Ageing Research Reviews最新文献

{"title":"Targeting brain connectivity in Alzheimer’s disease with repurposed drugs","authors":"Lorenzo Pini ,&nbsp;Bruno P. Imbimbo ,&nbsp;Alessandra Griffa ,&nbsp;Gilles Allali ,&nbsp;Nunzio Pomara","doi":"10.1016/j.arr.2025.103001","DOIUrl":"10.1016/j.arr.2025.103001","url":null,"abstract":"<div><div>Neuroimaging studies have highlighted both hyperconnectivity and hypoconnectivity across the Alzheimer's disease (AD) continuum, alongside task-induced activity changes. These alterations may reflect compensatory mechanisms or network breakdowns. While connectivity-based measures are not yet established as clinical biomarkers, they hold promises for evaluating therapeutic efficacy and informing the design of targeted interventions. Based on these insights, this review explores the potential of off-label FDA-approved drug repositioning as a cost-effective strategy to identify therapeutic approaches for AD. We examine the neurophysiological effects of certain repurposed drugs that modulate synaptic activity, reduce inflammation, enhance metabolic pathways and gut-brain axis interactions, in preclinical and clinical models. Emerging evidence suggests that these drugs (e.g., anticonvulsants, anti-diabetics, anti-inflammatory, and gastrointestinal agents) can influence brain connectivity and activity, mitigating cognitive deficits. By integrating connectivity-focused biomarkers into clinical trials, researchers can advance the development of disease-modifying treatments. This review underscores the importance of a connectivity-driven framework for repurposing existing drugs to address need for new treatments for AD.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 103001"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of third molar-derived dental pulp stem cells in Alzheimer’s disease: Current evidence and future directions","authors":"Pooja Wagaskar ,&nbsp;Meghraj Suryawanshi ,&nbsp;Ashwani Patil ,&nbsp;Vaishnavi Pardeshi","doi":"10.1016/j.arr.2025.102949","DOIUrl":"10.1016/j.arr.2025.102949","url":null,"abstract":"<div><div>Alzheimer’s disease (AD), the most common cause of dementia, is characterized by amyloid-β deposition, tau hyperphosphorylation, neuroinflammation, and progressive neuronal loss, with no curative therapy currently available. Dental pulp stem cells (DPSCs) derived from third molars represent an ethically accessible, minimally invasive, neural crest–derived mesenchymal stem cell source with self-renewal and multi-lineage differentiation potential. Preclinical evidence suggests that DPSCs exert neuroprotective effects by reducing oxidative stress and apoptosis, enhancing neurogenesis through synaptic repair and neuronal differentiation, and modulating neuroinflammation via microglial regulation. Their secretion of neurotrophic factors, including BDNF, GDNF, NGF, NT-3, CNTF, and HGF, further supports neuronal survival and functional recovery in Alzheimer’s disease models. Advances in 3D neurosphere and brain organoid models demonstrate the integration of DPSCs into neural circuitry, highlighting their translational potential. Nevertheless, challenges such as cell survival, migration, and functional integration within the diseased brain remain. Importantly, the use of extracted third molars avoids major ethical concerns associated with embryonic stem cells, making DPSCs a clinically relevant candidate for regenerative approaches. Future directions emphasize the development of exosome-based therapies, bioengineered scaffolds, gene-modified DPSC strategies, and personalized autologous interventions. Collectively, current evidence positions third molar–derived DPSCs as a promising avenue for disease-modifying and regenerative therapies in Alzheimer’s disease.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102949"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomerase-active urine-derived stem cells: Regenerative solutions for aging","authors":"Xi Cheng ,&nbsp;Qiao-Yu Fu ,&nbsp;Yun-Ling Zheng ,&nbsp;Gennadiy P. Moiseyev ,&nbsp;Fang-Chi Hsu ,&nbsp;Jian-Xing Ma ,&nbsp;Qing-Feng Li ,&nbsp;Anthony Atala ,&nbsp;Yuan-Yuan Zhang","doi":"10.1016/j.arr.2025.102939","DOIUrl":"10.1016/j.arr.2025.102939","url":null,"abstract":"<div><div>Aging is a complex process that leads to various pathologies and poses a significant socioeconomic challenge. Stem cell therapies offer a promising avenue for intervention, primarily through mechanisms like telomere maintenance and cellular rejuvenation. However, conventional stem cell sources often come with limitations such as invasive collection, ethical concerns, safety risks, and high costs, which impede their clinical application. Urine-derived stem cells (USCs), in contrast, present an appealing alternative for regenerative medicine. Uniquely, USCs contain two distinct populations: those with high telomerase activity (TA) and long telomeres, and those with low or undetectable TA. Notably, the unique presence of telomerase-active USCs provides a novel avenue for addressing telomere attrition, a primary hallmark of biological aging, and holds significant translational geroscience relevance. Unlike stem cells derived from bone marrow or adipose tissue, which lack TA, USCs are obtained non-invasively through routine urination, significantly reducing patient discomfort and ethical issues. Moreover, compared to induced pluripotent stem cells (iPSCs), USCs pose a lower risk of tumorigenicity and require less complex manipulation, simplifying their journey to clinical use. USCs demonstrate robust proliferative capacity, broad differentiation potential, and enhanced safety profiles, making them well-suited for addressing age-related tissue degeneration and functional decline. Preclinical studies have already shown their effectiveness in mitigating age-related disorders and facilitating personalized medicine through disease modeling and drug discovery. While USC-based therapies are still in early development, their unique properties—especially the presence of USCs with robust telomerase activity—position them as an accessible and promising platform for regenerative medicine to combat age-related decline.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102939"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging analysis for Alzheimer’s disease diagnosis using artificial intelligence: Methods, challenges, and opportunities","authors":"Qiye Shi ,&nbsp;Junbao Hou ,&nbsp;Xiaohan Peng ,&nbsp;Ziqi Xu ,&nbsp;Yang Wang ,&nbsp;Danna Cao","doi":"10.1016/j.arr.2025.102943","DOIUrl":"10.1016/j.arr.2025.102943","url":null,"abstract":"<div><div>Alzheimer’s disease(AD) is the most common cause of dementia and affects millions of people worldwide. The early and accurate diagnosis of AD is crucial for timely intervention and disease management. Magnetic resonance imaging (MRI) is a widely used noninvasive technique for assessing brain structure and function in patients with AD. However, conventional MRI analysis methods are often subjective, time-consuming, and depend on expert knowledge. Artificial intelligence (AI), particularly deep learning (DL), has emerged as a powerful tool for extracting meaningful information from large and complex MRI data and providing an automated and reliable diagnosis of AD. In this review, we summarize the recent advances and challenges in AI MRI for AD diagnosis, focusing on the following aspects: (1) types and characteristics of MRI data used for AD diagnosis; (2) the main AI models and architectures applied to MRI data analysis; (3) performance and evaluation metrics of AI models for AD diagnosis; (4) potential applications and limitations of AI models for AD diagnosis in clinical practice; and (5) future research directions for AI MRI for AD diagnosis. This review aims to provide a comprehensive and updated overview of the field and stimulate further research and advancements in AI-aided MRI for the diagnosis of AD.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102943"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicle-based biosensors for Alzheimer’s disease: A new frontier in precision diagnostics","authors":"Jinjin Pei ,&nbsp;Nishanthi Chella Perumal ,&nbsp;Panpan Meng ,&nbsp;Qianfa Long ,&nbsp;Chella Perumal Palanisamy","doi":"10.1016/j.arr.2025.102904","DOIUrl":"10.1016/j.arr.2025.102904","url":null,"abstract":"<div><div>Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, remains a diagnostic challenge due to its asymptomatic early stages and the lack of reliable, non-invasive biomarkers. Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-sized membrane-bound particles released by cells into biological fluids and have emerged as promising carriers of disease-specific biomarkers. These vesicles reflect the physiological and pathological state of their parental cells, encapsulating proteins, lipids, and nucleic acids relevant to AD pathology, such as amyloid-β, tau, and microRNAs. Recent advances in biosensor technology have enabled the development of highly sensitive and specific platforms to detect EV-associated biomarkers. Integrating EVs with biosensing approaches—ranging from electrochemical and optical sensors to nanomaterial-based systems—represents a promising strategy for early AD diagnosis, monitoring disease progression, and evaluating therapeutic efficacy. However, these technologies remain largely in preclinical or early translational stages, with further validation required in large-scale clinical cohorts. This review provides a comprehensive overview of the recent progress in EV-based biosensor technologies, highlighting their analytical performance, detection principles, and clinical relevance in AD diagnostics. Furthermore, we discuss the current challenges, such as standardization in EV isolation and characterization, and propose future perspectives for translating these innovative diagnostic tools into clinical practice. The integration of EV biology with advanced biosensing technologies represents an emerging advancement with strong potential for precision medicine in AD, although clinical translation will require rigorous validation and standardization.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102904"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diapause and aging: Two opposing yet intertwined biological phenomena","authors":"Hamidreza Khodajou-Masouleh ,&nbsp;Sogol Ghanbari","doi":"10.1016/j.arr.2025.102998","DOIUrl":"10.1016/j.arr.2025.102998","url":null,"abstract":"<div><div>Diapause is an evolutionarily conserved strategy that enables many organisms to survive prolonged exposure to harsh environmental stressors. During this state, organisms drastically reduce their metabolic rate, halt development, and enhance stress tolerance in an energy-efficient manner. Remarkably, many diapausing organisms appear to substantially slow or suspend aging as a result of profound metabolic depression and developmental arrest. Consequently, diapause and aging appear to be programmed in opposite directions, yet both rely on many of the same master regulatory genes and epigenetic modulators. This review explores the molecular mechanisms underlying diapause-induced stress resistance and metabolic suppression, offering critical insights into how dormant biological systems preserve function and delay aging. Manipulating these shared regulatory networks has led to significant extensions in lifespan and improvements in healthspan across various model organisms. Anhydrobiotic species such as <em>Artemia</em>, <em>Caenorhabditis elegans</em>, and tardigrades can nearly suspend aging during dormancy by downregulating metabolic pathways and accumulating protective macromolecules. Notably, the African turquoise killifish, which has adapted to life in ephemeral ponds, can provide a unique platform to study both diapause and aging within a single vertebrate model. Phenotypic plasticity may offer the most compelling evolutionary explanation for resolving the paradox of how the same regulatory network can produce opposite outcomes in diapause and aging. Overall, diapause offers a powerful natural framework for uncovering anti-aging mechanisms and holds great promise for guiding the development of novel interventions to promote longevity and healthy aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102998"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction","authors":"Shuo Zhang ,&nbsp;Zhigang Fan ,&nbsp;Dan Ji","doi":"10.1016/j.arr.2025.102925","DOIUrl":"10.1016/j.arr.2025.102925","url":null,"abstract":"<div><div>The “eye–brain axis” refers to the dynamic system of interactions between the eyes and the brain, collectively encompassing the visual signal transmission and integration pathways. The eyes and the brain exhibit structural and functional synergy, and visual dysfunction not only impairs information processing within the eye but also induces structural and functional remodeling of the central nervous system (CNS) via the eye–brain axis. For instance, the effects of glaucoma on the visual cortex are manifested as reduced blood perfusion and decreased efficiency of mitochondrial adenosine triphosphate (ATP) synthesis. Moreover, the eye can serve as an important window and biomarker for the early diagnosis and intervention of neurodegenerative diseases of the CNS. Relevant research findings include the parallelism of beta amyloid (Aβ) and phosphorylated Tau (p-Tau) between the retina and Alzheimer’s disease (AD), glaucomatous neurodegeneration with AD-like features, and the role of vascular endothelial growth factor C (VEGF-C) expression along the eye–brain lymphatic pathway in regulating intraocular pressure (IOP) and correcting macular edema. Therefore, eye–brain axis research provides novel perspectives for understanding the pathophysiological mechanisms underlying visual dysfunction and related disorders, while simultaneously supporting the development of cross–organ neuroprotective strategies. This review explores the anatomical foundations, immune regulation, and bidirectional interactions of the eye–brain axis, and evaluates its relevance to the diagnosis and treatment of visual dysfunction and degenerative diseases of the CNS.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102925"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics of In Vivo models of ischemic stroke: A systematic review with a systems biological perspective","authors":"Anaekshi Gogoi ,&nbsp;Manju Babu ,&nbsp;Abhina Gangadhar ,&nbsp;Riyama Shirin ,&nbsp;Deepthi Ann Thomas ,&nbsp;Jasmitha Jayaram ,&nbsp;Pratik Thakkar ,&nbsp;Arnab Datta","doi":"10.1016/j.arr.2025.102937","DOIUrl":"10.1016/j.arr.2025.102937","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>To discover therapeutic targets and biomarkers for ischemic stroke, a systems-level understanding of the altered brain proteome is necessary from various types of in vivo models. In the last two decades, despite accumulating numerous large-scale proteomics datasets on in vivo models of ischemic stroke, systematic classification and summarization of these data have not been attempted yet.</div></div><div><h3>Methods</h3><div>Following PRISMA, ARRIVE, and CAMARADES guidelines, we conducted a systematic review of proteomics studies done on various in vivo models of ischemic stroke (ivProt studies).</div></div><div><h3>Results</h3><div>Of 680 studies, 120 ivProt studies were shortlisted. They were classified based on TOAST stroke subtypes, model category, study duration, and sampled brain location. We collated 288 proteins deregulated in the brain tissue of MCAO-affected animals, 44 of which were reported in minimum two ivProt studies. A comparison of deregulated proteome between ivProt and clinical proteomics studies revealed consistent deregulation for 85 % of the commonly quantified proteins. The Gene Ontology analysis of the consensus stroke-perturbed proteome (n = 90) showed enrichment of annotation terms related to blood coagulation, HIF-signaling and secretory pathway. About 88 % of these proteins were found listed in an exosome database (ExoCarta), while 42 % overlapped with the therapeutic target database. Notably, this list contained eight successful drug targets (ANXA1, C3, DPYSL2, IDH1, IDH3A, PRKCE, PRKCG, and SERPINA1).</div></div><div><h3>Conclusion</h3><div>A web resource (<span><span>ivProt_Repository</span><svg><path></path></svg></span>) was created that may stimulate clinical validation of shortlisted proteins for biomarker discovery or proof-of-concept studies for therapeutic target discovery and help to establish novel pipelines for big data integration.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102937"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/cas genome editing for neurodegenerative diseases: Mechanisms, therapeutic advances, and clinical prospects","authors":"Kalpana Pandya ,&nbsp;Devendra Kumar","doi":"10.1016/j.arr.2025.102922","DOIUrl":"10.1016/j.arr.2025.102922","url":null,"abstract":"<div><div>Neurodegenerative diseases such as Alzheimerʼs disease (AD), Parkinsonʼs disease (PD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebral Ataxia (SCA), and Huntingtonʼs disease (HD) are major global health challenges. Current treatments are only symptomatic and do not address the underlying pathogenic genetic mechanisms. The development of the CRISPR/Cas genome editing technologies, has increased possibilities for targeted repair of pathological mutations. CRISPR/Cas9, Cas12, and Cas13 systems enable targeted editing and transcriptome modulation in various preclinical models. CRISPR/Cas9 disruption of mutant APP, Tau, and LRRK2 genes, reducing toxic protein aggregration in AD models has restored normal genetic function. While correction of CAG nucleotide repeats in HD, and reduction of alpha-synuclein expression in PD. RNA targeting systems like Cas13 offers additional therapeutics potential by selectively degrading disease assciated transcript without altering genomic DNA. Advancements in engineered Cas variants with enhanced specificity, such as SpCas9-HF1, base editors and prime editors, with innovative delivery strategies including adeno-associated virus (AAVs) and nanoparticle-based systems, have improved genome editing. However, challenges remain, including off-target effects, mosaicism, and delivery across the BBB, and long-term safety. Ethical consideration focuses on somatic versus germline editing, equitable access, and regulatory oversight. While somatic editing shows acceptance in treating neurological disorders. Germline interventions face strict regulations due to potential multigeneration impacts. Collectively, these technologies are the vanguard of precision molecular medicine, advancing from symptom management towards potentially curative gene therapies for neurological disorders.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102922"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dynamics in neurodegenerative diseases: Research hotspots and trends from 2005 to 2025","authors":"Shiliang Hu ,&nbsp;Zhen Yang ,&nbsp;Kaiming Bao ,&nbsp;Wenlong Hou ,&nbsp;Yuanyuan Qin ,&nbsp;Chu Wu ,&nbsp;QingMei Wang ,&nbsp;Xun Luo ,&nbsp;Li Luo","doi":"10.1016/j.arr.2025.102987","DOIUrl":"10.1016/j.arr.2025.102987","url":null,"abstract":"<div><h3>Background</h3><div>Dysregulation of mitochondrial dynamics, including fusion/fission, transport, mitophagy and biogenesis, plays a crucial role in neurodegenerative diseases. However, a systematic quantitative mapping of the knowledge structure (i.e., key research themes, foundational references, and citation/collaboration clusters) and evolving research trends (i.e., research hotspots over time) in this research field is lacking.</div></div><div><h3>Methods</h3><div>Empirical and review article on mitochondrial dynamics in neurodegenerative diseases, which published in English from 2005 to 2025, were retrieved from the Web of Science Core Collection and Scopus. BibliometriX, VOSviewer, and CiteSpace were applied to perform the bibliometric analysis and science mapping. Scientific performance analyses, collaborative networks of authors/institutions/countries, reference co-citation networks, keyword bursts analysis were conducted.</div></div><div><h3>Results</h3><div>A total of 834 documents were included, revealing a rapid growth in scientific productivity from 2005 to 2025. The United States, China, and Germany were the most productive countries, with institutions such as Case Western Reserve University and Texas Tech University serving as major hubs. Co-citation and keyword burst analyses reveal a distinct temporal shift: from foundational studies of fusion/fission machinery and oxidative stress toward an integrated Mitochondrial Quality Control paradigm encompassing mitophagy, dynamics, and biogenesis. Key emerging hotspots include mitochondrial biogenesis, mitochondrial transport, and quality control mechanisms. Translational frontiers prioritize enhancing PINK1/Parkin-mediated mitophagy, inhibiting Drp1-driven excessive fission, and activating PGC-1α-dependent biogenesis.</div></div><div><h3>Conclusion</h3><div>This bibliometric study maps the intellectual structure and evolutionary trajectory of mitochondrial dynamics research in neurodegenerative diseases. It documents a field-wide paradigm shift toward a translational agenda centered on the MQC framework. Furthermore, the findings highlight the necessity of integrating pharmacological interventions with lifestyle modifications and precision medicine approaches to overcome translational barriers and develop effective disease-modifying strategies.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102987"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}