"An Unusual Case of Bilateral Sudden Mixed Hearing Loss with Complete Remission": A Case Report and Pathophysiological Considerations.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Musat Gabriela Cornelia, Codrut Sarafoleanu, Lucia Radu, Ovidiu Musat, Ionut Tanase
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Abstract

Background: Sudden-onset bilateral mixed hearing loss in adults is an extremely rare condition but challenging to diagnose and treat. Conductive hearing loss is associated with otitis media, while the simultaneous presence of a sensorineural component requires supplementary investigation for possible shared pathophysiological mechanisms. Case Presentation: We report the case of a 41-year-old male who was admitted to our hospital with a 48 h history of bilateral, fast progressive hearing loss following a viral illness. The audiologic testing revealed bilateral severe mixed hearing loss. Tympanometry indicated the presence of middle-ear effusion, and myringotomy confirmed the existence of pressurized serous fluid. Treatment consisted of systemic and intratympanic corticosteroids, antibiotics, and supportive therapy. The patient had an unexpected full recovery of auditory function within one month. Discussion: Multiple hypotheses were considered. We hypothesized the coexistence of unrelated conductive and sensorineural hearing loss or a unifying pathological process. Theories discussed include a direct viral insult to the cochlear structures or even pressure-mediated damage to the basal cochlea due to the simultaneous inward displacement of the oval and round windows. The complete resolution of hearing loss is the indicator of a reversible etiology, possibly due to transient inner ear dysfunction secondary to middle-ear pathology or viral infection. Conclusions: This case illustrates the complexity of diagnosing acute mixed hearing loss. This report emphasizes a rare case of sudden-onset bilateral mixed hearing loss with a complete recovery, contributing valuable insight into under-reported and diagnostically complex presentations.

“一例罕见的双侧突发性混合性听力损失完全缓解”:一例报告和病理生理考虑。
背景:成人突发性双侧混合性听力损失是一种极其罕见的疾病,但诊断和治疗具有挑战性。传导性听力损失与中耳炎有关,而同时存在的感觉神经成分需要对可能的共同病理生理机制进行补充研究。病例介绍:我们报告一例41岁男性病例,他因病毒性疾病后48小时的双侧快速进行性听力损失而入院。听力学检查显示双侧严重混合性听力损失。鼓室测量显示存在中耳积液,鼓膜切开术证实存在加压浆液。治疗包括全身和鼓内皮质类固醇、抗生素和支持治疗。患者在一个月内出人意料地完全恢复了听觉功能。讨论:考虑了多个假设。我们假设不相关的传导性和感音神经性听力损失共存或统一的病理过程。所讨论的理论包括病毒对耳蜗结构的直接损伤,甚至由于椭圆形和圆形耳蜗窗同时向内移位而对基底耳蜗造成压力介导的损伤。听力损失的完全消退是可逆病因的指标,可能是由于中耳病理或病毒感染继发的短暂内耳功能障碍。结论:本病例说明了诊断急性混合性听力损失的复杂性。本报告强调了一个罕见的猝发性双侧混合性听力损失完全恢复的病例,为报告不足和诊断复杂的表现提供了有价值的见解。
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