Journal of Nanoparticle Research最新文献

{"title":"Hippocampal biochemical, histological alterations, and pain modulation induced by zinc oxide nanoparticles: a review from animal studies","authors":"Mozhgan Torabi,&nbsp;Sina Taghvimi,&nbsp;Feryal Savari,&nbsp;Azam Karimi","doi":"10.1007/s11051-025-06394-z","DOIUrl":"10.1007/s11051-025-06394-z","url":null,"abstract":"<div><p>Pain is a complex physiological process that can affect quality of life if it becomes chronic. Additionally, conventional analgesic drugs have long-term side effects. Recently, nanotechnology has been applied to the diagnosis and treatment of various diseases, and nanotechnology-based drug delivery has provided promising results in pain management. Zinc oxide nanoparticles (ZnO NPs) have gained attention in biomedical fields due to their unique physicochemical properties, which enhance their interaction with biological system. Currently, researchers have focused on the optimization and modification of ZnO NPs for medical usage. These nanoparticles can cross the blood–brain barrier and influence both histological and biochemical parameters of the nervous system. Several animal studies have evaluated their effects on pain perception, particularly focusing on brain regions like the hippocampus. ZnO NPs at low doses and in the acute phase have been reported to exert analgesic effects without causing neurotoxicity. Also, the effects of ZnO NPs have been studied in neurological behavior in animal’s models. In this review paper, we evaluated the ZnO NPs effects by examining the histological and biochemical alterations in brain tissue, specifically the hippocampus, and their underlying mechanisms related to pain management.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-magnetic sorted CD29 +/CD44 +/CD105 + Bone MSCs alleviate cyclosporine nephrotoxicity and renal fibrosis","authors":"Pingbao Zhang,&nbsp;Cuidi Xu,&nbsp;Xinhao Niu,&nbsp;Yongshen Luo,&nbsp;Jingjing Guo,&nbsp;Xiaoqing Xu,&nbsp;Hao Zen,&nbsp;Lifei Liang,&nbsp;Xiaotian Yan,&nbsp;Jiahen Wu,&nbsp;Ruiming Rong","doi":"10.1007/s11051-025-06388-x","DOIUrl":"10.1007/s11051-025-06388-x","url":null,"abstract":"<div><p>CD29/CD44/CD105-modified immunomagnetic liposomes (CD29/CD44/CD105-IMLs) were developed to isolate bone marrow mesenchymal stem cells (BMSCs) with distinct phenotypes. A key BMSC phenotype capable of alleviating chronic cyclosporine-induced nephropathy was identified through in vivo experiments in mice, demonstrating its potential as an effective adjunctive therapy for mitigating renal fibrosis-induced injury. Four weeks post-transplantation, mice receiving CD29⁺, CD44⁺, and CD105⁺ BMSC groups exhibited improved overall health compared to the control group. Western blot analysis of autophagy-related proteins LC3-II and P62 revealed significantly lower expression levels in the CD44⁺ BMSC group compared to the CD29⁺ and CD105⁺ BMSC groups. In vivo imaging further demonstrated enhanced chemotactic ability of CD44⁺ BMSCs in mice with chronic cyclosporine-induced nephropathy at various time points. These findings suggest that transplantation of CD29⁺/CD44⁺/CD105⁺ BMSCs can delay the progression of renal fibrosis in mice with cyclosporine-induced chronic kidney disease. Notably, CD44⁺ BMSCs exhibited superior efficacy in alleviating renal fibrosis compared to CD29⁺ and CD105⁺ BMSC groups.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06388-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the dispersion of functionalized carbon nanofibers (CNFs) in aqueous solution","authors":"Faping Li,&nbsp;Qing Su,&nbsp;Lisheng Liu","doi":"10.1007/s11051-025-06362-7","DOIUrl":"10.1007/s11051-025-06362-7","url":null,"abstract":"<div><p>Achieving stable and uniform suspensions of multiwalled carbon nanofibers (CNFs) is crucial for their practical applications. This study utilizes an acid treatment to functionalize CNFs, enabling their dispersion in water. Subsequently, a combination of sodium dodecyl sulfate (SDS) as a dispersant and ultrasonic processing is employed to enhance the dispersion of the functionalized CNFs. Techniques such as UV–Vis spectroscopy, surface tension measurements, zeta potential analysis, and adsorption isotherm evaluation are applied to assess the dispersion quality. Furthermore, the underlying dispersion mechanism is investigated through transmission electron microscopy (TEM) imaging. The experiments reveal that the optimal SDS concentration for dispersing functionalized CNFs in water is 0.25 g/L. TEM analysis demonstrates that SDS effectively disrupts the clustering of nanofiber bundles, significantly reducing their thickness. The dispersion process is driven by the interplay of hydrophobic interactions and the barrier effect of SDS molecules, which inhibit the re-aggregation of functionalized CNFs.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of microporous silica nanoparticles as a versatile nanocarrier for 5-fluorouracil delivery in colon cancer chemotherapy","authors":"Changwan Cui,&nbsp;Zhengrong Sun,&nbsp;Yu-Xuan Gao,&nbsp;Qiang Sun","doi":"10.1007/s11051-025-06383-2","DOIUrl":"10.1007/s11051-025-06383-2","url":null,"abstract":"<div><p>Silica (SiO₂) nanoparticles have gained significant attention as drug carriers for cancer chemotherapy due to their high surface area, biocompatibility, ultrahigh length-to-diameter ratio, and efficient cellular uptake. In this study, nanosized SiO₂ with a particle size of approximately 170 nm and a micropore size of 1.6 nm was synthesized as a versatile nanocarrier for loading 5-fluorouracil (5-Fu) for colon cancer chemotherapy. The resulting microporous SiO₂ nanoparticles exhibited a high 5-Fu loading capacity and demonstrated a pH-sensitive drug release profile. The 5-Fu@SiO₂ system showed significantly higher cytotoxicity against LoVo/5-Fu cells (5-Fu-resistant colon cancer cells) compared to free 5-Fu, while bare SiO₂ nanoparticles exhibited minimal cytotoxicity. The mechanism by which 5-Fu@SiO₂ overcomes drug resistance in LoVo/5-Fu cells is attributed to the high intracellular accumulation of 5-Fu and the elevated levels of reactive oxygen species (ROS) induced by the SiO₂ matrix, which enhances the cytotoxic effects of 5-Fu in resistant cancer cells.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the transformative potential of topological nanostructures in advanced pharmaceutical paradigms: an exploration of their complex realm","authors":"Oshik S,&nbsp;Prasiddhi Naik,&nbsp;Kiran Kumar G. B,&nbsp;Chethan Patil,&nbsp;Prakash Goudanavar","doi":"10.1007/s11051-025-06366-3","DOIUrl":"10.1007/s11051-025-06366-3","url":null,"abstract":"<div><p>Topological nanostructures in pharmaceuticals revolutionize drug delivery, immunotherapy, and molecular diagnostics with their molecular precision, spatial self-organization, and bio-functional flexibility. Three-dimensional structural complexity drives bio-interactions with unparalleled sensitivity and control in these intricate systems, which use nanoscale topological restrictions. DNA origami scaffolds, supramolecular clathrochelates, and programmable T-cell engagers enable dynamic, stimuli-responsive drug release, immune modulation, and targeted cellular interfacing. Spatiotemporal nanosystems orchestration, which is about carefully managing and syncing the location and timing of topological nanostructures such as vesicles and nanocages to enable precise and controlled drug delivery in biological systems, improves pharmacokinetic profiles and disrupts medication resistance, immunological clearance, and systemic toxicity. However, structural stability, synthetic scalability, biocompatibility, and regulatory scrutiny hinder these constructions’ translation. Computationally driven molecular topography, bio-orthogonal conjugation methods, where living entities can undergo a selective and efficient family of chemical reactions without interfering with their natural metabolic activities, and adaptive biomimetic frameworks promise transformative therapeutic landscapes as topology, nanotechnology, and pharmaceutical sciences merge. In the context of precision medicine and nano-pharmacology, this discussion aims to decipher the deep effects of topological nanostructures on biomedical innovation by probing their theoretical foundations, practicality for translation, and potential long-term clinical consequences.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-doped ZnS nanoparticles synthesized via single-source precursor: an efficient photocatalyst for dye degradation","authors":"Seema Maheshwari,&nbsp;Kuldeep Kaur,&nbsp;Shikha Bhogal,&nbsp;Ashok Kumar Malik","doi":"10.1007/s11051-025-06368-1","DOIUrl":"10.1007/s11051-025-06368-1","url":null,"abstract":"<div><p>Zinc sulphide nanoparticles (ZnS NPs) with high photocatalytic efficiency, high chemical stability, and resistance to photo-corrosion form promising photocatalysts for the degradation of environmental pollutants like dyes. Doping with transition metals like cobalt (Co) can further improve the photocatalytic efficiency of ZnS NPs by improving light absorption and reducing the recombination rate of photogenerated electron–hole pairs. The decomposition of single-source precursors (SSPs) offers a simple and effective route for obtaining high-quality metal sulphide NPs. In this paper, we explore the synthesis of Co-doped ZnS (Co-ZnS) NPs through the SSP method, offering a novel approach to enhance their photocatalytic properties. The Co-ZnS nanoparticles were prepared via solvothermal decomposition of Zn(II)-L-phenyl alanine dithiocarbamate [Zn-PHEDTC] and Co(II)-L-phenyl alanine dithiocarbamate [Co-PHEDTC] complexes as SSPs in diethylenetriamine (DETA) solvent at 190 °C. The structural, optical, and morphological properties of the synthesized materials were analyzed using UV–Vis spectroscopy, fluorescence spectroscopy, Fourier Transform Infrared Spectroscopy, High-Resolution Transmission Electron Microscopy, and Energy Dispersive X-ray Spectroscopy analysis. The results revealed the formation of NPs of size 3.27 nm with successful doping of Co dopants in the ZnS lattice, altered bandgap, and enhanced light absorption in the visible region. The photocatalytic activity of Co-ZnS NPs was investigated through the degradation of a model pollutant dye, Reactive Blue 81, using visible light irradiation. Co-ZnS was found to achieve a degradation efficiency of 95.98% in 60 min, which was higher than undoped ZnS (92.7% in 90 min). Thus, Co-doping enhanced the degradation efficiency while reducing the degradation time by nearly 33% due to reduced electron–hole recombination and improved charge carrier separation. The present study demonstrates the potential of Co-doped ZnS NPs synthesized through an SSP route as effective photocatalysts for environmental remediation, particularly in the degradation of textile dyes from wastewater. This approach not only overcomes the limitations of conventional water treatment methods but also underscores the environmental and technological benefits of Co-ZnS nanoparticles for sustainable photocatalytic applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145162237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necklace-architected Ag/AgBr/TiO₂ nanofiber composites: dual-mode catalysis for synchronous SERS detection and solar-driven decontamination of RhB/Cr(VI) in wastewater","authors":"Qingtao Chen,&nbsp;Xiangdong Shi,&nbsp;Xianghai Rao,&nbsp;Xiaoyun Qin,&nbsp;Ziyi Zheng,&nbsp;Heyi Ge,&nbsp;Yiying Ling,&nbsp;Jiong Li,&nbsp;Fenghua Chen","doi":"10.1007/s11051-025-06381-4","DOIUrl":"10.1007/s11051-025-06381-4","url":null,"abstract":"<div><p>Integrating photocatalytic degradation and surface-enhanced Raman spectroscopy (SERS) detection into a single nanocomposite platform offers transformative potential for intelligent wastewater treatment. Herein, we engineered necklace-architected Ag/AgBr/TiO₂ nanofiber composites through in situ growth of Ag/AgBr nanoparticles on electrospun porous TiO₂ nanofibers. The unique architecture synergizes dual-phase anatase/rutile alignment, (001)-faceted anatase TiO₂, and plasmonic Ag/AgBr-TiO₂ heterojunctions, achieving 100% RhB degradation in 10 min (vs. 23.3% UV/42.2% Vis) and 93.6% Cr(VI) reduction in 40 min under simulated sunlight, outperforming commercial P25, single-component counterparts, and previously reported TiO₂-based photocatalysts. Notably, this study pioneers the integration of SERS detection with photocatalytic decontamination in a single system, enabling real-time monitoring of RhB and Cr₂O₇²⁻ degradation processes via the plasmonic resonance of Ag/AgBr/TiO₂. The dual-mode “detect-and-treat” functionality leverages the necklace-like morphology for enhanced charge separation, light scattering, and molecular adsorption, establishing a paradigm for intelligent wastewater remediation.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetite nanoparticles doped with rare earth ions: synthesis, structural, and magnetic properties","authors":"A. V. Rutkauskas,&nbsp;O. N. Lis,&nbsp;S. E. Kichanov,&nbsp;E. V. Lukin,&nbsp;B. A. Abdurakhimov,&nbsp;G. S. Rymski,&nbsp;A. L. Zhaludkevich,&nbsp;I. I. Makoed,&nbsp;D. P. Kozlenko,&nbsp;A. Mutali","doi":"10.1007/s11051-025-06379-y","DOIUrl":"10.1007/s11051-025-06379-y","url":null,"abstract":"<div><p>Taking into account the practical significance of magnetite nanoparticles, several nanostructured magnetite samples with doping of 2.5% Sm, Dy, La, and Lu rare earth ions were synthesized using the co-precipitation method. The structural and magnetic properties of the obtained doped nanoparticles were investigated in detail using transmission electron microscopy, X-ray diffraction, small-angle X-ray scattering, and magnetic measurements. All the doped nanostructured magnetite samples have a cubic phase with spinel crystal structure <i>Fd</i> <span>(overline{3 })</span> <i>m</i>; a nanoparticle size is ranging from 20 to 32 nm. Changes in the characteristic Fe–O bond lengths indicated that the doping rare earth ions mainly occupy octahedral sites in the oxygen unit. The size of the nanoparticles depends on the type of doped rare earth due to difference in ionic radius. Neutron diffraction data indicated that the magnetic structure of doped magnetite nanoparticles is ferrimagnetic. The magnetic measurements showed a superparamagnetic state in all the doped magnetite nanoparticles. It is assumed that noticeable changes in the structural and magnetic properties of magnetite nanoparticles compared to bulk matter are primarily associated with a defect-rich structure on the surface of those nanoparticles and the effect of rare earth ions doping on it.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Enhancing magnetomechanical anticancer therapy: impact of nanoparticle aggregation","authors":"Artem A. Pianykh,&nbsp;Ivan L. Isaev,&nbsp;Sergey V. Komogortsev,&nbsp;Polina N. Semina,&nbsp;Artem S. Kostyukov,&nbsp;Daniil E. Khrennikov,&nbsp;Vladimir A. Felk,&nbsp;Sergey P. Polyutov,&nbsp;Sergey V. Karpov","doi":"10.1007/s11051-025-06360-9","DOIUrl":"10.1007/s11051-025-06360-9","url":null,"abstract":"","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of SnCdO3/rGO with high electrocatalytic performance for oxygen evolution reaction","authors":"Sumia Rubab,&nbsp;Abhinav Kumar,&nbsp;Sarah A. Alsalhi,&nbsp;Jayanti Makasana,&nbsp;Rekha M. M,&nbsp;G. Senthil Kumar,&nbsp;Mohammed A. Al-Anber,&nbsp;Sankar Narayan Das,&nbsp;Rahul Raj Chaudhary,&nbsp;Ankit D. Oza","doi":"10.1007/s11051-025-06369-0","DOIUrl":"10.1007/s11051-025-06369-0","url":null,"abstract":"<div><p>The production of highly effective and stable electrocatalysts for OER (oxygen evolution reaction) has become challenging for sustainable energy production. The present study uses the simple hydrothermal approach to prepare a noble-metal free electrocatalyst, i.e., SnCdO₃/rGO. The successful production of bimetallic oxide with rGO composite was proved by physiochemical data, illustrating the crystal structure of prepared SnCdO₃ material. Moreover, adding rGO to the SnCdO₃ leads to the dispersion of nanoparticles onto the nanosheets, improving the material’s overall surface area, as proven by BET analysis. The electrochemical testing verifies the transmission of four electron mechanisms by displaying the reduced Tafel value (36 mV dec⁻¹), and a reduced overpotential of 227 mV. These findings suggest that the material is highly active as a catalytic material during OER operation and remains stable for 50 h under the alkaline condition, as evidenced by the chronoamperometry testing. Hence, this novel electrocatalyst can potentially replace noble catalysts and open a new pathway for non-noble metal-based electrocatalysts in future energy conversion applications.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}