缺血性和出血性脑卒中不同细胞类型的组织病理学和超微结构变化。

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Houlian Zhang , Na Xing , Junmin Wang , Jing Zhang , Cao Jia , Yifei Li , Hualin Fan , Yiying Liu , Fatemeh Dialameh , Nannan Cheng , Yanyan Sun , Junyang Wang , Menglu Wang , Moxin Wu , Xiaoping Yin , Wei Zhu , Jing Li , Jiewen Zhang , Chao Jiang , Fei Xing , Jian Wang
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引用次数: 0

摘要

中风是一种中枢神经系统疾病,导致高发病率和死亡率,同时治疗选择有限。这种情况通常与超微结构水平上不同神经元成分的病理改变有关,包括细胞体、神经突和突触,以及星形胶质细胞、小胶质细胞和少突胶质细胞等胶质细胞。这些变化包括细胞体形状和大小的改变,神经突的破坏,以及突触密度和分布的变化。血脑屏障是大脑防御系统的重要组成部分,中风后也会受损,导致进一步的并发症。尽管脑卒中研究取得了显著进展,但对其超微结构病理改变的研究仍缺乏全面的综述。鉴于目前治疗中风的挑战,识别动态的亚细胞结构变化可以提高我们对中风后复杂病理过程的理解,最终提高临床诊断和治疗策略。本文旨在总结和分析通过透射电镜记录的缺血性和出血性中风的超微结构变化,为未来的研究和开发新的治疗方法提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke
Stroke is a disease of the central nervous system that leads to high rates of morbidity and mortality, along with limited treatment options. This condition is frequently linked to pathologic alterations at the ultrastructural level within diverse neuronal components, including cell bodies, neurites, and synapses, as well as in glial cells like astrocytes, microglia, and oligodendrocytes. These changes include alterations in the shape and size of cell bodies, disruption of neurites, and changes in the density and distribution of synapses. The blood-brain barrier, a crucial component of the brain's defense system, is also compromised following a stroke, leading to further complications. Although stroke research has significantly advanced, there is still a lack of comprehensive reviews on ultrastructural pathological changes. Given the current challenges in treating stroke, identifying dynamic subcellular structural changes can improve our understanding of the complex pathologic processes after a stroke, ultimately enhancing clinical diagnosis and therapeutic strategies. This review aims to summarize and analyze the ultrastructural changes documented through transmission electron microscopy in both ischemic and hemorrhagic stroke, providing insights for future research and developing novel treatments.
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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