Ageing Research Reviews最新文献

Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review 虚拟现实干预对老年阿尔茨海默病患者生活质量、认知功能和身体功能的有效性：一项系统综述

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-26 DOI: 10.1016/j.arr.2025.102785

Edgar Vásquez-Carrasco , Jordan Hernandez-Martinez , María Sepúlveda-Ramírez , Florencia Carmine , Cristian Sandoval , Hadi Nobari , Pablo Valdés-Badilla

{"title":"Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review","authors":"Edgar Vásquez-Carrasco , Jordan Hernandez-Martinez , María Sepúlveda-Ramírez , Florencia Carmine , Cristian Sandoval , Hadi Nobari , Pablo Valdés-Badilla","doi":"10.1016/j.arr.2025.102785","DOIUrl":"10.1016/j.arr.2025.102785","url":null,"abstract":"<div><div>This systematic review aimed to evaluate and synthesize the scientific evidence of virtual reality (VR) interventions on quality of life, cognitive function, and physical function in older people with Alzheimer's disease (AD). A systematic review search until March 2025 using seven generic databases: PubMed, EBSCOhost, CINAHL Complete, Cochrane, ProQuest, Scopus, and Web of Science. The PRISMA, RoB 2, and GRADEpro tools were used to assess the methodological quality, risk of bias, and certainty of the evidence.The protocol was registered in PROSPERO database, CRD42024629853. Of 3347 records identified across the databases, seven studies were analyzed using the PICOS format. This review included 517 older people with AD (mean age 76.5 years; 57.5 % female). Due to the heterogeneity of the assessment tools, a meta-analysis could not be performed. Although no consistent significant differences were found between the experimental and control groups, several individual studies reported improvements. Specifically, two studies showed improvements in quality of life and cognitive function, while three reported enhancements in physical function. The interventions included immersive cognitive training, exergaming, Kinect-based systems, and Physiomat platforms, with durations ranging from 4 to 16 weeks and frequencies of 2–5 sessions per week. Analysis of the reviewed studies suggests that VR interventions may benefit cognitive function, physical function, and, to a lesser extent, quality of life in older people with AD.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102785"},"PeriodicalIF":12.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telomeres as hallmarks of iPSC aging: A review on telomere dynamics during stemness and cellular reprogramming 端粒作为iPSC衰老的标志：在干细胞和细胞重编程过程中端粒动力学的综述。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-23 DOI: 10.1016/j.arr.2025.102773

Carlota Tavares-Marcos , Magda Correia , Bruno Bernardes de Jesus

{"title":"Telomeres as hallmarks of iPSC aging: A review on telomere dynamics during stemness and cellular reprogramming","authors":"Carlota Tavares-Marcos , Magda Correia , Bruno Bernardes de Jesus","doi":"10.1016/j.arr.2025.102773","DOIUrl":"10.1016/j.arr.2025.102773","url":null,"abstract":"<div><div>Telomeres, the protective ends of chromosome, are key to tissue repair and regeneration. Telomere shortening is linked to aging and age-related disorders, while excessive telomerase activity may support tissue regeneration or transformation. Some of the functions of telomeres and telomerase may be mediated by its important role in the process of stemness. Active telomerase, and subsequent telomerase-dependent telomere extension, supports stem-cells self-renewal and pluripotency - essential for tissue healing. During cellular reprogramming, differentiated cells are converted into induced pluripotent stem cells (iPSCs), which resemble embryonic stem cells. During iPSC derivation, telomere length is reset, enhancing iPSCs’ regenerative potential. During this process, incomplete telomerase activation and telomere extension can lead to genomic instability and/or haltered cell functionality. Understanding the intricate relation of telomeres, telomerase and stemness may be critical when designing novel cell-based therapies targeting degenerative diseases or to unlock strategies to delay aging. Here, we explore the recent bibliography linking these areas, raising awareness of their important when designing novel breakthroughs in health and longevity.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102773"},"PeriodicalIF":12.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the non-neuronal cholinergic machinery: A novel approach to mitigate cardiac aging 靶向非神经元胆碱能机制：一种减轻心脏衰老的新方法

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-22 DOI: 10.1016/j.arr.2025.102782

Samhita Chakraborty, Vikas Tiwari, Sanjay K. Banerjee

{"title":"Targeting the non-neuronal cholinergic machinery: A novel approach to mitigate cardiac aging","authors":"Samhita Chakraborty, Vikas Tiwari, Sanjay K. Banerjee","doi":"10.1016/j.arr.2025.102782","DOIUrl":"10.1016/j.arr.2025.102782","url":null,"abstract":"<div><div>Acetylcholine (ACh) secreted by the non-neuronal cholinergic system (NNCS), an intrinsic system found in the mammalian heart, is not dependent on neuronal inputs for its synthesis. Accumulating evidence demonstrates that ACh exerts multifaceted cardioprotective effects through the NNCS. Under extreme stress or demand, ACh slows heart rate by modulating cardiac chronotropy. Simultaneously, it protects the myocardium from ischemic, hypoxic, and other stressors. Beyond its direct effects on the heart, ACh has also been found to play a vital role in controlling mitochondrial homeostasis via specific signaling pathways in hearts. Through these pathways, ACh induces mitochondrial biogenesis and the renewal of the mitochondrial network while suppressing the generation of reactive oxygen species (ROS) within the mitochondria. Aging weakens the cardiac NNCS, lowering the heart's local ACh availability. Reducing mitochondrial activity and ROS-related inflammatory stress are essential indicators of cardiac aging and related disorders. As individuals age, mitochondria become less efficient at generating sufficient ATP to sustain the heart's ability to pump oxygen-rich blood and reduce cardiac performance. Therefore, the exciting prospect of increasing ACh secretion or stabilizing ACh levels through therapeutic targeting of the NNCS may provide a beacon of hope in the fight against age-related cardiovascular disorders. Further elucidating the mechanisms by which the NNCS regulates cardiac function through mitochondria may develop a novel treatment that rejuvenates the properties of this evolutionarily conserved system of the heart.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102782"},"PeriodicalIF":12.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects 推进t细胞免疫治疗细胞衰老和疾病：机制，挑战和临床前景

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-22 DOI: 10.1016/j.arr.2025.102783

Jizhun Wu , Lu Zhang , Zihan Zhao , Yuping Liu , Zhengxing Li , Xiaohang Feng , Lin Zhang , Xiang Yao , Jun Du , Liang Chen , Zhuolong Zhou

{"title":"Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects","authors":"Jizhun Wu , Lu Zhang , Zihan Zhao , Yuping Liu , Zhengxing Li , Xiaohang Feng , Lin Zhang , Xiang Yao , Jun Du , Liang Chen , Zhuolong Zhou","doi":"10.1016/j.arr.2025.102783","DOIUrl":"10.1016/j.arr.2025.102783","url":null,"abstract":"<div><div>Cellular senescence is a complex biological process with a dual role in tissue homeostasis and aging-related pathologies. Accumulation of senescent cells promotes chronic inflammation, tissue dysfunction, age-related diseases, and tumor suppression. Recent advancements in immunotherapy have positioned T cell-based approaches as precision tools for the targeted clearance of senescent cells, offering a novel avenue for anti-aging interventions. This review explores the molecular mechanisms underlying cellular senescence, focusing on its immunogenic features and interactions with T cells, including T-cell activation, antigen recognition, modulation of tumor microenvironment (TME), and immune evasion strategies. Innovations such as chimeric antigen receptor (CAR)-T cells, immune checkpoint therapies, and SASP-neutralizing approaches are highlighted as breakthrough strategies for enhancing senescent cell eradication. The integration of multi-omics and artificial intelligence is further catalyzing the development of personalized therapies to amplify immune surveillance and tissue rejuvenation. Clinically, T cell-based interventions hold promise for mitigating age-related pathologies and extending healthspan, yet challenges remain in optimizing target specificity, countering immunosuppressive niches, and overcoming immune senescence in aging populations. This review synthesizes current advances and challenges, highlighting the potential of T cell immunotherapy as a cornerstone of anti-aging medicine and emphasizing the need for interdisciplinary innovation to translate preclinical findings into transformative therapies for aging and age-related diseases.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102783"},"PeriodicalIF":12.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions 揭示中风后的大脑恢复力：从损伤到大脑通过通路激活、药物靶点和治疗干预的重新布线。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-21 DOI: 10.1016/j.arr.2025.102780

Ankit Singh , Khalandar Dhalayat , Shradheya V. Dhobale , Bijoyani Ghosh , Aishika Datta , Anupom Borah , Pallab Bhattacharya

{"title":"Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions","authors":"Ankit Singh , Khalandar Dhalayat , Shradheya V. Dhobale , Bijoyani Ghosh , Aishika Datta , Anupom Borah , Pallab Bhattacharya","doi":"10.1016/j.arr.2025.102780","DOIUrl":"10.1016/j.arr.2025.102780","url":null,"abstract":"<div><div>Synaptic plasticity is a neuron's intrinsic ability to make new connections throughout life. The morphology and function of synapses are highly susceptible to any pathological condition. Ischemic stroke is a cerebrovascular event that affects various brain regions, resulting in the loss of neural networks. Stroke can alter both structural and functional plasticity of synapses, leading to long-term functional disability. Upon ischemic insult, numerous glutamate-mediated synaptic destruction pathways and glial-mediated phagocytic activity are triggered, resulting in excessive synapse loss, altering synaptic plasticity. The conventional stroke therapies to improve synaptic plasticity are still limited and ineffectual, leading to sub-optimal recovery in patients. Therefore, promoting synaptic plasticity to ameliorate sensory-motor function may be a promising strategy for long-term recovery in stroke patients. Here, we review the involvement of different molecular pathways of glutamate and glia-mediated synapse loss, current pharmacological targets, and the emerging novel approaches to improve synaptic plasticity and sensory-motor impairment post-stroke.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102780"},"PeriodicalIF":12.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis 经颅直流电刺激联合运动训练治疗帕金森病的运动症状：系统回顾和荟萃分析

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-21 DOI: 10.1016/j.arr.2025.102781

Joon Ho Lee , Jin-Sun Jun , Nyeonju Kang , Ryul Kim , Beom Jin Choi , Kyeongho Byun , Kiwon Park , Jee-Young Lee , Beomseok Jeon

{"title":"Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis","authors":"Joon Ho Lee , Jin-Sun Jun , Nyeonju Kang , Ryul Kim , Beom Jin Choi , Kyeongho Byun , Kiwon Park , Jee-Young Lee , Beomseok Jeon","doi":"10.1016/j.arr.2025.102781","DOIUrl":"10.1016/j.arr.2025.102781","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to compare the acute and retention effects of motor training alone versus its combination with transcranial direct current stimulation (tDCS) on motor symptoms in Parkinson’s disease (PD) patients.</div></div><div><h3>Method</h3><div>Two independent reviewers searched for randomized controlled trials that applied motor training with active tDCS versus sham tDCS with motor function as an outcome measure for patients with PD. Random-effects meta-analyses were conducted to calculate standardized mean differences between the effects of motor training with active tDCS versus sham tDCS on motor function. A total of 16 randomized controlled trials (344 PD patients) were eligible for meta-analysis, resulting in 75 motor function comparisons for data synthesis.</div></div><div><h3>Results</h3><div>Motor training with active tDCS showed positive acute effects on overall motor function compared to motor training with sham tDCS, particularly improving step length and gait speed. Moderator variable analyses indicated that these acute effects persisted regardless of the number of sessions or the targeted brain regions for tDCS. Meta-regression analysis showed that a higher proportion of female participants and shorter PD duration were associated with greater acute effects. No positive retention effects of motor training with active tDCS on overall motor function were observed.</div></div><div><h3>Conclusions</h3><div>Our results suggest that combining motor training with tDCS improves motor function, particularly in gait-related parameters, in PD patients. However, these effects were not sustained over time, highlighting the temporary nature of the benefits. Sex differences may influence the acute effects of combined motor training and tDCS interventions.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102781"},"PeriodicalIF":12.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape 阿尔茨海默病治疗的进展：探索神经病理机制，彻底改变未来的治疗前景

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-20 DOI: 10.1016/j.arr.2025.102775

Vrashabh V. Sugandhi , Dnyandev G. Gadhave , Akanksha R. Ugale , Nilesh Kulkarni , Sopan N. Nangare , Harshal P. Patil , Seepra Rath , Rahul Saxena , Amol Lavate , Apeksha T. Patel , Ashish Jadhav , Keshav Raj Paudel

{"title":"Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape","authors":"Vrashabh V. Sugandhi , Dnyandev G. Gadhave , Akanksha R. Ugale , Nilesh Kulkarni , Sopan N. Nangare , Harshal P. Patil , Seepra Rath , Rahul Saxena , Amol Lavate , Apeksha T. Patel , Ashish Jadhav , Keshav Raj Paudel","doi":"10.1016/j.arr.2025.102775","DOIUrl":"10.1016/j.arr.2025.102775","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is still an excessively complicated neurological disorder that impacts millions of individuals globally. The ideal defensive feature of the central nervous system (CNS) is the intimate junction of endothelial cells, which functions as a biological barrier to safely control molecular transport throughout the brain. The blood-brain barrier (BBB) comprises tightly locked astrocyte cell junctions on CNS blood capillaries. This biological barrier shields the brain from hazardous toxins by preventing the entry of polar medications, cells, and ions. However, it is very challenging to provide any treatment to the brain for neurodegenerative illnesses like Alzheimer's. Different causative mechanisms, such as amyloid-β (Aβ) plaques, tubulin-associated unit (Tau) tangles, and neuroinflammation, cause neuronal dysfunction, leading to dementia and memory loss in the subject. Several treatments are approved for AD therapy, whereas most only help treat related symptoms. Disappointingly, current remedies have not been able to control the progression of AD due to associated side effects. Specific pathogenic mechanisms are involved in the initiation and development of this disease. Therefore, the expected survival of a patient with AD is limited and is approximately ten years. Hence, the pathogenic mechanism behind AD progression must be understood to better comprehend and improve the overall survival rate. This review highlighted the recent insights into AD pathogenesis, molecular mechanisms, advancements in theragnostic techniques, the existing updates of clinical trials, and emerging innovations for AD medicinal development. That has helped researchers develop other strategies to address the shortcomings of traditional medications.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102775"},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in biomaterials and regenerative medicine for diabetic foot ulcer therapy 生物材料与再生医学在糖尿病足溃疡治疗中的研究进展

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-20 DOI: 10.1016/j.arr.2025.102779

Yi-Ran Li , Xiao-Shan Lai , Hio-Fai Cheong , Ding-Kun Gui , Yong-Hua Zhao , You-Hua Xu

引用次数: 0

Xanthones as neuroprotective agents: A comprehensive review of their role in the prevention and treatment of neurodegenerative diseases 山酮类神经保护剂在神经退行性疾病预防和治疗中的作用综述

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-17 DOI: 10.1016/j.arr.2025.102772

Dibyajyoti Das , Aparoop Das , Kunal Bhattacharya , Kinku Pritam Koch , Dhirak Jyoti Deuri , Dipankar Saikia , Nongmaithem Randhoni Chanu , Satyendra Deka

{"title":"Xanthones as neuroprotective agents: A comprehensive review of their role in the prevention and treatment of neurodegenerative diseases","authors":"Dibyajyoti Das , Aparoop Das , Kunal Bhattacharya , Kinku Pritam Koch , Dhirak Jyoti Deuri , Dipankar Saikia , Nongmaithem Randhoni Chanu , Satyendra Deka","doi":"10.1016/j.arr.2025.102772","DOIUrl":"10.1016/j.arr.2025.102772","url":null,"abstract":"<div><div>Over the recent years, numerous research efforts have been focused toward xanthones, a class of heterocyclic compounds characterized by a three-ring core structure and a diverse range of biological activities. Despite extensive studies, no xanthone-based molecule has successfully progressed through clinical trials to reach pharmaceutical applications. Xanthones belong to the class of secondary metabolites that exist naturally, found in various plant species, and their structural diversity has been further expanded through synthetic modifications to enhance their pharmacological efficacy. This review provides a comprehensive description of the therapeutic potential of xanthone derivatives within the scope of neurodegenerative disorders, including Alzheimer's disease, Parkinson’s disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and neuroinflammation. Existing literature has been rigorously examined to highlight the pharmacological relevance of xanthones in these disorders. Additionally, the pathophysiological aspects of each disease are discussed in detail to establish a mechanistic understanding of how xanthone derivatives may exert neuroprotective effects. Furthermore, the SAR of xanthones is explored to elucidate key molecular features responsible for their bioactivity, providing insights into rational drug design. By synthesizing and critically analyzing the existing research, this review is focused in highlighting the therapeutic relevance of xanthones in neurodegenerative diseases and their potential as lead candidates for further drug development.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102772"},"PeriodicalIF":12.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between kidney and bones: New perspective for modulating osteoporosis 肾骨串扰：调节骨质疏松症的新视角

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-05-17 DOI: 10.1016/j.arr.2025.102776

Yan Duan , Li-juan Zhao , Yu-ting Lu , Juan Li , Shun-xiang Li

{"title":"Crosstalk between kidney and bones: New perspective for modulating osteoporosis","authors":"Yan Duan , Li-juan Zhao , Yu-ting Lu , Juan Li , Shun-xiang Li","doi":"10.1016/j.arr.2025.102776","DOIUrl":"10.1016/j.arr.2025.102776","url":null,"abstract":"<div><div>Growing evidence indicates an interesting interplay between kidney and bone. The pathophysiological condition of the skeletal system is intricately associated with the normal functioning of the kidneys. This relationship is modulated by various factors, including calcium and phosphate, 1-α-hydroxylase, erythropoietin (EPO), klotho, fibroblast growth factor 23 (FGF23), bone morphogenetic protein-7 (BMP-7), and extracellular vesicles (EVs). These interactions are notably evident in conditions such as chronic kidney disease with bone mineral density (CKD-BMD), renal osteodystrophy (ROD), and osteoporosis (OP). Furthermore, innovative methodologies such as cell co-culture, organ-on-a-chip, single-cell sequencing, and spatial transcriptomics are highlighted as instrumental in advancing the study of inter-organ interactions. This review, grounded in the pathogenesis, diagnostic and therapeutic modalities, and pharmacological treatments of OP, synthesizes evidence from molecular biology to clinical perspectives. It aims to establish a foundation for the development of more complex and physiologically relevant in vitro models and to propose potential therapeutic strategies.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"109 ","pages":"Article 102776"},"PeriodicalIF":12.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0