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Metabolites from Mangrove Symbiotic Actinomycete Streptomyces sp. 06168H-1 红树林共生放线菌链霉菌sp. 06168H-1的代谢物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05049-2
Wen-Ru Chou, Sheng-Wei Shih, Ming-Jen Cheng, Hsia-Wei Liu, Jyh-Yih Leu, Ming-Der Wu, Chung-Yi Chen, Jih-Jung Chen, Nanthaphong Khamthong, Huei-Mei Chen
{"title":"Metabolites from Mangrove Symbiotic Actinomycete Streptomyces sp. 06168H-1","authors":"Wen-Ru Chou,&nbsp;Sheng-Wei Shih,&nbsp;Ming-Jen Cheng,&nbsp;Hsia-Wei Liu,&nbsp;Jyh-Yih Leu,&nbsp;Ming-Der Wu,&nbsp;Chung-Yi Chen,&nbsp;Jih-Jung Chen,&nbsp;Nanthaphong Khamthong,&nbsp;Huei-Mei Chen","doi":"10.1007/s10600-026-05049-2","DOIUrl":"10.1007/s10600-026-05049-2","url":null,"abstract":"<p>One previously undescribed benzenoid analogue, streptomycesisin (<b>1</b>), together with two known ones, 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (<b>2</b>), 5-hydroxy-2-hydroxymethyl-3-methyl-7-methoxychromone (<b>3</b>), were isolated from the EtOAc extracts of mangrove-derived actinobacteria Streptomyces sp. 06168H-1. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"705 - 708"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Anacardic Acid Derivative from the Leaves of Knema globularia 一种从球莲叶中提取的新的无心酸衍生物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05047-4
Hieu Tran-Trung, Cao Van Anh, Hieu Nguyen-Ngoc, Hoang Van Trung, Nguyen Thi Trang, Pham Chau Anh, Nguyen Thi Thanh Huyen, Duong Chi, Le Duc Giang
{"title":"A New Anacardic Acid Derivative from the Leaves of Knema globularia","authors":"Hieu Tran-Trung,&nbsp;Cao Van Anh,&nbsp;Hieu Nguyen-Ngoc,&nbsp;Hoang Van Trung,&nbsp;Nguyen Thi Trang,&nbsp;Pham Chau Anh,&nbsp;Nguyen Thi Thanh Huyen,&nbsp;Duong Chi,&nbsp;Le Duc Giang","doi":"10.1007/s10600-026-05047-4","DOIUrl":"10.1007/s10600-026-05047-4","url":null,"abstract":"<p>A previously unreported anacardic acid derivative, namely globularic acid A (<b>1</b>), along with three known compounds, including knepachycarpic acid B (<b>2</b>), (<i>Z</i>)-2-(heptadec-12-en-1-yl)-6-hydroxybenzoic acid (<b>3</b>), and knepachycarpic acid A (<b>4</b>), were isolated from <i>Knema globularia</i> leaves by using various column chromatographic techniques. Their structures were established on the basis of UV, 1D, and 2D NMR, and HR-ESI-MS spectral data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"697 - 699"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Pyran Derivative Trienylpyran a from Mangrove-Derived Fungus Penicillium sclerotiorum MLM1043 红树真菌菌核青霉MLM1043的新吡喃衍生物三烯基吡喃a
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05048-3
Shiji Chen, Jiayi Feng, Sirong Li, Ru Wang, Ziteng Jia, Yunwen Qin, Yan Li, Guo-Lei Huang, Cai-Juan Zheng
{"title":"New Pyran Derivative Trienylpyran a from Mangrove-Derived Fungus Penicillium sclerotiorum MLM1043","authors":"Shiji Chen,&nbsp;Jiayi Feng,&nbsp;Sirong Li,&nbsp;Ru Wang,&nbsp;Ziteng Jia,&nbsp;Yunwen Qin,&nbsp;Yan Li,&nbsp;Guo-Lei Huang,&nbsp;Cai-Juan Zheng","doi":"10.1007/s10600-026-05048-3","DOIUrl":"10.1007/s10600-026-05048-3","url":null,"abstract":"<p>A new pyran derivative, trienylpyran A (<b>1</b>), along with four known compounds – ergosterol (<b>2</b>), cerevisterol (<b>3</b>), (22E)-5<i>α</i>,8<i>α</i>-epidioxyergosta-6,22-dien-3<i>β</i>-ol (<b>4</b>), alternariol (<b>5</b>) – were isolated from the mangrove-derived fungus <i>Penicillium sclerotiorum</i> MLM1043. The plane structure and absolute configuration of <b>1</b> was identified by comprehensive 1D, 2D NMR, HR-ESI-MS spectral data, combined with time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculations. Compounds <b>4</b> and <b>5</b> showed weak antibacterial activity against <i>Bacillus cereus</i>, with the same MIC value of 62.5 μg/mL.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"700 - 704"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Coumarins from the Family Apiaceae. IV. Khellactone and Vaginidiol Esters from Libanotis pyrenaica 标题蜂科新香豆素。四、产自牛油果的牛油果内酯和阴道二醇酯
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05039-4
D. N. Olennikov
{"title":"New Coumarins from the Family Apiaceae. IV. Khellactone and Vaginidiol Esters from Libanotis pyrenaica","authors":"D. N. Olennikov","doi":"10.1007/s10600-026-05039-4","DOIUrl":"10.1007/s10600-026-05039-4","url":null,"abstract":"<p>The Et<sub>2</sub>O extract from roots of <i>Libanotis pyrenaica</i> subsp. <i>pyrenaica</i> [<i>Seseli libanotis</i> (L.) W. D. J. Koch] growing in Baikal District contained khellactone and vaginidiol esters, including for the first time from the species hyuganins C and D, isopteryxin, phlojosibirin IV, d-laserpitin, edulisin II, archangelicin, and the new compound <b>1</b>. The structure of <b>1</b> was determined as 3′-<i>O</i>-angeloyl-4′-<i>O</i>-senecioyl-cis-vaginidiol (libanotiside I) using UV and NMR spectroscopy and mass spectrometry.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"664 - 667"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Dioscorea cirrhosa 薯蓣肝硬化的次生代谢物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05040-x
W. R. Chou, M. J. Cheng, S. T. Huang, H. M. Wu, W. J. Li, H. T. Li, C. Y. Chen
{"title":"Secondary Metabolites of Dioscorea cirrhosa","authors":"W. R. Chou,&nbsp;M. J. Cheng,&nbsp;S. T. Huang,&nbsp;H. M. Wu,&nbsp;W. J. Li,&nbsp;H. T. Li,&nbsp;C. Y. Chen","doi":"10.1007/s10600-026-05040-x","DOIUrl":"10.1007/s10600-026-05040-x","url":null,"abstract":"<p>A new flavonoid, 5,8-dihydroxy-2′-(2″,3″-epoxypropoxy)-7,3′,5′-trimethoxyflavone (<b>1</b>), along with 11 known flavonoids (<b>2–12</b>) were isolated from the rhizomes of <i>Dioscorea cirrhosa</i> Lour. (Dioscoreaceae). The structure of the new flavonoid was elucidated by physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"668 - 671"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convenient Approach to the Synthesis of Glycidyl Ethers and Halohydrins Containing Aliphatic and Cyclic Terpene Fragments 含有脂肪族和环萜烯片段的缩水甘油醚和卤代醇的便捷合成方法
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05051-8
E. A. Titov, A. V. Nemtarev, V. F. Mironov
{"title":"Convenient Approach to the Synthesis of Glycidyl Ethers and Halohydrins Containing Aliphatic and Cyclic Terpene Fragments","authors":"E. A. Titov,&nbsp;A. V. Nemtarev,&nbsp;V. F. Mironov","doi":"10.1007/s10600-026-05051-8","DOIUrl":"10.1007/s10600-026-05051-8","url":null,"abstract":"<p>A preparative method for producing γ-terpenyl ethers of glycerin α-halohydrin and terpenyl glycidyl ethers of interest for targeted design of physiologically active compounds was described. The proposed method was based on two sequential reactions, i.e., opening of an epichlorohydrin oxirane ring by a terpene alcohol in the presence of a catalyst and dehydrohalogenation of the halohydrin under basic conditions. The proposed optimized method featured mild conditions that allowed it to be recommended for functionalization of natural compounds. The method was tested with hemi-, mono-, sesqui-, and diterpene alcohols.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"714 - 723"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Dimeric Eudesmanoid with a Rare Cyclobutane Ring from Chloranthus multistachys 一种新的含稀有环丁烷环的二聚体菊酯类化合物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-08 DOI: 10.1007/s10600-026-05052-7
Xia Liu, Jia-Lin Guo, Jin Li, Yi-Han Sun, Yun-Zhe Li, Xin Gao, Hui Zhang
{"title":"A Novel Dimeric Eudesmanoid with a Rare Cyclobutane Ring from Chloranthus multistachys","authors":"Xia Liu,&nbsp;Jia-Lin Guo,&nbsp;Jin Li,&nbsp;Yi-Han Sun,&nbsp;Yun-Zhe Li,&nbsp;Xin Gao,&nbsp;Hui Zhang","doi":"10.1007/s10600-026-05052-7","DOIUrl":"10.1007/s10600-026-05052-7","url":null,"abstract":"<p>A novel dimeric eudesmanoid possessing a rare cyclobutane ring from <i>Chloranthus multistachys</i>, named bimultistanolide C (<b>1</b>), is a sesquiterpene dimer, which is two monomers linked together through a cyclobutane ring, possibly generated through [2+2] cycloaddition. The structure of the new compound was characterized by means of spectroscopic methods including 1D, 2D NMR, and HR-ESI-MS.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"724 - 726"},"PeriodicalIF":1.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Biphenyl Derivative from a Mangrove Endophytic Fungus Alternaria malorum FL39 红树林内生真菌褐变菌FL39的联苯新衍生物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-07 DOI: 10.1007/s10600-026-05035-8
Jinhui He, Liyi Zhang, Jiajinyu Gong, Shiheng Pan, Shenghang Zou, Wei Fan, Chunyuan Li, Yahong Xiong
{"title":"A New Biphenyl Derivative from a Mangrove Endophytic Fungus Alternaria malorum FL39","authors":"Jinhui He,&nbsp;Liyi Zhang,&nbsp;Jiajinyu Gong,&nbsp;Shiheng Pan,&nbsp;Shenghang Zou,&nbsp;Wei Fan,&nbsp;Chunyuan Li,&nbsp;Yahong Xiong","doi":"10.1007/s10600-026-05035-8","DOIUrl":"10.1007/s10600-026-05035-8","url":null,"abstract":"<p>A new biphenyl derivative, 3′,4,5,5′-tetramethoxy-2-methyl-1,1′-biphenyl (<b>1</b>), along with the known 3′-hydroxyalternariol-5-<i>O</i>-methyl ether (<b>2</b>), 5′-methoxy-6-methylbiphenyl-2,3′,4-triol (<b>3</b>), and porric acid D (<b>4</b>) were isolated from the mangrove endophytic fungus <i>Alternaria malorum</i> FL39. The structure of compound <b>1</b> was deduced by analysis of comprehensive spectra. Compounds <b>1</b> and <b>4</b> exhibited moderate antifungal activities against <i>Colletotrichum gloeosporioides</i>. Additionally, compound <b>1</b> showed weak antifungal activity against <i>Colletotrichum musae</i>, whereas compounds <b>1–3</b> showed weak antibacterial activity against <i>Escherichia coli</i> (serotypes O6).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"645 - 647"},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipids from Flower Petals of Crocus sativus and Their Pharmacological Activity 番红花花瓣脂质及其药理活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-08-07 DOI: 10.1007/s10600-026-05036-7
Sh. R. Makhmudova, N. K. Yuldasheva, S. D. Gusakova, S. Z. Nishanbaev, M. S. Soatova, D. A. Narbutaeva
{"title":"Lipids from Flower Petals of Crocus sativus and Their Pharmacological Activity","authors":"Sh. R. Makhmudova,&nbsp;N. K. Yuldasheva,&nbsp;S. D. Gusakova,&nbsp;S. Z. Nishanbaev,&nbsp;M. S. Soatova,&nbsp;D. A. Narbutaeva","doi":"10.1007/s10600-026-05036-7","DOIUrl":"10.1007/s10600-026-05036-7","url":null,"abstract":"<p>Lipids from flower petals of <i>Crocus sativus</i> L. (Iridaceae) growing in Uzbekistan were studied for the first time. The lipid content, group compositions, and classes and their fatty acid (FA) compositions were established. The content of neutral lipids (NL) in the petals was 2.23% (of raw-material mass); of polar lipids (PL), 1.97%. FAs of lipids included 16–21 components with NL dominated by FAs <i>α</i>-linoleic (18:2n6, 41.85%) and <i>α</i>-linolenic (<i>α</i>-18:3n3, 10.46%); PL, palmitic (16:0, 52.87–59.90%). The composition and content of lipophilic substances (LS) and the wound-healing activity of NL were determined.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"648 - 651"},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Acetophenone and Antiproliferative Constituents from the Roots of Melicope pteleifolia 一种新的苯乙酮及其抗增殖活性成分的研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-25 DOI: 10.1007/s10600-026-04990-6
Xin-Rui Liao, Feng Wu, Yan-Chao Yang, Gao-Rong Zhang, Wen-Zhe Ma, Lai-You Wang, Wen-Jian Lan
{"title":"A New Acetophenone and Antiproliferative Constituents from the Roots of Melicope pteleifolia","authors":"Xin-Rui Liao,&nbsp;Feng Wu,&nbsp;Yan-Chao Yang,&nbsp;Gao-Rong Zhang,&nbsp;Wen-Zhe Ma,&nbsp;Lai-You Wang,&nbsp;Wen-Jian Lan","doi":"10.1007/s10600-026-04990-6","DOIUrl":"10.1007/s10600-026-04990-6","url":null,"abstract":"<p>A new acetophenone (<b>1</b>) and 14 known compounds (<b>2–15</b>) were isolated from the roots of <i>Melicope pteleifolia</i>. Their structures were elucidated by means of comprehensive spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, as well as though comparison with published data. All isolated compounds were assessed for their in vitro cytotoxicity against human cancer cell lines using the SRB method. Among them, compound <b>13</b>, one of the flavonoids, exhibited the strongest cytotoxic activity, with an IC<sub>50</sub> value of 14.79 μM. Further investigation revealed that compound <b>13</b> could induce HCT116 cell apoptosis by suppressing the cleavage of Cleaved Caspase-3 and Cleaved PARP.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"483 - 488"},"PeriodicalIF":1.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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