Synthesis of microporous silica nanoparticles as a versatile nanocarrier for 5-fluorouracil delivery in colon cancer chemotherapy

IF 2.6 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-07-09 DOI:10.1007/s11051-025-06383-2

Changwan Cui, Zhengrong Sun, Yu-Xuan Gao, Qiang Sun

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引用次数: 0

Abstract

Silica (SiO₂) nanoparticles have gained significant attention as drug carriers for cancer chemotherapy due to their high surface area, biocompatibility, ultrahigh length-to-diameter ratio, and efficient cellular uptake. In this study, nanosized SiO₂ with a particle size of approximately 170 nm and a micropore size of 1.6 nm was synthesized as a versatile nanocarrier for loading 5-fluorouracil (5-Fu) for colon cancer chemotherapy. The resulting microporous SiO₂ nanoparticles exhibited a high 5-Fu loading capacity and demonstrated a pH-sensitive drug release profile. The 5-Fu@SiO₂ system showed significantly higher cytotoxicity against LoVo/5-Fu cells (5-Fu-resistant colon cancer cells) compared to free 5-Fu, while bare SiO₂ nanoparticles exhibited minimal cytotoxicity. The mechanism by which 5-Fu@SiO₂ overcomes drug resistance in LoVo/5-Fu cells is attributed to the high intracellular accumulation of 5-Fu and the elevated levels of reactive oxygen species (ROS) induced by the SiO₂ matrix, which enhances the cytotoxic effects of 5-Fu in resistant cancer cells.

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微孔二氧化硅纳米颗粒作为结肠癌化疗中5-氟尿嘧啶多用途纳米载体的合成

二氧化硅（SiO2）纳米颗粒由于其高表面积、生物相容性、超高长径比和高效的细胞摄取而成为癌症化疗药物载体。在本研究中，合成了粒径约为170 nm，微孔尺寸为1.6 nm的纳米SiO2，作为结肠癌化疗中5-氟尿嘧啶（5-Fu）的多功能纳米载体。所制备的SiO2微孔纳米颗粒具有较高的5-Fu负载能力，并具有ph敏感的药物释放特性。与游离5-Fu相比，5-Fu@SiO2系统对LoVo/5-Fu细胞（5-Fu耐药结肠癌细胞）的细胞毒性明显更高，而裸SiO2纳米颗粒的细胞毒性最小。5-Fu@SiO2克服LoVo/5-Fu细胞耐药的机制是由于5-Fu在细胞内的高积累和二氧化硅基质诱导的活性氧（ROS）水平的升高，从而增强了5-Fu对耐药癌细胞的细胞毒性作用。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.