npj Microgravity最新文献_第4页

Expiration analysis of the International Space Station formulary for exploration mission planning. 用于探索任务规划的国际空间站配方有效期分析。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-07-23 DOI: 10.1038/s41526-024-00414-3

Thomas E Diaz, Emma C Ives, Diana I Lazare, Daniel M Buckland

{"title":"Expiration analysis of the International Space Station formulary for exploration mission planning.","authors":"Thomas E Diaz, Emma C Ives, Diana I Lazare, Daniel M Buckland","doi":"10.1038/s41526-024-00414-3","DOIUrl":"10.1038/s41526-024-00414-3","url":null,"abstract":"Effective medications will be required to maintain human health for long-duration space operations. Previous studies have explored the stability and potency of several of the medications used on the International Space Station (ISS). This study is a comprehensive analysis of the expected terrestrial shelf-lives of the entire 2023 ISS formulary using 4 international registries. Of the 106 medications in the ISS formulary, shelf-life data was found in at least 1 of the registries for 91 (86%) medications. Of these 91 medications, 54 have an estimated terrestrial shelf-life of ≤36 months when stored in their original packaging. 14 will expire in less than 24 months. The results of this study provide operational insight to supplying a pharmacy for an exploration mission, optimize therapeutic outcomes, and prevent diseases associated with extended spaceflight operations. Ultimately, those responsible for the health of spaceflight crews will have to find ways to extend the expiration of medications to the complete mission duration or accept the elevated risk associated with administration of an expired medication.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"76"},"PeriodicalIF":4.4,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamic assessment of evaporation during molten steel testing onboard the International Space Station. 在国际空间站上进行熔融钢测试期间对蒸发的热力学评估。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-07-19 DOI: 10.1038/s41526-024-00416-1

Jannatun Nawer, Brian Stanford, Matthias Kolbe, Stephan Schneider, Stéphane Gossé, Rainer K Wunderlich, Markus Mohr, Aurelio Borzì, Antonia Neels, Douglas M Matson

{"title":"Thermodynamic assessment of evaporation during molten steel testing onboard the International Space Station.","authors":"Jannatun Nawer, Brian Stanford, Matthias Kolbe, Stephan Schneider, Stéphane Gossé, Rainer K Wunderlich, Markus Mohr, Aurelio Borzì, Antonia Neels, Douglas M Matson","doi":"10.1038/s41526-024-00416-1","DOIUrl":"10.1038/s41526-024-00416-1","url":null,"abstract":"Evaporation control is a critical facility resource during solidification experiments that limits processing time and must be tracked to ensure facility health. A thermodynamic analysis was performed on a ternary FeCrNi sample processed onboard the International Space Station (ISS) using ESA Electromagnetic Levitation (EML) facility in a microgravity environment. A non-ideal solution-based mathematical model was applied for the overall sample mass loss prediction during this study. The overall sample mass loss prediction is consistent with the post-flight mass loss measurements. The species-specific findings from this study were validated using post-mission SEM-EDX surface evaluations by three different facilities. The bulk composition prediction was validated using SEM-EDX and wet chemical analysis. The non-ideal solution model was then applied to predict the composition of the dust generated during EML testing. The thicknesses of the deposited layer on the EML coil at various locations were also calculated using the geometry of the facility and results were validated with near-real-time dust layer predictions from toxicity tracking software developed by the German Space Center (DLR) Microgravity User Support Center (MUSC).","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"77"},"PeriodicalIF":4.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spaceflight increases sarcoplasmic reticulum Ca²⁺ leak and this cannot be counteracted with BuOE treatment. 太空飞行会增加肌浆网 Ca2+ 泄漏，而这种现象无法通过使用 BuOE 来抵消。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-07-19 DOI: 10.1038/s41526-024-00419-y

Jessica L Braun, Val A Fajardo

{"title":"Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment.","authors":"Jessica L Braun, Val A Fajardo","doi":"10.1038/s41526-024-00419-y","DOIUrl":"10.1038/s41526-024-00419-y","url":null,"abstract":"Spending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for bringing Ca2+ from the cytosol into its storage site, the sarcoplasmic reticulum (SR), at the expense of ATP. We have recently demonstrated that, in the soleus of space-flown mice, the Ca2+ uptake ability of the SERCA pump is severely impaired and this may be attributed to increases in reactive oxygen/nitrogen species (RONS), to which SERCA is highly susceptible. The purpose of this study was therefore to investigate whether treatment with the antioxidant, Manganese(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+ (BuOE), could attenuate muscle atrophy and SERCA dysfunction. We received soleus muscles from the rodent research 18 mission which had male mice housed on the international space station for 35 days and treated with either saline or BuOE. Spaceflight significantly reduced the soleus:body mass ratio and significantly increased SERCA's ionophore ratio, a measure of SR Ca2+ leak, and 4-HNE content (marker of RONS), none of which could be rescued by BuOE treatment. In conclusion, we find that spaceflight induces significant soleus muscle atrophy and SR Ca2+ leak that cannot be counteracted with BuOE treatment. Future work should investigate alternative therapeutics that are specifically aimed at increasing SERCA activation or reducing Ca2+ leak.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"78"},"PeriodicalIF":4.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system. 利用人体肾脏微生理系统模拟微重力环境下细胞对血清和维生素 D 的反应。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-07-09 DOI: 10.1038/s41526-024-00415-2

Kevin A Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W MacDonald, Theo K Bammler, Justina Calamia, Kenneth E Thummel, Catherine K Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J Kelly

{"title":"Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system.","authors":"Kevin A Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W MacDonald, Theo K Bammler, Justina Calamia, Kenneth E Thummel, Catherine K Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J Kelly","doi":"10.1038/s41526-024-00415-2","DOIUrl":"10.1038/s41526-024-00415-2","url":null,"abstract":"The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of developing strategies to enable long- term spaceflight and better treatment of diseases on Earth. We used this unique environment to evaluate the effects of microgravity on kidney proximal tubule epithelial cell (PTEC) response to serum exposure and vitamin D biotransformation capacity. To test if microgravity alters the pathologic response of the proximal tubule to serum exposure, we treated PTECs cultured in a microphysiological system (PT-MPS) with human serum and measured biomarkers of toxicity and inflammation (KIM-1 and IL-6) and conducted global transcriptomics via RNAseq on cells undergoing flight (microgravity) and respective controls (ground). Given the profound bone loss observed in microgravity and PTECs produce the active form of vitamin D, we treated 3D cultured PTECs with 25(OH)D3 (vitamin D) and monitored vitamin D metabolite formation, conducted global transcriptomics via RNAseq, and evaluated transcript expression of CYP27B1, CYP24A1, or CYP3A5 in PTECs undergoing flight (microgravity) and respective ground controls. We demonstrated that microgravity neither altered PTEC metabolism of vitamin D nor did it induce a unique response of PTECs to human serum, suggesting that these fundamental biochemical pathways in the kidney proximal tubule are not significantly altered by short-term exposure to microgravity. Given the prospect of extended spaceflight, more study is needed to determine if these responses are consistent with extended (>6 months) exposure to microgravity.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"75"},"PeriodicalIF":4.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity. 冷大气压等离子体射流在微重力环境下的运行和抗菌作用演示。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-07-06 DOI: 10.1038/s41526-024-00408-1

A Rouillard, P Escot Bocanegra, A Stancampiano, S Dozias, J Lemaire, J M Pouvesle, E Robert, F Brulé-Morabito, M Demasure, S Rouquette

{"title":"Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity.","authors":"A Rouillard, P Escot Bocanegra, A Stancampiano, S Dozias, J Lemaire, J M Pouvesle, E Robert, F Brulé-Morabito, M Demasure, S Rouquette","doi":"10.1038/s41526-024-00408-1","DOIUrl":"10.1038/s41526-024-00408-1","url":null,"abstract":"Cold atmospheric pressure plasma (ionized gas) is an innovative medical tool for the treatment of infected wounds thanks to its potential to inactivate drug-resistant microorganisms and promote tissue regeneration and vascularization. The low power consumption, compactness, and versatility of Cold Atmospheric Pressure Plasma (CAPP) devices make them an ideal tool for risk mitigation associated with human spaceflights. This work presents results in microgravity on the operability of CAPP and its antimicrobial effect. The experiments carried out in parabolic flights make it possible to optimize the treatment conditions (i.e., the distance, the gas mixture) and to obtain the rapid inactivation (<15 s) of Escherichia coli samples. Interestingly, the inactivation efficiency of CAPP was higher during parabolic flights than under terrestrial conditions. Overall, these results encourage the further development of CAPP medical devices for its implementation during human spaceflights.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"74"},"PeriodicalIF":4.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A meta-analysis of semiconductor materials fabricated in microgravity. 对在微重力条件下制造的半导体材料进行元分析。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-06-26 DOI: 10.1038/s41526-024-00410-7

Ashley R Wilkinson, Frances Brewer, Hannah Wright, Ben Whiteside, Amari Williams, Lynn Harper, Anne M Wilson

引用次数: 0

Evaluation of body shape as a human body composition assessment in isolated conditions and remote environments. 在与世隔绝的条件下和偏远环境中，将体形评估作为人体成分评估。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-06-24 DOI: 10.1038/s41526-024-00412-5

Michael C Wong, Jonathan P Bennett, Lambert T Leong, Yong E Liu, Nisa N Kelly, John Cherry, Kate Kloza, Bosco Li, Sandra Iuliano, Jean Sibonga, Aenor Sawyer, Jeff Ayton, John A Shepherd

{"title":"Evaluation of body shape as a human body composition assessment in isolated conditions and remote environments.","authors":"Michael C Wong, Jonathan P Bennett, Lambert T Leong, Yong E Liu, Nisa N Kelly, John Cherry, Kate Kloza, Bosco Li, Sandra Iuliano, Jean Sibonga, Aenor Sawyer, Jeff Ayton, John A Shepherd","doi":"10.1038/s41526-024-00412-5","DOIUrl":"10.1038/s41526-024-00412-5","url":null,"abstract":"Individuals in isolated and extreme environments can experience debilitating side-effects including significant decreases in fat-free mass (FFM) from disuse and inadequate nutrition. The objective of this study was to determine the strengths and weaknesses of three-dimensional optical (3DO) imaging for monitoring body composition in either simulated or actual remote environments. Thirty healthy adults (ASTRO, male = 15) and twenty-two Antarctic Expeditioners (ABCS, male = 18) were assessed for body composition. ASTRO participants completed duplicate 3DO scans while standing and inverted by gravity boots plus a single dual-energy X-ray absorptiometry (DXA) scan. The inverted scans were an analog for fluid redistribution from gravity changes. An existing body composition model was used to estimate fat mass (FM) and FFM from 3DO meshes. 3DO body composition estimates were compared to DXA with linear regression and reported with the coefficient of determination (R2) and root mean square error (RMSE). ABCS participants received only duplicate 3DO scans on a monthly basis. Standing ASTRO meshes achieved an R2 of 0.76 and 0.97 with an RMSE of 2.62 and 2.04 kg for FM and FFM, while inverted meshes achieved an R2 of 0.52 and 0.93 with an RMSE of 2.84 and 3.23 kg for FM and FFM, respectively, compared to DXA. For the ABCS arm, mean weight, FM, and FFM changes were -0.47, 0.06, and -0.54 kg, respectively. Simulated fluid redistribution decreased the accuracy of estimated body composition values from 3DO scans. However, FFM stayed robust. 3DO imaging showed good absolute accuracy for body composition assessment in isolated and remote environments.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"72"},"PeriodicalIF":4.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning workflow for edge computed arrhythmia detection in exploration class missions. 探索类任务中边缘计算心律失常检测的机器学习工作流程。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-06-22 DOI: 10.1038/s41526-024-00409-0

Cyril Mani, Tanya S Paul, Patrick M Archambault, Alexandre Marois

{"title":"Machine learning workflow for edge computed arrhythmia detection in exploration class missions.","authors":"Cyril Mani, Tanya S Paul, Patrick M Archambault, Alexandre Marois","doi":"10.1038/s41526-024-00409-0","DOIUrl":"10.1038/s41526-024-00409-0","url":null,"abstract":"Deep-space missions require preventative care methods based on predictive models for identifying in-space pathologies. Deploying such models requires flexible edge computing, which Open Neural Network Exchange (ONNX) formats enable by optimizing inference directly on wearable edge devices. This work demonstrates an innovative approach to point-of-care machine learning model pipelines by combining this capacity with an advanced self-optimizing training scheme to classify periods of Normal Sinus Rhythm (NSR), Atrial Fibrillation (AFIB), and Atrial Flutter (AFL). 742 h of electrocardiogram (ECG) recordings were pre-processed into 30-second normalized samples where variable mode decomposition purged muscle artifacts and instrumentation noise. Seventeen heart rate variability and morphological ECG features were extracted by convoluting peak detection with Gaussian distributions and delineating QRS complexes using discrete wavelet transforms. The decision tree classifier's features, parameters, and hyperparameters were self-optimized through stratified triple nested cross-validation ranked on F1-scoring against cardiologist labeling. The selected model achieved a macro F1-score of 0.899 with 0.993 for NSR, 0.938 for AFIB, and 0.767 for AFL. The most important features included median P-wave amplitudes, PRR20, and mean heart rates. The ONNX-translated pipeline took 9.2 s/sample. This combination of our self-optimizing scheme and deployment use case of ONNX demonstrated overall accurate operational tachycardia detection.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"71"},"PeriodicalIF":4.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weightlessness leads to an increase granulosa cells in the growing follicle. 失重会导致生长卵泡中的颗粒细胞增加。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-06-22 DOI: 10.1038/s41526-024-00413-4

Anna Yu Kikina, Mariia S Matrosova, Elena Yu Gorbacheva, Ksenia K Gogichaeva, Konstantin A Toniyan, Valery V Boyarintsev, Oleg V Kotov, Irina V Ogneva

引用次数: 0

Physical exercise restores adult neurogenesis deficits induced by simulated microgravity. 体育锻炼可恢复模拟微重力导致的成人神经发生缺陷。

IF 4.4 1区物理与天体物理

npj Microgravity Pub Date : 2024-06-21 DOI: 10.1038/s41526-024-00411-6

Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel

{"title":"Physical exercise restores adult neurogenesis deficits induced by simulated microgravity.","authors":"Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel","doi":"10.1038/s41526-024-00411-6","DOIUrl":"10.1038/s41526-024-00411-6","url":null,"abstract":"Cognitive impairments have been reported in astronauts during spaceflights and documented in ground-based models of simulated microgravity (SMG) in animals. However, the neuronal causes of these behavioral effects remain largely unknown. We explored whether adult neurogenesis, known to be a crucial plasticity mechanism supporting memory processes, is altered by SMG. Adult male Long-Evans rats were submitted to the hindlimb unloading model of SMG. We studied the proliferation, survival and maturation of newborn cells in the following neurogenic niches: the subventricular zone (SVZ)/olfactory bulb (OB) and the dentate gyrus (DG) of the hippocampus, at different delays following various periods of SMG. SMG exposure for 7 days, but not shorter periods of 6 or 24 h, resulted in a decrease of newborn cell proliferation restricted to the DG. SMG also induced a decrease in short-term (7 days), but not long-term (21 days), survival of newborn cells in the SVZ/OB and DG. Physical exercise, used as a countermeasure, was able to reverse the decrease in newborn cell survival observed in the SVZ and DG. In addition, depending on the duration of SMG periods, transcriptomic analysis revealed modifications in gene expression involved in neurogenesis. These findings highlight the sensitivity of adult neurogenesis to gravitational environmental factors during a transient period, suggesting that there is a period of adaptation of physiological systems to this new environment.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"69"},"PeriodicalIF":4.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0