Mozhgan Torabi, Sina Taghvimi, Feryal Savari, Azam Karimi
{"title":"氧化锌纳米颗粒诱导的海马生化、组织学改变和疼痛调节：动物研究综述","authors":"Mozhgan Torabi, Sina Taghvimi, Feryal Savari, Azam Karimi","doi":"10.1007/s11051-025-06394-z","DOIUrl":null,"url":null,"abstract":"<div><p>Pain is a complex physiological process that can affect quality of life if it becomes chronic. Additionally, conventional analgesic drugs have long-term side effects. Recently, nanotechnology has been applied to the diagnosis and treatment of various diseases, and nanotechnology-based drug delivery has provided promising results in pain management. Zinc oxide nanoparticles (ZnO NPs) have gained attention in biomedical fields due to their unique physicochemical properties, which enhance their interaction with biological system. Currently, researchers have focused on the optimization and modification of ZnO NPs for medical usage. These nanoparticles can cross the blood–brain barrier and influence both histological and biochemical parameters of the nervous system. Several animal studies have evaluated their effects on pain perception, particularly focusing on brain regions like the hippocampus. ZnO NPs at low doses and in the acute phase have been reported to exert analgesic effects without causing neurotoxicity. Also, the effects of ZnO NPs have been studied in neurological behavior in animal’s models. In this review paper, we evaluated the ZnO NPs effects by examining the histological and biochemical alterations in brain tissue, specifically the hippocampus, and their underlying mechanisms related to pain management.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hippocampal biochemical, histological alterations, and pain modulation induced by zinc oxide nanoparticles: a review from animal studies\",\"authors\":\"Mozhgan Torabi, Sina Taghvimi, Feryal Savari, Azam Karimi\",\"doi\":\"10.1007/s11051-025-06394-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Pain is a complex physiological process that can affect quality of life if it becomes chronic. Additionally, conventional analgesic drugs have long-term side effects. Recently, nanotechnology has been applied to the diagnosis and treatment of various diseases, and nanotechnology-based drug delivery has provided promising results in pain management. Zinc oxide nanoparticles (ZnO NPs) have gained attention in biomedical fields due to their unique physicochemical properties, which enhance their interaction with biological system. Currently, researchers have focused on the optimization and modification of ZnO NPs for medical usage. These nanoparticles can cross the blood–brain barrier and influence both histological and biochemical parameters of the nervous system. Several animal studies have evaluated their effects on pain perception, particularly focusing on brain regions like the hippocampus. ZnO NPs at low doses and in the acute phase have been reported to exert analgesic effects without causing neurotoxicity. Also, the effects of ZnO NPs have been studied in neurological behavior in animal’s models. In this review paper, we evaluated the ZnO NPs effects by examining the histological and biochemical alterations in brain tissue, specifically the hippocampus, and their underlying mechanisms related to pain management.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"27 7\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-025-06394-z\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06394-z","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Hippocampal biochemical, histological alterations, and pain modulation induced by zinc oxide nanoparticles: a review from animal studies
Pain is a complex physiological process that can affect quality of life if it becomes chronic. Additionally, conventional analgesic drugs have long-term side effects. Recently, nanotechnology has been applied to the diagnosis and treatment of various diseases, and nanotechnology-based drug delivery has provided promising results in pain management. Zinc oxide nanoparticles (ZnO NPs) have gained attention in biomedical fields due to their unique physicochemical properties, which enhance their interaction with biological system. Currently, researchers have focused on the optimization and modification of ZnO NPs for medical usage. These nanoparticles can cross the blood–brain barrier and influence both histological and biochemical parameters of the nervous system. Several animal studies have evaluated their effects on pain perception, particularly focusing on brain regions like the hippocampus. ZnO NPs at low doses and in the acute phase have been reported to exert analgesic effects without causing neurotoxicity. Also, the effects of ZnO NPs have been studied in neurological behavior in animal’s models. In this review paper, we evaluated the ZnO NPs effects by examining the histological and biochemical alterations in brain tissue, specifically the hippocampus, and their underlying mechanisms related to pain management.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
