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Chemistry of Natural Compounds最新文献

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Synthesis and Cytotoxicity Against M-HeLa, HuTu 80, and MCF-7 Human Cancer Cells of the First Nucleoterpenoids of the Isosteviol Diterpenoid Platform Isosteviol 二萜平台的首个核苷酸类化合物的合成及其对 M-HeLa、HuTu 80 和 MCF-7 人癌细胞的细胞毒性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-13 DOI: 10.1007/s10600-024-04520-2
O. V. Andreeva, M. G. Belenok, I. Yu. Strobykina, L. F. Saifina, A. P. Lyubina, A. S. Sapunova, A. D. Voloshina, B. F. Garifullin, V. E. Semenov, V. E. Kataev
{"title":"Synthesis and Cytotoxicity Against M-HeLa, HuTu 80, and MCF-7 Human Cancer Cells of the First Nucleoterpenoids of the Isosteviol Diterpenoid Platform","authors":"O. V. Andreeva,&nbsp;M. G. Belenok,&nbsp;I. Yu. Strobykina,&nbsp;L. F. Saifina,&nbsp;A. P. Lyubina,&nbsp;A. S. Sapunova,&nbsp;A. D. Voloshina,&nbsp;B. F. Garifullin,&nbsp;V. E. Semenov,&nbsp;V. E. Kataev","doi":"10.1007/s10600-024-04520-2","DOIUrl":"10.1007/s10600-024-04520-2","url":null,"abstract":"<p>Conjugates of the diterpenoid isosteviol with uracil and 6-methyluracil (nucleoterpenoids) were synthesized and showed moderate <i>in vitro</i> cytotoxicity (IC<sub>50</sub> values in the range 11.6–51.0 μM) against M-HeLa, HuTu 80, and MCF-7 human cancer cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1061 - 1065"},"PeriodicalIF":0.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and Purification of Protein from Ovis aries Placenta 从羱羊胎盘中分离和纯化蛋白质
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04532-y
A. L. Hu, A. Wali, X. M. Zhao, G. Turdu, Y. H. Gao, Z. Yang, R. Kelaimu, G. T. Mavlonov, A. A. Mamadrakhimov, H. A. Aisa, A. Yili
{"title":"Isolation and Purification of Protein from Ovis aries Placenta","authors":"A. L. Hu,&nbsp;A. Wali,&nbsp;X. M. Zhao,&nbsp;G. Turdu,&nbsp;Y. H. Gao,&nbsp;Z. Yang,&nbsp;R. Kelaimu,&nbsp;G. T. Mavlonov,&nbsp;A. A. Mamadrakhimov,&nbsp;H. A. Aisa,&nbsp;A. Yili","doi":"10.1007/s10600-024-04532-y","DOIUrl":"10.1007/s10600-024-04532-y","url":null,"abstract":"<p>The total protein extract of sheep placenta was fractionated by tandem anion-exchange chromatography over Toyopearl DEAE-650M and gel filtration over Toyopearl HW-55F. The obtained homogeneous protein exhibited antiproliferative activity in HeLa and HCT-116 cell culture (IC<sub>50</sub> 0.80 ± 0.27 and 1.73 ± 0.03 mg/mL, respectively). The amino-acid composition of the purified protein was determined. Tandem mass spectral sequencing and subsequent annotation using a database identified the purified protein as a calponin homolog.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1119 - 1122"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two New Aromatic Sesquiterpenes from Cigar Tobacco and Their Effects on the Aroma of Cigars 雪茄烟中的两种新芳香族倍半萜及其对雪茄香气的影响
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04517-x
Yu-Ping Wu, Hua-Yin Liu, Gui-Juan Zhao, Gui-Feng Li, Guang-Hai Zhang, Wei-Guang Wang, Guang-Hui Kong, Jin Wang, Qiu-Fen Hu
{"title":"Two New Aromatic Sesquiterpenes from Cigar Tobacco and Their Effects on the Aroma of Cigars","authors":"Yu-Ping Wu,&nbsp;Hua-Yin Liu,&nbsp;Gui-Juan Zhao,&nbsp;Gui-Feng Li,&nbsp;Guang-Hai Zhang,&nbsp;Wei-Guang Wang,&nbsp;Guang-Hui Kong,&nbsp;Jin Wang,&nbsp;Qiu-Fen Hu","doi":"10.1007/s10600-024-04517-x","DOIUrl":"10.1007/s10600-024-04517-x","url":null,"abstract":"<p>Two new aromatic sesquiterpenes, 2-(3-isopropyl-4,5-dimethoxybenzyl)-4-methylfuran (<b>1</b>) and (5-(3-isopropyl-4,5-dimethoxybenzyl)furan-3-yl)methanol (<b>2</b>) were isolated from the stems of cigar tobacco (a variety of <i>Nicotiana tabacum</i>). Their structures were determined by spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, compound <b>2</b> has a weak, sweet fragrance. They can enhance the sweet aroma style of cigar smoke and have potential value for use as an essence for cigar tobacco.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1046 - 1050"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloids of Lindelofia macrostyla and a New Unsaturated Carboxylic Acid 大叶女贞的生物碱和一种新的不饱和羧酸
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04525-x
R. M. Ruzibaeva, N. I. Mukarramov, A. R. Khurramov, R. Ya. Okmanov, Kh. M. Bobakulov, B. Tashkhodzhaev, N. D. Abdullaev
{"title":"Alkaloids of Lindelofia macrostyla and a New Unsaturated Carboxylic Acid","authors":"R. M. Ruzibaeva,&nbsp;N. I. Mukarramov,&nbsp;A. R. Khurramov,&nbsp;R. Ya. Okmanov,&nbsp;Kh. M. Bobakulov,&nbsp;B. Tashkhodzhaev,&nbsp;N. D. Abdullaev","doi":"10.1007/s10600-024-04525-x","DOIUrl":"10.1007/s10600-024-04525-x","url":null,"abstract":"<p>The new alkaloid lindelofamine N-oxide (1) and the known 1-exo-carboxypyrrolizidine (2) and the quaternary salt of the isoquinoline alkaloid <i>O</i>-methylarmepavine methyliodide (3) were isolated from <i>Lindelofia macrostyla</i> (Bunge) Popov for the first time. The structures were established by NMR spectroscopy, the absolute configuration was determined using X-ray diffraction analysis of the chiral centers of the last two as 1<i>R</i>,4<i>R</i>,8<i>S</i> and 1<i>S</i>, respectively. The new carboxylic acid (2<i>S</i>,3<i>R</i>)-2-hydroxy-2-isopropyl-3-{[(<i>E</i>)-2-methylbut-2-enoyl]oxy}butanoic acid, the structure and absolute configuration (2<i>S</i>,3<i>R</i>) of which were proven by NMR spectroscopy and an XSA, was also isolated.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1084 - 1090"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Components and Antibacterial Properties of Essential Oil from Zingiber densissimum 细辛精油的化学成分和抗菌特性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04552-8
Tan Viet Pham, Ngoc An Nguyen, Hanh Thi Dieu Nguyen, Phan Thi Doan Trang, Hong Thien Van, Kim Cong Vu, Quoc Hung Nguyen, Thanh Tho Le, Nga Nguyen-Phi
{"title":"Chemical Components and Antibacterial Properties of Essential Oil from Zingiber densissimum","authors":"Tan Viet Pham,&nbsp;Ngoc An Nguyen,&nbsp;Hanh Thi Dieu Nguyen,&nbsp;Phan Thi Doan Trang,&nbsp;Hong Thien Van,&nbsp;Kim Cong Vu,&nbsp;Quoc Hung Nguyen,&nbsp;Thanh Tho Le,&nbsp;Nga Nguyen-Phi","doi":"10.1007/s10600-024-04552-8","DOIUrl":"10.1007/s10600-024-04552-8","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1178 - 1180"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition, Antibacterial, Synergistic Antibacterial and Cytotoxic Activities of the Essential Oil of Dimetia hedyotidea 地肤子精油的化学成分、抗菌、协同抗菌和细胞毒活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04550-w
Xiran Chen, Chunlei Qu, Zijian Yuan, Qinglin Ma
{"title":"Chemical Composition, Antibacterial, Synergistic Antibacterial and Cytotoxic Activities of the Essential Oil of Dimetia hedyotidea","authors":"Xiran Chen,&nbsp;Chunlei Qu,&nbsp;Zijian Yuan,&nbsp;Qinglin Ma","doi":"10.1007/s10600-024-04550-w","DOIUrl":"10.1007/s10600-024-04550-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1172 - 1175"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential Oil Composition and Acetylcholinesterase Inhibitory Activity of Sindora coriacea 香叶精油成分和乙酰胆碱酯酶抑制活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04553-7
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh
{"title":"Essential Oil Composition and Acetylcholinesterase Inhibitory Activity of Sindora coriacea","authors":"Abubakar Siddiq Salihu,&nbsp;Wan Mohd Nuzul Hakimi Wan Salleh","doi":"10.1007/s10600-024-04553-7","DOIUrl":"10.1007/s10600-024-04553-7","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1181 - 1182"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition of the Essential Oil of Syzygium wrayi 茜草精油的化学成分
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-11 DOI: 10.1007/s10600-024-04544-8
Faezatul Alwani Mohd Rahim, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Mohd Hafiz Arrmi
{"title":"Chemical Composition of the Essential Oil of Syzygium wrayi","authors":"Faezatul Alwani Mohd Rahim,&nbsp;Wan Mohd Nuzul Hakimi Wan Salleh,&nbsp;Abubakar Siddiq Salihu,&nbsp;Mohd Hafiz Arrmi","doi":"10.1007/s10600-024-04544-8","DOIUrl":"10.1007/s10600-024-04544-8","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1155 - 1157"},"PeriodicalIF":0.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First Report on GC-MS Characterization of Volatile Constituents and In Vitro Antidiabetic Activity of the Fruits Part of Boerhavia rubicunda from the Himachal Pradesh Himalayas 关于喜马偕尔邦喜马拉雅山红楠木果实部分挥发性成分的气相色谱-质谱表征和体外抗糖尿病活性的首次报告
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-09 DOI: 10.1007/s10600-024-04546-6
Shivani Sharma, Shagun Sharma, Pratibha Sharma, Harcharan Singh Dhaliwal, Vivek Sharma
{"title":"First Report on GC-MS Characterization of Volatile Constituents and In Vitro Antidiabetic Activity of the Fruits Part of Boerhavia rubicunda from the Himachal Pradesh Himalayas","authors":"Shivani Sharma,&nbsp;Shagun Sharma,&nbsp;Pratibha Sharma,&nbsp;Harcharan Singh Dhaliwal,&nbsp;Vivek Sharma","doi":"10.1007/s10600-024-04546-6","DOIUrl":"10.1007/s10600-024-04546-6","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1160 - 1162"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New Carbamates of the Alkaloid Songorine and Their Effects on Cancer Cell Growth 合成松果菊碱的新型氨基甲酸酯及其对癌细胞生长的影响
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2024-11-09 DOI: 10.1007/s10600-024-04529-7
U. Kh. Kurbanov, N. I. Mukarramov, E. O. Terenteva, U. B. Khamidova, O. T. Juraev, Sh. S. Azimova
{"title":"Synthesis of New Carbamates of the Alkaloid Songorine and Their Effects on Cancer Cell Growth","authors":"U. Kh. Kurbanov,&nbsp;N. I. Mukarramov,&nbsp;E. O. Terenteva,&nbsp;U. B. Khamidova,&nbsp;O. T. Juraev,&nbsp;Sh. S. Azimova","doi":"10.1007/s10600-024-04529-7","DOIUrl":"10.1007/s10600-024-04529-7","url":null,"abstract":"<p>Six new derivatives were synthesized by reacting the alkaloid songorine (<b>1</b>) with isocyanates. Their structures were confirmed by IR, mass, <sup>1</sup>H and <sup>13</sup>C NMR spectral methods. The effects of the obtained compounds on tumor cell growth in vitro were studied. 21-Ethyl-1-O-3′-chlorophenylcarbamate-15-hydroxy-4-methyl-16-methylene-7,20-cycloveatchan-12-one (<b>3c</b>) exhibited cytotoxicity against HeLa and HEp-2 lines at a concentration of 100 μg/mL. The other songorine derivatives caused dose-dependent proliferation of cancer cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1102 - 1106"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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