运动是对抗心血管老化的灵丹妙药。

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Zihang Feng , Yuan Xing , Wei Yi , Feng Gao , Yang Sun , Xing Zhang
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引用次数: 0

摘要

全球人口结构向老龄化的转变使心血管老化及其相关病理对健康构成越来越大的挑战。新出现的证据强调了运动在减轻与年龄相关的心血管结构和功能改变以及预防与年龄相关的心血管疾病方面的关键作用。然而,介导这些运动诱导的益处促进心血管健康衰老的精确分子机制仍未完全确定。目前的研究进展表明,运动通过多种协同机制发挥其抗衰老作用,包括减弱常规心血管危险因素、心血管结构重塑、代谢优化、线粒体功能增强和运动介导的组织间通讯。这些机制共同有助于更健康的心血管老化。深入了解运动是如何促进心血管健康老化的,不仅能提高我们对心血管老化的理解,还能阐明预防心血管老化和治疗心血管疾病的潜在方法。本文系统地讨论了运动介导的抗心血管衰老的当代研究成果,并批判性地评估了该领域潜在的临床应用和未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise as elixir to combat cardiovascular ageing
The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains incompletely mapped. Current progresses suggest that exercise exerts its anti-ageing effects through multiple synergistic mechanisms, including attenuation of conventional cardiovascular risk factors, cardiovascular structural remodeling, metabolic optimization, mitochondrial functional enhancement, and exerkine-mediated inter-tissue communication. These mechanisms collectively contribute to a more healthy cardiovascular ageing. Gaining a deeper insight into how exercise promotes healthy cardiovascular ageing not only advances our understanding of cardiovascular ageing but also illuminates potential approaches to prevent cardiovascular ageing and treat cardiovascular diseases. This review systematically discusses contemporary findings on exercise-mediated anti-cardiovascular ageing, and critically evaluates potential clinical applications and future research directions in the field.
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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