Quantitative Imaging in Medicine and Surgery最新文献

{"title":"Clinical utility of dynamic chest radiography in the oblique view to evaluate cardiac contraction: a case description.","authors":"Hiroaki Hiraiwa, Shin Nagai, Ryota Ito, Kiyota Kondo, Shingo Kazama, Toru Kondo, Shiro Adachi, Kenji Furusawa, Akihito Tanaka, Ryota Morimoto, Takahiro Okumura, Toyoaki Murohara","doi":"10.21037/qims-24-1679","DOIUrl":"10.21037/qims-24-1679","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2632-2641"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided minimally invasive treatment of nonfunctional parathyroid cysts: a description of five cases.","authors":"Mengyao Zhao, Zeyang Dong, Xixi Sun, Lizhi Zheng, Bin Huang","doi":"10.21037/qims-24-1921","DOIUrl":"10.21037/qims-24-1921","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2658-2665"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter integrity of default mode network after a 3-month aerobic dance program in patients with amnestic mild cognitive impairment: a secondary analysis of a randomized clinical trial.","authors":"Han Wu, Yi Zhu, Xi Yang, Jiahuan Li, Fanfan Meng, Ming Qi, Hongyuan Ding, Shui Tian, Tong Wang","doi":"10.21037/qims-24-1212","DOIUrl":"10.21037/qims-24-1212","url":null,"abstract":"<p><strong>Background: </strong>Exercise is an effective non-pharmacological strategy to enhance cognitive function in individuals with mild cognitive impairment (MCI). Our previous studies confirmed that aerobic dance can increase the amplitude of low-frequency fluctuations (LFF) in bilateral fronto-temporal, entorhinal, anterior cingulate, and para-hippocampal cortices. However, its effects on structural connections remain unclear. The present study comprised a secondary analysis of a randomized clinical trial and aimed to examine the impact of a 3-month aerobic dance program on white matter integrity of default mode network (DMN) in older adults with amnestic MCI, as assessed by magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>A total of 112 patients with memory decline were recruited, 38 of whom completed cognitive assessments and magnetic resonance scans and were randomized to the exercise group (n=19) or the control group (n=19). The exercise group received 3 months of aerobic dance and health education, whereas the control group only received health education. All participants underwent cognitive assessments and MRI scans at baseline and after the 3-month intervention. A series of neuropsychological assessments, including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Wechsler Memory Scale-Revised Logical Memory (WMS-RLM), Trail Making Test Part A&B (TMT-A&B), Symbol Digit Modalities Test (SDMT), and Forward and Backward Digit Span Task (DST) Chinese version, were used to assess the participants' global cognitive function, memory function, and executive function. Structural connections of the hippocampus-hub temporal network were analyzed using the network-based statistic.</p><p><strong>Results: </strong>Finally, 16 participants in each group were included in the statistics and analysis. There was no statistical difference in cognitive functions at 3 months in the control group compared with those at baseline. However, the cognitive functions of the exercise group improved significantly after 3 months of aerobic dance, including MMSE (P=0.006), MoCA (P=0.009), WMS-RLM (P=0.005), TMT-A (P=0.007), and DST (P=0.025). Moreover, the exercise group had significantly improved WMS-RLM (P=0.003) compared to the control group after 3 months of intervention. In addition, they showed significant increases in structural connections within the DMN, including the structural connection between hippocampus and para-hippocampus, hippocampus and fusiform gyrus, hippocampus and middle temporal gyrus, and precuneus and middle temporal gyrus. The structural connection between DMN and supplementary motor area was also significantly increased in the exercise group, correlating positively with MMSE (R=0.31, P=0.04) and negatively with TMT-A (R=-0.40, P=0.011), respectively.</p><p><strong>Conclusions: </strong>A 3-month aerobic dance program may enhance the structural connections in the hippocampus-hub temporal network ","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2016-2028"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography-guided <i>vs</i>. coronary angiography-guided percutaneous coronary intervention: a systematic review and meta-analysis.","authors":"Jiayi Luo, Yu Xue, Zimin Xu, Kai Xu, Yang Li, Yaling Han","doi":"10.21037/qims-24-1628","DOIUrl":"10.21037/qims-24-1628","url":null,"abstract":"<p><strong>Background: </strong>The superiority of optical coherence tomography (OCT) guidance over coronary angiography (CA) guidance in optimizing therapy in patients undergoing percutaneous coronary intervention (PCI) remains uncertain. Consequently, we conducted a comprehensive meta-analysis with the objective of providing a higher level of evidence.</p><p><strong>Methods: </strong>The databases of PubMed/Medline, Embase, and Cochrane Central were searched in March 2024. The outcomes of this meta-analysis included all-cause death, cardiovascular death, major adverse cardiovascular events (MACE), restenosis, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), post-intervention minimum stent area (MSA), post-intervention minimum lumen diameter (MLD), and follow-up MLD. Statistical analysis was conducted using RevMan 5.3 and STATA version 18. The degree of heterogeneity was evaluated using the I² statistical test. When I² exceeded 50%, heterogeneity was deemed to be substantial, prompting the application of a random effects model; conversely, a fixed effects model was employed. The results were expressed as risk ratio (RR) and mean deviation (MD) with their corresponding 95% confidence interval (CI).</p><p><strong>Results: </strong>A total of 25 articles were included in the study. In terms of clinical outcomes, OCT-guided PCI was associated with a significant reduction in all-cause death (RR =0.62; 95% CI: 0.47-0.83; P=0.001), cardiovascular death (RR =0.47; 95% CI: 0.32-0.69; P<0.0001), and MACE (RR =0.65; 95% CI: 0.54-0.77; P<0.00001). Meanwhile, no statistically significant differences were observed for restenosis (RR =0.91; 95% CI: 0.73-1.13; P=0.38), MI (RR =0.83; 95% CI: 0.69-1.00; P=0.05), TLR (RR =0.86; 95% CI: 0.66-1.10; P=0.23), and TVR (RR =0.82; 95% CI: 0.63-1.07; P=0.15). In terms of surrogate endpoints, OCT-guided PCI was associated with a significant enhancement of MSA (MD =0.30; 95% CI: 0.04-0.56; P=0.03) and MLD at follow-up (MD =0.12; 95% CI: 0.02-0.22; P=0.02). Nevertheless, no significant increase in the post-intervention MLD was observed (MD =0.04; 95% CI: -0.02 to 0.10; P=0.19).</p><p><strong>Conclusions: </strong>Compared with CA, the use of OCT for PCI guidance may be an effective strategy to optimize treatment.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2246-2257"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of ultra-microangiography for biliary atresia.","authors":"Lingling Deng, Xuemei Qi, Gang Wang, Lijun Wang, Shaoling Liu","doi":"10.21037/qims-24-1586","DOIUrl":"10.21037/qims-24-1586","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Color Doppler flow imaging (CDFI) has auxiliary diagnostic value for biliary atresia (BA), as it can detect positive blood flow signals under the liver capsule; however, it has low sensitivity and is easily affected by respiration. Ultra-microangiography (UMA) is a microvascular imaging technique that focuses on low-speed blood flow, and can display microvascular structures that traditional CDFI cannot. This study aimed to explore the application value of UMA in the diagnosis of BA by analyzing and comparing the microvascular detection capabilities of CDFI and UMA in infants with BA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective study of 52 infants diagnosed with BA via intraoperative cholangiography or surgical exploration at Shandong Provincial Hospital Affiliated to Shandong First Medical University between January 2022 and February 2024 was conducted. An additional 105 newborns and infants with similar gender ratios and ages admitted to the hospital for jaundice were included in the study as control subjects. Prior to treatment, all subjects underwent two-dimensional ultrasonography, CDFI, and UMA to measure the microvascular color pixel percentage (CPP) under the liver capsule. The subjects' clinical laboratory information, including age, weight, gamma-glutamyl transpeptidase (GGT), total bilirubin (TB), and direct bilirubin (DB), was collected. The independent sample &lt;i&gt;t&lt;/i&gt;-test was used for the normally distributed continuous variables, while the Mann-Whitney &lt;i&gt;U&lt;/i&gt;-test was used for the non-normally distributed continuous variables, and Fisher's exact test was used for the categorical variables. Receiver operating characteristic curves were used to evaluate the diagnostic value of the CPP measured by UMA (CPP&lt;sub&gt;UMA&lt;/sub&gt;) in BA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference between the two groups in terms of age and weight (P=0.057 and 0.613, respectively). The hepatic artery diameter, GGT, TB, and DB of the BA group were significantly higher than those of the control group (P=0.007, 0.005, 0.003, and 0.001, respectively). The maximum length and width of the gallbladder of the BA group were significantly lower than those of the control group (P=0.005 and 0.001, respectively). The CPP&lt;sub&gt;UMA&lt;/sub&gt; values of the control and BA groups were 60.7%±5.7% and 72.2%±5.6%, respectively, and were significantly higher than the CPPs measured by CDFI (CPP&lt;sub&gt;CDFI&lt;/sub&gt;), which were 22.1%±4.1% and 24.9%±4.4%, for the control and BA groups, respectively. Comparisons of the CPP&lt;sub&gt;UMA&lt;/sub&gt; values between the BA and control groups, as well as comparisons of the CPP&lt;sub&gt;UMA&lt;/sub&gt; and CPP&lt;sub&gt;CDFI&lt;/sub&gt; values within the BA group and within the control group, all showed statistically significant differences (all P=0.001), while there was no statistically significant difference in the CPP&lt;sub&gt;CDFI&lt;/sub&gt; values between the BA and control groups (P=0.055). The optimal cut-off value for the CPP&lt;su","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"1784-1792"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat-separated T1 mapping for liver function analysis on gadoxetic acid-enhanced MR imaging: 2D two-point Dixon Look-Locker inversion recovery sequence for differentiation of Child-Pugh class B/C from Child-Pugh class A/chronic liver disease.","authors":"Ye Rin Hwang, Miri Seo, Ute Goerke, Mahesh Bharath Keerthivasan, MunYoung Paek, Seong Jin Park, Myung-Won You","doi":"10.21037/qims-24-805","DOIUrl":"10.21037/qims-24-805","url":null,"abstract":"<p><strong>Background: </strong>T1 relaxation time is a tissue-specific parameter that correlates with liver fibrosis, and can be a valuable tool for detecting and staging of liver disease. However, T1 can be affected by histological factors such as fat, so it is necessary to study the effects of hepatic steatosis when assessing liver function and fibrosis. The purpose of this study is to investigate the fat separation effect of T1 mapping using Dixon watermap Look-Locker inversion recovery (LLIR) in the assessment of liver function on gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>A total of 226 patients who underwent 3T MRI, including a 2D Dixon fat-separated LLIR T1 mapping, were included retrospectively. Two independent readers measured pre- and post-contrast T1 relaxation times (preT1 and postT1) on composite and watermap T1, and reproducibility was evaluated. The correlation of T1 parameters with biochemical and imaging biomarkers of liver function were assessed on both composite and Dixon watermap images; T1 parameters included averaged preT1, postT1 values, changes between pre- and post-T1liver (deltaT1) and adjusted T1liver (postT1liver - T1spleen/T1spleen). And the diagnostic performance of T1 parameters for Child-Pugh (CP) class was also evaluated.</p><p><strong>Results: </strong>Inter- and intra-reader reproducibility showed almost perfect agreement [intraclass correlation coefficient (ICC) 0.929-0.999]. Watermap preT1 (r=-0.125, P=0.068) and watermap deltaT1 (r=0.055, P=0.414) showed loss of correlation with fat fraction (FF) compared with preT1 and deltaT1. Albumin, total bilirubin (TB), hepatobiliary enhancement grade, and R2* (1/T2*), were significantly associated with watermap T1, eliminating the effect of FF. Area under the curve (AUC) of preT1, watermap preT1, deltaT1, postT1, watermap adjusted T1, and adjusted T1 were 0.681 [standard error (SE) 0.114], 0.748 (SE 0.098), 0.921 (SE 0.033), 0.951 (SE 0.018), 0.950 (SE 0.018), and 0.973 (SE 0.013) respectively, for differentiating patient with CP class B/C from CP-A/chronic liver disease (CLD).</p><p><strong>Conclusions: </strong>T1 values using Dixon watermap LLIR eliminated the confounding effect of fat and showed the correlation with serological and imaging markers of liver function. Adjusted T1, watermap adjusted T1, and postT1 showed the highest diagnostic performance in differentiating CP class B/C from CP-A/CLD.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"1753-1767"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of lumbar disc degeneration characteristics and bone mineral density in patients with osteoporosis based on the Roussouly classification.","authors":"Shundan Zhao, Mengjiao Chen, Shaoqing Chen, Yingying Huang, Wangcan Ma, Zhihan Yan, Jiawei He","doi":"10.21037/qims-24-1872","DOIUrl":"10.21037/qims-24-1872","url":null,"abstract":"<p><strong>Background: </strong>Lumbar disc degeneration (LDD), endplate damage, and osteoporosis (OP) are closely linked; however, research on the influence of sagittal alignment on bone mineral density (BMD) and LDD is limited. This study aimed to explore the relationship between BMD, degenerative changes in intervertebral discs (IVDs), and endplate damage in patients with OP based on the Roussouly classification.</p><p><strong>Methods: </strong>This retrospective study included 150 patients with and 150 without OP. Dual-energy X-ray absorptiometry (DXA) measured L1-4 vertebral BMD. Magnetic resonance imaging (MRI) assessed Pfirrmann grading (as a marker for disc dehydration status) and grading of endplate damage in the L1-S1 segments. The vertebral osteophyte score was evaluated. IVD degeneration and endplate damage were compared between groups and correlated with BMD. Patients were divided into four subgroups according to the Roussouly classification (based on different sagittal morphologies of spinopelvic anatomy) for further analysis.</p><p><strong>Results: </strong>The Pfirrmann scores and endplate damage scores of the OP group at L1/2-L5/S1 were significantly higher than those of the control group (P<0.001). A negative correlation was observed between BMD and both Pfirrmann scores and endplate damage scores in the OP group (P<0.05). In the control group, no significant differences were observed in BMD and lumbar IVD parameters at L1/2-L5/S1 among the four patient subtypes. In the OP group, type II patients had the lowest BMD. Type I and II patients exhibited significantly greater disc dehydration and greater endplate damage sat L1/2-L5/S1 than type III and IV patients (P<0.05), with type II experiencing severe degeneration. Similarly, at the L4/5 and L5/S1 segments, type I and II patients demonstrated significantly greater disc dehydration and endplate damage compared to the type IV patients. Furthermore, type II patients showed more pronounced disc dehydration and endplate damage than type III patients. The correlation between BMD and IVD parameters was stronger in type I and II patients than in type III (P<0.05), with type II showing the strongest correlation. No significant correlation was found in type IV patients.</p><p><strong>Conclusions: </strong>Patients with OP exhibited higher degrees of lumbar disc dehydration and endplate damage than the control group. A negative correlation was observed between BMD and the extent of lumbar disc dehydration, as well as endplate damage. Type II patients exhibited the lowest BMD. Types I and II displayed significantly greater LDD and endplate damage than types III and IV, with type II experiencing more severe degeneration than type I.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2494-2511"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning for identifying cervical ossification of the posterior longitudinal ligament: a systematic review and meta-analysis.","authors":"Felix Corr, Dustin Grimm, Paul Leach","doi":"10.21037/qims-24-1485","DOIUrl":"10.21037/qims-24-1485","url":null,"abstract":"<p><strong>Background: </strong>Ossification of the posterior longitudinal ligament (OPLL) is a significant contributor for unintentional durotomy following anterior spinal surgery, neural compression, and cervical myelopathy. While traditional diagnostic methods like plain radiography are commonly used, they may yield false negatives. The diagnostic accuracy and reliability of artificial intelligence methods for detecting this condition remain largely unexplored. This study aimed to systematically evaluate the performance of deep learning models (DLMs) in diagnosing and predicting cervical OPLL.</p><p><strong>Methods: </strong>This systematic review assesses the utilization of DLMs in diagnosing and predicting OPLL. Inclusion criteria were defined as the use of DLM for the diagnosis and prediction of cervical OPLL in adult patients. Databases included PubMed, Google Scholar, Cochrane Library, ScienceDirect, and BASE. The risk of bias was assessed using the QUADAS-2 tool.</p><p><strong>Results: </strong>Seven studies with a pooled sample size of 3,373 patients were included. The pooled accuracy, area under the curve, sensitivity, and accuracy are 0.93, 0.92, 0.88, and 0.9. DLM demonstrated superior diagnostic performance, outperforming human comparator groups in terms of sensitivity (0.86 <i>vs.</i> 0.77), specificity (0.98 <i>vs.</i> 0.74), and accuracy (0.89 <i>vs.</i> 0.76). The meta-analysis with a pooled sample size of 1,016 patients revealed the highest proportion of right-identified OPLL subtypes in the mixed- and continuous subtypes (0.93 and 0.87). Accuracy and sensitivity of DLM were higher in the upper compared to the lower cervical spine.</p><p><strong>Conclusions: </strong>Despite limitations in methodological variations and deep learning challenges, the findings support integrating these models into diagnostic protocols. Their robust performance suggests potential value in clinical practice, offering improved diagnostic accuracy and enhanced subtype differentiation.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"1719-1740"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic chest radiography in post-lobectomy recovery: a novel approach to evaluating pulmonary function and thoracic structures in patients with primary lung cancer.","authors":"Kazuki Hayashi, Takuya Shiratori, Keiko Ueda, Keigo Okamoto, Yoko Kataoka, Yo Kawaguchi, Yasuhiko Ohshio, Jun Hanaoka","doi":"10.21037/qims-24-1714","DOIUrl":"10.21037/qims-24-1714","url":null,"abstract":"<p><strong>Background: </strong>Lobectomy for lung cancer leads to changes in thoracic structures and reduced pulmonary function, but real-time evaluation of compensatory mechanisms has been challenging. This study employed dynamic chest radiography to examine post-lobectomy changes in the projected lung area and excursion of diaphragm, as evaluated by sequential chest radiography, and determine their correlation with pulmonary function recovery.</p><p><strong>Methods: </strong>This single-center and cross-sectional study was conducted at the Shiga University of Medical Science Hospital and included 65 patients who underwent lobectomy between May 2018 and December 2020. Dynamic chest radiography was performed preoperatively and at 1, 3, 6, and 12 months postoperatively alongside standard pulmonary function tests. We evaluated the postoperative trends in pulmonary function, projected lung area, and excursion of diaphragm. The results were analyzed using the Mann-Whitney <i>U</i> test and Fisher's exact test. Additionally, correlations between changes in the pulmonary function and dynamic chest radiography (DCR) parameters were assessed using Spearman's rank correlation coefficients. The utility of DCR in predicting postoperative pulmonary function recovery was further examined using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Significant correlations were observed between the maximum projected lung area and pulmonary function recovery, particularly in upper lobectomy cases (correlation with vital capacity at 1 month postoperatively: r=0.72, P<0.01). This correlation was observed consistently across various surgical procedures, which suggests that early postoperative projected lung area measurements can predict pulmonary function recovery at 12 months. Excursion of diaphragm, especially in upper lobectomy cases, also showed a positive correlation with pulmonary function recovery (correlation with vital capacity at 1 month postoperatively: r=0.55, P<0.01). Receiver operating characteristic curve analysis validated the predictive capability of early postoperative projected lung area for long-term pulmonary function recovery with area under the curve of 0.815 [95% confidence interval (CI): 0.636-0.994] for upper lobectomy and 0.798 (95% CI: 0.564-0.982) for lower lobectomy groups.</p><p><strong>Conclusions: </strong>Dynamic chest radiography, which assessed the projected lung area and excursion of diaphragm, emerged as a promising non-invasive tool for monitoring post-lobectomy recovery and guiding rehabilitation efforts. These findings indicate its potential as an early predictor of pulmonary recovery, advocating for its integration into the perioperative care of patients with lung cancer. Future research should expand patient cohorts and refine predictive models using preoperative dynamic chest radiography to enhance post-lobectomy outcomes.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"2232-2245"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the International Society of Lymphology and Taiwan Lymphoscintigraphy Staging systems: correlation, reliability, and a quantitative severity index in extremity lymphedema.","authors":"Qiushuang Li, Qingqing Tang, Kaihang Luo, Shuai Zhang, Xiang Zhou, Yi Yang, Ping Li, Jian Qi, Yuancheng Zhang","doi":"10.21037/qims-24-1926","DOIUrl":"10.21037/qims-24-1926","url":null,"abstract":"<p><strong>Background: </strong>The accurate assessment and staging of lymphedema are critical for effective management. This study sought to compare the International Society of Lymphology (ISL) staging system with the Taiwan Lymphoscintigraphy Staging (TLS) system, and to evaluate the reliability of both lymphedema staging systems.</p><p><strong>Methods: </strong>A retrospective study of patients with primary or secondary extremity lymphedema was conducted. Lymphedema was staged using both the ISL staging system and the TLS system. The correlation between the systems was analyzed using the Spearman's rank correlation coefficient, and the inter- and intra-observer reliability of the TLS system was assessed using the intraclass correlation coefficient (ICC). A severity index based on limb circumference differences adjusted for body mass index (BMI) was also developed, and its correlation with both staging systems was verified by a one-way analysis of variance (ANOVA) analysis.</p><p><strong>Results: </strong>In total, 50 patients (mean age: 56.1±12.9 years, BMI: 24.7±3.6 kg/m²) were included in the study. A statistically significant correlation was found between the ISL staging system and the TLS system (r=0.49, P<0.05). The severity index was also significantly correlated with the ISL staging system (r=0.56, P<0.05) and the TLS system (r=0.37, P<0.05). Additionally, both systems showed high inter- and intra-observer reliability (ICC >0.90). The ANOVA results revealed significant differences in the severity index among the different ISL staging system stages and TLS system grades (P<0.05), highlighting the utility of the severity index in distinguishing varying levels of lymphedema severity.</p><p><strong>Conclusions: </strong>The ISL staging system and the TLS system showed strong agreement and reliability. The TLS system, with its quantitative imaging approach, is particularly suited for research, while the ISL staging system remains useful for routine clinical practice. The severity index offers an effective quantitative measure for assessing lymphedema severity.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 3","pages":"1822-1833"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}