Ageing Research Reviews最新文献

{"title":"A systematic review of multivariate studies in cognitive aging: Introducing the concept of cognitive organization","authors":"E. Garcia-Cabello ,&nbsp;A. Habich ,&nbsp;Y. Molina ,&nbsp;L. Perestelo-Pérez ,&nbsp;J. Barroso ,&nbsp;D. Ferreira","doi":"10.1016/j.arr.2025.102997","DOIUrl":"10.1016/j.arr.2025.102997","url":null,"abstract":"<div><div>Despite ample research on cognitive aging, it is still largely unknown whether cognition is organized in a distinct manner, with different cognitive domains and subcomponents interrelating with each other. It is also unknown whether this cognitive organization is stable or changes with increasing age. Following the PRISMA guidelines statement, we conducted a systematic review of multivariate studies of cognitive aging with the aim to identify a potential cognitive organization in healthy aging. We consulted Embase, PsycInfo and Medline electronic databases from 2000 to October 2025. The methodological quality of the included studies was analysed using CASP tools and a narrative synthesis of the selected articles was performed. We screened 1518 references and a total of 14 research articles met selection criteria and were included. We found convergent findings across studies suggesting a cognitive organization of four factors: memory, language, executive functions, and processing speed. This cognitive organization was rather consistent across studies, cohorts, and methodologies. A fifth factor for visuospatial abilities was identified in several studies. Some studies reported that processing speed may influence age-related changes in the direct performance of other cognitive domains. However, the current evidence did not allow concluding on the effect of age in this cognitive organization. Therefore, it is yet to be clarified whether this cognitive organization remains invariant throughout age. Advancing in our understanding of cognitive aging can result in a more accurate and personalized clinical assessment and intervention in people at risk of cognitive impairment.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102997"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response relationship of resistance training and the effects on circulating biomarkers of inflammation or neuroplasticity in older adults: A systematic review and meta-analysis","authors":"Orgesa Qipo ,&nbsp;Guoda Gajauskaitė ,&nbsp;Wouter A.J. Vints ,&nbsp;Oron Levin ,&nbsp;Nerijus Masiulis ,&nbsp;Ivan Bautmans","doi":"10.1016/j.arr.2025.102917","DOIUrl":"10.1016/j.arr.2025.102917","url":null,"abstract":"<div><div>Resistance Training (RT) is considered a promising intervention to counteract inflammation and cognitive decline. However, the relationship between RT dose (training duration, frequency, intensity, volume, rest period) and RT-induced changes in circulating biomarkers of inflammation and neuroplasticity remains unclear. The aim of this systematic review and meta-analysis was to determine the overall and dose-response effects of RT on circulating biomarkers of inflammation and neuroplasticity in older adults. Electronic databases (PubMed, Web of Science and Scopus) were systematically screened for relevant studies. The search identified 8306 articles, of which 36 randomized controlled trials (RCTs) were included. Effect sizes (ES) were calculated, and a meta-analysis (RT-effects) and meta-regression (dose-response) were performed when possible. Risk of bias was assessed using the Cochrane Risk of Bias (ROB) 2.0 tool. Meta-analysis showed that RT significantly increased neuroplasticity biomarkers including IGF-1, BDNF, and FGF-21 (ES=0.51, 95 %CI [0.19, 0.84], p = 0.002). Greater improvements were observed with longer training periods (≥20 weeks), a higher number of exercises (≥8), higher weekly training volume and total training program volume, and shorter rest in between exercises (90–120 s). Additionally, RT significantly reduced pro-inflammatory biomarkers including TNF-α, CAF, IL-6, IL-1β, KYN and CRP (ES=-0.66, 95 %CI [-0.80, −0.52], p &lt; 0.001)), with more pronounced effects seen with a higher frequency (at least 3 times per week) and a higher intensity (≥70 % 1RM). Although RT also increased anti-inflammatory biomarkers (IL-10, IL-13, and IL-4, ES=0.75 95 %CI [0.45, 1.04], p &lt; 0.001) the limited number of studies prevented a meta-regression analysis to determine a significant dose-response relationship. These findings demonstrate that RT can significantly improve circulating biomarkers of neuroplasticity and inflammation and highlight key dose-response relationships critical for optimizing RT programs.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102917"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic potential of early exercise in Alzheimer's disease: Focus on the brain-spleen axis","authors":"Tao Wang ,&nbsp;Lili Feng ,&nbsp;Zhenjun Tian","doi":"10.1016/j.arr.2025.102980","DOIUrl":"10.1016/j.arr.2025.102980","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is the predominant cause of cognitive dysfunction, with global prevalence increasing annually. AD progression is principally driven by the accumulation of amyloid-β (Aβ) and hyperphosphorylated microtubule-associated protein tau (p-Tau), which trigger a subsequent cascade of neuroinflammatory responses within the central nervous system (CNS). This pathological cascade is regulated by reciprocal CNS-peripheral immune crosstalk. The brain-spleen axis has emerged as a critical conduit that orchestrates splenic immune activity and CNS-peripheral immune crosstalk during AD progression. Notably, through the brain-spleen axis, early-life and preclinical exercise may restore splenic vagal-sympathetic homeostasis, re-establish immune equilibrium, and then mitigate neuroinflammation. This review advances a testable hypothesis that early exercise prevents or attenuates AD pathology through the brain-spleen axis, potentially accelerating the development of innovative therapeutic targets such as non-invasive brain stimulation.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102980"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between early life circumstances and multi-system biological aging: A systematic review and meta-analysis","authors":"Zhuoqi Luo,&nbsp;Haiyan Ren,&nbsp;Lukman Ahmed Wali,&nbsp;Shuo Wang,&nbsp;Fang Zhou","doi":"10.1016/j.arr.2025.102942","DOIUrl":"10.1016/j.arr.2025.102942","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically investigate the relationship between early life circumstances and multi-system biological aging and to synthesize evidence on mediating and moderating factors.</div></div><div><h3>Methods</h3><div>Studies from PubMed, EMBASE, Web of Science, Scopus, PsycInfo, CNKI, and SinoMed were searched from inception to February 2025. We included observational studies examining the relationship between early life circumstances (including adverse childhood experiences, childhood socio-economic status, perinatal factors, and childhood personal traits) and multi-system biological aging (composite algorithms based on multi-system clinical biomarkers, such as phenotypic age, Klemera-Doubal method biological age, homeostatic dysregulation, and Pace of Aging). A multi-level random-effects meta-analysis was employed for data synthesis. Sensitivity, moderator, and subgroup analyses were conducted to explore sources of heterogeneity and test robustness.</div></div><div><h3>Results</h3><div>A total of 23 studies containing 344,852 participants were included. 16 of these were included in a meta-analysis, which showed a statistically significant correlation between early life circumstances and multi-system biological aging (Cohen's <em>d</em> = 0.18, 95 %CI: 0.12–0.24, <em>p</em> &lt; 0.0001). Moderator analysis and subgroup analysis indicated that the type, period, and assessment method of early life circumstances, the multi-system biological aging indicators, age, geographic location, study quality, and covariate adjustment significantly influenced the association. The neighbourhood and living environment was a mediator, while age and sex served as moderators. Socioeconomic status, psychosocial factors, and healthy lifestyles exhibited both mediating and moderating effects.</div></div><div><h3>Conclusions</h3><div>Adverse early life circumstances are associated with accelerated multi-system biological aging. These findings provide a foundation for identifying at-risk populations and formulating targeted interventions to decelerate biological aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102942"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sea urchin bioactive compounds: emerging interventions for age-related diseases","authors":"Beatriz Escobar-Doncel ,&nbsp;Anastasia Papakosta ,&nbsp;Jon Storm-Mathisen ,&nbsp;Evandro Fei Fang","doi":"10.1016/j.arr.2025.102979","DOIUrl":"10.1016/j.arr.2025.102979","url":null,"abstract":"<div><div>Among the marine bioresources, sea urchins are emerging as a promising provider of bioactive compounds with broad therapeutic potentials, including for ageing and age-related diseases. This review highlights the therapeutic promise of sea urchin bioactive compounds, covering evidence from both laboratory and clinical studies. Compounds found in sea urchin such as carotenoids, polyhydroxynaphthoquinones (PHNQs), and flavonoids demonstrate antioxidant and anti-inflammatory properties with notable cell viability improvements, targeting conditions like metabolic syndrome, cardiovascular disease, neurodegenerative disorders, as well as ophthalmic, dermatological, and post-menopausal conditions. Sea urchins hold great nutritional value, rich in proteins, minerals, and trace elements, which further supports their potential health benefits in humans. However, challenges remain, including the risk of adverse effects at high doses, limited bioavailability, species-specific bioactivities, and the limited understanding of their molecular mechanisms of action. Future research should focus on elucidating these mechanisms, as well as conducting rigorous preclinical and clinical investigations to validate their therapeutic efficacy. With continued research, we shall develop strategies for the best use of sea urchins including for health benefits.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102979"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing patterns in causes, risk factors, and life expectancy among the oldest old (aged 95+ years)","authors":"Haoxian Tang ,&nbsp;Xiaojing Chen ,&nbsp;Jingtao Huang ,&nbsp;Qinglong Yang ,&nbsp;Kunyao Liang ,&nbsp;Xianghui Qiu ,&nbsp;Junshaung Tang ,&nbsp;Cuihong Tian ,&nbsp;Nan Luo ,&nbsp;Mengyue Lin ,&nbsp;Xuan Zhang ,&nbsp;Shiwan Wu ,&nbsp;Xiulian Deng ,&nbsp;Hanyuan Lin ,&nbsp;Jianan Hong ,&nbsp;Jiasheng Wen ,&nbsp;Liwen Jiang ,&nbsp;Pan Chen ,&nbsp;Wenfeng Lin ,&nbsp;Wenqi Chen ,&nbsp;Yequn Chen","doi":"10.1016/j.arr.2025.102985","DOIUrl":"10.1016/j.arr.2025.102985","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The global population is aging rapidly, extending into the oldest old. However, increased longevity does not always translate into enhanced health. While genetic and environmental factors influence lifespan, evidence indicates that targeted interventions can substantially enhance the likelihood of reaching 100 years. This study aimed to characterize disease and risk factor patterns among the oldest-old to identify actionable targets for promoting health and functional capacity in this rapidly growing population.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This study identified 18 countries with the largest populations aged 95 years and older using data from the Global Burden of Disease (GBD) 2023 study and the United Nations World Population Prospects 2024. Disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) from 1990 to 2023 were quantified, ranked, and visualized across three major cause categories (non-communicable, communicable and nutritional diseases, and injuries) and risk factors (behavioral, environmental/occupational, and metabolic) by using the GBD 2023 estimates. Temporal trends were assessed using estimated annual percentage change derived from log-linear regression models, calculated separately for periods before and after the COVID-19 pandemic peak. K-means clustering was employed to identify cross-country burden patterns, with the optimal number of clusters determined via the silhouette method. Temporal trends in health-adjusted life expectancy (HALE) were examined, and frontier analysis was applied to estimate the potential for further HALE improvement across countries.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;From 1990–2023, the absolute disease burden among individuals aged 95 + years increased more than fivefold, primarily driven by non-communicable diseases, accounting for ∼86 % of the total DALYs. Ischemic heart disease remained the leading cause, particularly for YLLs, followed by Alzheimer’s disease and other dementias, which predominated in YLDs, followed by stroke and chronic kidney disease. During the COVID-19 pandemic peak (2019–2021), mental health disorders, including depression and anxiety, demonstrated a marked increase. Cluster analysis in 2023 revealed two distinct national patterns: one dominated by acute cardiovascular conditions and the other by chronic multi-system diseases. Absolute burdens of metabolic, behavioral, and environmental/occupational risk factors increased over time, although their relative contributions declined; high systolic blood pressure (YLLs), high fasting plasma glucose (YLDs), and kidney dysfunction remained the leading risk factors. The average HALE increased from 1.86 years in 1990–2.16 years in 2019, declined during the pandemic, and partially recovered by 2023. Frontier analysis indicated nearly a twofold potential for further HALE improvement under current socioeconomic conditions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusio","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102985"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) – possible combination use","authors":"Savani Ulpathakumbura ,&nbsp;Sicong Kenric Lu ,&nbsp;Rasika Gunarathne ,&nbsp;John Zhiyong Yang ,&nbsp;Johnson Liu ,&nbsp;Xiaodong Jin ,&nbsp;Qiang Zhou ,&nbsp;Jun Lu","doi":"10.1016/j.arr.2025.102992","DOIUrl":"10.1016/j.arr.2025.102992","url":null,"abstract":"<div><div>Aging is a complex biological process characterized by the gradual deterioration of cellular functions, leading to an increased susceptibility to chronic diseases. In the search for interventions to promote healthy aging and extend lifespan, Pyrroloquinoline Quinone (PQQ) and Nicotinamide Mononucleotide/Nicotinamide Riboside (NMN/NR) have emerged as promising anti-aging agents. PQQ exerts its anti-aging effect primarily through enhancing mitochondrial biogenesis, exerting antioxidant activity, and modulating inflammatory pathways. On the other hand, NMN/NR act as key precursors in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in energy metabolism, cellular homeostasis, and DNA repair, thereby promoting longevity. This review systematically compares the mechanisms of action and efficacy of those compounds in mitigating age-related complications. Furthermore, this emphasizes the potent synergistic effect when PQQ and NMN/NR are used in combined formulations, highlighting their complementary pathways to support healthy aging. Despite supporting preliminary data and patented formulations, strong scientific evidence encouraging the synergistic anti-aging potential of PQQ and NMN/NR remains limited, highlighting the need for robust studies. Collectively, PQQ and NMN/NR offer distinct complementary strategies to promote healthy aging and prevent age-related diseases; their combination could offer a more effective approach to enhance healthy aging and longevity.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102992"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145749203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease","authors":"Zhenkai Zhang ,&nbsp;Haonan Xu ,&nbsp;Fuxia Zhao ,&nbsp;Zheyue Han ,&nbsp;Juan Pan ,&nbsp;Mengmeng Li ,&nbsp;Wei Guan ,&nbsp;Peng Jiang ,&nbsp;Zhichao Hao ,&nbsp;Yiqiang Zhang ,&nbsp;Xiaochi Ma ,&nbsp;Haixue Kuang ,&nbsp;Yan Liu","doi":"10.1016/j.arr.2025.103005","DOIUrl":"10.1016/j.arr.2025.103005","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a multifaceted neurodegenerative disorder, defined pathologically by the accumulation of Aβ plaques and Tau neurofibrillary tangles, accompanied by widespread metabolic dysregulation. Recently, “metabolic reprogramming (MetR)”, referring to the dynamic adaptation of cellular metabolic networks in response to environmental or functional demands, has emerged as a novel conceptual perspective for understanding AD. In the context of AD, the dysregulation of MetR is manifested by widespread disturbances in glucose, lipid, and amino acid metabolism, in addition to mitochondrial impairment. The distinctive therapeutic potential of natural products (NPs) in the management of AD is highlighted by their ability to act synergistically to rebalance disrupted metabolic pathways, owing to their multitarget actions, low toxicity, and broad bioactivity. This review provides a comprehensive overview of the pathological characteristics and molecular basis of “metabolic–mitochondrial” reprogramming in AD and focuses on the potential mechanisms of NPs in this context. Elucidation of these mechanisms is expected to provide novel theoretical foundations and strategic directions for early diagnosis, targeted intervention, and the pharmacological development of NPs–based therapies for AD.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 103005"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and regional burden of 34 key pathogens in the elderly population in 2021: A systematic analysis of the global burden of disease study 2021","authors":"Lin Chen ,&nbsp;Kai Zhang ,&nbsp;Xiaoli Liu ,&nbsp;Yushi Fan ,&nbsp;Xinyun Zhang ,&nbsp;Sheng Zhang ,&nbsp;Xuehuan Wen ,&nbsp;Songjie Bai ,&nbsp;Qing Wang ,&nbsp;Wei Cui ,&nbsp;Zhongheng Zhang ,&nbsp;Minfeng Tong ,&nbsp;Gensheng Zhang","doi":"10.1016/j.arr.2025.102944","DOIUrl":"10.1016/j.arr.2025.102944","url":null,"abstract":"<div><h3>Background</h3><div>Infectious diseases caused by bacterial and viral pathogens remain major contributors to global mortality and disease burden, especially for older adults. Despite progress in disease control, the pathogen-specific burden across multiple disease categories, especially among the elderly population, has not been comprehensively quantified. This study estimates the global and regional burden of 34 key pathogens in 2021, with a specific focus on mortality and disability-adjusted life years (DALYs) in older adults.</div></div><div><h3>Method</h3><div>This study utilized data from the Global Burden of Disease (GBD) 2021 study to estimate mortality and DALYs attributable to 34 key bacterial and viral pathogens across 204 countries and territories. Pathogen-specific contributions were determined using the GBD comparative risk assessment framework and cause-of-death ensemble modeling. Age-standardized death and DALYs rate were calculated, and variations were examined across Socio-demographic Index (SDI) categories and geographic regions. Uncertainty intervals (UIs) were generated through Monte Carlo simulations.</div></div><div><h3>Findings</h3><div>In 2021, <em>Staphylococcus aureus</em> was the leading pathogen, responsible for 325,165 deaths (95 % UI: 281,827–356,269) and 4766,188 DALYs (95 % UI 4218,780–5202,881), with age-standardized rate of 32.40 death (95 % UI 27.94–35.53) and 459.37 DALYs (95 % UI 404.90–501.85) per 100,000 population. Pathogens such as <em>Respiratory syncytial virus</em>, <em>Enteropathogenic E. coli</em>, and <em>Aeromonas</em> caused the least global burden. Regionally, <em>Staphylococcus aureus</em> was the primary cause of mortality and DALYs in 15 of 21 GBD regions, with the highest mortality in Eastern Sub-Saharan Africa and the highest DALYs rate in Southern Sub-Saharan Africa. <em>Streptococcus pneumoniae</em> and <em>Staphylococcus aureus</em> were the leading contributors to infectious disease burden in elder populations, with their impact increasing with age. A strong inverse correlation was observed between SDI and age-standardized rate of death and DALYs, with lower SDI regions, such as Sub-Saharan Africa, bearing the highest burden.</div></div><div><h3>Interpretation</h3><div>This study highlights the disproportionate impact of infectious pathogens on older adults, particularly in low-SDI regions, and underscores the need for targeted interventions, resource allocation, and healthcare improvements to address this growing public health challenge. These findings provide critical insights to inform global strategies for reducing pathogen-related mortality and disability among the elderly population.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102944"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades","authors":"Yucheng Luo ,&nbsp;Yuang Song ,&nbsp;Minxi Zeng ,&nbsp;Bin Li ,&nbsp;Ye Li ,&nbsp;Ziqing Dong","doi":"10.1016/j.arr.2025.102959","DOIUrl":"10.1016/j.arr.2025.102959","url":null,"abstract":"<div><div>Aging is one of the factors for the decline in adipose tissue browning and, consequently, age-related metabolic disorders. Metabolic disorders will in turn accelerate aging and lead to a vicious circle. Therefore, the research on the reduced browning of adipose tissue that occurs with aging, that is, adipose tissue browning aging, is necessary and of great significance for the development of metabolically healthy aging. In this study, we performed a bibliometric analysis of 2527 published articles on aging of adipose tissue browning and created a panorama from different levels so that readers could quickly understand the current state of the research field. The burst analysis and timeline analysis were used to identify the research frontiers in the field, and the newly published documents were discussed and summarized. In addition, we performed bioinformatic analysis on the GEO-derived dataset to identify the altered genes and enriched pathways associated with browning during aging. Combined with bibliometric analysis, the most concerned pathway was identified as adipogenesis, and the most concerned genes were PPARG, ADIPOQ and TG. In summary, this study provided a comprehensive picture of the current status of adipose tissue browning and aging research and identified research frontiers. Finally, the pathways and genes of most interest were identified by combined bioinformatic analysis.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102959"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145600530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}