Reports (MDPI)最新文献_第4页

A Unique Case of Foreign Body Acquired by Stabbing and Retained for 7 Years in the Sigmoid Colon 乙状结肠刺入异物并保留7年的独特病例

Reports (MDPI) Pub Date : 2023-05-24 DOI: 10.3390/reports6020024

Iulia Cristina Pîrvulescu, Alfred Najm, Eduard Cristian Popa, A. Chiotoroiu, S. Crețoiu, B. Gașpar

{"title":"A Unique Case of Foreign Body Acquired by Stabbing and Retained for 7 Years in the Sigmoid Colon","authors":"Iulia Cristina Pîrvulescu, Alfred Najm, Eduard Cristian Popa, A. Chiotoroiu, S. Crețoiu, B. Gașpar","doi":"10.3390/reports6020024","DOIUrl":"https://doi.org/10.3390/reports6020024","url":null,"abstract":"The ingestion of foreign bodies is a common cause for presentation in the emergency department by pediatric, adult, or elderly psychiatric patients. Swallowed foreign bodies sometimes represent a great challenge for surgeons due to the obstruction or perforation of the digestive tube’s upper or lower segments. Occasionally, the foreign bodies detected in the lower parts of the digestive tube (colon and rectum) could be introduced through the anal route with the risk of perforation of the rectum or sigmoid colon. In this report, we describe a unique case of a foreign body located in the sigmoid colon, where it arrived due to backstabbing and was retained for 7 years without acute symptoms. The 43-year-old male patient came to the emergency department with pain in the left iliac fossa. Before his presentation, a computerized tomography (CT) scan examination had suggested a foreign body. A surgical approach was decided. The surgery started as an exploratory laparoscopy and was converted to a xiphoid-pubic incision to extract the foreign body (a piece of glass about 8 cm long) through a sigmoid colotomy followed by a double-layer sigmoidorrhaphy. The postoperative evolution of the patient was uneventful. As far as we know, this is the first case of a patient with a foreign glass body positioned in the sigmoid colon that got there by stabbing and not by ingestion or introduced per anum. In conclusion, we suggest that aggressive behavior and abdominal wall penetration by different sharp objects should be considered when foreign bodies are detected in the abdomen.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43056163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rescue of Low-Yield DNA Samples for Next-Generation Sequencing Using Vacuum Centrifugal Concentration in a Clinical Workflow 在临床工作流程中使用真空离心浓缩拯救低产量DNA样品用于下一代测序

Reports (MDPI) Pub Date : 2023-05-23 DOI: 10.3390/reports6020023

L. K. Vestergaard, Nicolai S. Mikkelsen, Douglas N P Oliveira, T. Poulsen, E. Hoegdall

{"title":"Rescue of Low-Yield DNA Samples for Next-Generation Sequencing Using Vacuum Centrifugal Concentration in a Clinical Workflow","authors":"L. K. Vestergaard, Nicolai S. Mikkelsen, Douglas N P Oliveira, T. Poulsen, E. Hoegdall","doi":"10.3390/reports6020023","DOIUrl":"https://doi.org/10.3390/reports6020023","url":null,"abstract":"The implementation of next-generation sequencing (NGS) in clinical oncology has enabled the analysis of multiple cancer-associated genes for diagnostics and treatment purposes. The detection of pathogenic and likely pathogenic mutations is crucial to manage the disease. Obtaining the mutational profile may be challenging in samples with low yields of DNA—reflected by the type of biological material, such as formalin-fixed paraffin-embedded tissue (FFPE), needle biopsies, and circulating free/tumor DNA, as well as a sparse tumor content. Moreover, standardized strict procedures for the extraction of DNA in a clinical setting might contribute to lower amounts of DNA per µL. The detection of variants in low-yield DNA samples remains a challenge in clinical diagnostics, where molecular analyses such as NGS are needed. Here, we performed vacuum centrifugation on DNA extracted from five FFPE tissue blocks, with concentrations below 0.2 ng/µL. Through NGS analysis, we found that low-yield DNA samples could be concentrated to sufficient levels, without compromising the mutational profile.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46471072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of a Combination of Medical Cannabis, Melatonin, and Oxygen–Ozone Therapy on Glioblastoma Multiforme: A Case Report 医用大麻、褪黑素和氧-臭氧联合治疗多发性胶质母细胞瘤的疗效：一例报告

Reports (MDPI) Pub Date : 2023-05-05 DOI: 10.3390/reports6020022

Marina Antonini, Cristina Aguzzi, A. Fanelli, A. Frassineti, Laura Zeppa, M. Morelli, G. Pastore, M. Nabissi, Margherita Luongo

{"title":"The Effects of a Combination of Medical Cannabis, Melatonin, and Oxygen–Ozone Therapy on Glioblastoma Multiforme: A Case Report","authors":"Marina Antonini, Cristina Aguzzi, A. Fanelli, A. Frassineti, Laura Zeppa, M. Morelli, G. Pastore, M. Nabissi, Margherita Luongo","doi":"10.3390/reports6020022","DOIUrl":"https://doi.org/10.3390/reports6020022","url":null,"abstract":"Glioblastoma is the most aggressive malignant tumor overall and remains an incurable neoplasm with a median survival of 15 months. Since 2005, the gold standard treatment for glioblastoma has remained unchanged, and it is a common goal of the scientific community to work towards a better prognosis and improved survival for glioblastoma patients. Herein, we report a case of glioblastoma multiforme in a patient with a poor prognosis who, following partial removal of the neoplasm, refused conventional therapy consisting of a combination of radiotherapy and temozolomide-based chemotherapy due to personal serious side effects. The patient started an unconventional therapeutic path by alternating periods of oxygen–ozone therapy with concomitant administration of legal medical cannabis products (Bedrocan and Bedrolite) and melatonin. This approach resulted in a complete and durable remission of the disease and long survival. Indeed, the patient is still alive. The exceptional result obtained here encourages us to share and carefully investigate this unconventional treatment as a possible future direction in the management of glioblastoma.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48905461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality Functioning in Current Epilepsy Patients and People Recovered from Epilepsy 当前癫痫患者和癫痫恢复期患者的人格功能

Reports (MDPI) Pub Date : 2023-05-01 DOI: 10.3390/reports6020021

Weixi Kang, Antonio Malvaso

引用次数: 0

Intersectional Differences in Health Care Outcomes among Patients with Musculoskeletal Disorders in Germany 德国肌肉骨骼疾病患者医疗保健结果的交叉差异

Reports (MDPI) Pub Date : 2023-04-29 DOI: 10.3390/reports6020020

P. Brzoska, Kübra Annac, Y. Yılmaz-Aslan

{"title":"Intersectional Differences in Health Care Outcomes among Patients with Musculoskeletal Disorders in Germany","authors":"P. Brzoska, Kübra Annac, Y. Yılmaz-Aslan","doi":"10.3390/reports6020020","DOIUrl":"https://doi.org/10.3390/reports6020020","url":null,"abstract":"In all regions of the world, musculoskeletal disorders are a significant contributor to the burden of chronic illnesses. The effectiveness of treatments, such as rehabilitation, may vary intersectionally across demographic and other categories. The present study examines this intersectionality with respect to a lack of improvement in health conditions after rehabilitation of patients in Germany. Routine data from 298,617 patients aged 18–65 years residing in Germany who received rehabilitation because of arthropathies, dorsopathies, or soft tissue disorders during 2006–2016 were included in the analysis. Odds of the outcome were compared across demographic groups and across diagnostic sub-groups by means of multivariable logistic regression. Interaction terms were included to examine intersectional differences across these groups and over time. Women were more likely than men to have an impairment despite treatment (adjusted odds ratio [aOR] = 1.11; 95%-CI = 1.08, 1.13). In addition, patients in semi-skilled/unskilled employment were at higher odds of a poor outcome compared to patients in skilled positions (aOR = 1.13; 95%-CI = 1.10–1.17). Nationality also affected health care outcomes, with Turkish nationals and nationals from a Yugoslav successor state having higher odds of a poor outcome than Germans (aOR = 1.56; 95%-CI = 1.45–1.67 and aOR = 1.52; 95%-CI = 1.41–1.65, respectively). The findings highlight the importance of an intersectional perspective in health research and practice and can support the development of strategies and measures that aim to reduce disparities in health care.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47942286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Sarcoid-Lymphoma Syndrome with Various Etiological Factors 多种病因的肉瘤样淋巴瘤综合征1例

Reports (MDPI) Pub Date : 2023-04-23 DOI: 10.3390/reports6020019

Kazuki Furuyama, M. Tsukita, Y. Shirato, Yusaku Sasaki, Y. Ashino, Toshio Hattori

{"title":"A Case of Sarcoid-Lymphoma Syndrome with Various Etiological Factors","authors":"Kazuki Furuyama, M. Tsukita, Y. Shirato, Yusaku Sasaki, Y. Ashino, Toshio Hattori","doi":"10.3390/reports6020019","DOIUrl":"https://doi.org/10.3390/reports6020019","url":null,"abstract":"A 75-year-old female with a history of stomach cancer and depression was referred to our hospital for left cervical lymphadenopathy. The biopsy of her left cervical lymph node revealed noncaseating granulomas with multinucleated giant cells. The positron emission tomography/computed tomography (PET/CT) indicated general lymphadenopathy (left supraclavicular left axillary, hepatic lymph nodes), except for the hilar lymph node. Both histology by transbronchial lung biopsy (TBLB) and analysis of broncho alveolar lavage fluid (BALF) were indicative of sarcoidosis. C-reactive protein (CRP) and soluble interleukin-2 receptor (sIL-2R) were increased in the sera. An alternative cause of granulomatous disease was ruled out, and on follow-up, she was diagnosed with sarcoidosis. Two years later, she was hospitalized for fever, anorexia, lymph node tenderness, and erythema nodosum with significant increases in CRP and sIL-2R. After admission, the repetitive axillary lymph biopsy showed the same histological findings as before, but the G-band staining showed clonal abnormalities. Bone marrow biopsy revealed abnormal lymphocytes with petal-like nuclei. Finally, she was diagnosed with malignant lymphoma infiltrating the bone marrow. After CHOP-based chemotherapy, her laboratory data, lymphadenopathy, and clinical findings improved, and she was discharged from the hospital on the 90th day. Careful medical treatment, including genetic analysis of the lymph node, is necessary in patients with sarcoidosis if lymphadenopathy is predominant.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42202858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer Pembrolizumab致单纯性促肾上腺皮质激素缺乏继发性肾上腺功能不全：两例癌症的报告

Reports (MDPI) Pub Date : 2023-04-17 DOI: 10.3390/reports6020018

I. Onoyama, Minoru Kawakami, Kazuhisa Hachisuga, Shoji Maenohara, Keisuke Kodama, H. Yagi, M. Yasunaga, T. Ohgami, K. Asanoma, H. Yahata, Yuya Kitamura, R. Sakamoto, Daisuke Kiyozawa, Kiyoko Kato

{"title":"Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer","authors":"I. Onoyama, Minoru Kawakami, Kazuhisa Hachisuga, Shoji Maenohara, Keisuke Kodama, H. Yagi, M. Yasunaga, T. Ohgami, K. Asanoma, H. Yahata, Yuya Kitamura, R. Sakamoto, Daisuke Kiyozawa, Kiyoko Kato","doi":"10.3390/reports6020018","DOIUrl":"https://doi.org/10.3390/reports6020018","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) enhance antitumoral immune mechanisms and are used to treat various types of solid tumors including those that are microsatellite instability (MSI)-high. Uterine endometrial cancer is one of the most frequent tumor types that shows MSI-high, and, consequently, opportunities to use ICIs for endometrial cancer treatment are increasing. While using ICIs, it is important to monitor and manage various immune-related adverse events (irAEs). Here, we report two cases of secondary adrenal insufficiency during treatment of endometrial cancer with pembrolizumab. Both cases showed appetite loss and general fatigue after the 6th or 12th cycle of pembrolizumab. They were admitted to our hospital because of remarkable hyponatremia. Both cases showed no adrenocorticotropic hormone (ACTH) or cortisol response to CRH loading tests. Other pituitary hormone levels were normal, and MRI revealed no sign of hypophysitis in either patient. They were diagnosed with secondary adrenal insufficiency due to isolated ACTH deficiency and recovered soon after the administration of hydrocortisone and hydration. Thus, we should be aware of irAEs with the use of ICIs. In particular, adrenocortical insufficiency is sometimes lethal without appropriate treatment. Because the clinical symptoms are fatigue, appetite loss, and nausea, patients might be misjudged to have symptoms related to cancer. Checking serum morning cortisol before ICIs use and monitoring serum sodium levels could provide clues to diagnose secondary adrenal insufficiency.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infarcted Wandering Spleen: Case Report from Tirunesh Beijing General Hospital, Addis Ababa, Ethiopia 游离脾梗死:埃塞俄比亚首都亚的斯亚贝巴蒂鲁内什北京总医院1例报告

Reports (MDPI) Pub Date : 2023-04-15 DOI: 10.11648/j.reports.20230301.12

Mengistu Solomon Sefu, YabsiraMichael Tsegaye, Michael Berega Sibhat

引用次数: 0

A Bridge to Nowhere: Enabling Autonomy in a Case of Failed ECMO Rescue of Bleomycin-Induced Pulmonary Toxicity 通往虚无的桥梁:在一例失败的ECMO抢救博莱霉素引起的肺毒性中实现自主

Reports (MDPI) Pub Date : 2023-03-20 DOI: 10.3390/reports6010017

JamesS. Hall, M. Khilkin, S. Murphy, G. Botros

引用次数: 0

Long-Term Outcome and Quality of Life in Patients Treated for Head and Neck Sarcoma during Pediatric Age: Considerations from a Series of 4 Cases 儿童时期头颈部肉瘤患者的长期预后和生活质量:来自一系列4例病例的考虑

Reports (MDPI) Pub Date : 2023-03-17 DOI: 10.3390/reports6010016

Martina Buchignani, Arrigo Pellacani, Sara Negrello, M. Di Bartolomeo, M. Cellini, Alessia Pancaldi, Alessandra Buttafoco, C. Migliozzi, L. Iughetti, L. Chiarini, A. Anesi

{"title":"Long-Term Outcome and Quality of Life in Patients Treated for Head and Neck Sarcoma during Pediatric Age: Considerations from a Series of 4 Cases","authors":"Martina Buchignani, Arrigo Pellacani, Sara Negrello, M. Di Bartolomeo, M. Cellini, Alessia Pancaldi, Alessandra Buttafoco, C. Migliozzi, L. Iughetti, L. Chiarini, A. Anesi","doi":"10.3390/reports6010016","DOIUrl":"https://doi.org/10.3390/reports6010016","url":null,"abstract":"Pediatric sarcomas are rare malignancies accounting for about 10% of solid tumors in childhood. Sarcomas represent a heterogeneous group of malignancies, especially they include Rhabdomyosarcoma (RMS) and Non-Rhabdomyosarcoma Type Sarcomas (STSNR). Therapeutic management of pediatric sarcomas is challenging. Multidisciplinary approach including chemotherapy, surgery and radiotherapy is the treatment of choice. The correct management of affected patients can be demanding, especially in terms of preserving a good quality of life (QoL). In the present study we described our experience with a series of patients diagnosed with head and neck non-metastatic sarcoma between January 1995 and December 2020, referred to Pediatric Oncology or to Maxillo-Facial Surgery of University Hospital of Modena and Reggio Emilia.The survivors were asked to complete questionnaires on health-related quality of life (HRQoL; PedsQL and EORTC QLQ-H&N 43). We found satisfactory results in terms of global HRQoL; although outstanding issues persist, such as deterioration in masticatory function, and speech. Long-term sequelae of multimodality treatment may lead to both significant aesthetic-functional and psychosocial implications that need to be further investigate during the whole the care pathway.","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42584286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0