npj Microgravity最新文献

Management of corneal injuries in spaceflight and recommendations for planetary missions.

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-03-11 DOI: 10.1038/s41526-025-00462-3

Alex Suh, Joshua Ong, Ethan Waisberg, John Berdahl, Andrew G Lee

引用次数: 0

The utility of animal models to inform the next generation of human space exploration.

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-22 DOI: 10.1038/s41526-025-00460-5

Isla Duporge, Talmo Pereira, Santiago Castiello de Obeso, Julius G Bright Ross, Stephen J Lee, Allyson G Hindle

引用次数: 0

Plyometric training increases thickness and volume of knee articular cartilage in mice.

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-13 DOI: 10.1038/s41526-025-00458-z

Marco Chiaberge, Neelima Thottappillil, Anna-Maria Liphardt, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Anja Niehoff, Mark Shelhamer, Colin Norman, Marc J Philippon, Johnny Huard, Aaron W James, Chen-Ming Fan

{"title":"Plyometric training increases thickness and volume of knee articular cartilage in mice.","authors":"Marco Chiaberge, Neelima Thottappillil, Anna-Maria Liphardt, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Anja Niehoff, Mark Shelhamer, Colin Norman, Marc J Philippon, Johnny Huard, Aaron W James, Chen-Ming Fan","doi":"10.1038/s41526-025-00458-z","DOIUrl":"10.1038/s41526-025-00458-z","url":null,"abstract":"Degeneration and thinning of articular cartilage lead to osteoarthritis and may result from reduced joint loading during e.g. bed rest or as a result of microgravity during space flight. Anabolic physical exercises for cartilage are not well studied to date. We built an experimental apparatus for plyometric training with mice to test potential benefits of jumping for articular cartilage. The exercise group (JUMP) performed jump training for 9 weeks and was compared with sedentary mice (control, CON) and hindlimb-suspended (HLS) mice (to simulate reduced loading) for the same duration. Knee cartilage was assessed via 3-dimensional reconstruction of micro-CT scans and histology. We observed significant thinning and volume reduction of articular cartilage at the medial tibial-femoral point of contact in the HLS group. Clustering of chondrocytes was present in HLS. By contrast, the JUMP group showed both cartilage thickening and volume increase. We observed a similar trend on trabecular bone thickness and volume. Our results show that plyometric training can stimulate cartilage thickness and volume in mice. This suggests further investigation of this mode of exercise as a countermeasure to prevent cartilage atrophy in disuse scenarios such as long duration spaceflight, and for patients at risk of developing osteoarthritis.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"5"},"PeriodicalIF":4.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validated space radiation exposure predictions from earth to mars during Artemis-I.

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-11 DOI: 10.1038/s41526-025-00459-y

Tony C Slaba, Shirin Rahmanian, Stuart George, Diego Laramore, John W Norbury, Charles M Werneth, Cary Zeitlin

引用次数: 0

Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight.

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-02-03 DOI: 10.1038/s41526-024-00456-7

Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

{"title":"Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight.","authors":"Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser","doi":"10.1038/s41526-024-00456-7","DOIUrl":"10.1038/s41526-024-00456-7","url":null,"abstract":"Returning to the moon and traveling to Mars represent the main targets of human space exploration missions within the upcoming decades. Comparable to microgravity, partial gravity in these destinations is assumed to dysregulate immune functions, thereby threatening astronauts´ health. To investigate the impact of partial gravity on immune cell attachment to vessel endothelia, THP-1 cells and HUVEC cell layers were monitored in a flow chamber system during parabolic flight in lunar (0.16 g) or Martian (0.38 g) gravity. Focus was set on floating speed, cell adhesion, surface molecule expression and cytoskeletal reorganization under basal and TNF-induced inflammatory environment. Floating speed of THP-1 cells was increased in partial gravity, which was accompanied by a successively lower adhesion to the endothelial HUVEC cells. Expression levels of the adhesion markers Mac-1 on THP-1 cells as well as ICAM-1 on HUVECs were found elevated in lunar and Martian gravity, which was aggravated by TNF. Analysis of cytoskeletal organization in HUVECs revealed reduced intracellular F-actin microfilament networks and a stronger cell directionality with stress fiber alignment at cell borders in partial gravity, which was intensified by TNF. In summary, altered immune cell - endothelium interactions as quantified in partial gravity conditions show similarities to cellular behavior in microgravity. However, the different magnitudes of effects in dependence of gravitational level still need to be assessed in further investigations.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"4"},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulated deep space exposure on seeds utilizing the MISSE flight facility. 利用MISSE飞行设施模拟种子的深空暴露。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-01-17 DOI: 10.1038/s41526-024-00451-y

Jeffrey T Richards, Todd E Mortenson, Cory J Spern, Timothy A Mousseau, Jennifer L Gooden, Lashelle E Spencer, Christina L Khodadad, Jason A Fischer, Alexander D Meyers, Chad K Papenfuhs, Jeffrey G Buell, Howard G Levine, Dinah I Dimapilis, Ye Zhang

{"title":"Simulated deep space exposure on seeds utilizing the MISSE flight facility.","authors":"Jeffrey T Richards, Todd E Mortenson, Cory J Spern, Timothy A Mousseau, Jennifer L Gooden, Lashelle E Spencer, Christina L Khodadad, Jason A Fischer, Alexander D Meyers, Chad K Papenfuhs, Jeffrey G Buell, Howard G Levine, Dinah I Dimapilis, Ye Zhang","doi":"10.1038/s41526-024-00451-y","DOIUrl":"10.1038/s41526-024-00451-y","url":null,"abstract":"The MISSE-Seed project was designed to investigate the effects of space exposure on seed quality and storage. The project tested the Multipurpose Materials International Space Station Experiment-Flight Facility (MISSE-FF) hardware as a platform for exposing biological samples to the space environment outside the International Space Station (ISS). Furthermore, it evaluated the capability of a newly designed passive sample containment canister as a suitable exposure unit for biological samples for preserving their vigor while exposing to the space environment to study multi-stressor effects. The experiment was launched to the ISS on Northrup Grumman (NG)-15. The exposure lasted eight months outside the ISS in the MISSE-FF at the Zenith position. The specimens consisted of eleven seed varieties. Temperature dataloggers and thermoluminescent dosimeters were included in each container to record environmental data. We presented here the hardware and experimental design, environmental profiles, and seed survival from post-flight germination tests.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"3"},"PeriodicalIF":4.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypergravity is more challenging than microgravity for the human sensorimotor system. 对于人类的感觉运动系统来说，超重力比微重力更具挑战性。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-01-10 DOI: 10.1038/s41526-024-00452-x

Loïc Chomienne, Patrick Sainton, Fabrice R Sarlegna, Lionel Bringoux

引用次数: 0

Space exploration and risk of Parkinson's disease: a perspective review. 空间探索与帕金森病风险：观点综述。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-01-03 DOI: 10.1038/s41526-024-00457-6

Nilufar Ali, Afshin Beheshti, Greg Hampikian

引用次数: 0

Impact of near continuous low dose rate neutron irradiation on pregnancy outcomes in mice. 近连续低剂量中子辐照对小鼠妊娠结果的影响

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-12-19 DOI: 10.1038/s41526-024-00438-9

Jon G Steller, Rebecca S Blue, April E Ronca, Andrew Goodspeed, Theresa L Powell, Thomas Jansson

{"title":"Impact of near continuous low dose rate neutron irradiation on pregnancy outcomes in mice.","authors":"Jon G Steller, Rebecca S Blue, April E Ronca, Andrew Goodspeed, Theresa L Powell, Thomas Jansson","doi":"10.1038/s41526-024-00438-9","DOIUrl":"10.1038/s41526-024-00438-9","url":null,"abstract":"The effects of galactic cosmic radiation on reproductive physiology remain largely unknown. We determined the impact of near-continuous low-dose-rate Californium-252 neutron irradiation (1 mGy/day) as a space-relevant analog on litter size and number of resorptions at embryonic day (E) 12.5 (n = 19 radiated dams, n = 20 controls) and litter size, number of resorptions, fetal growth, and placental signaling and transcriptome (RNA sequencing) at E18.5 (n = 21 radiated dams, n = 20 controls) in pregnant mice. A significantly increased early resorption rate and decreased placental weight were observed in irradiated mice. There were no statistically significant differences in litter size, fetal weight, length, or malformation rate between the groups. Near-continuous radiation had no significant effects on the mechanistic target of rapamycin (mTOR), endoplasmic reticulum stress or inflammatory signaling, rate of double-stranded DNA breaks, and had minimal effects on gene expression in the placenta. These data suggest that near-continuous, low-level galactic cosmic radiation has a limited impact on pregnancy outcomes.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"113"},"PeriodicalIF":4.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats. Sprague-Dawley大鼠心血管对模拟微重力的适应性存在性别差异。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-12-19 DOI: 10.1038/s41526-024-00450-z

Ebrahim Elsangeedy, Dina N Yamaleyeva, Nicholas P Edenhoffer, Allyson Deak, Anna Soloshenko, Jonathan Ray, Xuming Sun, Omar H Shaltout, Nildris Cruz-Diaz, Brian Westwood, Daniel Kim-Shapiro, Debra I Diz, Shay Soker, Victor M Pulgar, April Ronca, Jeffrey S Willey, Liliya M Yamaleyeva

{"title":"Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats.","authors":"Ebrahim Elsangeedy, Dina N Yamaleyeva, Nicholas P Edenhoffer, Allyson Deak, Anna Soloshenko, Jonathan Ray, Xuming Sun, Omar H Shaltout, Nildris Cruz-Diaz, Brian Westwood, Daniel Kim-Shapiro, Debra I Diz, Shay Soker, Victor M Pulgar, April Ronca, Jeffrey S Willey, Liliya M Yamaleyeva","doi":"10.1038/s41526-024-00450-z","DOIUrl":"10.1038/s41526-024-00450-z","url":null,"abstract":"Men and women have different cardiovascular responses to spaceflight; however, few studies have focused on direct comparisons between sexes. We investigated the mechanisms of aortic stiffening in socially and sexually mature 20-week-old male and female Sprague Dawley (SD) rats exposed to hindlimb unloading (HLU) for 14 days. Pulse wave velocity (PWV) was greater in the aortic arch of females after HLU versus control females (n = 6-8). HLU had no effect on aortic PWV in males (n = 5-6). Aortic α smooth muscle actin, myosin, collagen, elastin, and collagen-to-elastin ratio were not different in rats of either sex following HLU. The levels of G protein-coupled estrogen receptor (GPER) were lower in the aorta of SD females exposed to HLU compared with female controls but were not altered in males. HLU females also had lower aortic PPARγ, increased oxidative stress markers, and diastolic dysfunction compared with control females. GPER agonist G1 prevented the increase in PWV and 8-hydroxy-2'-deoxyguanosine without altering PPARγ or p47phox in HLU females (n = 4 in each group) suggesting that lower GPER may contribute to arterial stiffening in the setting of simulated microgravity. This study highlights sex-specific vascular adaptations to the state of simulated microgravity.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"110"},"PeriodicalIF":4.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0