npj Microgravity最新文献_第4页

Numerical study on the effect of microgravity on biomechanics in human lumbar intervertebral discs. 微重力对人腰椎间盘生物力学影响的数值研究。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-12 DOI: 10.1038/s41526-025-00483-y

Bing Qin, Xin Gao, Jiwen Wu, Lu Zhou, Zhiyu Qian, Qiaoqiao Zhu

引用次数: 0

Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition. 南极隔离期间短暂的灰质下降：睡眠、运动和认知的作用。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-11 DOI: 10.1038/s41526-025-00497-6

David Roalf, Mathias Basner, Joanne C Beer, Russell T Shinohara, Kosha Ruparel, Tyler M Moore, David F Dinges, Alexander C Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J Ecker, Karthik Prabhakaran, Mustafa M Almuqbel, Michael G Smith, Christopher W Jones, Bernd Johannes, Darius A Gerlach, Beth Healey, Floris P van den Berg, Hanns-Christian Gunga, Tracy R Melzer, Bruce V Taylor, Ruben C Gur

{"title":"Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition.","authors":"David Roalf, Mathias Basner, Joanne C Beer, Russell T Shinohara, Kosha Ruparel, Tyler M Moore, David F Dinges, Alexander C Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J Ecker, Karthik Prabhakaran, Mustafa M Almuqbel, Michael G Smith, Christopher W Jones, Bernd Johannes, Darius A Gerlach, Beth Healey, Floris P van den Berg, Hanns-Christian Gunga, Tracy R Melzer, Bruce V Taylor, Ruben C Gur","doi":"10.1038/s41526-025-00497-6","DOIUrl":"10.1038/s41526-025-00497-6","url":null,"abstract":"Astronauts face significant stress in space, and understanding its neurobiological basis is key to assessing risk and resilience. Analogue environments, like the Antarctic Concordia Station, replicate isolated, confined, and extreme (ICE) conditions. This study assessed brain structure changes in 25 crewmembers who spent 12 months at Concordia, with MRI scans conducted before, immediately after, and five months post-mission. The study included 25 controls scanned over a similar interval and 4 \"flying phantom\" individuals who were scanned at all sites. Gray matter in the temporal and parietal lobes, hippocampus, pallidum, and thalamus as well as global white matter decreased during the mission in crewmembers, with all but the thalamus returning to baseline after five months. Brain ventricle volume increased, and better sleep correlated with less brain volume loss, highlighting its potentially protective role. These findings emphasize the importance of understanding mechanisms driving brain changes, particularly with growing interest in extended space missions in ICE environments.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"39"},"PeriodicalIF":4.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A moonshot for female astronaut health, a win for all astronauts and space exploration. 女性宇航员健康的登月计划，所有宇航员和太空探索的胜利。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-08 DOI: 10.1038/s41526-025-00495-8

Ruth M Farrell, Jennifer A Fogarty, Marisa Covington, Mary Van Baalen, Serena Aunon-Chancellor, Jon G Steller

引用次数: 0

Theoretical investigation of an atomic Fabry Perot interferometer based acceleration sensor for microgravity environments. 基于原子法布里珀罗干涉仪的微重力环境加速度传感器的理论研究。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-07 DOI: 10.1038/s41526-025-00499-4

Manju Perumbil, Matthew J Blacker, Stuart S Szigeti, Simon A Haine

{"title":"Theoretical investigation of an atomic Fabry Perot interferometer based acceleration sensor for microgravity environments.","authors":"Manju Perumbil, Matthew J Blacker, Stuart S Szigeti, Simon A Haine","doi":"10.1038/s41526-025-00499-4","DOIUrl":"10.1038/s41526-025-00499-4","url":null,"abstract":"We investigate the use of an atomic Fabry-Perot interferometer (FPI) with a pulsed non-interacting Bose-Einstein condensate (BEC) source as a space-based acceleration sensor. We derive an analytic approximation for the device's transmission under a uniform acceleration, which we use to compute the device's attainable acceleration sensitivity using the classical Fisher information. In the ideal case of a high-finesse FPI and an infinitely narrow momentum width atomic source, we find that when the device length is limited, the atomic FPI can achieve greater acceleration sensitivity than a Mach-Zender (MZ) interferometer of equivalent device length. Under the more realistic case of a finite momentum width source, we identify the ideal cavity length for the best sensitivity. Although the MZ interferometer now offers enhanced sensitivity within currently achievable parameter regimes, our analysis demonstrates that the atomic FPI holds potential as a promising future alternative if narrow momentum width atomic sources can be engineered.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"37"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implied gravity promotes coherent motion perception. 隐含重力促进连贯运动感知。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-07 DOI: 10.1038/s41526-025-00498-5

Xiqian Lu, Bogeng Song, Shaoshuai Zhang, Shujia Zhang, Mei Huang, Ying Wang, Yi Jiang

{"title":"Implied gravity promotes coherent motion perception.","authors":"Xiqian Lu, Bogeng Song, Shaoshuai Zhang, Shujia Zhang, Mei Huang, Ying Wang, Yi Jiang","doi":"10.1038/s41526-025-00498-5","DOIUrl":"10.1038/s41526-025-00498-5","url":null,"abstract":"Gravity, a constant in Earth's environment, constrains not only physical motion but also our estimation of motion trajectories. Early studies show that natural gravitational acceleration facilitates the manual interception of free-falling objects. However, whether implied gravity affects the perception of coherent motion patterns from local motion cues remains poorly understood. Here, we designed a motion coherence threshold task to measure the visual discrimination of coherent global motion with natural (1 g) and reversed (-1 g) gravitational accelerations. Across five experiments, we showed that the perceptual thresholds of motion coherence were significantly lower under the natural gravity than the reversed gravity condition, regardless of variations in stimulus parameters and visual contexts. These convergent results suggest that the human visual system inherently extracts the gravitational acceleration cues conveyed by local motion signals and integrates them into a unified global motion, thereby facilitating the visual perception of complex motion patterns in natural environments.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"36"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic, transcriptomic and metabolomic changes in Klebsiella pneumoniae after long term exposure to simulated microgravity. 长期暴露于模拟微重力环境后肺炎克雷伯菌的表型、转录组学和代谢组学变化。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-05 DOI: 10.1038/s41526-025-00489-6

Xia Wang, Zili Chai, Wenting Liu, Tianye Jia, Zilong Yang, Fengwei Zhang, Fuqiang Kang, Qiming Wang, Xianwei Ye, Hongguang Ren, Xiaodong Zai, Junjie Yue, Yuan Jin

{"title":"Phenotypic, transcriptomic and metabolomic changes in Klebsiella pneumoniae after long term exposure to simulated microgravity.","authors":"Xia Wang, Zili Chai, Wenting Liu, Tianye Jia, Zilong Yang, Fengwei Zhang, Fuqiang Kang, Qiming Wang, Xianwei Ye, Hongguang Ren, Xiaodong Zai, Junjie Yue, Yuan Jin","doi":"10.1038/s41526-025-00489-6","DOIUrl":"10.1038/s41526-025-00489-6","url":null,"abstract":"Klebsiella pneumoniae (K. pneumoniae) has been detected on space stations. Microgravity is a key environmental factor in spaceflight, however, research on the phenotypic, genetic, and metabolic changes K. pneumoniae undergoes due to long-term exposure to microgravity is still limited. K. pneumoniae was cultured under normal gravity (NG) and simulated microgravity (SMG) for 56 days, showing phenotypic changes like slower growth, larger and rounder cell morphology, and increased biofilm formation in SMG. RNA sequencing analysis revealed that the DEGs were associated primarily with metabolic and growth pathways, including those involved in biofilm formation. Metabolomic analysis revealed changes in the activity of the phenylalanine metabolic pathway, which was the most significantly enriched pathway, due to the interaction between the mhp gene cluster and related DEMs. Co-expression network analysis revealed intricate relationships between DEGs and DEMs, notably in arginine and proline metabolism. This study provides insights into K. pneumoniae's response mechanisms to microgravity.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"35"},"PeriodicalIF":4.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the scientific and economic impacts of the experiments conducted onboard the International Space Station. 评估在国际空间站上进行的实验的科学和经济影响。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-03 DOI: 10.1038/s41526-025-00485-w

Max Wang, Ken Savin

引用次数: 0

High-risk private space missions have potential impact on government-sponsored programs. 高风险的私人太空任务对政府资助的项目有潜在的影响。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-03 DOI: 10.1038/s41526-025-00474-z

Hansjörg Schwertz, Dana Tulodziecki

引用次数: 0

Impact of peripheral skin cooling on neuroendocrine leukocytic and hematological reactions during Hypergravity. 外周皮肤冷却对超重力时神经内分泌、白细胞和血液学反应的影响。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-02 DOI: 10.1038/s41526-025-00486-9

Michael Nordine, Niklas Kagelmann, Jan Kloka, Hanns-Christian Gunga, Viktor Heinz, Niklas Pilz, Oliver Opatz, Tomas L Bothe

{"title":"Impact of peripheral skin cooling on neuroendocrine leukocytic and hematological reactions during Hypergravity.","authors":"Michael Nordine, Niklas Kagelmann, Jan Kloka, Hanns-Christian Gunga, Viktor Heinz, Niklas Pilz, Oliver Opatz, Tomas L Bothe","doi":"10.1038/s41526-025-00486-9","DOIUrl":"10.1038/s41526-025-00486-9","url":null,"abstract":"Optimal neuroendocrine responses are essential during hypergravity (+Gz) exposure. Peripheral skin cooling (PSC) may enhance neuroendocrine function, potentially improving +Gz resiliency and influencing leukocyte and hematologic factors. This study investigated whether PSC augments the cumulative +Gz stress index (CGSI) and shifts it toward noradrenergic dependency. Eighteen men underwent a graded +Gz profile in a crossover design, with PSC applied using Arctic Sun cooling pads. Neuroendocrine and blood profiles were assessed pre- and post-+Gz. CGSI did not differ between groups, but serum osmolality increased only in PSC (p = 0.03). In PSC, CGSI correlated with norepinephrine (p < 0.01, r = 0.71) and other markers, suggesting enhanced norepinephrine responsiveness despite similar serum levels. This response may be cardio-protective for space missions and ICU patients. Additionally, baseline serum metanephrine emerged as a potential marker for +Gz resilience, with PSC showing potential leukocytic and hematologic involvement in CGSI.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"30"},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In space fabrication of Janus base nano matrix for improved assembly and bioactivity. 在空间制备中改进Janus基纳米基质的组装和生物活性。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2025-07-02 DOI: 10.1038/s41526-025-00482-z

Anne Yau, Maxwell Landolina, Mari Anne Snow, Pinar Mesci, Brandon Williams, James B Hoying, Jana Stoudemire, Rayyanah Barnawi, Peggy Whitson, Rose Hernandez, Derek Duflo, Honglu Wu, Yupeng Chen

引用次数: 0