Design, current states, and challenges of nanomaterials in anti-neuroinflammation: A perspective on Alzheimer’s disease

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-01-27 DOI:10.1016/j.arr.2025.102669

Xinyang Hong , Tongkai Chen , Yunyun Liu , Jun Li , Dongqing Huang , Kaiyu Ye , Wanchen Liao , Yulin Wang , Mengling Liu , Ping Luan

引用次数: 0

Abstract

Alzheimer's disease (AD), an age-related neurodegenerative disease, brings huge damage to the society, to the whole family and even to the patient himself. However, until now, the etiological factor of AD is still unknown and there is no effective treatment for it. Massive deposition of amyloid-beta peptide(Aβ) and hyperphosphorylation of Tau proteins are acknowledged pathological features of AD. Recent studies have revealed that neuroinflammation plays a pivotal role in the pathology of AD. With the rise of nanomaterials in the biomedical field, researchers are exploring how the unique properties of these materials can be leveraged to develop effective treatments for AD. This article has summarized the influence of neuroinflammation in AD, the design of nanoplatforms, and the current research status and inadequacy of nanomaterials in improving neuroinflammation in AD.

查看原文本刊更多论文

纳米材料在抗神经炎症中的设计、现状和挑战：阿尔茨海默病的视角。

阿尔茨海默病（Alzheimer's disease， AD）是一种与年龄相关的神经退行性疾病，给社会、家庭乃至患者自身带来了巨大的危害。然而，到目前为止，阿尔茨海默病的病因尚不清楚，也没有有效的治疗方法。淀粉样β肽（Aβ）的大量沉积和Tau蛋白的过度磷酸化是AD公认的病理特征。近年来的研究表明，神经炎症在阿尔茨海默病的病理中起着关键作用。随着纳米材料在生物医学领域的兴起，研究人员正在探索如何利用这些材料的独特性质来开发有效的阿尔茨海默病治疗方法。本文综述了神经炎症对阿尔茨海默病的影响、纳米平台的设计、纳米材料在改善阿尔茨海默病神经炎症方面的研究现状和不足。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.