Quantitative Imaging in Medicine and Surgery最新文献

{"title":"CMMIQA: a prompt-driven cross-modality multi-organ medical image quality assessment model.","authors":"Siyi Xun, Yue Sun, Yapeng Wang, Mingwei Wang, Mingxiang Wu, Xiaohong Liu, Tao Tan","doi":"10.21037/qims-2025-127","DOIUrl":"10.21037/qims-2025-127","url":null,"abstract":"<p><strong>Background: </strong>Three-dimensional (3D) medical imaging technology plays an important role in clinical diagnosis, whose image quality is the cornerstone of effective diagnosis and optimization of imaging equipment. Therefore, the assessment of medical images quality has received a wide range of attention. In this paper, we are committed to developing a way that can comprehensively assess the quality of medical images of different modality and organs.</p><p><strong>Methods: </strong>We first used real rather than synthetic data to create the first 3D Cross-Modality Multi-Organ Medical Image Quality Assessment Database (CMMIQA-DB) for assessment of computed tomography (CT) and magnetic resonance imaging (MRI) image quality. Based on the database, a Cross-Modality Multi-Organ Medical Image Quality Assessment model with hybrid-convolution (Hybrid-conv) and aware prompts was proposed. This model uses a Hybrid-conv network to extract features from a variety of modality images. Simultaneously, quality regression training is performed with the help of aware prompts, and the quality prediction scores of different modality images are finally produced.</p><p><strong>Results: </strong>The experimental results of Spearman rank correlation coefficient (SRCC), Pearson linear correlation coefficient (PLCC), and root mean square error (RMSE) on reached 0.7476, 0.7153 and 0.3345 respectively, and the experimental results of 0.8618, 0.8705 and 0.1589 on manually labeled two-dimensional (2D) dataset respectively.</p><p><strong>Conclusions: </strong>Experimental results show that this model is superior to existing no-reference image quality assessment (IQA) methods and medical IQA models, while being able to transfer to other 2D and 3D medical image datasets as a foundation.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6326-6339"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous-time random walk and fractional order calculus models histogram analysis of glioma biomarkers, including <i>IDH1</i>, <i>ATRX</i>, <i>MGMT</i>, and <i>TERT</i>, on differentiation.","authors":"Yujie Ding, Hongquan Zhu, Yuanhao Li, Yufei Liu, Yan Xie, Jiaxuan Zhang, Yan Fu, Shihui Li, Li Li, Nanxi Shen, Wenzhen Zhu","doi":"10.21037/qims-2024-2725","DOIUrl":"10.21037/qims-2024-2725","url":null,"abstract":"<p><strong>Background: </strong>The focus of neuro-oncology research has changed from histopathologic grading to molecular characteristics, and medical imaging routinely follows this change. This study aimed to demonstrate the feasibility of using continuous-time random walk (CTRW) and fractional order calculus (FROC) models, together with histogram analysis, in identifying the states of molecular biomarkers of diffuse gliomas in adults.</p><p><strong>Methods: </strong>A total of 111 diffuse glioma patients undergoing multi-b-value diffusion-weighted imaging (DWI) were included. The histogram parameters of CTRW, FROC, and mono-exponential models were compared between diffuse gliomas with different molecular states [isocitrate dehydrogenase 1 (<i>IDH1</i>), X-linked alpha-thalassemia/mental retardation syndrome (<i>ATRX</i>), O6-methylguanine-DNA methyltransferase (<i>MGMT</i>), and telomere reverse transcriptase (<i>TERT</i>)] using independent samples <i>t</i>-test or Mann-Whitney <i>U</i> test. The diagnostic performance of each diffusion parameter was evaluated using receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>Statistically significant differences (P<0.05) were found between <i>IDH1</i>-mutant and wildtype gliomas in all diffusion parameters except for the kurtosis D_CTRW, 90^th percentile α_CTRW, kurtosis β_FROC, 90^th percentile µ_FROC, and kurtosis apparent diffusion coefficient (ADC). Moreover, the areas under the curve (AUCs) of the 10^th percentile β_CTRW, as well as the 10^th percentile, mean, and median β_FROC were significantly higher than all ADC histogram parameters following the DeLong test (P<0.05) in <i>IDH1</i> genotyping. The 90th percentile ADC (AUC =0.797) provided the highest diagnostic efficiency among individual parameters in <i>ATRX</i> genotyping of <i>IDH1</i>-mutant gliomas. The median β_CTRW (AUC =0.758) and 10^th percentile β_CTRW (AUC =0.869) provided the highest differential efficiency for <i>MGMT</i> and <i>TERT</i>, respectively.</p><p><strong>Conclusions: </strong>The CTRW and FROC models demonstrate good diagnostic performance in predicting different molecular subtypes in diffuse gliomas, and provide new imaging biomarkers for probing tumor structural heterogeneity at a subvoxel level.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6118-6136"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between ultrasonic features and expression of immunohistochemical factors in invasive ductal carcinoma of the breast.","authors":"Yan Yang, Lian Cheng","doi":"10.21037/qims-24-1975","DOIUrl":"10.21037/qims-24-1975","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Breast cancer is the most common malignancy among women globally, with invasive ductal carcinoma (IDC) accounting for approximately 80% of all breast cancer cases. IDC exhibits significant heterogeneity in terms of pathological manifestations and prognosis, which are largely influenced by the expression of immunohistochemical (IHC) factors. The study aimed to investigate the correlation between ultrasonic features and the expression of IHC factors in IDC of the breast.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted of the clinical data of patients with IDC confirmed by surgery and pathology from January 2019 to December 2022, with ultrasonography performed pre-operation and standard sonograms retained. Specifically, the correlation between sonographic signs and the expression of IHC factors such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), E-cadherin, and Ki-67 was investigated using the univariate and binary logistic regression analyses. E-cadherin was included due to its role in epithelial-mesenchymal transition and metastasis in IDC. Key sonographic features (e.g., Adler grade, morphology, posterior echo) and IHC factors were analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study identified significant associations between specific ultrasonic features and IHC factor expression. For ER expression, irregular shape [odds ratio (OR) =1.694, 95% confidence interval (CI): 1.032-2.309, P=0.011], reduced posterior echo (OR =1.904, 95% CI: 1.211-2.901, P=0.008), and hyperechoic halo (OR =3.705, 95% CI: 1.277-7.903, P=0.003) were associated with ER-positive expression, while Adler grade II-III was associated with ER-negative expression (OR =0.390, 95% CI: 0.127-0.745, P&lt;0.001). For PR expression, hyperechoic halo (OR =4.905, 95% CI: 2.664-11.231, P=0.01) was associated with PR-positive expression, while smooth margin (OR =0.513, 95% CI: 0.132-0.784, P&lt;0.001) and maximum diameter ≥2 cm (OR =0.622, 95% CI: 0.267-0.874, P=0.005) were associated with PR-negative expression. Calcification (OR =1.806, 95% CI: 1.237-4.584, P=0.002) and maximum diameter ≥2 cm (OR =1.409, 95% CI: 1.194-2.385, P=0.01) were associated with HER-2-positive expression. Lymphatic metastasis (OR =1.450, 95% CI: 1.057-2.328, P=0.03) and Adler grade II-III (OR =0.704, 95% CI: 0.406-1.242, P=0.02) were associated with E-cadherin-positive expression. Reduced posterior echo was associated with Ki-67-negative expression (OR =0.307, 95% CI: 0.106-0.684, P=0.02). The areas under the ROC curves for each IHC factor were as follows: ER, 0.832; PR, 0.756; HER-2, 0.675; E-cadherin, 0.684; Ki-67, 0.703.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Since IHC factors are correlated with ultrasonic features to some extent, their biological behaviors can be preliminarily identified through analyses of their sonographic features, thereby providing a reference for clinically individualized treatment reg","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6044-6052"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of computer-assisted surgery system in a child with multiple traumas: a case report.","authors":"Chaojin Wang, Ying He, Jing Zhao, Feifei Wang, Shuai Jiang, Chengzhan Zhu, Haoyu Liang, Bin Wei, Xiwei Hao, Qian Dong","doi":"10.21037/qims-24-1862","DOIUrl":"10.21037/qims-24-1862","url":null,"abstract":"<p><strong>Background: </strong>Severe traumatic liver rupture in children has a high mortality rate. The computer-assisted surgery (CAS) system is an effective medical image simulation tool, which can display the adjacent relationship between the liver and surrounding tissues (especially compressed blood vessels) in a three-dimensional (3D), dynamic and complete way, and assist in precise liver resection. It provides important guidance for preoperative planning and intraoperative navigation. This chapter reports the individualized computer-assisted surgical planning and progress of a case of complex pediatric abdominal trauma.</p><p><strong>Case description: </strong>A 3-year-old girl was admitted to the hospital due to a severe abdominal crush injury caused by a car accident. Contrast-enhanced computed tomography (CT) showed grade V liver injuries [2018 American Association for the Surgery of Trauma-Organ Injury Scale (2018 AAST-OIS)], as well as splenic and renal contusion. Emergency CAS was performed to repair liver contusion. Biliary fluid was drained from the chest cavity after the operation, and contrast-enhanced CT showed diaphragmatic rupture and intrahepatic pseudoaneurysm. The ruptured diaphragm was repaired by laparotomy with the assistance of a Hisense CAS system, and the intrahepatic pseudoaneurysm was treated by interventional therapy. The child responded well to the comprehensive treatment, and no complications such as bile leakage and infection were found after the operation. Regular imaging and laboratory tests confirmed that the child recovered stably, and the child displayed satisfactory physical development and growth during the follow-up period.</p><p><strong>Conclusions: </strong>The CAS system can predict surgical risk, and has important clinical value for in the treatment of children with multiple traumas.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6526-6534"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of breast cancer subtypes and correlation with biological status using functional magnetic resonance imaging: comparison with amide proton transfer-weighted imaging and diffusion-weighted imaging.","authors":"Mingzhe Xu, Dongqiu Shan, Renzhi Zhang, Jing Li, Lanwei Guo, Xuejun Chen, Jinrong Qu","doi":"10.21037/qims-24-2174","DOIUrl":"10.21037/qims-24-2174","url":null,"abstract":"<p><strong>Background: </strong>Differentiating molecular subtypes and identifying biological markers in breast cancer (BC) are essential for prognostic stratification and treatment selection. This study aimed to compare the effectiveness of amide proton transfer-weighted imaging (APTWI) and diffusion-weighted imaging (DWI) in differentiating molecular subtypes and predicting the biological status of BC.</p><p><strong>Methods: </strong>This retrospective study included 109 women (aged 50.8±10.8 years) with BC who underwent 3T APTWI and DWI between May 2023 and January 2024. Patients were categorized by molecular subtypes and expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67. Magnetization transfer ratio asymmetry (MTRasym) and apparent diffusion coefficient (ADC) values were measured. The area under the receiver operating characteristic (ROC) curve (AUC) was used to assess the performance of MTRasym and ADC values in distinguishing subtypes. Pearson's correlation analysis was used to examine the relationship between MTRasym, ADC values, and the Ki-67 proliferation index.</p><p><strong>Results: </strong>Triple-negative (TN) cancers (3.03%±0.56%) had significantly higher MTRasym values than luminal A (2.25%±1.00%) and luminal B (2.39%±0.81%) cancers (P=0.006, 0.012). HER2-enriched cancers (2.93%±0.71%) also had significantly higher MTRasym than luminal A cancers (P=0.039). MTRasym and ADC values were significantly higher in ER-negative (ER-) than they were in ER-positive (ER+) cancers (P<0.001, P=0.040), and MTRasym values were higher in PR-negative (PR-) and high-Ki-67 cancers (P<0.001, P=0.013). AUC values for MTRasym ranged from 0.699 to 0.799, depending on the subtype and biological marker comparison. MTRasym and ADC values showed a weak positive correlation with the Ki-67 index (r=0.37, P<0.001, and r=0.31, P=0.003).</p><p><strong>Conclusions: </strong>APTWI is more effective than DWI for differentiating BC subtypes and predicting biological markers, providing valuable insights for clinical management.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6102-6117"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial adipose tissue provides incremental value in predicting major adverse cardiac events in systemic sclerosis patients without pulmonary arterial hypertension beyond traditional risk factors.","authors":"Jingfeng Huang, Le Yang, Binhua Xie, Fangjie Shen, Xiaodong Zheng, Qianjiang Ding, Yuning Pan, Xinzhong Ruan","doi":"10.21037/qims-24-2385","DOIUrl":"10.21037/qims-24-2385","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Systemic sclerosis (SSc) patients face greater odds of developing cardiovascular disease. In this study, patient clinical characteristics, coronary artery calcium score (CACS) values, and epicardial fat volume (EFV) were analyzed to identify predictors of major adverse cardiovascular events (MACE) among SSc patients without pulmonary arterial hypertension (PAH).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study enrolled 202 SSc patients and 202 controls from the First Affiliated Hospital of Ningbo University. SSc patients were separated into two groups based on their MACE status. The relationship between EFV and MACE incidence was assessed with Kaplan-Meier curves and Cox proportional hazards regression models, calculating hazard ratios (HRs) and 95% confidence intervals (CIs). Discrimination efficiency was evaluated based on global chi-square, concordance index (C-index), net reclassification index (NRI), and integrated discrimination improvement (IDI) index results. The incremental value of EFV as a predictor of MACE incidence was analyzed among these SSc patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;SSc patients presented with higher CACS values relative to controls {33.5 [interquartile range (IQR), 0-128.5] &lt;i&gt;vs.&lt;/i&gt; 0 (IQR, 0-88.25), P=0.006}, and EFV was similarly elevated among SSc patients [120 (IQR, 93.5-148.5) &lt;i&gt;vs.&lt;/i&gt; 110 (IQR, 89.5-142.5), P=0.037]. These patients underwent follow-up for a median of 48 (IQR, 36-60) months, during which 25.2% (51/202) of these patients experienced MACEs. The mean CACS value among MACE patients was significantly higher than that for non-MACE patients [88 (IQR, 19-144) &lt;i&gt;vs.&lt;/i&gt; 0 (IQR, 0-123), P=0.003], as was the mean EFV [160 (IQR, 138-192) &lt;i&gt;vs.&lt;/i&gt; 110 (IQR, 84-130), P&lt;0.001]. Multivariable Cox regression revealed that EFV was independently associated with the risk of MACE incidence (HR: 1.027, 95% CI: 1.015-1.041, P=0.001). Time-dependent Youden index analyses revealed that the optimal EFV cut-off for the prediction of MACE incidence was 126 cm&lt;sup&gt;3&lt;/sup&gt;, and this value was therefore used to separate participants into groups with low and high EFV levels. Kaplan-Meier analyses demonstrated that relative to low-EFV patients, high-EFV patients exhibited significantly lower MACE-free survival (P&lt;0.01). EFV values were found to aid in the prediction of MACE incidence more effectively when combined with traditional risk factors, increasing the C-index from 0.77 to 0.84 (P&lt;0.01), with a corresponding increase in the global c&lt;sup&gt;2&lt;/sup&gt; from 45.2 to 52.2 (P&lt;0.01), and corresponding significant increases in IDI and NRI values (0.12 and 0.46, respectively, both P&lt;0.01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;High EFV levels are independently associated with MACE risk among SSc patients, with poorer prognostic outcomes being evident among patients with SSc even if they were unaffected by PAH. The introduction of EFV offers incremental utility over traditional risk factors alone for t","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6087-6101"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic extracellular volume fraction based on dual-energy computed tomography iodine maps: association with diabetes.","authors":"Xiaoyi Cai, Bing Zhang, Haijing Sui, Gongbo Xue, Xiaoming Huang, Ling Liu, Guohua Wang, Xiaoran Yan, Hongyan Liu","doi":"10.21037/qims-24-2419","DOIUrl":"10.21037/qims-24-2419","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic fibrosis is closely related to blood glucose levels in diabetes, and pancreatic extracellular volume fraction (fECV) can quantify pancreatic fibrosis. The aim of this study was to investigate the correlation between pancreatic fECV measured by dual-energy computed tomography (DECT) iodine maps and hemoglobin A1c (HbA1c), and the feasibility of fECV in evaluating the progression of diabetes.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 213 patients who underwent abdominal contrast-enhanced DECT examinations; they were divided into two groups: non-diabetes (Group ND) and diabetes (Group D). Group ND included normal blood glucose (Group ND_N) and pre-diabetes (Group ND_PD). Group D included good blood glucose control (Group D_C) and poor blood glucose control (Group D_NC). HbA1c data were collected through electronic medical records. Pancreatic fECV was derived from DECT equilibrium phase iodine maps. Correlations between pancreatic fECV and HbA1c and comparisons of fECV among different groups were evaluated with Spearman's correlation and analysis of variance (ANOVA). Logistic regression analysis was conducted to investigate the association between pancreatic fECV and diabetes. Diagnostic value of fECV was assessed by receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>HbA1c was positively correlated with fECV (r_s=0.457, P<0.001). Pancreatic fECV was the independent indicator to assess the progression of diabetes [odds ratio (OR) =1.449; 95% confidence interval (CI): 1.265-1.659; P<0.001]. Pancreatic fECV in Group D was significantly higher than that in Group ND. There were significant differences during pairwise comparisons, excluding Group ND_N and Group ND_PD. The area under the curve (AUC) of fECV was 0.732 (95% CI: 0.664-0.799, sensitivity 60.20%, specificity 79.20%) between Group ND and Group D.</p><p><strong>Conclusions: </strong>Pancreatic fECV is positively correlated with HbA1c, the independent indicator to assess the progression of diabetes, and could indirectly reflect pathophysiological changes of pancreas with diabetes and indicate progression of diabetes from imaging.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"5969-5979"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of cardiac CT parameters in patients undergoing surgical correction for tricuspid regurgitation: a prospective study.","authors":"Young Joo Suh, Seung Hyun Lee, Sak Lee, Aaron Youngjae Kim, Young Jin Kim","doi":"10.21037/qims-2024-2915","DOIUrl":"10.21037/qims-2024-2915","url":null,"abstract":"<p><strong>Background: </strong>Predictive value of perioperative cardiac computed tomography (CT) parameters, for long-term postoperative outcomes following tricuspid valve (TV) surgery is unclear. We investigated the prognostic value of perioperative cardiac CT-derived tricuspid annular and right ventricular (RV) parameters on long-term postoperative adverse outcomes after TV surgery.</p><p><strong>Methods: </strong>We prospectively enrolled 66 patients who underwent corrective TV surgery for tricuspid regurgitation between June 2019 and January 2021 and had preoperative cardiac CT. Postoperative cardiac CT was performed 6 months after surgery. RV volume parameters were analyzed on the preoperative and postoperative cardiac CT images; the TV annulus diameter was measured from the preoperative CT. Postoperative adverse outcomes included death from any cause, unplanned postoperative admission, residual tricuspid regurgitation (≥ moderate), or RV systolic pressure >50 mmHg on postoperative echocardiography performed postoperative 6 months or later. Cox proportional hazard regression analyses were performed to identify significant imaging parameters associated with postoperative adverse outcomes. Restricted mean survival time was compared between groups at postoperative timepoints of 1 and 2 years.</p><p><strong>Results: </strong>During postoperative follow-up period (mean 597.9±182.2 days), adverse outcomes occurred in 8 (12.1%) of 66 patients. Postoperative CT revealed RV volume changes of -21.6%±20.1% and -19.4%±23.3% for RV end-diastolic volume (RVEDV)/body surface area (BSA) and RV end-systolic volume (RVESV)/BSA, respectively. After adjusting for age, longer tricuspid annulus diameter (TAD)_4ch/BSA and larger RVEDV/BSA and RV stroke volume (RVSV)/BSA on preoperative CT, and a greater extent of postoperative RVEDV/BSA reduction showed significant association with adverse outcomes. Among imaging parameters, the largest intergroup difference was observed in comparison by preoperative RVSV/BSA (cutoff 37.2 mL/m²) at postoperative 1-year timepoint (difference of 3.0 months, P<0.001) and RVEDV/BSA (cutoff 169.2 mL/m²) at postoperative 2-year timepoint (difference of 8.7 months, P<0.001).</p><p><strong>Conclusions: </strong>Perioperative cardiac CT imaging-based TAD and RV volume can provide independent prognostic information for postoperative adverse outcomes in patients undergoing TV surgery.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"5940-5954"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of MRI-based S1 vertebral bone quality score in assessing bone mineral density for adolescent idiopathic scoliosis.","authors":"Dandan Yang, Chuan Liu, Yaqi Zhu, Jinming Gu, Ting Gao","doi":"10.21037/qims-24-2209","DOIUrl":"10.21037/qims-24-2209","url":null,"abstract":"<p><strong>Background: </strong>Several studies have confirmed that magnetic resonance imaging (MRI) vertebral bone quality (VBQ) score can be used as a tool for opportunistic osteoporosis screening. However, obtaining the original VBQ score for patients with adolescent idiopathic scoliosis (AIS) can be challenging, especially in cases of severe scoliosis, and its stability may be affected. We aimed to assess the diagnostic potential of the VBQ method based on T1-weighted MRI of the first sacral vertebra (S1) in assessing bone mineral density (BMD) for patients with AIS.</p><p><strong>Methods: </strong>A total of 137 patients with AIS were retrospectively enrolled in the study. The S1 VBQ score and S1 Hounsfield units (HU) were measured based on MRI and computed tomography (CT), respectively. The S1 VBQ score was calculated based on the T1-weighted signal intensity of the S1 vertebra. Univariate analysis was performed to compare the differences between the normal-BMD cohort (QCT Z-score >-2.0) and low-BMD cohort (QCT Z-score ≤-2.0). Pearson correlation analysis was applied to determine the associations among S1 VBQ, S1 HU, and QCT Z-score. Independent factors associated with low BMD were determined through multivariate logistic regression. A receiver operating characteristic analysis was performed to assess the diagnostic performance of S1 VBQ in assessing low BMD.</p><p><strong>Results: </strong>Among the included patients, there were 93 in the normal-BMD group and 44 in the low-BMD group. A significantly higher S1 VBQ score was found in the low-BMD cohort than in the normal-BMD cohort (P<0.001). There was a moderate correlation of S1 VBQ with QCT Z-score (r=-0.450; P<0.001) and S1 HU (r=-0.405; P<0.001). The S1 HU had a strong correlation with the QCT Z-score (r=0.671; P<0.001). The multivariate logistic regression analysis revealed that the S1 VBQ score was independently correlated with low BMD [odds ratio =3.394; 95% confidence interval (CI): 1.498-7.689; P=0.003]. An S1 VBQ score threshold of 3.2 yielded 86.4% sensitivity, 74.2% specificity, and an area under the curve of 0.836 in identifying low BMD.</p><p><strong>Conclusions: </strong>The MRI-S1 VBQ score provides a novel means for assessing BMD in patients with AIS. It could serve as a tool for the opportunistic screening of low BMD before spinal surgery.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6426-6435"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing myocardial hyperemia in acute myocarditis with 3T contrast-enhanced whole-heart magnetic resonance imaging: a feasibility study.","authors":"Zhiyong Chen, Zhangli Xing, Enshuang Zheng, Yunjing Xue, Bin Sun","doi":"10.21037/qims-24-2293","DOIUrl":"10.21037/qims-24-2293","url":null,"abstract":"<p><strong>Background: </strong>Early gadolinium enhancement (EGE) assessment for myocardial hyperemia is generally considered the least robust of the three Lake Louis Criteria (LLC), which is attributable to the limitations of the technique. The purpose of this study was to assess the feasibility of the contrast-enhanced whole-heart magnetic resonance imaging (CE WH-MRI) as a novel method for the diagnosis of acute myocarditis.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of 54 patients admitted to Fujian Medical University Union Hospital between May 2020 to March 2024 with clinically suspected acute myocarditis. The diagnostic guidelines established by the European Society of Cardiology (ESC) were applied in this study. Additionally, we included 43 healthy individuals as controls. The hyperintense areas in the late gadolinium enhancement (LGE) and CE WH-MRI images were doubtfully or reliably interpreted by the two observers. The left ventricular (LV) myocardium was divided into 17 segments according to American Heart Association (AHA) consensus, which allowed us to evaluate the presence of hyperemia-weighted patterns or LGE.</p><p><strong>Results: </strong>The final population included 43 patients. The acquisition time of CE WH-MRI was 8.2±1.3 min. Myocardial hyperemia-weighted patterns in CE WH-MRI images were found in 41 of 43 (95.35%) participants. LGE was detected in 29 of 43 (67.44%) patients. Comparative analysis between CE WH-MRI and two-dimensional LGE sequences revealed myocardial involvement in 322 and 210 segments, respectively.</p><p><strong>Conclusions: </strong>This study established the viability of CE WH-MRI in identifying myocardial hyperemia-weighted patterns among patients with acute myocarditis. Additionally, through the combination of quantitative cardiac magnetic resonance (CMR) with the established LLC, CE WH-MRI could provide additive value in enhancing the accuracy of acute myocarditis diagnosis.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6414-6425"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}