npj Microgravity最新文献

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Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest. 7天俯卧床休息后颈部血管的异质性和偏侧性反应。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-10-16 DOI: 10.1038/s41526-025-00524-6
Fengxia Yu, Xia Ma, Yawen Liu, Rui Wang, Zixu Huang, Yiwen Wang, Jianxiong Zhang, Ruihua Dong, Peng-Gang Qiao, Wei Zheng, Linxue Qian, Pengling Ren, Zhenchang Wang
{"title":"Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest.","authors":"Fengxia Yu, Xia Ma, Yawen Liu, Rui Wang, Zixu Huang, Yiwen Wang, Jianxiong Zhang, Ruihua Dong, Peng-Gang Qiao, Wei Zheng, Linxue Qian, Pengling Ren, Zhenchang Wang","doi":"10.1038/s41526-025-00524-6","DOIUrl":"https://doi.org/10.1038/s41526-025-00524-6","url":null,"abstract":"<p><p>This study aimed to investigate cervical vessel hemodynamics during 7 days of -6° head-down tilt (HDT) bed rest (BR) and 5 days of recovery in 40 healthy males, focusing on bilateral analysis and dynamic temporal monitoring. Diameter, flow velocity, and blood flow volume (BFV) of bilateral common (CCAs), internal (ICAs), external carotid arteries and vertebral arteries (VAs) were measured at eight time points using ultrasound. Cervical vessels exhibited heterogeneous and lateralized responses. Left VA exhibited the most pronounced BFV and velocity fluctuations, with significant reductions during HDT and recovery to baseline post-HDT, while right VA remained stable. CCAs and ICAs had dynamic diameter and velocity changes, but stable BFVs. Left VA BFV reduction was significantly associated with right VA dominance, elevated heart rate, and increased mean arterial pressure at HDT 3 d. Despite stable total BFV, left VA BFV declined during BR, warranting further monitoring.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"70"},"PeriodicalIF":4.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight. 亚轨道太空飞行中极端加速、微重力和减速对枯草芽孢杆菌的影响。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-10-06 DOI: 10.1038/s41526-025-00526-4
Eric Yang, Jibin Jeffrey Dhanaraj, Palalle G Tharushi Perera, Zoltan Vilagosh, Gail N Iles, Stefan Krämer, Gunnar Florin, Denver P Linklater, The Hong Phong Nguyen, Chaitali Dekiwadia, Saulius Juodkazis, Rodney J Croft, Elena P Ivanova
{"title":"Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight.","authors":"Eric Yang, Jibin Jeffrey Dhanaraj, Palalle G Tharushi Perera, Zoltan Vilagosh, Gail N Iles, Stefan Krämer, Gunnar Florin, Denver P Linklater, The Hong Phong Nguyen, Chaitali Dekiwadia, Saulius Juodkazis, Rodney J Croft, Elena P Ivanova","doi":"10.1038/s41526-025-00526-4","DOIUrl":"10.1038/s41526-025-00526-4","url":null,"abstract":"<p><p>The effects of extreme acceleration, microgravity, and deceleration of a suborbital spaceflight on Bacillus subtilis ATCC 6051 spores were investigated. B. subtilis spores were exposed to a maximum acceleration of ~13 g, a microgravity phase of 6 min, deceleration of 30 g (~300 m/s<sup>2</sup>), and a maximum rotating velocity of 220 <sup>o</sup>s<sup>-1</sup> upon re-entry into Earth's atmosphere. Post-flight analysis showed the spores exhibited no change in morphology or viability, confirming that B. subtilis spores are resilient to space flight conditions.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"65"},"PeriodicalIF":4.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behaviors of lunar regolith simulants under varying gravitational conditions. 月球风化模拟物在不同重力条件下的行为。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-10-01 DOI: 10.1038/s41526-025-00501-z
Ian P Madden, Sathyashri Muruganandam, Amine Missaoui, Oliver Gries, Jonathan Kollmer, Olfa D'Angelo, Suman Sinha-Ray
{"title":"Behaviors of lunar regolith simulants under varying gravitational conditions.","authors":"Ian P Madden, Sathyashri Muruganandam, Amine Missaoui, Oliver Gries, Jonathan Kollmer, Olfa D'Angelo, Suman Sinha-Ray","doi":"10.1038/s41526-025-00501-z","DOIUrl":"10.1038/s41526-025-00501-z","url":null,"abstract":"<p><p>Understanding the behavior of regolith in varying gravity conditions, is critical for space exploration and future missions. In this work, the gravity-driven hopper flow of lunar regolith simulant in different gravitational accelerations (terrestrial, lunar) is first observed experimentally. Numerical simulations (DEM) are then developed to understand the role which cohesive interparticle forces play in such gravity-driven flow, using the theoretical framework of granular Bond number. Qualitative comparison between a terrestrial experiment and numerical simulation validated this framework. Following that, we numerically studied the dynamic behavior under varying gravitational conditions (from terrestrial to lunar to asteroid gravitational accelerations). We find that this behavior is extremely sensitive to the interplay of the gravity conditions and the attractive/cohesive forces among particles. The numerical and experimental results show that the complex interaction of these forces can drastically change the dynamics of the material producing effects relevant for variable gravity applications.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"69"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence of effective cardiovascular countermeasures during spaceflights: insights from wearable monitoring. 航天飞行期间有效心血管对策的证据:来自可穿戴监测的见解。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-30 DOI: 10.1038/s41526-025-00522-8
Paniz Balali, Elena Luchitskaya, Amin Hossein, Elza Abdessater, Vitalie Faoro, Olivier Debeir, Jens Tank, Enrico Gianluca Caiani, Philippe van de Borne, Pierre-François Migeotte, Jeremy Rabineau
{"title":"Evidence of effective cardiovascular countermeasures during spaceflights: insights from wearable monitoring.","authors":"Paniz Balali, Elena Luchitskaya, Amin Hossein, Elza Abdessater, Vitalie Faoro, Olivier Debeir, Jens Tank, Enrico Gianluca Caiani, Philippe van de Borne, Pierre-François Migeotte, Jeremy Rabineau","doi":"10.1038/s41526-025-00522-8","DOIUrl":"10.1038/s41526-025-00522-8","url":null,"abstract":"<p><p>Microgravity induces profound cardiovascular changes, prompting space agencies to develop countermeasures to preserve their crewmembers' health. This study aimed to use a portable device based on electro-, impedance- and seismo-cardiography, to monitor a series of cardiovascular features in 17 cosmonauts. Our results showed that the evolution of cardiac time intervals, blood pressure, stroke volume, and cardiac systolic kinetic energy depended on the chosen baseline position. After five months in space, heart rate increased compared to the supine baseline on Earth (p = 0.013, d = 0.86) but not to the sitting position. Similarly, a marker of cardiac contractility (PEP/LVET ratio) decreased relative to the sitting baseline (p = 0.004, d = 1.09) but not the supine reference. All measured features, except heart rate, returned to baseline within three days post-landing. These findings support the efficacy of current countermeasures in facilitating rapid cardiovascular re-adaptation to terrestrial gravity.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"68"},"PeriodicalIF":4.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corner angle effects on capillary rise along curved interior corners. 角对毛细管沿弯曲内角上升的影响。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-26 DOI: 10.1038/s41526-025-00519-3
Zongyu Wu, Bo Wu, Yu Zhang, Guangyu Li, Chao Jiang, Yong Chen, Kai Li
{"title":"Corner angle effects on capillary rise along curved interior corners.","authors":"Zongyu Wu, Bo Wu, Yu Zhang, Guangyu Li, Chao Jiang, Yong Chen, Kai Li","doi":"10.1038/s41526-025-00519-3","DOIUrl":"10.1038/s41526-025-00519-3","url":null,"abstract":"<p><p>Liquid management is becoming increasingly essential as spacecraft carry more liquid, which includes liquid propellants. Interior corners are commonly used as components in spacecraft liquid management systems to passively position or maintain liquid. Under microgravity, the capillary flow along the curved interior corner plays a significant role in the behavior of liquids in spacecraft. To manage and transport liquids in space efficiently, it requires a full understanding of capillary flows in interior corners. In this work, the influence of corner angle on capillary flows in curved interior corners is studied experimentally. A series of drop tower experiments to simulate the microgravity environment are conducted to discuss the movement of liquid in the interior corner. Experimental results show that the liquid moves faster as the corner angle decreases. This feature can be utilized to design the liquid transport devices and provide valuable advices for liquid management in space.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"67"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system. 航天暴露/微重力对心理免疫神经内分泌系统的影响。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-26 DOI: 10.1038/s41526-025-00487-8
Miriam Capri, Nicola Montano, Sara Piccirillo, Marco Narici, Francesca Ferranti, Mauro Maccarrone
{"title":"Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system.","authors":"Miriam Capri, Nicola Montano, Sara Piccirillo, Marco Narici, Francesca Ferranti, Mauro Maccarrone","doi":"10.1038/s41526-025-00487-8","DOIUrl":"10.1038/s41526-025-00487-8","url":null,"abstract":"<p><p>Spaceflight missions represent a new exposome, unpredicted by evolution. Life-threatening agents activate non-specific stress responses involving the psycho-immune-neuroendocrine network. The main molecular pathways regulating this network and those affected by spaceflight exposome/microgravity are reported in various experimental setups. They include gut microbiota-derived metabolites, potentially valuable for countermeasure development. Meaningfully, the application of neuromodulation techniques, like the non-invasive transcutaneous vagal stimulation, for the prevention of pathophysiological alterations related to stress responses, is discussed.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"66"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Increasing seated reaction forces with lower body negative pressure. 作者更正:增加坐位反作用力与下体负压。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-13 DOI: 10.1038/s41526-025-00527-3
Suhas Rao Velichala, Jonathan Kim, Alan R Hargens
{"title":"Author Correction: Increasing seated reaction forces with lower body negative pressure.","authors":"Suhas Rao Velichala, Jonathan Kim, Alan R Hargens","doi":"10.1038/s41526-025-00527-3","DOIUrl":"10.1038/s41526-025-00527-3","url":null,"abstract":"","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"64"},"PeriodicalIF":4.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term microgravity experiments reveal a new mechanism for particle aggregation in suspension. 长期微重力实验揭示了悬浮微粒聚集的新机制。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-09 DOI: 10.1038/s41526-025-00523-7
Fabian Kleischmann, Bernhard Vowinckel, Eckart Meiburg, Paolo Luzzatto-Fegiz
{"title":"Long-term microgravity experiments reveal a new mechanism for particle aggregation in suspension.","authors":"Fabian Kleischmann, Bernhard Vowinckel, Eckart Meiburg, Paolo Luzzatto-Fegiz","doi":"10.1038/s41526-025-00523-7","DOIUrl":"10.1038/s41526-025-00523-7","url":null,"abstract":"<p><p>Microgravity experiments on board the International Space Station, combined with particle-resolved direct numerical simulations, were conducted to investigate the long-term flocculation behavior of clay suspensions in saline water in the absence of gravity. After an initial homogenization of the suspensions, different clay compositions were continuously monitored for 99 days, allowing a detailed analysis of aggregate growth through image processing. The results indicate that the onboard oscillations (g-jitter) may have accelerated the aggregation process. Aggregate growth driven by these oscillations is found to occur at a faster rate than aggregation caused by Brownian motion. Complementary numerical simulations confirm this hypothesis and also demonstrate that parameters such as the oscillation amplitude and the solid volume fraction influence growth acceleration. These findings highlight that oscillations may act as a previously unrecognized mechanism that contributes to particle aggregation in fluids.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"63"},"PeriodicalIF":4.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12420831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies. 航天相关神经眼综合征的无创监测:对飞行方法需求的响应。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-01 DOI: 10.1038/s41526-025-00502-y
Elana A Meer, Lauren E Church, Benjamin A Johnson, James Rohde, Alexandra J Sinclair, Susan P Mollan, Lonnie Petersen, James D Polk, Aenor J Sawyer
{"title":"Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.","authors":"Elana A Meer, Lauren E Church, Benjamin A Johnson, James Rohde, Alexandra J Sinclair, Susan P Mollan, Lonnie Petersen, James D Polk, Aenor J Sawyer","doi":"10.1038/s41526-025-00502-y","DOIUrl":"10.1038/s41526-025-00502-y","url":null,"abstract":"<p><p>Spaceflight-Associated Neuro-Ocular Syndrome (SANS) affects astronaut vision, causing refraction and acuity changes during and after long-duration missions. As space agencies plan for extended exploration, real-time SANS detection is crucial. A systematic review of PubMed and EMBASE yielded 72 relevant studies out of 196 screened. Current measurement techniques, including invasive and noninvasive intracranial pressure (ICP) assessments and novel technologies, have limitations in quantifying SANS changes and lack remote monitoring capability. Emerging tools such as telemetric ICP monitoring, optical coherence tomography (OCT), and ultrasound show promise but require further validation. Given the constraints of invasive techniques in space, non-invasive technologies should be tested in terrestrial analogs before spaceflight implementation. The precise SANS etiology will determine optimal monitoring approaches, whether ICP-focused, ocular-based, or a combination of both. No single technology can independently track SANS progression, emphasizing the need for multiparametric integration and post hoc analysis to enhance in-flight monitoring and mitigation strategies.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"61"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase-field modeling of colloid-polymer mixtures in microgravity. 微重力下胶体-聚合物混合物的相场模拟。
IF 4.1 1区 物理与天体物理
npj Microgravity Pub Date : 2025-09-01 DOI: 10.1038/s41526-025-00500-0
Lauren Barnes, Boris Khusid, Lou Kondic, William V Meyer, Anand U Oza
{"title":"Phase-field modeling of colloid-polymer mixtures in microgravity.","authors":"Lauren Barnes, Boris Khusid, Lou Kondic, William V Meyer, Anand U Oza","doi":"10.1038/s41526-025-00500-0","DOIUrl":"10.1038/s41526-025-00500-0","url":null,"abstract":"<p><p>Colloid-polymer mixtures are an archetype for modeling phase transition processes, as they exhibit a low-density gas phase, high-density crystalline phase and an intervening liquid phase. While their equilibrium behavior has been studied extensively, the role of hydrodynamics in driving their phase separation is not yet understood. We present a theoretical model that describes hydrodynamic interactions in colloid-polymer mixtures in a microgravity environment. Our phase-field model consists of the Cahn-Hilliard equation, which describes phase separation processes in multicomponent mixtures, coupled with the Stokes equation for viscous fluid flow. We account for the dependence of the suspension viscosity on the colloid concentration, and the so-called Korteweg stresses that arise at the interfaces of colloidal phases. We process video microscopy images from NASA's Binary Colloid Alloy Test (BCAT) experiments, which were performed on the International Space Station. While terrestrial experiments would be dominated by gravitational forces and buoyancy-driven flows, the microgravity environment of the BCAT experiments allows for the visualization of phase separation by low interfacial tension, and thus enables a quantitative comparison between experiment and our model predictions.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"62"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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