Reports (MDPI)最新文献

{"title":"Epstein-Barr Virus-Induced Acute Pancreatitis-A Case Report and a Review of Literature.","authors":"Fiza Waseem, Aun Bin Tariq, Nahian Kazi, Muaad Reyad Abdulla, Ahmed H Abdelhafiz","doi":"10.3390/reports9030308","DOIUrl":"10.3390/reports9030308","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Epstein-Barr virus (EBV) is a common infection that rarely causes acute pancreatitis. EBV-associated acute pancreatitis is an uncommon but potentially serious complication that may result from direct viral invasion of pancreatic tissue or immune-mediated inflammation. Because its presentation can overlap with other causes of acute pancreatitis, EBV may be overlooked when common aetiologies are not identified. Recognising EBV as a potential cause is important for accurate diagnosis and appropriate management, particularly in patients presenting with pancreatitis alongside features of acute EBV infection; <b>Case Presentation</b>: We report a case of 58-year-old female with EBV-induced acute pancreatitis. She had a flu like illness two weeks prior to hospital admission, tested positive for EBV IgM antibodies and received supportive treatment by her general practitioner. However, her condition deteriorated, leading to hospital admission. She developed epigastric pain and investigations showed elevated serum lipase, impaired liver function tests and acute kidney injury. CT abdomen showed hepatosplenomegaly, lymphadenopathy and peripancreatic oedema consistent with acute pancreatitis. She was initially treated with antibiotics, however; her condition worsened and she developed severe hypotension requiring intensive care admission. Aggressive fluid resuscitation, inotropic support and continuous veno-venous haemofiltration (CVVH) were required. She gradually improved and subsequently was stepped down to the medical ward for supportive care and rehabilitation. She made full recovery and was discharged home after a 6-week length of stay; <b>Conclusions</b>: EBV-associated acute pancreatitis is an uncommon but potentially severe complication of EBV infection. EBV should be considered in patients with acute pancreatitis when common aetiologies have been excluded, particularly when pancreatitis occurs alongside features of acute viral infection. Early recognition and appropriate supportive management may be important in preventing or limiting severe complications.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descemet Membrane Detachment Presenting as Graft Edema After Arcuate Keratotomy in an Eye with Previous Penetrating Keratoplasty-A Case Report.","authors":"Mohammed M Abusayf, Nada F Alsaif, Razan A Alotaibi","doi":"10.3390/reports9030302","DOIUrl":"10.3390/reports9030302","url":null,"abstract":"<p><p><b>Introduction and Clinical Significance</b>: Descemet membrane detachment (DMD) is an uncommon but potentially vision-threatening complication of anterior segment surgery. Although immune-mediated graft rejection is a recognized cause of postoperative graft edema following arcuate keratotomy (AK) in eyes with previous penetrating keratoplasty (PKP), structural complications such as DMD may present with similar clinical findings and require fundamentally different management. We report a case of DMD initially misdiagnosed as acute graft rejection following manual AK in a post-PKP eye. <b>Case Presentation</b>: A 47-year-old female with a 20-year history of PKP in the right eye (RE) presented with decreased vision three weeks after undergoing manual AK using a diamond blade to correct high astigmatism. The procedure was complicated by an intraoperative wound leak requiring suturing. Postoperatively, she developed corneal edema and was initially misdiagnosed with acute graft rejection. Despite treatment with topical and systemic corticosteroids, her condition did not improve. Upon referral to our clinic, slit-lamp examination and anterior segment optical coherence tomography (AS-OCT) revealed a near-total, nonplanar DMD. The patient underwent a single air descemetopexy session involving three sequential intracameral air injections, resulting in Descemet membrane apposition and improvement in graft clarity. At 3-month follow-up, visual acuity had improved from hand motion to 20/200, with IOP within normal limits. Longer-term follow-up was unavailable. <b>Conclusions</b>: DMD should be considered as a cause of graft edema after AK in post keratoplasty eyes especially in the presence of complications.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imatinib-Associated Interstitial Lung Disease with a Fibrotic NSIP Pattern on Transbronchial Lung Cryobiopsy: A Case Report and Review of the Literature.","authors":"Pier-Valerio Mari, Lorenzo Carriera, Filippo Lococo, Stefano Margaritora, Simone Ielo, Veronica Ojetti, Giulio Onelli, Fabrizio Liberati, Vittorio Pietrangeli","doi":"10.3390/reports9030303","DOIUrl":"10.3390/reports9030303","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Interstitial lung disease (ILD) is an uncommon but potentially serious complication of imatinib. Its histopathological characterization has so far relied on surgical biopsy or transbronchial forceps sampling, and no case characterized by transbronchial lung cryobiopsy (TBLC) has been reported. The single previous description of a non-specific interstitial pneumonia (NSIP) pattern with imatinib came from a surgical specimen and was cellular in type, with complete radiological resolution after withdrawal. <b>Case Presentation</b>: A 69-year-old never-smoker began imatinib 400 mg daily for Philadelphia chromosome-positive chronic myeloid leukemia; chest computed tomography performed immediately beforehand was normal. Approximately three months later, she developed dyspnea, dry cough and a cutaneous rash, progressing to acute respiratory failure with forced vital capacity 49% and diffusing capacity 30% of predicted. Avian exposure had ceased one month before symptom onset, and she had never received amiodarone. Although serum precipitins were unavailable, hypersensitivity pneumonitis was considered less likely given the temporal relationship but could not be definitively excluded. TBLC yielded specimens showing fibrotic thickening of the alveolar septa by hyaline collagen deposition with a focal lymphomonocytic infiltrate, corresponding to a fibrotic NSIP pattern. After drug withdrawal and administration of corticosteroids, forced vital capacity rose to 82% of predicted. Multidisciplinary discussion concluded that this was drug-induced ILD, graded probable on the Naranjo scale. Imatinib was subsequently replaced by bosutinib for insufficient molecular response, without pulmonary recurrence. <b>Conclusions</b>: Imatinib-associated ILD may present with an organizing-pneumonia-like radiological pattern followed by a fibrosing pattern, with cryobiopsy performed later demonstrating fibrotic NSIP. Because no tissue was obtained during the acute phase, this sequence remains a hypothesis rather than a demonstrated evolution. Cryobiopsy can be performed safely when surgical biopsy is not appropriate.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Stepwise Technique for Retrieval of a Seized and Stripped Dental Implant Cover Screw: A Case Report.","authors":"Keisuke Seki, Kenji Ito, Juntaro Sanada, Taiki Akiyama, Yoshiyuki Hagiwara","doi":"10.3390/reports9030304","DOIUrl":"10.3390/reports9030304","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> In two-stage implant treatment the cover screw must be removed at second-stage surgery. Removal is occasionally prevented by cold welding or seizure. When the drive slot is damaged by escalating torque, no standard salvage protocol has been established, and the implant body itself may ultimately require removal. <b>Case Presentation:</b> During second-stage surgery for three implants placed in the mandibular right posterior region (#44, #45, #46) of a 68-year-old man, the cover screw at the #46 site was seized and could not be loosened with a manual screwdriver. An attempt at removal with a contra-angle implant driver, set first to 20 Ncm and then to 35 Ncm, stripped the drive slot. The procedure was suspended, and a revision was performed two weeks later. A tungsten carbide bur was used under water irrigation to prepare a straight slot across the damaged screw head, and a crown remover with a narrowed flat-blade tip was engaged in this slot. The screw was retrieved intact and the internal connection of the implant remained serviceable. A healing abutment was connected and the implant was restored with a definitive prosthesis, which was in function at the most recent review. At seven weeks after delivery, the distance from the implant platform to the crestal bone was greater at #46 than at the two adjacent implants. <b>Conclusions:</b> This report describes a salvage technique that preserved the implant body without the use of a system-specific retrieval kit. The peri-implant bone level observed at the treated site indicates that the procedure may have been accompanied by a loss of crestal bone, and whether the technique is reproducible will require further cases.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Granular Changes on Epipharyngeal Endoscopy and Allergen Sensitization in Chronic Epipharyngitis.","authors":"Manabu Mogitate","doi":"10.3390/reports9030300","DOIUrl":"10.3390/reports9030300","url":null,"abstract":"<p><p><b>Background:</b> Granular changes observed under band-limited epipharyngeal endoscopy are considered a characteristic finding of chronic epipharyngitis; however, their biological significance remains unclear. This study investigated whether granular changes are associated with allergen sensitization and peripheral allergic biomarkers in patients with chronic epipharyngitis. <b>Methods:</b> A retrospective analysis was conducted in 59 patients with chronic epipharyngitis. Granular changes were graded endoscopically as 0 (absent), 1 (mild-to-moderate), or 2 (severe). Nasal eosinophil counts, peripheral blood eosinophil counts, total immunoglobulin E (IgE), mite-specific IgE, house dust-specific IgE, and peripheral blood CD4/CD8 ratios were evaluated. Comparisons among groups were performed using the Kruskal-Wallis and Mann-Whitney U tests, and correlations were assessed using Spearman's rank correlation analysis. <b>Results:</b> Patients with granular changes demonstrated significantly higher mite-specific IgE and house dust-specific IgE levels than those without granular changes. In comparisons between patients without granular changes (grade 0) and those with granular changes (grades 1 and 2), significant differences were observed for mite-specific IgE (<i>p</i> = 0.016) and house dust-specific IgE (<i>p</i> = 0.016). In contrast, nasal eosinophil counts, peripheral blood eosinophil counts, total IgE levels, and CD4/CD8 ratios showed no significant associations with granular changes. Furthermore, Spearman correlation analysis revealed no significant correlations between granular change scores and any evaluated biomarker. <b>Conclusions:</b> Granular changes on epipharyngeal endoscopy were associated with sensitization to mite and house dust allergens but were not associated with peripheral eosinophil counts, total IgE levels, or CD4/CD8 ratios. These findings suggest that the presence of granular changes may be associated with allergen sensitization; however, no association with increasing granular severity was observed. Further studies incorporating local immune profiling and cytokine analyses are warranted to clarify the biological significance of granular changes.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Renal Vein Pseudo-Fenestration.","authors":"Daniel Gondorf, George Triantafyllou, Nikolaos-Achilleas Arkoudis, Georgios Velonakis, Kostis Gyftopoulos, Maria Piagkou","doi":"10.3390/reports9030299","DOIUrl":"10.3390/reports9030299","url":null,"abstract":"<p><p>We describe a rare case of LRV pseudo-fenestration in a 68-year-old female identified on contrast-enhanced multidetector computed tomography. Unlike true fenestration, in which a single vessel splits and reunites, this pseudo-fenestration resulted from the convergence of two distinct hilar venous trunks. Multiplanar and three-dimensional reconstructions demonstrated that the left suprarenal vein drained into the superior limb, whereas the left gonadal vein drained into the inferior limb, reflecting a consistent and anatomically meaningful tributary pattern. This configuration is most plausibly explained by incomplete or asymmetric embryological fusion of the cardinal venous system. Accurate preoperative recognition of this variant is clinically important to reduce the risk of iatrogenic injury during laparoscopic donor nephrectomy, adrenal venous sampling, and other retroperitoneal or endovascular procedures.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged Treatment of Cutaneous Calcinosis with Polylactic Acid Matrix, Negative Pressure Wound Therapy and Skin Grafting: A Case Report.","authors":"Paulina González-Aguilar, Mario Aurelio Martínez-Jiménez, Arturo Ortiz-Álvarez, Jose L Ramirez-Garcialuna","doi":"10.3390/reports9030301","DOIUrl":"10.3390/reports9030301","url":null,"abstract":"<p><p>Background and Clinical Significance: Dystrophic calcinosis cutis involves calcium deposition in damaged or chronically inflamed tissues despite normal calcium and phosphate metabolism. Although typically associated with systemic sclerosis and dermatomyositis, it is rare in rheumatoid arthritis. Ulceration over calcified deposits may impair healing and function. This case highlights a staged reconstructive strategy to remove calcified tissue and achieve definitive wound closure. Case Presentation: A 73-year-old woman with a 22-year history of rheumatoid arthritis presented with painful, partially confluent pretibial ulcerations, purulent drainage, impaired mobility, and extrusion of chalk-like material. Radiographic and histopathological findings supported dystrophic calcinosis cutis. Deep-tissue culture grew <i>Escherichia coli</i>, treated with intravenous ertapenem. Tangential excision of necrotic tissue and accessible calcific deposits resulted in an irregular full-thickness defect extending to the pretibial fascia. A synthetic polylactic acid matrix was applied with single-use negative pressure wound therapy for 14 days, followed by split-thickness skin grafting on day 21. Graft take exceeded 90%, and residual areas epithelialized without regrafting. At 12 months, the wound remained completely epithelialized without recurrent ulceration, with pain resolution and return to baseline activities. Conclusions: In this patient with ulcerated dystrophic calcinosis cutis associated with rheumatoid arthritis, staged reconstruction using surgical excision, a polylactic acid matrix, single-use negative pressure wound therapy, and split-thickness skin grafting facilitated recipient-bed preparation and definitive cutaneous closure of the post-excisional defect. This case supports the feasibility of this sequence for wound reconstruction in selected complex ulcerated lesions. Further studies are needed to define its comparative role.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limb-Sparing Resection with Prophylactic Tibial Fixation and Medial Gastrocnemius Flap Reconstruction for Recurrent Leiomyosarcoma in a Previously Irradiated Leg: A Case Report.","authors":"Georgi P Luchev, Lyubomir Gaydarski, Svetoslav A Slavchev, Ahmed Al-Sadek, Vera Megdanova, Iva N Dimitrova, Georgi P Georgiev","doi":"10.3390/reports9030298","DOIUrl":"10.3390/reports9030298","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Local recurrence of extremity leiomyosarcoma after multiple operations and radiotherapy presents a major therapeutic challenge. Adequate oncologic clearance must be balanced against preservation of skeletal stability and reliable wound coverage within a scarred and poorly vascularized tissue bed; <b>Case presentation</b>: A 78-year-old woman presented with a painful recurrent leiomyosarcoma of the anterior proximal third of the right leg after three previous operations and adjuvant radiotherapy. Preoperative magnetic resonance imaging demonstrated a recurrent soft-tissue lesion extending to the anterior surface of the proximal tibia. Staging computed tomography of the chest, abdomen, and pelvis showed no distant metastatic disease before definitive surgery. A one-stage limb-sparing procedure was performed, including resection of the recurrent tumor bed and an approximately 7-cm anterior cortical lamella of the proximal tibia containing an area considered suspicious for neoplastic involvement. A locking tibial plate was applied prophylactically to reduce the risk of pathological fracture. The approximately 12 × 10-cm soft-tissue defect was covered with a muscle flap from the medial head of the gastrocnemius and a free skin graft harvested from the paraumbilical region. Gross pathological examination identified an 8-cm subcutaneous tumor formation. Histopathological examination demonstrated well-differentiated leiomyosarcoma; the spindle cells expressed vimentin, actin, and desmin. All examined resection lines were free of tumor infiltration. No pathogenic microorganism was isolated, and no early postoperative complication was documented. The patient mobilized with walking aids and protected weight bearing for 30 days. At approximately 16 months, the flap and skin graft provided stable coverage, no postoperative tibial fracture or clinically apparent implant-related complication had occurred, and the patient was independently ambulatory. Postoperative MRI demonstrated expected postoperative changes and a small indeterminate subcutaneous focus without diffusion restriction, requiring continued surveillance; <b>Conclusions</b>: This case illustrates the feasibility of combining oncologic resection, prophylactic tibial stabilization, and vascularized soft-tissue reconstruction in a previously irradiated extremity. The documented early functional and reconstructive outcome supports this individualized limb-sparing approach, although longer oncologic surveillance is required.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data.","authors":"Lisa Lotta Cirkel, Isabel Klein, Karel Kostev","doi":"10.3390/reports9030296","DOIUrl":"10.3390/reports9030296","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care, yet large multicenter data from Germany are limited.</p><p><strong>Methods: </strong>This retrospective multicenter analysis used anonymized inpatient administrative data from 49 German hospitals; eligible oral cavity cancer hospitalizations were contributed by 34 of these hospitals. Adult inpatient hospitalizations (≥18 years) with malignant neoplasms of the oral cavity, defined using ICD-10-GM codes C00-C06, recorded between January 1 2019 and 31 December 2024 were included. The primary outcome was hospital LOS in days. Multimorbidity was quantified using the van Walraven-weighted Elixhauser Comorbidity Score. Prolonged hospitalization was defined as LOS ≥ 7 days and LOS ≥ 14 days. Associations between demographic, clinical, and treatment-related variables and LOS were examined using multivariable Poisson regression models. Because overdispersion was present, a negative binomial mixed model was additionally fitted as a sensitivity analysis. To account for inter-hospital variability, hospital was included as a random intercept in all multivariable models. Associations with prolonged LOS were analyzed using multivariable logistic regression models. All analyses were performed at the hospitalization level.</p><p><strong>Results: </strong>A total of 3957 inpatient hospitalizations for oral cavity cancer were included. Mean age was 65.6 years, and 66.2% of hospitalizations involved male patients. The median LOS was 6 days (interquartile range [IQR] 3-13; mean 10.2 days, standard deviation 11.8). Overall, 49.4% of hospitalizations had an LOS ≥ 7 days and 23.5% had an LOS ≥ 14 days. Older age, particularly >80 years, and higher comorbidity burden were associated with longer LOS (adjusted Poisson rate ratio [RR] for age > 80 years 1.17, 95% CI 1.13-1.21; high comorbidity burden RR 1.58, 95% CI 1.54-1.63). Several treatment-related variables, including surgical procedures in the oral and facial region, lymphatic system operations, blood transfusions, and complex intensive care treatment, were associated with prolonged hospitalization (e.g., blood transfusion RR 1.80, 95% CI 1.76-1.85; complex intensive care RR 1.70, 95% CI 1.65-1.75). Chemotherapy-related hospitalizations were associated with shorter LOS.</p><p><strong>Conclusions: </strong>LOS varied substantially across inpatient hospitalizations for oral cavity cancer in Germany. Older age, higher comorbidity burden, and markers of more complex inpatient treatment were associated with extended hospital stay. These findings may help identify hospitalizations at increased risk of prolonged LOS and inform inpatient planning and resource allocation.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Refractory Hypotension Following Patent Blue V Injection: A Case of Atypical Perioperative Anaphylaxis.","authors":"Francesco Russano, Vittoria Patti, Cinzia Bettin, Massimiliano Caravello, Davide Brugnolo, Paolo Del Fiore","doi":"10.3390/reports9030295","DOIUrl":"10.3390/reports9030295","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Patent Blue V (PBV) is widely used for sentinel lymph node mapping but may rarely cause severe hypersensitivity reactions. These reactions can present atypically, with predominant cardiovascular collapse and minimal cutaneous manifestations, potentially delaying recognition and treatment. <b>Case Presentation</b>: We report the case of a 52-year-old woman who developed sudden and prolonged refractory hypotension shortly after PBV injection during melanoma surgery. The reaction initially occurred in the absence of bronchospasm or early significant cutaneous manifestations. Profound cardiovascular collapse preceded the delayed appearance of erythema and piloerection, making early recognition of perioperative anaphylaxis particularly challenging. Hemodynamic instability required aggressive fluid resuscitation and prolonged vasopressor support. Subsequent diagnostic work-up, including serum tryptase measurement and allergological evaluation, confirmed PBV-induced anaphylaxis. PBV-induced anaphylaxis may present with isolated cardiovascular collapse without typical clinical features. <b>Conclusions</b>: Early recognition and prompt hemodynamic support are essential to optimize outcomes in the perioperative setting.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}