Zihang Feng , Yuan Xing , Wei Yi , Feng Gao , Yang Sun , Xing Zhang
{"title":"运动是对抗心血管老化的灵丹妙药。","authors":"Zihang Feng , Yuan Xing , Wei Yi , Feng Gao , Yang Sun , Xing Zhang","doi":"10.1016/j.arr.2025.102848","DOIUrl":null,"url":null,"abstract":"<div><div>The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains incompletely mapped. Current progresses suggest that exercise exerts its anti-ageing effects through multiple synergistic mechanisms, including attenuation of conventional cardiovascular risk factors, cardiovascular structural remodeling, metabolic optimization, mitochondrial functional enhancement, and exerkine-mediated inter-tissue communication. These mechanisms collectively contribute to a more healthy cardiovascular ageing. Gaining a deeper insight into how exercise promotes healthy cardiovascular ageing not only advances our understanding of cardiovascular ageing but also illuminates potential approaches to prevent cardiovascular ageing and treat cardiovascular diseases. This review systematically discusses contemporary findings on exercise-mediated anti-cardiovascular ageing, and critically evaluates potential clinical applications and future research directions in the field.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"111 ","pages":"Article 102848"},"PeriodicalIF":12.4000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exercise as elixir to combat cardiovascular ageing\",\"authors\":\"Zihang Feng , Yuan Xing , Wei Yi , Feng Gao , Yang Sun , Xing Zhang\",\"doi\":\"10.1016/j.arr.2025.102848\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains incompletely mapped. Current progresses suggest that exercise exerts its anti-ageing effects through multiple synergistic mechanisms, including attenuation of conventional cardiovascular risk factors, cardiovascular structural remodeling, metabolic optimization, mitochondrial functional enhancement, and exerkine-mediated inter-tissue communication. These mechanisms collectively contribute to a more healthy cardiovascular ageing. Gaining a deeper insight into how exercise promotes healthy cardiovascular ageing not only advances our understanding of cardiovascular ageing but also illuminates potential approaches to prevent cardiovascular ageing and treat cardiovascular diseases. This review systematically discusses contemporary findings on exercise-mediated anti-cardiovascular ageing, and critically evaluates potential clinical applications and future research directions in the field.</div></div>\",\"PeriodicalId\":55545,\"journal\":{\"name\":\"Ageing Research Reviews\",\"volume\":\"111 \",\"pages\":\"Article 102848\"},\"PeriodicalIF\":12.4000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ageing Research Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1568163725001941\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ageing Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568163725001941","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Exercise as elixir to combat cardiovascular ageing
The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains incompletely mapped. Current progresses suggest that exercise exerts its anti-ageing effects through multiple synergistic mechanisms, including attenuation of conventional cardiovascular risk factors, cardiovascular structural remodeling, metabolic optimization, mitochondrial functional enhancement, and exerkine-mediated inter-tissue communication. These mechanisms collectively contribute to a more healthy cardiovascular ageing. Gaining a deeper insight into how exercise promotes healthy cardiovascular ageing not only advances our understanding of cardiovascular ageing but also illuminates potential approaches to prevent cardiovascular ageing and treat cardiovascular diseases. This review systematically discusses contemporary findings on exercise-mediated anti-cardiovascular ageing, and critically evaluates potential clinical applications and future research directions in the field.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.