Wenliang Yu , Yao Li , Zeyang Liu , Siqi Hua , Ziyi Tan , Wei Tang , Mengyue Gao , Xiaoran Zhou , Zichun Hua
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引用次数: 0
Abstract
Objective
Cognitive impairment and dementia are prevalent and costly diseases, affecting 5–8 % of individuals aged 60 and above globally. Bifidobacterium, a low-cost probiotic, has shown potential in treating dementia, but its efficacy remains controversial. To investigate the effects of Bifidobacterium on various dementia-related functional tests and biomarkers in different patient populations with cognitive impairment and dementia.
Methods
Systematic searches were conducted on February 15, 2025, across Embase, PubMed, Medline, Wanfang, and ClinicalTrials.gov. The risk of bias was assessed using NOS. The study is registered with PROSPERO (CRD42023460809).
Results
After rigorous screening, 18 studies encompassing 1195 patients were included. The results revealed that Bifidobacterium significantly improved cognitive function (MMSE, WMD = 2.26, 95 % CI = 1.69–2.83, compared to placebo: p = 0.049), particularly in patients under 70 (MMSE, WMD = 2.81, 95 % CI = 1.97–3.65). For patients over 70, better outcomes were achieved without B. breve-based treatments (MMSE, WMD = 2.43, 95 % CI = 1.76–3.09, compared to the group age under 70 or the group over 70 and receiving B. breve-based treatments: p = 0.0133). Additionally, Bifidobacterium significantly enhance patients’ memory, language, visuospatial, attention and executive abilities, potentially through the downregulation of triglycerides (WMD = −19.52, 95 % CI = −32.28 to −6.66, p = 0.039) and MDA (SMD = −0.72, 95 % CI = −1.07 to −0.37, p = 0.0057).
Conclusions
These findings provide key insights into the efficacy of Bifidobacterium, supporting personalized treatment strategies and reducing the treatment burden for patients with cognitive impairment and dementia.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.