肠道-脑轴微生物群能逆转人类神经退行性疾病吗？

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2025.102664

Xingxing Yuan , Serge Yannick Ouedraogo , Modou Lamin Jammeh , Lucette Simbiliyabo , John Nute Jabang , Mariam Jaw , Alansana Darboe , Yurong Tan , Ousman Bajinka

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引用次数: 0

摘要

居住在肠道中的数万亿微生物种群最近表明，它们可以用作治疗各种疾病的药物。肠道微生物群-脑轴界面是微生物群展示其药用价值的一个独特途径。当肠道微生物多样性下降（生态失调）时，这种药用价值进一步显现。生态失调导致神经退行性疾病（ndd）。本综述的目的是确定肠道菌群诱导治疗策略的临床意义。在引导这个重要的兴趣领域的同时，我们将阐明研究的ndd的研究差距，前景和潜在的反向干预。除了我们之前的工作外，我们还从PubMed数据库中检索了相关的英文文献。在搜索期间，“肠道微生物群和神经退行性疾病”被用作关键词。筛选标准为：摘要、全文、元分析、随机对照试验、综述、近5年的文献。在我们不懈的探索中，对这些文章进行了分析，以了解肠道微生物群-脑轴的前景和研究差距。这一章就是这种细致工作的结果。包括神经影像学研究在内的肠道微生物群-脑轴研究需要更多令人信服的数据来提供临床意义。解决涉及肠道微生物群-脑轴的结构（病理足迹）和功能变化（疾病表现）需要一个整体的方法。虽然药物治疗如化疗和化学生物治疗方法的成功率较低，但非药物干预在逆转ndd方面更有用。由于无法在临床早期发现ndd，因此预防性药物治疗是最必要和最好的干预策略。肠道驱动疗法在治疗难治性神经系统疾病方面有很大的帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

The trillions of microbial populations residing in the gut have recently shown that they can be used as a remedy for various diseases. The gut microbiota-brain-axis interface is one unique pathway that the microbiota demonstrates its medicinal value. This medicinal value is further seen when there is a decline in gut microbial diversity (dysbiosis). Dysbiosis leads to neurodegenerative disorders (NDDs). The objective of this review is to ascertain the clinical significance of gut microbiota induced therapeutic strategies. While navigating this important area of interest, we will elucidate the research gaps, the prospects and the potential reverse interventions of the studied NDDs. In addition to our previous work, relevant literature published in English were searched and retrieved from the PubMed database. The ‘gut microbiota and Neurodegenerative disorders’ were used as keywords during the search period. The Filters applied are: Abstract, Full text, Meta-Analysis, Randomized Controlled Trial, Reviews, in the last 5 years. The articles were analyzed in our unrelenting quest to make sense of the prospects and research gap in gut microbiota-brain-axis. This chapter is a result of this meticulous work. More convincing data from researches on gut microbiota-brain-axis are required to provide clinical significance including neuroimaging studies. Addressing the structural (pathological footprints) and the functional changes (diseases manifestation) involving gut microbiota-brain-axis require a holistic approach. While the pharmacological therapies such as chemotherapeutic and chemobiotic treatment approaches come with low success rates, non-pharmacological interventions are found to be more useful in reversing NDDs. The inability to detect NDDs at an early stage in their clinical history, makes preventive medicinal approaches the must needed and best intervention strategy. Gut-driven treatments have a lot to offer in the management of refractory neurologic diseases.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.