Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge.

IF 4.1 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES
B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung, J Puig, K Mikhailova, H Coker, A Marks, R Gilbert, R Scott, R Barker, P Glowe, Eliah G Overbey, C E Mason
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Abstract

Long-duration space missions pose serious challenges to astronaut nutrition and health due to the altered environment of Low Earth Orbit (LEO). This study examines the nutritional composition of crops grown in space, identifying deficiencies in key nutrients such as calcium and magnesium, along with variable antioxidant profiles. These imbalances may impact astronaut physiology, particularly bone health and immune function, and are potentially linked to altered gene expression pathways in microgravity. Emerging evidence also suggests increased intestinal permeability, referred as leaky gut syndrome, which further disrupts nutrient absorption and immune regulation. To mitigate these issues, we evaluate targeted strategies including bioengineering of nutrient-dense crops, incorporation of antioxidant-rich species, and personalized nutrition guided by pharmacogenomics. Approaches such as biofortification and tailored supplementation are proposed to address these challenges. This work contributes to the development of resilient space agriculture systems that support astronaut health during deep space missions and future planetary habitation.

喂养宇宙:解决个性化的太空营养和肠道渗漏的挑战。
由于低地球轨道环境的改变,长时间空间任务对宇航员的营养和健康构成了严重挑战。这项研究考察了在太空中种植的作物的营养成分,确定了钙和镁等关键营养素的缺乏,以及不同的抗氧化剂特征。这些失衡可能会影响宇航员的生理机能,特别是骨骼健康和免疫功能,并可能与微重力下基因表达途径的改变有关。新出现的证据还表明,肠道通透性增加,被称为漏肠综合征,这进一步破坏了营养吸收和免疫调节。为了缓解这些问题,我们评估了有针对性的策略,包括营养密集作物的生物工程,富含抗氧化剂的物种的结合,以及药物基因组学指导下的个性化营养。提出了诸如生物强化和量身定制的补充等方法来应对这些挑战。这项工作有助于发展弹性空间农业系统,支持宇航员在深空任务和未来行星居住期间的健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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