经颅直流电刺激联合运动训练治疗帕金森病的运动症状：系统回顾和荟萃分析

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-05-21 DOI:10.1016/j.arr.2025.102781

Joon Ho Lee , Jin-Sun Jun , Nyeonju Kang , Ryul Kim , Beom Jin Choi , Kyeongho Byun , Kiwon Park , Jee-Young Lee , Beomseok Jeon

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引用次数: 0

摘要

背景：我们的目的是比较运动训练单独与联合经颅直流电刺激（tDCS）对帕金森病（PD）患者运动症状的急性和保留效应。方法：两名独立审稿人检索了随机对照试验，将运动训练与活动tDCS相比，假性tDCS具有运动功能，作为PD患者的结果测量。进行随机效应荟萃分析，计算活动tDCS与假tDCS对运动功能影响的标准化平均差异。共有16项随机对照试验（344例PD患者）符合meta分析的条件，产生75项运动功能比较以进行数据综合。结果：与假性tDCS运动训练相比，主动tDCS运动训练对整体运动功能有积极的急性影响，特别是改善步长和步态速度。调节变量分析表明，无论tDCS的会话次数或目标脑区如何，这些急性效应都持续存在。meta回归分析显示，女性参与者比例越高，PD持续时间越短，急性效应越大。然而，主动tDCS的运动训练对整体运动功能没有积极的保留作用。结论：我们的研究结果表明，运动训练与tDCS相结合可以改善PD患者的运动功能，特别是步态相关参数。然而，这些效果并没有随着时间的推移而持续，这凸显了这些好处的暂时性。性别差异可能影响运动训练和tDCS联合干预的急性效果。

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Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis

Background

We aimed to compare the acute and retention effects of motor training alone versus its combination with transcranial direct current stimulation (tDCS) on motor symptoms in Parkinson’s disease (PD) patients.

Method

Two independent reviewers searched for randomized controlled trials that applied motor training with active tDCS versus sham tDCS with motor function as an outcome measure for patients with PD. Random-effects meta-analyses were conducted to calculate standardized mean differences between the effects of motor training with active tDCS versus sham tDCS on motor function. A total of 16 randomized controlled trials (344 PD patients) were eligible for meta-analysis, resulting in 75 motor function comparisons for data synthesis.

Results

Motor training with active tDCS showed positive acute effects on overall motor function compared to motor training with sham tDCS, particularly improving step length and gait speed. Moderator variable analyses indicated that these acute effects persisted regardless of the number of sessions or the targeted brain regions for tDCS. Meta-regression analysis showed that a higher proportion of female participants and shorter PD duration were associated with greater acute effects. No positive retention effects of motor training with active tDCS on overall motor function were observed.

Conclusions

Our results suggest that combining motor training with tDCS improves motor function, particularly in gait-related parameters, in PD patients. However, these effects were not sustained over time, highlighting the temporary nature of the benefits. Sex differences may influence the acute effects of combined motor training and tDCS interventions.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.