Reports (MDPI)最新文献

{"title":"Extensive Cholesteatoma Compromising the Entire Ipsilateral Skull Base: Excision Through a Multi-Corridor Surgical Technique.","authors":"Lyubomir Rangachev, Julian Rangachev, Tzvetomir Marinov, Sylvia Skelina, Todor M Popov","doi":"10.3390/reports8030148","DOIUrl":"10.3390/reports8030148","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Petrous bone cholesteatoma is a rare and complex condition that poses significant challenges in terms of its diagnosis and treatment. This benign yet locally aggressive lesion can cause extensive destruction of the surrounding structures, potentially leading to serious complications. <b>Case Presentation</b>: We present a case of extensive petrous bone cholesteatoma involving nearly the entire skull base. High-resolution CT and MRI were used to assess the extent of the lesion and its relationship with critical neurovascular structures. The cholesteatoma extended from the petrous apex to the clivus, involving the internal auditory canal and Meckel's cave, encasing the internal carotid artery, and compressing the brainstem. The surgical strategy included combined endoscopic transsphenoidal and transclival techniques with a retrolabyrinthine approach. The endoscopic component provided access to the anterior and central skull base regions, whereas the retrolabyrinthine approach allowed us to gain access to the posterior petrous area. Careful dissection was performed to separate the cholesteatoma from the internal carotid artery and the brainstem. Neuromonitoring was performed throughout the procedure to ensure cranial nerve integrity. This combined approach enabled gross total resection, and postoperative imaging confirmed successful tumor removal. The patient's recovery was uneventful, and no new neurological deficits were observed. <b>Conclusions</b>: The successful management of this complex case demonstrates the efficacy and safety of combining endoscopic surgical approaches for extensive skull base cholesteatomas. This multi-corridor approach allows for maximal tumor resection while also minimizing the risks to critical neurovascular structures.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methamphetamine-Associated Corneal Ulcer: Case Report.","authors":"Amy Conner, Brian K Foutch","doi":"10.3390/reports8030147","DOIUrl":"10.3390/reports8030147","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> This case report highlights the rare but potentially sight-threatening presentation of corneal ulcers associated with methamphetamine abuse. Identifying the signs of illicit drug use is critical, as ocular complications may be overlooked without proper social history or lab confirmation. <b>Case Presentation:</b> A 48-year-old Hispanic male presented with progressive bilateral vision loss over four weeks, describing his condition as \"blind vision.\" Two weeks earlier, he had visited the emergency room after a fall caused by impaired vision and was prescribed insulin, metronidazole, and fluoroquinolone drops. At ophthalmology follow-up, visual acuity was 20/400 OD and 20/800 OS. Examination revealed bilateral stromal corneal ulcers with infiltrates. Notable systemic signs-pockmarks, poor dentition, thin body habitus, and jittery behavior-raised suspicion for methamphetamine use. He was treated with bandage contact lenses, dehydrated amniotic membranes, and a steroid-antibiotic combination drop. <b>Conclusions:</b> This case underscores the importance of recognizing physical signs of methamphetamine abuse, even in the absence of disclosed history. Emergency room laboratory testing confirmed methamphetamine use. Awareness of drug-induced ocular effects allows for appropriate patient education, timely intervention, and referral to addiction services. Patients should be warned that continued drug use may result in irreversible vision loss.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Management of Hydroxyquinoline Hypersensitivity in Pessary Care: A Case-Based Approach to Tailored Treatment.","authors":"Nadege Assassi, Lindsay Robinson, Cathy Zhang, Jill Maura Rabin","doi":"10.3390/reports8030145","DOIUrl":"10.3390/reports8030145","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Many women use pessaries to manage their symptoms of pelvic organ prolapse. Hydroxyquinoline is the active ingredient in gels and ointments that are often used to lubricate a pessary prior to vaginal insertion and to provide antimicrobial effects while the pessary is in situ. <b>Case Presentation</b>: A 74-year-old woman with multiple medication allergies develops vulvovaginal erythema and pruritus after increasing vaginal Trimo-San application frequency for pessary care and maintenance. These symptoms are deemed to be consistent with an allergic reaction to hydroxyquinoline, the active ingredient in Trimo-San. <b>Conclusions</b>: This report highlights the importance of personalized treatment in pessary management. It also demonstrates how personalized medicine can optimize outcomes and improve treatment adherence among individuals with complex medical histories.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Tissue Mosaicism in 45,X0/46,XY: Diagnostic Complexity in a Newborn with Ambiguous Genitalia.","authors":"Mariola Krzyścin, Agnieszka Brodowska, Dominika Pietrzyk, Katarzyna Zając, Elżbieta Sowińska-Przepiera","doi":"10.3390/reports8030146","DOIUrl":"10.3390/reports8030146","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: The 45,X0/46,XY mosaic karyotype is categorized as a disorder of sex development and can lead to atypical sexual development. Latent mosaicism involving Y chromosomal segments may be much more prevalent than previously assumed, according to a growing number of findings. This primarily depends on how sensitive cytogenetic methods are-such as traditional karyotype screening, FISH methods, or molecular analyses. <b>Case Presentation</b>: We present the case of a 10-week-old infant with hermaphroditic external genitalia. During pregnancy, ultrasonography revealed severe fetal development difficulties, including severe widespread edema. An abnormal 45,X0/46,XY mosaic karyotype was discovered during a genetic amniocentesis conducted during the 16th week of pregnancy. The infant was born in average general condition at 39 + 6 weeks of gestation. Physical examination of the infant revealed features of facial dysmorphia, webbed neck, and hermaphroditic external genitalia. The testicle was palpable on the left side, but the gonad was absent on the right. Laboratory tests revealed a typical hormonal profile of the mini-puberty period in boys. Moreover, a hormone panel and thyroid ultrasound were performed; congenital hypothyroidism was diagnosed. Three separate independent sources of biological material were used in cytogenetic analysis to determine the karyotype: skin fibroblasts (to confirm tissue mosaicism), oral epithelial cells (FISH), and peripheral blood lymphocytes. It showed that a mosaic occurred very early in embryogenesis by confirming the existence of karyotypes 45,X and 46,XY in various tissues (mosaic tissue distribution). <b>Conclusions</b>: Tissue mosaicism should be compared to the analysis of tissues from other embryonic origins, including blood and oral tissue. Support for gender identity and treatment decisions, including the prediction of the future risk of gonadoblastoma, as well as multidisciplinary care, is necessary.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Fertility Management After Pituitary Adenoma Surgery: Lessons from a Rural Japanese Case and Practical Review.","authors":"Daisuke Numahata, Kosuke Kojo, San-E Ishikawa, Takumi Kuramae, Ayumi Nakazono, Kaoru Yanagida, Hiroyuki Nishiyama, Tatsuya Takayama","doi":"10.3390/reports8030144","DOIUrl":"10.3390/reports8030144","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Pituitary adenomas, also termed pituitary neuroendocrine tumors, pose a significant risk of hypogonadotropic hypogonadism (HH) after surgical resection, with profound consequences for fertility and sexual function in young patients. <b>Case Presentation:</b> We present the case of a 29-year-old man from rural Japan who developed severe HH and azoospermia following two transsphenoidal resections for a large pituitary adenoma. Despite early engagement with neurosurgery teams, fertility management was delayed by the absence of on-site endocrinology expertise and limited local oncofertility resources. After comprehensive endocrine evaluation and counseling, the patient began combined human chorionic gonadotropin and recombinant follicle-stimulating hormone therapy, resulting in full recovery of sexual function and normalization of semen parameters, ultimately leading to spontaneous conception and the birth of a healthy child. Building on this real-world case, we provide a narrative review of current practical management strategies for HH after pituitary surgery, including the utility of hormone-stimulation tests, Japanese guideline-based subsidy systems, and best-practice approaches to hormonal replacement. <b>Conclusions:</b> This case underscores not only the necessity for early, interdisciplinary collaboration and preoperative counseling but also highlights a rare instance in which a patient with a benign tumor received care that did not address his fertility-related needs, emphasizing that such considerations should be integrated into preoperative counseling even for non-malignant conditions. Strengthening regional oncofertility networks and improving healthcare providers' awareness of fertility-preservation options remain essential for improving outcomes.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum Endometritis and Sepsis Associated with <i>Gardnerella vaginalis</i> and <i>Anaerococcus tetradius</i>: Case Report and Literature Review.","authors":"Justina Martikaitytė, Agnė Bartulevičienė, Virginija Paliulytė, Darius Dasevičius, Diana Ramašauskaitė","doi":"10.3390/reports8030143","DOIUrl":"10.3390/reports8030143","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b><i>Anaerococcus tetradius</i> (<i>A. tetradius</i>) and <i>Gardnerella vaginalis</i> (<i>G. vaginalis</i>) are rare etiological factors for postpartum endometritis and are typically associated with bacterial vaginosis. However, in some cases, <i>G. vaginalis</i> and <i>A. tetradius</i> can cause serious postpartum endometritis with complications such as sepsis. <b>Case Presentation:</b> 26-year-old pregnant woman expecting monochorionic diamniotic twins presented to the hospital at 35 weeks and 3 days of gestation and two male infants were delivered via the Cesarean section. On the fifth day after delivery, the patient began to complain of intense abdominal pain, a fever of 37.9 °C, and overall weakness. Blood tests revealed neutrophilic leukocytosis, increased C-reactive protein (CRP) of 225.4 mg/L. Upon examination, abdominal distension, tenderness on palpation, and positive symptoms of peritoneal irritation were present and the site of the abdominal incision was inflamed with flowing foul-smelling greenish pus. Ultrasound examination revealed free fluid collection in the peritoneal cavity, under the liver, and around the uterus. Later, the condition of the patient worsened with progressing hypotension and respiratory distress. As a result, suppurative peritonitis and sepsis was suspected and the patient underwent urgent total hysterectomy without oophorectomy. Acute endometritis, focal myometritis, and chronic cervicitis were concluded from histopathological examination of the removed uterus. Microbiological tests showed the most abundant growth of <i>A. tetradius</i> in the wound cultures and great abundance of <i>G. vaginalis</i> in the abdominal cavity cultures. After trying three different treatment schemes and difficulties with determining the antibiotic sensitivity tests for pathogens, the antibacterial therapy was escalated to Meropenem, which was found to be effective, and the patient was discharged home. <b>Conclusions:</b> This case report highlights the severity of complications of postpartum endometritis that can be caused by rare pathogens (such as <i>G. vaginalis</i> and <i>A. tetradius</i>), and strategies for how to manage it. The clinical presentation of a patient should be monitored closely for several days after Cesarean section and if endometritis is suspected, microbiological cultures are necessary to determine the cause of infection and implement an appropriate treatment.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Membranoproliferative Glomerulonephritis: Is the Role of Vaccination in Immune Reactivation a Casual or Causal Effect?","authors":"Celia Rodríguez Tudero, Alberto Martín Arribas, Marco Dominguez Davalos, Elena Jiménez Mayor, José Carlos De La Flor","doi":"10.3390/reports8030141","DOIUrl":"10.3390/reports8030141","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Membranoproliferative glomerulonephritis (MPGN) is a rare and heterogeneous pattern of immune-mediated glomerular injury, often associated with infections, autoimmune disorders, or monoclonal gammopathies. Idiopathic cases remain a diagnostic challenge and frequently require empirical immunosuppressive treatment. There is increasing interest in environmental triggers that may activate the immune system in genetically or immunologically predisposed individuals. We report an unusual case of idiopathic immune complex-mediated MPGN with a relapsing course potentially associated with vaccine-induced immune reactivation. <b>Case Presentation:</b> A 35-year-old male with no significant medical history aside from untreated dyslipidemia and active smoking presented with a hypertensive emergency and acute kidney injury (AKI). Laboratory investigations revealed nephrotic-range proteinuria, microscopic hematuria, and reduced estimated glomerular filtration rate (eGFR). Kidney biopsy demonstrated type I immune complex-mediated MPGN with a diffuse endocapillary proliferative pattern and granular subendothelial deposits (IgG+++, C3+++, C1q++). An extensive work-up ruled out secondary causes, supporting a diagnosis of idiopathic MPGN. Immunosuppressive therapy with corticosteroids and mycophenolate mofetil led to a partial clinical response. However, after receiving multiple vaccinations, the patient experienced clinical deterioration. A second biopsy revealed persistent proliferative changes and new deposits of IgM++, C4d++, and both kappa and lambda light chains. This prompted a reintroduction of immunosuppressive therapy, which resulted in subsequent clinical improvement. <b>Conclusions:</b> This case supports the hypothesis that vaccine-induced immune reactivation may serve as a potential trigger for disease relapse in idiopathic MPGN. Clinicians should remain alert to environmental stimuli that may influence disease activity in immune-mediated glomerulopathies. Further research is needed to elucidate the underlying immunopathogenic mechanisms.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiologic and Pathologic Insights in Combined Hepatocellular-Cholangiocarcinoma: A Report of Three Cases.","authors":"Katrīna Marija Konošenoka, Nauris Zdanovskis, Aina Kratovska, Artūrs Šilovs, Veronika Zaiceva","doi":"10.3390/reports8030142","DOIUrl":"10.3390/reports8030142","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare primary liver malignancy exhibiting both hepatocellular and cholangiocellular features. Due to overlapping clinical, imaging, and pathological characteristics with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCC), diagnosis remains challenging. Early and accurate differentiation is critical for optimal treatment planning. <b>Case Presentation</b>: We report three histologically confirmed cases of cHCC-CC with different imaging features, biomarker profiles, treatment strategies, and clinical outcomes. Patient 1, a 69-year-old female, presented with a large centrally located liver mass exhibiting iCC-like imaging features and mildly elevated AFP and CA 19-9 levels. Biopsy confirmed poorly differentiated cHCC-CC. Treatment involved palliative chemotherapy, with a survival of 16 months following diagnosis. Patient 2, an 80-year-old female with a small lesion in a cirrhotic liver, demonstrated an HCC-like enhancement pattern but normal AFP levels. Surgical resection was performed, and histology confirmed cHCC-CC with a dual phenotype. Despite initial remission, intrahepatic recurrence developed, treated with TACE and systemic therapy. The patient later transitioned to palliative care due to progression and survived 36 months. Patient 3, a 67-year-old male with chronic hepatitis C, presented with an HCC-like lesion and elevated AFP. Due to comorbidities, surgical resection was not feasible, and the patient was treated with percutaneous microwave ablation as a safer alternative. Biopsy during ablation confirmed cHCC-CC; follow-up was ongoing at submission. <b>Conclusions</b>: These cases highlight the diagnostic complexity and clinical variability of cHCC-CC. Imaging may be misleading, and tumor markers do not reliably predict subtype or prognosis. Histological confirmation is essential, particularly in patients with atypical imaging or discordant biomarker profiles. Individualized management, informed by tumor biology and patient condition, remains critical. Further research is needed to refine diagnostic criteria and develop tailored therapeutic strategies for this challenging tumor entity.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Servo-Ventilation for Central Sleep Apnea in an Anemic Patient with Cardiac Disease: A Case Report.","authors":"Bianca Domokos-Gergely, Gabriel-Flaviu Brișan, Doina Todea","doi":"10.3390/reports8030140","DOIUrl":"10.3390/reports8030140","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Obstructive sleep apnea (OSA) is a common comorbidity in patients with cardiac and metabolic disorders. The coexistence of central sleep apnea with Cheyne-Stokes breathing (CSA-CSB) in heart failure patients, especially those with preserved ejection fraction (HFpEF), represents a diagnostic and therapeutic challenge. Data on continuous positive airway pressure (CPAP) failure and successful adaptation to servo-ventilation (ASV) in the context of complex comorbidities remain limited. <b>Case Presentation</b>: We present the case of a 74-year-old male with a history of type 2 diabetes mellitus, paroxysmal atrial fibrillation, HFpEF, essential hypertension, and bladder carcinoma. He was referred for pre-operative OSA screening, reporting excessive daytime sleepiness, insomnia, and witnessed apneas. Initial respiratory polygraphy revealed severe sleep-disordered breathing with dominant CSA-CSB and moderate OSA. Laboratory investigations also revealed severe iron-deficiency anemia, which was managed with parenteral iron supplementation. The patient underwent CPAP titration, which led to modest improvement and residual high apnea-hypopnea index (AHI). After persistent symptoms and an inadequate CPAP response, an ASV device was initiated with significant clinical and respiratory improvement, demonstrating normalization of hypoxic burden and optimal adherence. <b>Conclusions</b>: CSA-CSB in HFpEF patients with anemia poses unique therapeutic difficulties. This case highlights the importance of individualized diagnostic and therapeutic strategies, including transitioning to ASV in CPAP-refractory cases, which can lead to improved adherence, reduced hypoxia, and better overall outcomes in high-risk patients.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteonevus of Nanta-A Rare Case Report of a Cellular Blue Nevus with Ossification.","authors":"Camilla Soendergaard Kristiansen, Anna Louise Norling, Birgitte Bols, Christian Lyngsaa Lang","doi":"10.3390/reports8030139","DOIUrl":"10.3390/reports8030139","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Osteonevus of Nanta is a rare histological phenomenon characterized by bone formation within a benign melanocytic nevus, most commonly in intradermal nevi of the head and neck. Although osteonevus of Nanta is rare, ossification in a cellular blue nevus is even more uncommon. To date, only one case of a cellular blue nevus with ossification has been documented. This case report adds to the limited literature and emphasizes the clinical importance of recognizing this rare phenomenon, as osteonevus of Nanta has been potentially associated with malignant melanoma. <b>Case Presentation</b>: A 72-year-old woman presented with an asymptomatic, pigmented scalp lesion that had recently increased in size. On clinical examination, the tumor appeared as a well-demarcated, firm, and nodular mass with dark blueish to violet pigmentation that measured 15 × 12 × 7 mm. To ensure a definitive diagnosis and rule out malignancy, the lesion was excised with narrow margins. Histological examination revealed a cellular blue nevus with prominent osseous metaplasia. Due to the absence of clear margins, a wider re-excision was performed. No residual tumor was found, and the patient remained asymptomatic with no recurrence. <b>Conclusions</b>: This case represents only the second published example of a cellular blue nevus with ossification. While osteonevus of Nanta is benign, its potential association with malignant melanoma, as well as its clinical resemblance to malignant entities such as nodular melanoma, malignant blue nevus, and pigmented basal cell carcinoma, underscores the need for thorough clinical and histopathologic evaluation.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"8 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}