npj Microgravity最新文献

The effects of space radiation on the transcriptome of heart right ventricle tissue. 空间辐射对心脏右心室组织转录组的影响。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-21 DOI: 10.1038/s41526-025-00506-8

Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A Goukassian

{"title":"The effects of space radiation on the transcriptome of heart right ventricle tissue.","authors":"Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A Goukassian","doi":"10.1038/s41526-025-00506-8","DOIUrl":"https://doi.org/10.1038/s41526-025-00506-8","url":null,"abstract":"Deep space represents a challenging environment for human exploration and can be accompanied by harmful health-related risks. We aimed to assess the effect of simplified galactic cosmic ray simulated (simGCRsim) and gamma (γ) ionizing radiation (IR) on transcriptome changes in right ventricular (RV) tissue after a single low dose (0.5 Gy, 500 MeV/nucleon) full body exposure in C57BL/6J male and female mice. In females, no differentially expressed genes (DEGs) and only 2 upregulated genes in males exposed to γ-IR were revealed. In contrast, exposure to simGCRsim-IR resulted in 4 DEGs in females and 371 DEGs in males, suggesting longer-lasting and sex-biased DEGs after simGCRsim-IR. Overrepresentation analysis of DEGs in simGCRsim-IR males revealed significant enrichment in pathways related to muscle contraction, hypertrophic cardiomyopathy, oxytocin release, the regulation of cytoskeleton, and genes associated with Alzheimer's, Huntington's, and Parkinson's diseases. Our results suggested the RV transcriptome exhibits distinct responses after exposure based on both the IR and sex.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"46"},"PeriodicalIF":4.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks. 通过异质基因调控网络探索空间电离辐射效应的分子和模块见解。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-18 DOI: 10.1038/s41526-025-00508-6

Mengqin Yuan, Tao Zhang, Haizhou Liu, Min Long, Quan Wang, Wei Jiang

{"title":"Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks.","authors":"Mengqin Yuan, Tao Zhang, Haizhou Liu, Min Long, Quan Wang, Wei Jiang","doi":"10.1038/s41526-025-00508-6","DOIUrl":"10.1038/s41526-025-00508-6","url":null,"abstract":"Space ionizing radiation is a major risk factor for astronauts, yet its molecular mechanisms remain poorly understood. This study employs an integrative approach to investigate the effects of space ionizing radiation on molecules, modules, biological functions, associated diseases, and potential therapeutic drugs. Using paired samples from five donors subjected to acute ex vivo 2Gy gamma-ray irradiation, we analyzed miRNA and gene expression profiles in human peripheral blood lymphocytes collected 24 h post-exposure, combined with heterogeneous network analysis, identifying 179 key molecules (23 transcription factors, 10 miRNAs, and 146 genes) and 5 key modules. Functional enrichment analysis revealed associations with processes such as cell cycle regulation, cytidine deamination, cell differentiation, viral carcinogenesis, and apoptosis. Radiation was also significantly linked to neoplasms and digestive system diseases. Furthermore, we predicted 20 potential therapeutic compounds, including small molecules (e.g., Navitoclax) and Traditional Chinese Medicine ingredients (e.g., Genistin, Saikosaponin D), which may alleviate radiation-induced damage such as pulmonary fibrosis and oxidative stress. These findings provide novel insights into the molecular mechanisms of space ionizing radiation and may contribute to developing effective strategies to protect astronaut health during space missions.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"44"},"PeriodicalIF":4.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge. 喂养宇宙：解决个性化的太空营养和肠道渗漏的挑战。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-18 DOI: 10.1038/s41526-025-00490-z

B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung, J Puig, K Mikhailova, H Coker, A Marks, R Gilbert, R Scott, R Barker, P Glowe, Eliah G Overbey, C E Mason

{"title":"Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge.","authors":"B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung, J Puig, K Mikhailova, H Coker, A Marks, R Gilbert, R Scott, R Barker, P Glowe, Eliah G Overbey, C E Mason","doi":"10.1038/s41526-025-00490-z","DOIUrl":"10.1038/s41526-025-00490-z","url":null,"abstract":"Long-duration space missions pose serious challenges to astronaut nutrition and health due to the altered environment of Low Earth Orbit (LEO). This study examines the nutritional composition of crops grown in space, identifying deficiencies in key nutrients such as calcium and magnesium, along with variable antioxidant profiles. These imbalances may impact astronaut physiology, particularly bone health and immune function, and are potentially linked to altered gene expression pathways in microgravity. Emerging evidence also suggests increased intestinal permeability, referred as leaky gut syndrome, which further disrupts nutrient absorption and immune regulation. To mitigate these issues, we evaluate targeted strategies including bioengineering of nutrient-dense crops, incorporation of antioxidant-rich species, and personalized nutrition guided by pharmacogenomics. Approaches such as biofortification and tailored supplementation are proposed to address these challenges. This work contributes to the development of resilient space agriculture systems that support astronaut health during deep space missions and future planetary habitation.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"45"},"PeriodicalIF":4.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Free surface bubbly flow in an open capillary channel. 自由表面气泡流动在一个开放的毛细管通道。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-16 DOI: 10.1038/s41526-025-00496-7

Bo Wu, Zongyu Wu, Yong Chen, Guangyu Li, Wen Yao

引用次数: 0

Cryogenic helium subsurface pressurization in terrestrial and low-gravity: experiments and flow visualization. 低温氦在地面和低重力下的地下加压：实验和流动可视化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-15 DOI: 10.1038/s41526-025-00504-w

Jinze Yu, J N Chung, S R Darr, M Taliaferro, G R Warrier, J W Hartwig

{"title":"Cryogenic helium subsurface pressurization in terrestrial and low-gravity: experiments and flow visualization.","authors":"Jinze Yu, J N Chung, S R Darr, M Taliaferro, G R Warrier, J W Hartwig","doi":"10.1038/s41526-025-00504-w","DOIUrl":"10.1038/s41526-025-00504-w","url":null,"abstract":"Pressurization of cryogenic propellant storage tanks is required for propellant thermodynamic conditioning and for enabling propellant transfer from a supply tank to another tank or an engine. In microgravity, the pressurization gas may be injected directly into the liquid propellant if the nozzle is submerged in liquid. Known as helium subsurface pressurization (HSP), the incoming warm helium gas causes immediate evaporation of the propellant into the helium bubbles which subcools the liquid. For HSP of cryogenic liquids in reduced gravity environments, there are many unknowns such as the rate of evaporation, change in temperature of helium after injection, bubble growth rate, and boil-off and pressurization rates. The purpose of this paper is to present new experimental data and flow visualization of subsurface gaseous helium injection into liquid nitrogen in terrestrial gravity and low-gravity. Varied parameters include injector size (0.25, 1.0 mm), injection flow rate (10-9-10-5 kg/s), and temperature (170-260 K). The new data clearly shows the role of gravity, buoyancy, and inertial forces on multiple cryogenic subsurface parameters of interest.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"42"},"PeriodicalIF":4.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic biology for space exploration. 用于太空探索的合成生物学。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-12 DOI: 10.1038/s41526-025-00488-7

Silvano Onofri, Ralf Moeller, Daniela Billi, Michele Balsamo, Anke Becker, Eugenio Benvenuto, Alessia Cassaro, Ilaria Catanzaro, Charles S Cockell, Angiola Desiderio, Tom Ellis, José Eduardo Gonzáles-Pastor, Christiane Hahn, Natalie Leys, Patrick Leo, Marie-Christine Maurel, Claudia Pacelli, Bruno Pavletic, Caterina Ripa, Lynn J Rothschild, Leonardo Surdo

引用次数: 0

Numerical study on the effect of microgravity on biomechanics in human lumbar intervertebral discs. 微重力对人腰椎间盘生物力学影响的数值研究。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-12 DOI: 10.1038/s41526-025-00483-y

Bing Qin, Xin Gao, Jiwen Wu, Lu Zhou, Zhiyu Qian, Qiaoqiao Zhu

引用次数: 0

Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition. 南极隔离期间短暂的灰质下降：睡眠、运动和认知的作用。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-11 DOI: 10.1038/s41526-025-00497-6

David Roalf, Mathias Basner, Joanne C Beer, Russell T Shinohara, Kosha Ruparel, Tyler M Moore, David F Dinges, Alexander C Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J Ecker, Karthik Prabhakaran, Mustafa M Almuqbel, Michael G Smith, Christopher W Jones, Bernd Johannes, Darius A Gerlach, Beth Healey, Floris P van den Berg, Hanns-Christian Gunga, Tracy R Melzer, Bruce V Taylor, Ruben C Gur

{"title":"Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition.","authors":"David Roalf, Mathias Basner, Joanne C Beer, Russell T Shinohara, Kosha Ruparel, Tyler M Moore, David F Dinges, Alexander C Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J Ecker, Karthik Prabhakaran, Mustafa M Almuqbel, Michael G Smith, Christopher W Jones, Bernd Johannes, Darius A Gerlach, Beth Healey, Floris P van den Berg, Hanns-Christian Gunga, Tracy R Melzer, Bruce V Taylor, Ruben C Gur","doi":"10.1038/s41526-025-00497-6","DOIUrl":"10.1038/s41526-025-00497-6","url":null,"abstract":"Astronauts face significant stress in space, and understanding its neurobiological basis is key to assessing risk and resilience. Analogue environments, like the Antarctic Concordia Station, replicate isolated, confined, and extreme (ICE) conditions. This study assessed brain structure changes in 25 crewmembers who spent 12 months at Concordia, with MRI scans conducted before, immediately after, and five months post-mission. The study included 25 controls scanned over a similar interval and 4 \"flying phantom\" individuals who were scanned at all sites. Gray matter in the temporal and parietal lobes, hippocampus, pallidum, and thalamus as well as global white matter decreased during the mission in crewmembers, with all but the thalamus returning to baseline after five months. Brain ventricle volume increased, and better sleep correlated with less brain volume loss, highlighting its potentially protective role. These findings emphasize the importance of understanding mechanisms driving brain changes, particularly with growing interest in extended space missions in ICE environments.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"39"},"PeriodicalIF":4.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A moonshot for female astronaut health, a win for all astronauts and space exploration. 女性宇航员健康的登月计划，所有宇航员和太空探索的胜利。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-08 DOI: 10.1038/s41526-025-00495-8

Ruth M Farrell, Jennifer A Fogarty, Marisa Covington, Mary Van Baalen, Serena Aunon-Chancellor, Jon G Steller

引用次数: 0

Theoretical investigation of an atomic Fabry Perot interferometer based acceleration sensor for microgravity environments. 基于原子法布里珀罗干涉仪的微重力环境加速度传感器的理论研究。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-07 DOI: 10.1038/s41526-025-00499-4

Manju Perumbil, Matthew J Blacker, Stuart S Szigeti, Simon A Haine

{"title":"Theoretical investigation of an atomic Fabry Perot interferometer based acceleration sensor for microgravity environments.","authors":"Manju Perumbil, Matthew J Blacker, Stuart S Szigeti, Simon A Haine","doi":"10.1038/s41526-025-00499-4","DOIUrl":"10.1038/s41526-025-00499-4","url":null,"abstract":"We investigate the use of an atomic Fabry-Perot interferometer (FPI) with a pulsed non-interacting Bose-Einstein condensate (BEC) source as a space-based acceleration sensor. We derive an analytic approximation for the device's transmission under a uniform acceleration, which we use to compute the device's attainable acceleration sensitivity using the classical Fisher information. In the ideal case of a high-finesse FPI and an infinitely narrow momentum width atomic source, we find that when the device length is limited, the atomic FPI can achieve greater acceleration sensitivity than a Mach-Zender (MZ) interferometer of equivalent device length. Under the more realistic case of a finite momentum width source, we identify the ideal cavity length for the best sensitivity. Although the MZ interferometer now offers enhanced sensitivity within currently achievable parameter regimes, our analysis demonstrates that the atomic FPI holds potential as a promising future alternative if narrow momentum width atomic sources can be engineered.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"37"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0