Ageing Research Reviews最新文献_第6页

Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: A systematic review and meta-analysis 基于数字的干预措施对健康老年人肌肉减少症合格标准结果的影响：系统回顾和荟萃分析

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2025.102663

Hyuma Makizako , Daijo Shiratsuchi , Shoma Akaida , Mana Tateishi , Keisuke Maeda , Katsuya Iijima , Hiroyuki Shimada , Tatsuro Inoue , Minoru Yamada , Ryo Momosaki , Hidetaka Wakabayashi , Koichi Yamamoto , Hidenori Arai

{"title":"Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: A systematic review and meta-analysis","authors":"Hyuma Makizako , Daijo Shiratsuchi , Shoma Akaida , Mana Tateishi , Keisuke Maeda , Katsuya Iijima , Hiroyuki Shimada , Tatsuro Inoue , Minoru Yamada , Ryo Momosaki , Hidetaka Wakabayashi , Koichi Yamamoto , Hidenori Arai","doi":"10.1016/j.arr.2025.102663","DOIUrl":"10.1016/j.arr.2025.102663","url":null,"abstract":"<div><h3>Background</h3><div>While the digital-based interventions targeting older adults to prevent age-related health problems such as sarcopenia have grown rapidly in recent years, there are no meta-analyses indicating synthesized pooled estimates.</div></div><div><h3>Objective</h3><div>To examine the effects of digital-based interventions on sarcopenia-related measures, including physical performance and muscle mass, in healthy community-dwelling older adults.</div></div><div><h3>Methods</h3><div>Systematic searches were performed on MEDLINE, Web of Science, and Cochrane Library for eligible studies published up to 31 March 2023. The mean difference with a 95 % confidence interval was calculated. Methodological quality was assessed using Cochrane RoB 2.0. The GRADE criteria were used to assess evidence certainty.</div></div><div><h3>Results</h3><div>Thirteen randomized controlled trials with 742 participants were included in the meta-analysis. Handgrip strength, usual walking speed, five times sit-to-stand performance, and 30-second chair stand test showed significant enhancements with the digital-based interventions. However, there were no significant effects of digital-based interventions in appendicular muscle mass. The overall evidence certainty was low.</div></div><div><h3>Conclusions</h3><div>Although digital-based interventions for healthy older adults are effective in improving physical functions, evidence certainty is low. Additional randomized controlled trials are thus required to further validate the findings.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102663"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Colony-Forming Cells (ECFCs) in cerebrovascular aging: Focus on the pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and treatment prospects

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2025.102672

Sharon Negri , Zeke Reyff , Eva Troyano-Rodriguez , Madison Milan , Jennifer Ihuoma , Sherwin Tavakol , Helen Shi , Roland Patai , Raymond Jiang , Jonah Mohon , Jed Boma-Iyaye , Zoltan Ungvari , Anna Csiszar , Andriy Yabluchanskiy , Francesco Moccia , Stefano Tarantini

{"title":"Endothelial Colony-Forming Cells (ECFCs) in cerebrovascular aging: Focus on the pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and treatment prospects","authors":"Sharon Negri , Zeke Reyff , Eva Troyano-Rodriguez , Madison Milan , Jennifer Ihuoma , Sherwin Tavakol , Helen Shi , Roland Patai , Raymond Jiang , Jonah Mohon , Jed Boma-Iyaye , Zoltan Ungvari , Anna Csiszar , Andriy Yabluchanskiy , Francesco Moccia , Stefano Tarantini","doi":"10.1016/j.arr.2025.102672","DOIUrl":"10.1016/j.arr.2025.102672","url":null,"abstract":"<div><div>Endothelial colony-forming cells (ECFCs), a unique endothelial progenitor subset, are essential for vascular integrity and repair, providing significant regenerative potential. Recent studies highlight their role in cerebrovascular aging, particularly in the pathogenesis of vascular cognitive impairment and dementia (VCID). Aging disrupts ECFC functionality through mechanisms such as oxidative stress, chronic inflammation, and cellular senescence, leading to compromised vascular repair and reduced neurovascular resilience. ECFCs influence key cerebrovascular processes, including neurovascular coupling (NVC), blood-brain barrier (BBB) integrity, and vascular regeneration, which are critical for cognitive health. Age-related decline in ECFC quantity and functionality contributes to vascular rarefaction, diminished cerebral blood flow (CBF), and BBB permeability—processes that collectively exacerbate cognitive decline. This review delves into the multifaceted role of ECFCs in cerebrovascular aging and underscores their potential as therapeutic targets in addressing age-related vascular dysfunctions, presenting new directions for mitigating the effects of aging on brain health.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102672"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia in trauma patients: A systematic review and meta-analysis 创伤患者的 "肌少症"：系统回顾与荟萃分析。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102628

Jin-Zhi Zhang , Chang-Hai Liu , Ya-Lin Shen , Xiao-Na Song , Hong Tang , Hong Li

{"title":"Sarcopenia in trauma patients: A systematic review and meta-analysis","authors":"Jin-Zhi Zhang , Chang-Hai Liu , Ya-Lin Shen , Xiao-Na Song , Hong Tang , Hong Li","doi":"10.1016/j.arr.2024.102628","DOIUrl":"10.1016/j.arr.2024.102628","url":null,"abstract":"<div><div>Sarcopenia is associated with poor prognosis and mortality following injury. This systematic review and meta-analysis aimed to analyze diagnostic criteria for sarcopenia, as well as to assess its prevalence and impact on health outcomes among trauma patients. We conducted a literature search on MEDLINE, EMBASE, and the Cochrane Library from inception to June 2023. A total of 27 studies were included, involving 8692 individuals (55.5 % men) with a mean age ranging from 42.2 to 80.5 years. The pooled prevalence of sarcopenia in trauma patients was 36.0 % [95 % confidence interval (CI): 29.1–43.0 %, <em>I</em><sup>2</sup> = 97.8 %], with a 39.3 % prevalence (95 % CI: 31.0–48.5 %, <em>I</em><sup>2</sup> = 96.8 %) in men and a 39.0 % prevalence (95 % CI: 31.4–46.2 %, <em>I</em><sup>2</sup> = 94.4 %) in women. Trauma patients with sarcopenia were more prone to complications [risk ratio (RR): 1.16, 95 % CI: 1.03–1.31, <em>I</em><sup>2</sup> = 45.8 %] and less able to discharge independently (RR: 0.74, 95 % CI: 0.63–0.86, <em>I</em><sup>2</sup> = 33.3 %). The risk of death in trauma patients with sarcopenia was higher than in non-sarcopenic patients [hazard ratio (HR): 1.64, 95 % CI: 1.31–2.04]. Sarcopenia is commonly present in trauma patients and has a negative impact on prognosis. Early assessment and interventions for sarcopenia should be conducted in trauma patients.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102628"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging role of oxygen redox in pathological progression of disorders 线粒体氧氧化还原在神经退行性疾病病理进展中的新作用。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2025.102660

Shuang-Yu Li , Xue-Yan Gong , Ferdinand Ndikuryayo , Wen-Chao Yang

{"title":"The emerging role of oxygen redox in pathological progression of disorders","authors":"Shuang-Yu Li , Xue-Yan Gong , Ferdinand Ndikuryayo , Wen-Chao Yang","doi":"10.1016/j.arr.2025.102660","DOIUrl":"10.1016/j.arr.2025.102660","url":null,"abstract":"<div><div>Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington disease, pose serious threats to human health, leading to substantial economic burdens on society and families. Despite extensive research, the underlying mechanisms driving these diseases remain incompletely understood, impeding effective diagnosis and treatment. In recent years, growing evidence has highlighted the crucial role of oxidative stress in the pathogenesis of various neurodegenerative diseases. However, there is still a lack of comprehensive reviews that systematically summarize the impact of mitochondrial oxidative stress on neurodegenerative diseases. This review aims to address this gap by summarizing the molecular mechanisms by which mitochondrial oxidative stress promotes the initiation and progression of neurodegenerative disorders. Furthermore, it discusses the potential of antioxidant-based therapeutic strategies for the treatment of these diseases. By shedding light on the role of mitochondrial oxidative stress in neurodegenerative diseases, this review not only serves as a valuable reference for further research on the disease mechanisms, but also offers novel perspectives for the treatment of these disorders.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102660"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactylation modification in cardio-cerebral diseases: A state-of-the-art review 心脑疾病中的乳酸化修饰：最新进展综述。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102631

Zi Liao , Bei Chen , Tong Yang , Wenli Zhang , Zhigang Mei

{"title":"Lactylation modification in cardio-cerebral diseases: A state-of-the-art review","authors":"Zi Liao , Bei Chen , Tong Yang , Wenli Zhang , Zhigang Mei","doi":"10.1016/j.arr.2024.102631","DOIUrl":"10.1016/j.arr.2024.102631","url":null,"abstract":"<div><div>Cardio-cerebral diseases (CCDs), encompassing conditions such as coronary heart disease, myocardial infarction, stroke, Alzheimer's disease, et al., represent a significant threat to human health and well-being. These diseases are often characterized by metabolic abnormalities and remodeling in the process of pathology. Glycolysis and hypoxia-induced lactate accumulation play critical roles in cellular energy dynamics and metabolic imbalances in CCDs. Lactylation, a post-translational modification driven by excessive lactate accumulation, occurs in both histone and non-histone proteins. It has been implicated in regulating protein function across various pathological processes in CCDs, including inflammation, angiogenesis, lipid metabolism dysregulation, and fibrosis. Targeting key proteins involved in lactylation, as well as the enzymes regulating this modification, holds promise as a therapeutic strategy to modulate disease progression by addressing these pathological mechanisms. This review provides a holistic picture of the types of lactylation and the associated modifying enzymes, highlights the roles of lactylation in different pathological processes, and synthesizes the latest clinical evidence and preclinical studies in a comprehensive view. We aim to emphasize the potential of lactylation as an innovative therapeutic target for preventing and treating CCD-related conditions.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102631"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Objectively measured environmental features and their association with cognition and dementia: A systematic review and meta-analysis 客观测量的环境特征及其与认知和痴呆的关系：系统回顾和荟萃分析。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102630

Linlin Da , Xia Song , Zimu Jia , Nicholas Gary Lamont Myers , Jin Sun , Jingkai Wei , Daniel Jung , Feiyang Li , Suhang Song

{"title":"Objectively measured environmental features and their association with cognition and dementia: A systematic review and meta-analysis","authors":"Linlin Da , Xia Song , Zimu Jia , Nicholas Gary Lamont Myers , Jin Sun , Jingkai Wei , Daniel Jung , Feiyang Li , Suhang Song","doi":"10.1016/j.arr.2024.102630","DOIUrl":"10.1016/j.arr.2024.102630","url":null,"abstract":"<div><div>Dementia affects millions of people worldwide. Since effective treatments are still lacking, it is important to identify factors that may help prevent dementia. Recent studies suggest environmental factors may affect dementia risk, but findings are inconsistent and often rely on subjective measures. This study evaluated the association between objectively measured environmental factors, such as air pollution and built environment features, and the risk of dementia and cognitive decline. We systematically reviewed studies that employed objective measures of environmental factors and reported their association with dementia risk and cognitive decline. Meta-analysis was performed to synthesize data on environmental exposures and the onset of dementia. Air pollution exposure was linked to higher dementia risk (PMx risk ratio 1.09; 95 % CI 1.06,1.12) (NOx risk ratio 1.10; 95 % CI 1.01,1.20) and cognitive decline, while exposure to park areas or green/blue spaces was generally associated with reduced dementia risk (risk ratio 0.94; 95 % CI 0.92,0.96) and slower cognitive decline. Living closer to major roads increased the risk of dementia (risk ratio 1.10; 95 % CI 1.06,1.13), and cognitive impairment. Street layouts with better connectivity and walkability are associated with a reduced risk of cognitive impairment. Access to local amenities, such as food stores, community centers, and healthcare amenities, supports cognitive health. These findings underscore the importance of considering environmental factors in dementia prevention and highlight the need for further research to clarify the role of urban design in supporting cognitive health.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102630"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies 从发病到进展：α-突触核蛋白在突触核蛋白病中的时间谱。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102640

James A. Wiseman , Kreesan Reddy , Birger Victor Dieriks

{"title":"From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies","authors":"James A. Wiseman , Kreesan Reddy , Birger Victor Dieriks","doi":"10.1016/j.arr.2024.102640","DOIUrl":"10.1016/j.arr.2024.102640","url":null,"abstract":"<div><div>This review provides an in-depth analysis of the complex role of alpha-synuclein (α-Syn) in the development of α-synucleinopathies, with a particular focus on its structural diversity and the resulting clinical variability. The ability of α-Syn to form different strains or polymorphs and undergo various post-translational modifications significantly contributes to the wide range of symptoms observed in disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), as well as in lesser-known non-classical α-synucleinopathies. The interaction between genetic predispositions and environmental factors further complicates α-synucleinopathic disease pathogenesis, influencing the disease-specific onset and progression. Despite their common pathological hallmark of α-Syn accumulation, the clinical presentation and progression of α-synucleinopathies differ significantly, posing challenges for diagnosis and treatment. The intricacies of α-Syn pathology highlight the critical need for a deeper understanding of its biological functions and interactions within the neuronal environment to develop targeted therapeutic strategies. The precise point at which α-Syn aggregation transitions from being a byproduct of initial disease triggers to an active and independent driver of disease progression – through the propagation and acceleration of pathogenic processes – remains unclear. By examining the role of α-Syn across various contexts, we illuminate its dual role as both a marker and a mediator of disease, offering insights that could lead to innovative approaches for managing α-synucleinopathies.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102640"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities 神经系统疾病中的胶质细胞极化：分子机制和治疗机会。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102638

Yuqing Liu , Lei Wu , Weijun Peng , Xiaoyuan Mao

{"title":"Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities","authors":"Yuqing Liu , Lei Wu , Weijun Peng , Xiaoyuan Mao","doi":"10.1016/j.arr.2024.102638","DOIUrl":"10.1016/j.arr.2024.102638","url":null,"abstract":"<div><div>Glial cell polarization plays a pivotal role in various neurological disorders. In response to distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate neural repair following injury, underscoring the importance of glial phenotypic polarization in modulating central nervous system function. This review presents an overview of glial cell polarization, focusing on astrocytes and microglia. It explores the involvement of glial polarization in neurological diseases such as Alzheimer's disease, Parkinson's disease, stroke, epilepsy, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis and meningoencephalitis. Specifically, it emphasizes the role of glial cell polarization in disease pathogenesis through mechanisms including neuroinflammation, neurodegeneration, calcium signaling dysregulation, synaptic dysfunction and immune response. Additionally, it summarizes various therapeutic strategies including pharmacological treatments, dietary supplements and cell-based therapies, aimed at modulating glial cell polarization to ameliorate brain dysfunction. Future research focused on the spatio-temporal manipulation of glial polarization holds promise for advancing precision diagnosis and treatment of neurological diseases.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102638"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay of NAD and hypoxic stress and its relevance for ageing NAD与缺氧应激的相互作用及其与衰老的相关性。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102646

Johannes Burtscher , Vanna Denti , Johanna M. Gostner , Alexander KH Weiss , Barbara Strasser , Katharina Hüfner , Martin Burtscher , Giuseppe Paglia , Martin Kopp , Tobias Dünnwald

{"title":"The interplay of NAD and hypoxic stress and its relevance for ageing","authors":"Johannes Burtscher , Vanna Denti , Johanna M. Gostner , Alexander KH Weiss , Barbara Strasser , Katharina Hüfner , Martin Burtscher , Giuseppe Paglia , Martin Kopp , Tobias Dünnwald","doi":"10.1016/j.arr.2024.102646","DOIUrl":"10.1016/j.arr.2024.102646","url":null,"abstract":"<div><div>Nicotinamide adenine dinucleotide (NAD) is an essential regulator of cellular metabolism and redox processes. NAD levels and the dynamics of NAD metabolism change with increasing age but can be modulated via the diet or medication. Because NAD metabolism is complex and its regulation still insufficiently understood, achieving specific outcomes without perturbing delicate balances through targeted pharmacological interventions remains challenging. NAD metabolism is also highly sensitive to environmental conditions and can be influenced behaviorally, e.g., by exercise. Changes in oxygen availability directly and indirectly affect NAD levels and may result from exposure to ambient hypoxia, increased oxygen demand during exercise, ageing or disease. Cellular responses to hypoxic stress involve rapid alterations in NAD metabolism and depend on many factors, including age, glucose status, the dose of the hypoxic stress and occurrence of reoxygenation phases, and exhibit complex time-courses. Here we summarize the known determinants of NAD-regulation by hypoxia and evaluate the role of NAD in hypoxic stress. We define the specific NAD responses to hypoxia and identify a great potential of the modulation of NAD metabolism regarding hypoxic injuries.</div><div>In conclusion, NAD metabolism and cellular hypoxia responses are strongly intertwined and together mediate protective processes against hypoxic insults. Their interactions likely contribute to age-related changes and vulnerabilities. Targeting NAD homeostasis presents a promising avenue to prevent/treat hypoxic insults and – conversely – controlled hypoxia is a potential tool to regulate NAD homeostasis.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102646"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactylation: The metabolic accomplice shaping cancer's response to radiotherapy and immunotherapy

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2025.102670

Danqing Yu , Qingping Zhong , Yanlin Wang , Chang Yin , Minghua Bai , Ji Zhu , Jinggang Chen , Huaming Li , Weifeng Hong

{"title":"Lactylation: The metabolic accomplice shaping cancer's response to radiotherapy and immunotherapy","authors":"Danqing Yu , Qingping Zhong , Yanlin Wang , Chang Yin , Minghua Bai , Ji Zhu , Jinggang Chen , Huaming Li , Weifeng Hong","doi":"10.1016/j.arr.2025.102670","DOIUrl":"10.1016/j.arr.2025.102670","url":null,"abstract":"<div><div>Protein lactylation, an emerging post-translational modification, is providing new insights into tumor biology and challenging our current understanding of cancer mechanisms. Our review illuminates the intricate roles of lactylation in carcinogenesis, tumor progression, and therapeutic responses, positioning it as a critical linchpin connecting metabolic reprogramming, epigenetic modulation, and treatment outcomes. We provide an in-depth analysis of lactylation's molecular mechanisms and its far-reaching impact on cell cycle regulation, immune evasion strategies, and therapeutic resistance within the complex tumor microenvironment. Notably, this review dissects the paradoxical nature of lactylation in cancer immunotherapy and radiotherapy. While heightened lactylation can foster immune suppression and radioresistance, strategically targeting lactylation cascades opens innovative avenues for amplifying the efficacy of current treatment paradigms. We critically evaluate lactylation's potential as a robust diagnostic and prognostic biomarker and explore frontier therapeutic approaches targeting lactylation. The synergistic integration of multi-omics data and artificial intelligence in lactylation research is catalyzing significant strides towards personalized cancer management. This review not only consolidates current knowledge but also charts a course for future investigations. Key research imperatives include deciphering tumor-specific lactylation signatures, optimizing synergistic strategies combining lactylation modulation with immune checkpoint inhibitors and radiotherapy, and comprehensively assessing the long-term physiological implications of lactylation intervention. As our understanding of lactylation's pivotal role in tumor biology continues to evolve, this burgeoning field promises to usher in transformative advancements in cancer diagnosis, treatment modalitie.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102670"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0