npj Microgravity最新文献_第3页

25-hydroxysterol mitigates microgravity-induced retinal damage by suppressing microglial inflammation through disrupting lipid raft formation. 25-羟基甾醇通过破坏脂质筏形成，抑制小胶质细胞炎症，减轻微重力诱导的视网膜损伤。

IF 4.1 1区物理与天体物理

npj Microgravity Pub Date : 2025-08-01 DOI: 10.1038/s41526-025-00507-7

Jee Hoon Lee, Dae Yu Kim

引用次数: 0

BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling. BMP9通过调节TGFβ和BMP信号通路减轻微重力相关的废用性骨质疏松症。

IF 4.1 1区物理与天体物理

npj Microgravity Pub Date : 2025-08-01 DOI: 10.1038/s41526-025-00510-y

Haoyang Zhao, Mengfan Yang, Yujiao Liu, Xiaolin Tu, Gaohai Shao

引用次数: 0

Heart rate variability adaptation due to head-down tilt bed rest: insights from pooled data of six campaigns. 由上下倾斜卧床引起的心率变异性适应：来自六个运动汇总数据的见解。

IF 4.1 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-31 DOI: 10.1038/s41526-025-00509-5

Sarah Solbiati, Enrico Gianluca Caiani

{"title":"Heart rate variability adaptation due to head-down tilt bed rest: insights from pooled data of six campaigns.","authors":"Sarah Solbiati, Enrico Gianluca Caiani","doi":"10.1038/s41526-025-00509-5","DOIUrl":"10.1038/s41526-025-00509-5","url":null,"abstract":"Microgravity challenges cardiovascular regulation, necessitating adaptive responses to maintain homeostasis. This retrospective study examines the changes in heart rate variability (HRV) induced by head-down tilt (HDT) bed rest, a ground-based analog for microgravity. Standardized 24-h Holter electrocardiograms (ECG) were collected from 66 male volunteers across six ESA HDT campaigns of different durations (5, 21, and 60 days). HRV indices, including time, frequency, and nonlinear metrics, were computed to evaluate autonomic modulation during HDT and following re-exposure to orthostatic stress. Results showed decreased high- and low-frequency power during HDT, indicating impaired autonomic modulation. Additional alterations were observed at HDT discontinuation, likely reflecting cardiovascular deconditioning and gravity readaptation. The use of harmonized protocols and a large pooled dataset provided valuable insights into cardiovascular adaptation to HDT. These findings emphasize the importance of standardized protocols and large pooled datasets in future studies investigating cardiovascular responses to simulated microgravity.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"48"},"PeriodicalIF":4.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery of bone microarchitecture and density four years after spaceflight: two case studies. 太空飞行四年后骨微结构和密度的恢复：两个案例研究。

IF 4.1 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-28 DOI: 10.1038/s41526-025-00511-x

Bryn E Matheson, Matthias Walle, Anna-Maria Liphardt, Paul A Hulme, Martina Heer, Sara R Zwart, Jean D Sibonga, Scott M Smith, Leigh Gabel, Steven K Boyd

{"title":"Recovery of bone microarchitecture and density four years after spaceflight: two case studies.","authors":"Bryn E Matheson, Matthias Walle, Anna-Maria Liphardt, Paul A Hulme, Martina Heer, Sara R Zwart, Jean D Sibonga, Scott M Smith, Leigh Gabel, Steven K Boyd","doi":"10.1038/s41526-025-00511-x","DOIUrl":"10.1038/s41526-025-00511-x","url":null,"abstract":"Spaceflight is known to negatively impact bone health, but the duration of these effects remains unclear. These two case studies investigated bone microarchitecture, density, and remodelling up to 4 years after long-duration spaceflight, aiming to inform countermeasure development and guide future research efforts. High-resolution peripheral quantitative computed tomography (HR-pQCT) and dual X-ray absorptiometry (DXA) scans were conducted on two crew members at pre-flight and up to 48-months post-spaceflight. Both crew members exhibited significant bone loss in the tibia at return from spaceflight, while only one crew member showed losses in the radius. After 4 years of recovery, one crew member achieved full recovery, while the second experienced persistent trabecular deficits that were compensated by significant cortical thickening. These results provide insight into the need for tailored countermeasures and prolonged monitoring to optimize skeletal health for future long-duration space missions, with implications for bone health research on mechanical unloading and reloading.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"47"},"PeriodicalIF":4.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of space radiation on the transcriptome of heart right ventricle tissue. 空间辐射对心脏右心室组织转录组的影响。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-21 DOI: 10.1038/s41526-025-00506-8

Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A Goukassian

{"title":"The effects of space radiation on the transcriptome of heart right ventricle tissue.","authors":"Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A Goukassian","doi":"10.1038/s41526-025-00506-8","DOIUrl":"10.1038/s41526-025-00506-8","url":null,"abstract":"Deep space represents a challenging environment for human exploration and can be accompanied by harmful health-related risks. We aimed to assess the effect of simplified galactic cosmic ray simulated (simGCRsim) and gamma (γ) ionizing radiation (IR) on transcriptome changes in right ventricular (RV) tissue after a single low dose (0.5 Gy, 500 MeV/nucleon) full body exposure in C57BL/6J male and female mice. In females, no differentially expressed genes (DEGs) and only 2 upregulated genes in males exposed to γ-IR were revealed. In contrast, exposure to simGCRsim-IR resulted in 4 DEGs in females and 371 DEGs in males, suggesting longer-lasting and sex-biased DEGs after simGCRsim-IR. Overrepresentation analysis of DEGs in simGCRsim-IR males revealed significant enrichment in pathways related to muscle contraction, hypertrophic cardiomyopathy, oxytocin release, the regulation of cytoskeleton, and genes associated with Alzheimer's, Huntington's, and Parkinson's diseases. Our results suggested the RV transcriptome exhibits distinct responses after exposure based on both the IR and sex.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"46"},"PeriodicalIF":4.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks. 通过异质基因调控网络探索空间电离辐射效应的分子和模块见解。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-18 DOI: 10.1038/s41526-025-00508-6

Mengqin Yuan, Tao Zhang, Haizhou Liu, Min Long, Quan Wang, Wei Jiang

{"title":"Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks.","authors":"Mengqin Yuan, Tao Zhang, Haizhou Liu, Min Long, Quan Wang, Wei Jiang","doi":"10.1038/s41526-025-00508-6","DOIUrl":"10.1038/s41526-025-00508-6","url":null,"abstract":"Space ionizing radiation is a major risk factor for astronauts, yet its molecular mechanisms remain poorly understood. This study employs an integrative approach to investigate the effects of space ionizing radiation on molecules, modules, biological functions, associated diseases, and potential therapeutic drugs. Using paired samples from five donors subjected to acute ex vivo 2Gy gamma-ray irradiation, we analyzed miRNA and gene expression profiles in human peripheral blood lymphocytes collected 24 h post-exposure, combined with heterogeneous network analysis, identifying 179 key molecules (23 transcription factors, 10 miRNAs, and 146 genes) and 5 key modules. Functional enrichment analysis revealed associations with processes such as cell cycle regulation, cytidine deamination, cell differentiation, viral carcinogenesis, and apoptosis. Radiation was also significantly linked to neoplasms and digestive system diseases. Furthermore, we predicted 20 potential therapeutic compounds, including small molecules (e.g., Navitoclax) and Traditional Chinese Medicine ingredients (e.g., Genistin, Saikosaponin D), which may alleviate radiation-induced damage such as pulmonary fibrosis and oxidative stress. These findings provide novel insights into the molecular mechanisms of space ionizing radiation and may contribute to developing effective strategies to protect astronaut health during space missions.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"44"},"PeriodicalIF":4.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge. 喂养宇宙：解决个性化的太空营养和肠道渗漏的挑战。

IF 4.1 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-18 DOI: 10.1038/s41526-025-00490-z

B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung, J Puig, K Mikhailova, H Coker, A Marks, R Gilbert, R Scott, R Barker, P Glowe, Eliah G Overbey, C E Mason

{"title":"Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge.","authors":"B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung, J Puig, K Mikhailova, H Coker, A Marks, R Gilbert, R Scott, R Barker, P Glowe, Eliah G Overbey, C E Mason","doi":"10.1038/s41526-025-00490-z","DOIUrl":"10.1038/s41526-025-00490-z","url":null,"abstract":"Long-duration space missions pose serious challenges to astronaut nutrition and health due to the altered environment of Low Earth Orbit (LEO). This study examines the nutritional composition of crops grown in space, identifying deficiencies in key nutrients such as calcium and magnesium, along with variable antioxidant profiles. These imbalances may impact astronaut physiology, particularly bone health and immune function, and are potentially linked to altered gene expression pathways in microgravity. Emerging evidence also suggests increased intestinal permeability, referred as leaky gut syndrome, which further disrupts nutrient absorption and immune regulation. To mitigate these issues, we evaluate targeted strategies including bioengineering of nutrient-dense crops, incorporation of antioxidant-rich species, and personalized nutrition guided by pharmacogenomics. Approaches such as biofortification and tailored supplementation are proposed to address these challenges. This work contributes to the development of resilient space agriculture systems that support astronaut health during deep space missions and future planetary habitation.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Free surface bubbly flow in an open capillary channel. 自由表面气泡流动在一个开放的毛细管通道。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-16 DOI: 10.1038/s41526-025-00496-7

Bo Wu, Zongyu Wu, Yong Chen, Guangyu Li, Wen Yao

引用次数: 0

Cryogenic helium subsurface pressurization in terrestrial and low-gravity: experiments and flow visualization. 低温氦在地面和低重力下的地下加压：实验和流动可视化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-15 DOI: 10.1038/s41526-025-00504-w

Jinze Yu, J N Chung, S R Darr, M Taliaferro, G R Warrier, J W Hartwig

{"title":"Cryogenic helium subsurface pressurization in terrestrial and low-gravity: experiments and flow visualization.","authors":"Jinze Yu, J N Chung, S R Darr, M Taliaferro, G R Warrier, J W Hartwig","doi":"10.1038/s41526-025-00504-w","DOIUrl":"10.1038/s41526-025-00504-w","url":null,"abstract":"Pressurization of cryogenic propellant storage tanks is required for propellant thermodynamic conditioning and for enabling propellant transfer from a supply tank to another tank or an engine. In microgravity, the pressurization gas may be injected directly into the liquid propellant if the nozzle is submerged in liquid. Known as helium subsurface pressurization (HSP), the incoming warm helium gas causes immediate evaporation of the propellant into the helium bubbles which subcools the liquid. For HSP of cryogenic liquids in reduced gravity environments, there are many unknowns such as the rate of evaporation, change in temperature of helium after injection, bubble growth rate, and boil-off and pressurization rates. The purpose of this paper is to present new experimental data and flow visualization of subsurface gaseous helium injection into liquid nitrogen in terrestrial gravity and low-gravity. Varied parameters include injector size (0.25, 1.0 mm), injection flow rate (10-9-10-5 kg/s), and temperature (170-260 K). The new data clearly shows the role of gravity, buoyancy, and inertial forces on multiple cryogenic subsurface parameters of interest.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"42"},"PeriodicalIF":4.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic biology for space exploration. 用于太空探索的合成生物学。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-12 DOI: 10.1038/s41526-025-00488-7

Silvano Onofri, Ralf Moeller, Daniela Billi, Michele Balsamo, Anke Becker, Eugenio Benvenuto, Alessia Cassaro, Ilaria Catanzaro, Charles S Cockell, Angiola Desiderio, Tom Ellis, José Eduardo Gonzáles-Pastor, Christiane Hahn, Natalie Leys, Patrick Leo, Marie-Christine Maurel, Claudia Pacelli, Bruno Pavletic, Caterina Ripa, Lynn J Rothschild, Leonardo Surdo

引用次数: 0