Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.

IF 2.3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chunfeng Zhao, Xiaofan Qiu, Xinyu Luo, Ying Peng, Yu Yin, Lisha Nie, Jinhui Wang, Heng Liu
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引用次数: 0

Abstract

Background: Spastic cerebral palsy (SCP) is associated with extensive alterations in regional cortical morphology. However, the specific effects of SCP on the topological organization of morphological brain networks remain largely unknown. This study aimed to investigate these effects and explore their potential correlations with clinical manifestations in SCP children.

Methods: Structural magnetic resonance imaging and clinical data were collected from 31 children with SCP and 29 sex- and age-matched children with typical development. Single-subject morphological brain networks were constructed separately based on four different morphological indices [i.e., the cortical thickness (CT), fractal dimension, gyrification index, and sulcus depth], which were further characterized using graph-based network approaches. Permutation tests were used to examine between-group differences in regional morphology, interregional morphological connectivity (MC), and graph-based network properties. For magnetic resonance imaging (MRI)-based features showing significant between-group differences, Spearman partial correlations were used to examine their relationships with the clinical variables in the patients.

Results: Compared with the control group, the SCP group only showed alterations in the CT-based morphological brain networks. Specifically, the SCP group displayed an increased characteristic path length (t=3.909, P=4.0×10-4), which was negatively correlated with the verbal comprehension index (rho=-0.435, P=0.023), processing speed index (rho=-0.452, P=0.018), and full-scale intelligence quotient (rho=-0.471, P=0.013) of the SCP children, and positively correlated with the Gross Motor Function Classification System (rho=0.399, P=0.039) and Manual Ability Classification System (rho=0.459, P=0.016). Further, the SCP group showed decreased MC for 161 connections. These connections were mainly linked to the right area 25 (a part of the anterior cingulate cortex) at the nodal level and to regions in the default mode network at the subnetwork level. Among these, the MC between the right area 11l, part of the orbital and polar frontal cortex, and the right medial belt complex, part of the early auditory cortex, was positively correlated with the Communication Function Classification System in the SCP children (rho=0.662, P=1.7×10-4). These results remained unchanged after excluding preterm children from the SCP group.

Conclusions: SCP is associated with abnormal morphological brain network topology, which may contribute to disturbances in motor and cognition in patients.

Abstract Image

Abstract Image

Abstract Image

痉挛型脑瘫儿童脑形态网络的中断及其与多种症状的关系
背景:痉挛性脑瘫(SCP)与区域皮层形态的广泛改变有关。然而,SCP对脑形态网络拓扑组织的具体影响在很大程度上仍然未知。本研究旨在探讨这些影响,并探讨其与SCP患儿临床表现的潜在相关性。方法:收集31例SCP患儿和29例性别、年龄匹配的典型发育患儿的结构磁共振成像及临床资料。基于皮质厚度(CT)、分形维数、旋转指数和脑沟深度四种不同形态学指标分别构建单受试者脑形态网络,并利用基于图的网络方法对其进行表征。排列测试用于检查区域形态、区域间形态连通性(MC)和基于图的网络特性的组间差异。对于基于磁共振成像(MRI)的特征显示组间显著差异,使用Spearman偏相关来检查其与患者临床变量的关系。结果:与对照组相比,SCP组仅表现出基于ct的脑形态网络的改变。其中,SCP组的特征路径长度增加(t=3.909, P=4.0×10-4),与SCP儿童的言语理解指数(rho=-0.435, P=0.023)、处理速度指数(rho=-0.452, P=0.018)、全面智商(rho=-0.471, P=0.013)呈负相关,与大肌肉运动功能分类系统(rho=0.399, P=0.039)、手工能力分类系统(rho=0.459, P=0.016)呈正相关。此外,SCP组显示161个连接的MC下降。这些连接在节点水平上主要连接到右侧25区(前扣带皮层的一部分),在子网络水平上主要连接到默认模式网络的区域。其中,右脑11区(部分眶额叶皮层和极额叶皮层)和右脑内侧带复区(部分早期听觉皮层)之间的MC与SCP患儿沟通功能分类系统呈正相关(rho=0.662, P=1.7×10-4)。在将早产儿从SCP组中排除后,这些结果保持不变。结论:SCP与脑网络拓扑结构异常有关,可能导致患者运动和认知功能障碍。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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