Crosstalk between kidney and bones: New perspective for modulating osteoporosis

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-05-17 DOI:10.1016/j.arr.2025.102776

Yan Duan , Li-juan Zhao , Yu-ting Lu , Juan Li , Shun-xiang Li

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引用次数: 0

Abstract

Growing evidence indicates an interesting interplay between kidney and bone. The pathophysiological condition of the skeletal system is intricately associated with the normal functioning of the kidneys. This relationship is modulated by various factors, including calcium and phosphate, 1-α-hydroxylase, erythropoietin (EPO), klotho, fibroblast growth factor 23 (FGF23), bone morphogenetic protein-7 (BMP-7), and extracellular vesicles (EVs). These interactions are notably evident in conditions such as chronic kidney disease with bone mineral density (CKD-BMD), renal osteodystrophy (ROD), and osteoporosis (OP). Furthermore, innovative methodologies such as cell co-culture, organ-on-a-chip, single-cell sequencing, and spatial transcriptomics are highlighted as instrumental in advancing the study of inter-organ interactions. This review, grounded in the pathogenesis, diagnostic and therapeutic modalities, and pharmacological treatments of OP, synthesizes evidence from molecular biology to clinical perspectives. It aims to establish a foundation for the development of more complex and physiologically relevant in vitro models and to propose potential therapeutic strategies.

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肾骨串扰：调节骨质疏松症的新视角

越来越多的证据表明肾脏和骨骼之间有一种有趣的相互作用。骨骼系统的病理生理状况与肾脏的正常功能密切相关。这种关系受到多种因素的调节，包括钙和磷酸盐、1-α-羟化酶、促红细胞生成素（EPO）、klotho、成纤维细胞生长因子23 （FGF23）、骨形态发生蛋白7 （BMP-7）和细胞外囊泡（ev）。这些相互作用在慢性肾脏病伴骨密度（CKD-BMD）、肾性骨营养不良（ROD）和骨质疏松症（OP）等疾病中尤为明显。此外，诸如细胞共培养、器官芯片、单细胞测序和空间转录组学等创新方法被强调为推进器官间相互作用研究的工具。本文从OP的发病机制、诊断和治疗方式、药物治疗等方面综述了从分子生物学到临床的证据。其目的是为开发更复杂和生理相关的体外模型奠定基础，并提出潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.