Antibacterial Pyrroloquinolines from Cigar-Tobacco-Derived Endophytic Fungus Aspergillus puniceus

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-07-23 DOI:10.1007/s10600-025-04750-y

Guang-Hui Kong, Hua-Yin Liu, Guang-Hai Zhang, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Yu-Ping Wu, Ling-Duo Bu

{"title":"Antibacterial Pyrroloquinolines from Cigar-Tobacco-Derived Endophytic Fungus Aspergillus puniceus","authors":"Guang-Hui Kong, Hua-Yin Liu, Guang-Hai Zhang, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Yu-Ping Wu, Ling-Duo Bu","doi":"10.1007/s10600-025-04750-y","DOIUrl":null,"url":null,"abstract":"In this study, two new pyrroloisoquinolines, cigarpyrro A and B (1 and 2), together with five known pyrroloisoquinolines (3–7) were isolated from the cigar-tobacco-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds 1 and 2 used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"731 - 736"},"PeriodicalIF":0.9000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04750-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, two new pyrroloisoquinolines, cigarpyrro A and B (1 and 2), together with five known pyrroloisoquinolines (3–7) were isolated from the cigar-tobacco-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds 1 and 2 used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.

Abstract Image

查看原文本刊更多论文

雪茄烟草内生真菌曲霉的抗菌吡咯喹啉类

本研究从雪茄烟草内生真菌曲霉（Aspergillus puniceus）中分离到两种新的pyroloisoquinoline， cigarpyrro A和B(1和2)，以及5种已知的pyroloisoquinoline（3-7）。它们的结构是通过HR-ESI-MS和广泛的一维和二维核磁共振光谱研究确定的。化合物1和2对5种病原菌（金黄色葡萄球菌（SEA）、大肠杆菌（EPEC）、化脓性链球菌（GAS）、枯草芽孢杆菌（QST713）和变形杆菌）的抑菌活性进行了评价。有趣的是，化合物1和2对上述菌株的抑菌效果显著，抑菌直径在15.4±1.8 ~ 25.2±1.6 mm范围内，且大部分抑菌直径均高于阳性对照。此外，还对化合物1和2作为防腐剂的潜在价值进行了评价，认为它们具有作为卷烟纸防腐剂的潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.