial thalamic and periaqueductal FLAIR hyperintensities that were absent on follow-up imaging, supporting the retrospective diagnosis; the persistent amnestic syndrome was compatible with Korsakoff syndrome. B-complex vitamin supplementation was initiated, followed by 10 weekly 60 min cognitive rehabilitation sessions and a family-supported home program. Family members reported improved retention of recent information and greater daily independence, but formal post-treatment neuropsychological reassessment could not be completed. <b>Conclusions</b>: This case highlights the difficulty of recognizing non-alcoholic WE during a complicated postoperative course. The observed functional changes cannot be attributed specifically to rehabilitation because vitamin supplementation, nutritional recovery, spontaneous recovery, and rehabilitation occurred within the same follow-up period.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Multidrug-Resistant <i>Morganella morganii</i> Urinary Tract Infection in a Dapagliflozin-Treated Man with Bladder Outlet Obstruction and Incomplete Ureteral Duplication: A Case Report.","authors":"Camelia Nicolae, Madalina Andreea Munteanu, Razvan Petca, Stefan Alexandru Rascu, Razvan Alexandru Danau","doi":"10.3390/reports9030292","DOIUrl":"10.3390/reports9030292","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background and Clinical Significance:&lt;/b&gt; Sodium-glucose cotransporter-2 (SGLT2) inhibitors cause persistent glucosuria, which has been hypothesized to facilitate urinary tract infection (UTI) when urinary stasis or anatomic variants coexist; causality, however, remains unproven and almost certainly multifactorial. &lt;b&gt;Case Presentation:&lt;/b&gt; A 72-year-old man treated with dapagliflozin 10 mg/day for 4 months presented with 3 days of dysuria and nocturia, without fever or systemic signs. One month before SGLT2 inhibitor initiation, urological work-up had been unremarkable: prostate ~50 cm&lt;sup&gt;3&lt;/sup&gt;, post-void residual (PVR) 0 mL, and a negative midstream culture. At presentation we obtained a midstream clean-catch specimen before antibiotics. Dipstick showed glucose 2+ (~100 mg/dL, as expected with SGLT2 inhibition), leukocyte esterase 3+ and nitrites negative; microscopy revealed 45 leukocytes/high-power field with pronounced bacteriuria. Quantitative culture grew &lt;i&gt;Morganella morganii&lt;/i&gt; at 1 × 10&lt;sup&gt;5&lt;/sup&gt; CFU/mL in pure culture. Antimicrobial susceptibility (VITEK&lt;sup&gt;®&lt;/sup&gt; 2 Compact, EUCAST v14.0, 2024) demonstrated resistance to ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, ceftriaxone, ceftazidime, gentamicin and trimethoprim-sulfamethoxazole, with susceptibility (S) retained only to piperacillin-tazobactam, levofloxacin/norfloxacin, cefepime and carbapenems (ertapenem, meropenem). Imaging revealed a right duplicated ureter with distal fusion (single bladder insertion, no dilatation or obstruction) and benign prostatic hyperplasia with PVR ~100 mL; renal function was preserved, two blood culture sets (pre-antibiotic) were negative, and repeat urine culture on day 7 was sterile. Management/outcome: The episode was classified as a localized (cystitis-range) UTI per European Association of Urology (EAU) criteria (no fever, flank pain or bacteremia). Meropenem 1 g intravenously every 8 h (3 g/day) was given for 10 days after urology/infectious-disease review. Dapagliflozin was held at presentation and not restarted during the 3-month follow-up period; reintroduction was planned only after full urological reassessment with cardiology input. Transurethral resection of the prostate (TUR-P) was performed 18 days after completing antibiotics (28 days after presentation) for bladder outlet obstruction refractory to tamsulosin 0.4 mg daily, with complete resolution of symptoms, normalization of inflammatory markers and PVR 0 mL. No recurrence occurred during 3 months of follow-up after TUR-P. &lt;b&gt;Conclusions:&lt;/b&gt; This single case illustrates a temporal association-not proven causation-between SGLT2-related glucosuria, incomplete emptying and a non-obstructive duplicated ureter that likely created a permissive milieu for opportunistic Morganella UTI. The narrative is hypothesis-generating; urinary stasis was the dominant modifiable factor. Culture-guided therapy, individualized decisions on SGLT2 continuation, and definitive","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachydactyly Type A1 Caused by an <i>IHH</i> Variant in a Patient with Disproportionate Short Stature: A Case Report.","authors":"Inés García de Pablo, María Cristina Ontoria Betancort, Francisco Martínez Bugallo, Sebastián Eustaquio Martín Pérez, Isidro Miguel Martín Pérez","doi":"10.3390/reports9030294","DOIUrl":"10.3390/reports9030294","url":null,"abstract":"<p><p><b>Introduction and Clinical Significance:</b> Skeletal dysplasias comprise a genetically heterogeneous group of disorders with substantial phenotypic overlap, often complicating diagnosis. Clinical exome sequencing (CES) can facilitate molecular diagnosis in children with unexplained disproportionate short stature. <b>Case Presentation:</b> An 8-year-old boy presented with severe short stature (-3.24 SDS), brachydactyly, relative macrocephaly, broad nasal bridge, and mild calf hypertrophy. Endocrine evaluation confirmed growth hormone deficiency (GHD). Following negative <i>SHOX</i> testing, CES identified a heterozygous likely pathogenic <i>IHH</i> variant (c.446G>A; p.Arg149His), establishing the diagnosis of brachydactyly type A1 (BDA1). Recombinant human growth hormone (rhGH), initiated for GHD, resulted in improved growth velocity and height SDS. Transient unilateral prepubertal gynecomastia developed during treatment and resolved after temporary rhGH withdrawal, with no recurrence following reinitiation. <b>Conclusions:</b> This case highlights the diagnostic value of CES in children with disproportionate short stature after unrevealing targeted testing and illustrates that GHD may coexist with <i>IHH</i>-related skeletal dysplasia. An integrated genetic and endocrine evaluation can refine diagnosis, identify coexisting treatable endocrine disorders, and guide individualized management.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Horner's Syndrome in Labour Neuroaxial Analgesia: Diagnosis, Management and Follow-Up.","authors":"Yong-Shun Thoo, Mariana Fernandes, Marie-Joe Dib, Corinne Grandjean, Ouanes Amine Ben Saad","doi":"10.3390/reports9030289","DOIUrl":"10.3390/reports9030289","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Horner's syndrome is an uncommon but recognised complication of neuroaxial analgesia in obstetric procedures, with an incidence of 0.4-4%. <b>Case Presentation:</b> This case report describes a 28-year-old primigravida who developed unilateral Horner's syndrome approximately one hour after lumbar epidural analgesia placement for labour pain relief. Upon examination the patient presented with left-sided ptosis, anisocoria, and unexpected sensory blockade extending to the T3-T4 level, accompanied by localised numbness in the left breast and transient upper limb paraesthesia. The pathophysiology of Horner's syndrome involves cephalad spread of local anaesthetic toward the superior cervical sympathetic chain, disrupting sympathetic innervation to the ocular and facial areas. Primary and secondary damage to the sympathetic pathways in the central nervous offer a wide differential diagnosis. The management was conservative, including reduction in epidural bolus infusion rates and careful monitoring. The patient experienced complete resolution of all symptoms within five hours and delivered vaginally without complications. <b>Conclusions:</b> This case demonstrates the characteristically benign and self-limited nature of this complication, emphasising the importance of clinical awareness, proper reassurance of patients, and avoidance of unnecessary diagnostic testing.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verification Index for the Repositioning of a Single Implant Analog in the Correct Place: A Clinical Technical Case Report.","authors":"Socratis Thomaidis","doi":"10.3390/reports9030288","DOIUrl":"10.3390/reports9030288","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Implant impressions can present inaccuracies, affected by many factors, such as impression technique, impression material, and parallelism or lack thereof among the implants. The use of a verification index can assess the accuracy of the mastercast and can be used in order to adjust the inaccuracy of the mastercast. This article presents a technical variation in established verification-index procedures, followed by implant analog repositioning, which can be used in case of an impression inaccuracy; <b>Case Presentation</b>: A patient with a moderate gag reflex received an implant. The impression of an implant and a prepared tooth was made. At the metal try-in, an inaccuracy of the mastercast was found, attributed to the final impression. A technique was illustrated, describing a polymethyl methacrylate (PMMA) verification index fabrication, followed by implant analog repositioning in the removable die of the master cast with the use of acrylic resin. This method may be used as an alternative to repeating the impression in selected clinical situations, but it is time-consuming, technique-sensitive, and needs meticulous handling; <b>Conclusions</b>: This is a viable technique and may represent an alternative to repeating the impression in selected clinical situations. Therefore, the clinical workflow can be reduced by one appointment. It can be helpful for patients with a moderate to severe gag reflex, since it can minimize the discomfort and stress for the patient and the dentist.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbimazole-Induced Severe Acquired Aplastic Anemia in a Patient with Graves' Disease: A Case Report.","authors":"Rahaf A Alghamdi, Hind A Alshankiti, Adel F Al-Marzouki, Yara M Daous","doi":"10.3390/reports9030287","DOIUrl":"10.3390/reports9030287","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Carbimazole is a widely used medication to treat Graves' disease, although it can rarely cause acquired aplastic anemia, a complication that happens in less than 0.01% of people. <b>Case Presentation:</b> We report a 36-year-old woman treated with supratherapeutic dose carbimazole who, after approximately six months of treatment, developed high grade fever, severe menorrhagia, spontaneous epistaxis, and pancytopenia. Her bone marrow biopsy showed severe bone marrow failure with only 5% cellularity and trilineage hypoplasia. Other potential causes were ruled out. Immediate discontinuation of carbimazole was done, and supportive care, including blood transfusions, broad-spectrum antibiotics, G-CSF, and eltrombopag, was started. The patient deteriorated during her hospital stay, developed neutropenic sepsis and acute respiratory failure from diffuse alveolar hemorrhage, which required intubation and pulse steroid therapy. She was stabilized and discharged, with a referral to a tertiary medical center for starting antithymocyte globulin (ATG) immunosuppressive therapy, which she subsequently completed; two months after discharge she was transfusion independent with near-normalization of her blood counts. <b>Conclusions:</b> This case serves as a stark reminder of how lethal thionamide-induced bone marrow failure can be, highlighting the vital need for immediate drug cessation, swift intensive care, and thorough patient education on early warning signs.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Bowel Obstruction Caused by Entrapment of a Meckel Diverticulum Within an Ileo-Mesenteric Fibrous Band: A Case Report.","authors":"Abdallah Shurrab, Awad Dmour, Mouaiad Abu Alika, Muhammad Moosa, Lucian-Cristian Bulat","doi":"10.3390/reports9030286","DOIUrl":"10.3390/reports9030286","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract and an uncommon cause of small bowel obstruction in adults, in which the diverticulum or a band arising from it typically constricts the adjacent bowel. Entrapment of the diverticulum itself within a pre-existing fibrous band is exceedingly rare; <b>Case Presentation</b>: A 42-year-old man with no previous abdominal surgery presented with colicky abdominal pain, distension and bilious vomiting. Contrast-enhanced computed tomography demonstrated small bowel loops dilated to 35.4 mm with a pelvic transition point of undetermined cause. At emergency laparotomy, a fibrous ileo-mesenteric band delimited a constricting orifice through which the Meckel's diverticulum had herniated and become strangulated at its base, with secondary obstruction and ischemia of the adjacent ileum. Division of the band restored perfusion; the bowel remained viable and stapled diverticulectomy was performed without segmental resection. The patient recovered without complications. In most reported cases of Meckel's diverticulum causing small bowel obstruction, the diverticulum or a band arising from it constricts the adjacent bowel. In this case the mechanism is reversed: the diverticulum was the entrapped structure itself, herniating through and strangulating within the orifice of a pre-existing ileo-mesenteric fibrous band. This configuration is exceptionally rare; <b>Conclusions</b>: Meckel's diverticulum should be considered among the possible causes of small bowel obstruction in adults with no history of abdominal surgery. Recognition of this unusual anatomical configuration may facilitate intraoperative identification and appropriate assessment of bowel viability.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}