npj Microgravity最新文献_第2页

Virtual reality-based sensory stimulation preferences at Amundsen-Scott South Pole station in Antarctica. 在南极洲阿蒙森-斯科特南极站基于虚拟现实的感官刺激偏好。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-05-11 DOI: 10.1038/s41526-025-00471-2

Stijn J J Thoolen, John-Michael Watson, Abigail M Fellows, Pooja P Bovard, Gary E Strangman, Jay C Buckey, Aleksandra S Stankovic

{"title":"Virtual reality-based sensory stimulation preferences at Amundsen-Scott South Pole station in Antarctica.","authors":"Stijn J J Thoolen, John-Michael Watson, Abigail M Fellows, Pooja P Bovard, Gary E Strangman, Jay C Buckey, Aleksandra S Stankovic","doi":"10.1038/s41526-025-00471-2","DOIUrl":"10.1038/s41526-025-00471-2","url":null,"abstract":"Virtual Reality (VR)-based sensory stimulation can provide relaxation and psychological restoration in isolated, confined and extreme conditions such as long-duration spaceflight, but it remains unclear which aspects of VR would be most beneficial. To investigate individual preferences for various VR attributes, 25 overwintering crew members at the Amundsen-Scott South Pole Station in Antarctica underwent 16 variations of VR stimulation at the end of their mission, with manipulations in delivery mode (VR vs. laptop), content (nature vs. city environments), duration (4 vs. 10 min), and sensory augmentation (with or without temperature cues). Data collection included pre- and post-intervention surveys on perceived quality (value, immersiveness, restorativeness) and mood, as well open-ended qualitative feedback. We found that VR was viable and restorative in a high-fidelity spaceflight analog. Although longer-lasting nature scenes were preferred overall, interindividual variation in preferences for sensory stimulation emphasizes the need for a personalized approach.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"15"},"PeriodicalIF":4.4,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain and cerebrospinal fluid 3D center of mass shift after spaceflight. 航天飞行后脑和脑脊液三维质心偏移。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-05-08 DOI: 10.1038/s41526-025-00468-x

Katherine G Warthen, Stuart H Sater, Larry A Kramer, Khader M Hasan, Michael A Williams, Millennia Young, Brandon R Macias, Steven S Laurie, Bryn A Martin

{"title":"Brain and cerebrospinal fluid 3D center of mass shift after spaceflight.","authors":"Katherine G Warthen, Stuart H Sater, Larry A Kramer, Khader M Hasan, Michael A Williams, Millennia Young, Brandon R Macias, Steven S Laurie, Bryn A Martin","doi":"10.1038/s41526-025-00468-x","DOIUrl":"https://doi.org/10.1038/s41526-025-00468-x","url":null,"abstract":"A subset of long-duration spaceflight astronauts at the International Space Station has been documented to develop spaceflight associated neuro-ocular syndrome (SANS). Researchers have sought to understand SANS by quantification of ocular and brain structural changes thought to be associated with weightlessness induced headward fluid shift. Brain tissue shift and cerebrospinal fluid (CSF) redistribution has been observed as measured by MRI on return to Earth, and not fully quantified. To improve the understanding of this phenomenon, we developed and applied automated methods to quantify 3D center of mass shift within the skull of the extra-axial cerebrospinal fluid (eaCSF) and brain after long-duration spaceflight in astronauts (N = 13) and controls not exposed to microgravity (N = 10). 3D center of mass shift of brain tissue and CSF was computed based on registration of an individual skull segmentation at a baseline timepoint versus follow-up. 3D center of mass shift was quantified in the Gx, Gy, and Gz axis defined as -posterior/+anterior, -left/+right, -inferior/+superior, respectively. For astronauts, average MRI follow-up time pre- to post-flight was 697 ± 137 days (average flight duration = 179 ± 59 days with post-flight MRIs collected an average of 2.23 ± 1.64 days after return to Earth). For controls, average MRI follow-up time was 307 ± 19 days. For astronauts, a superior Gz shift in whole brain was present (+ 0.74 ± 0.28 mm, p < 0.0001) with a concomitant inferior Gz shift in eaCSF (-2.45 ± 0.99 mm, p < 0.0001). In the control cohort, brain tissue Gz shift (-0.082 ± 0.048 mm) and eaCSF Gz shift (0.096 ± 0.26 mm) were not statistically significant. Gy shift lacked significance in both controls and astronauts. These findings support that sustained exposure to weightlessness impacts the overall position of fluids and tissues within the skull.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"14"},"PeriodicalIF":4.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopy with microfluidics in microgravity using FlightScope. 使用FlightScope进行微重力下微流体显微镜观察。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-05-06 DOI: 10.1038/s41526-025-00470-3

Thomas Wareing, Alexander Stokes, Katrina E Crompton, Koren Murphy, Jack Dawson, Yusuf Furkan Ugurluoglu, Connor Richardson, Hongquan Li, Manu Prakash, Adam J M Wollman

引用次数: 0

Author Correction: Spaceflight causes strain-dependent gene expression changes in the kidneys of mice. 作者更正：太空飞行导致小鼠肾脏中菌株依赖性基因表达的变化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-04-09 DOI: 10.1038/s41526-025-00467-y

Rebecca H Finch, Geraldine Vitry, Keith Siew, Stephen B Walsh, Afshin Beheshti, Gary Hardiman, Willian A da Silveira

引用次数: 0

Spaceflight causes strain-dependent gene expression changes in the kidneys of mice. 太空飞行导致小鼠肾脏中菌株依赖性基因表达的变化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-03-25 DOI: 10.1038/s41526-025-00465-0

Rebecca H Finch, Geraldine Vitry, Keith Siew, Stephen B Walsh, Afshin Beheshti, Gary Hardiman, Willian A da Silveira

{"title":"Spaceflight causes strain-dependent gene expression changes in the kidneys of mice.","authors":"Rebecca H Finch, Geraldine Vitry, Keith Siew, Stephen B Walsh, Afshin Beheshti, Gary Hardiman, Willian A da Silveira","doi":"10.1038/s41526-025-00465-0","DOIUrl":"10.1038/s41526-025-00465-0","url":null,"abstract":"Incidence of kidney stones in astronauts is a major risk factor associated with long-term missions, caused by increased blood calcium levels due to bone demineralisation triggered by microgravity and space radiation. Transcriptomic changes have been observed in tissues during spaceflight, including the kidney. We analysed kidney transcriptome patterns in two different strains of mice flown on the International Space Station, C57BL/6J and BALB/c. Here we show a link between spaceflight and transcriptome patterns associated with dysregulation of lipid and extracellular matrix metabolism and altered transforming growth factor-beta signalling. A stronger response was seen in C57BL/6J mice than BALB/c. Genetic differences in hyaluronan metabolism between strains may confer protection against extracellular matrix remodelling through the downregulation of epithelial-mesenchymal transition. We intend for our findings to contribute to the development of new countermeasures against kidney disease in astronauts and people here on Earth.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"11"},"PeriodicalIF":4.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity. 机械敏感通道ELKIN1调节细胞对模拟微重力的适应。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-03-16 DOI: 10.1038/s41526-025-00466-z

Daphne Wang, Giulia Silvani, Lioba Schroeter, Remi Brynn, Joshua Chou, Kate Poole

{"title":"The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity.","authors":"Daphne Wang, Giulia Silvani, Lioba Schroeter, Remi Brynn, Joshua Chou, Kate Poole","doi":"10.1038/s41526-025-00466-z","DOIUrl":"10.1038/s41526-025-00466-z","url":null,"abstract":"In conditions of microgravity the human body undergoes extensive alterations in physiological function. However, it has proven challenging to determine how these changes are mediated at the molecular and cellular level. Here, we investigated whether ELKIN1, a mechanically activated ion channel, regulates changes in cellular and molecular structures in conditions of simulated microgravity. Deletion of ELKIN1 inhibited the simulated microgravity-induced alterations of cellular structure and attachment. In addition, cells lacking ELKIN1 did not exhibit changes in focal adhesion structures and redistribution of the YAP1 transcription factor in response to simulated microgravity, consistent with wild type cells. Finally, melanoma cell invasion of a collagen gel, from organotypic spheroids, was reduced in simulated microgravity, in an ELKIN1 dependent manner. Thus, the force sensing molecule, ELKIN1, modulates the impact of microgravity at both the molecular and cellular levels, revealing one of the molecular mechanisms that underpins cellular adaptations to conditions of microgravity.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"10"},"PeriodicalIF":4.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions. TRPML1离子通道促进模拟微重力条件下HepaRG细胞的分化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-03-15 DOI: 10.1038/s41526-025-00461-4

Huancai Fan, Dongyuan Lü, Zheng Lu, Hangyu Li, Zijuan Qi, Shujin Sun, Dongshi Guan, Mian Long, Ming Gao, Sijin Liu

{"title":"TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.","authors":"Huancai Fan, Dongyuan Lü, Zheng Lu, Hangyu Li, Zijuan Qi, Shujin Sun, Dongshi Guan, Mian Long, Ming Gao, Sijin Liu","doi":"10.1038/s41526-025-00461-4","DOIUrl":"10.1038/s41526-025-00461-4","url":null,"abstract":"Stem cell differentiation must be regulated by intricate and complex interactions between cells and their surrounding environment, ensuring normal organ and tissue morphology such as the liver1. Though it is well acknowledged that microgravity provides necessary mechanical force signals for cell fate2, how microgravity affects growth, differentiation, and communication is still largely unknown due to the lack of real experimental scenarios and reproducibility tools. Here, Rotating Flat Chamber (RFC) was used to simulate ground-based microgravity effects to study how microgravity effects affect the differentiation of HepaRG (hepatic progenitor cells) cells. Unexpectedly, the results show that RFC conditions could promote HepaRG cell differentiation which exhibited increased expression of Alpha-fetoprotein (AFP), albumin (ALB), and Recombinant Cytokeratin 18 (CK18). Through screening a series of mechanical receptors, the ion channel TRPML1 was critical for promoting the differentiation effect under RFC conditions. Once TRPML1 was activated by stimulated microgravity effects, the concentration of lysosomal calcium ions was increased to activate the Wnt/β-catenin signaling pathway, which finally led to enhanced cell differentiation of HepaRG cells. In addition, the cytoskeleton was remodeled under RFC conditions to influence the expression of PI (3,5) P2, which is the best-known activator of TRPML1. In summary, our findings have established a mechanism by which simulated microgravity promotes the differentiation of HepaRG cells through the TRPML1 signaling pathway, which provides a potential target for the regulation of hepatic stem/progenitor cell differentiation and embryonic liver development under real microgravity conditions.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"9"},"PeriodicalIF":4.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of corneal injuries in spaceflight and recommendations for planetary missions. 航天飞行中角膜损伤的处理和行星任务的建议。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-03-11 DOI: 10.1038/s41526-025-00462-3

Alex Suh, Joshua Ong, Ethan Waisberg, John Berdahl, Andrew G Lee

引用次数: 0

The utility of animal models to inform the next generation of human space exploration. 利用动物模型为下一代人类太空探索提供信息。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-22 DOI: 10.1038/s41526-025-00460-5

Isla Duporge, Talmo Pereira, Santiago Castiello de Obeso, Julius G Bright Ross, Stephen J Lee, Allyson G Hindle

引用次数: 0

Plyometric training increases thickness and volume of knee articular cartilage in mice. 增强训练增加小鼠膝关节软骨的厚度和体积。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-13 DOI: 10.1038/s41526-025-00458-z

Marco Chiaberge, Neelima Thottappillil, Anna-Maria Liphardt, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Anja Niehoff, Mark Shelhamer, Colin Norman, Marc J Philippon, Johnny Huard, Aaron W James, Chen-Ming Fan

{"title":"Plyometric training increases thickness and volume of knee articular cartilage in mice.","authors":"Marco Chiaberge, Neelima Thottappillil, Anna-Maria Liphardt, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Anja Niehoff, Mark Shelhamer, Colin Norman, Marc J Philippon, Johnny Huard, Aaron W James, Chen-Ming Fan","doi":"10.1038/s41526-025-00458-z","DOIUrl":"10.1038/s41526-025-00458-z","url":null,"abstract":"Degeneration and thinning of articular cartilage lead to osteoarthritis and may result from reduced joint loading during e.g. bed rest or as a result of microgravity during space flight. Anabolic physical exercises for cartilage are not well studied to date. We built an experimental apparatus for plyometric training with mice to test potential benefits of jumping for articular cartilage. The exercise group (JUMP) performed jump training for 9 weeks and was compared with sedentary mice (control, CON) and hindlimb-suspended (HLS) mice (to simulate reduced loading) for the same duration. Knee cartilage was assessed via 3-dimensional reconstruction of micro-CT scans and histology. We observed significant thinning and volume reduction of articular cartilage at the medial tibial-femoral point of contact in the HLS group. Clustering of chondrocytes was present in HLS. By contrast, the JUMP group showed both cartilage thickening and volume increase. We observed a similar trend on trabecular bone thickness and volume. Our results show that plyometric training can stimulate cartilage thickness and volume in mice. This suggests further investigation of this mode of exercise as a countermeasure to prevent cartilage atrophy in disuse scenarios such as long duration spaceflight, and for patients at risk of developing osteoarthritis.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"5"},"PeriodicalIF":4.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0