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Secondary Metabolites of Kalanchoe beharensis 白桦尺蠖的次生代谢物
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04725-z
K. E. Chang, S. T. Huang, W. J. Li, M. J. Cheng, H. T. Li, C. Y. Chen
{"title":"Secondary Metabolites of Kalanchoe beharensis","authors":"K. E. Chang,&nbsp;S. T. Huang,&nbsp;W. J. Li,&nbsp;M. J. Cheng,&nbsp;H. T. Li,&nbsp;C. Y. Chen","doi":"10.1007/s10600-025-04725-z","DOIUrl":"10.1007/s10600-025-04725-z","url":null,"abstract":"<p>A new chromone, 2,3-dihydroxy-5,6,7,8-tetramethylchromone (<b>1</b>), along with 13 known compounds, including <i>o</i>-hydroxybenzoic acid (<b>2</b>), <i>p</i>-hydroxybenzoic acid (<b>3</b>), <i>p</i>-hydroxybenzaldehyde (<b>4</b>), vanillin (<b>5</b>), isovanillin (<b>6</b>), vanillic acid (<b>7</b>), ferulic acid (<b>8</b>), isoferulic acid (<b>9</b>), methyl ferulate (<b>10</b>), protocatechuic acid (<b>11</b>), eugenitol (<b>12</b>), isoeugenitol (<b>13</b>), and 8-methyleugenitol (<b>14</b>), were isolated from the leaves of <i>Kalanchoe beharensis</i> (Crassulaceae). The structure of the new chromone derivative was elucidated by chemical and physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"636 - 638"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Megastigmane Glycosides with α-Glucosidase Inhibitory Activity from Viburnum urceolatum Fruits 具有α-葡萄糖苷酶抑制活性的巨地甲苷类
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04734-y
Zi-Han Wang, Hong-Juan Zhou, Meng-Ya Yang, Jian-Hua Shao, Chun-Chao Zhao
{"title":"Megastigmane Glycosides with α-Glucosidase Inhibitory Activity from Viburnum urceolatum Fruits","authors":"Zi-Han Wang,&nbsp;Hong-Juan Zhou,&nbsp;Meng-Ya Yang,&nbsp;Jian-Hua Shao,&nbsp;Chun-Chao Zhao","doi":"10.1007/s10600-025-04734-y","DOIUrl":"10.1007/s10600-025-04734-y","url":null,"abstract":"<p>A new megastigmane glycoside (<b>1</b>), viburcoside A, and four known analogs (<b>2–5</b>) were isolated from the methanol extract of Viburnum urceolatum fruits. The structure, including the absolute configuration of compound <b>1</b>, was elucidated by extensive spectroscopic analysis (NMR and HR-ESI-MS), DP4+ NMR and ECD calculations, and enzyme hydrolysis. In the in vitro assay, viburcoside A (<b>1</b>) exhibited the potential inhibition of α-glucosidase with the IC<sub>50</sub> value of 16.03 μM, compared with the positive control acarbose (IC<sub>50</sub> = 18.84 μM).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"673 - 675"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Characteristics and Antioxidant Activity of Two Novel Water-Soluble Polysaccharides from Acanthopanax leucorrhizus 两种新型白沙五加水溶性多糖的结构特征及抗氧化活性研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04727-x
H. B. Hu, Z. Y. Cheng, M. H. Han, H. P. Liang, Y. Wu, H. S. Hu, L. L. Zhang
{"title":"Structural Characteristics and Antioxidant Activity of Two Novel Water-Soluble Polysaccharides from Acanthopanax leucorrhizus","authors":"H. B. Hu,&nbsp;Z. Y. Cheng,&nbsp;M. H. Han,&nbsp;H. P. Liang,&nbsp;Y. Wu,&nbsp;H. S. Hu,&nbsp;L. L. Zhang","doi":"10.1007/s10600-025-04727-x","DOIUrl":"10.1007/s10600-025-04727-x","url":null,"abstract":"<p>Two novel water-soluble polysaccharides (ALPS-21 and ALPS-32) were isolated and purified from <i>Acanthopanax leucorrhizus</i>. Their structures were investigated by HPGPC, HPLC, IR, methylation and NMR, and the antioxidant activity was evaluated <i>in vitro</i> by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH<sup><b>·</b></sup>), hydroxyl radical (HO<sup><b>·</b></sup>), and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS<sup><b>·</b>+</sup>) assay. Results showed that ALPS-21 was a 4.36 kDa neutral heteropolysaccharide composed of glucose, galactose, mannose, xylose in a ratio of 3.5:1.3:0.9:2.1, whereas ALPS-32 was a 5.78 kDa acidic heteropolysaccharide composed of glucose, galactose, mannose, and glucopyranuronic acid in a ratio of 4.5:1.3:1.1:1.0. Moreover, ALPS-21 and ALPS-32 can scavenge DPPH<sup><b>·</b></sup>, HO<sup><b>·</b></sup>, and ABTS<sup><b>·</b>+</sup> in a dose-dependent manner, suggesting that ALPS-21 and ALPS-32 may be promising as a potential natural antioxidant.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"621 - 625"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Cordyceps militaris 蛹虫草的次生代谢物
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04751-x
Ying-Jung Tseng, Su-Ting Huang, Ming-Jen Cheng, Chung-Yi Chen
{"title":"Secondary Metabolites of Cordyceps militaris","authors":"Ying-Jung Tseng,&nbsp;Su-Ting Huang,&nbsp;Ming-Jen Cheng,&nbsp;Chung-Yi Chen","doi":"10.1007/s10600-025-04751-x","DOIUrl":"10.1007/s10600-025-04751-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"758 - 760"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents from the Seeds of Quinoa Varieties 藜麦品种种子的化学成分
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04749-5
Suleyman Temel, Kagan Kokten, Bilal Keskin, Celile Aylin Oluk
{"title":"Chemical Constituents from the Seeds of Quinoa Varieties","authors":"Suleyman Temel,&nbsp;Kagan Kokten,&nbsp;Bilal Keskin,&nbsp;Celile Aylin Oluk","doi":"10.1007/s10600-025-04749-5","DOIUrl":"10.1007/s10600-025-04749-5","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"755 - 757"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic Iridoid Glycosides from the Aerial Parts of Paederia foetida 黄连地上部的细胞毒性环烯醚萜苷
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04735-x
Jiang Hu, Guihua Yu, Fengming Xu, Tao Lv, Qiang Li, Feng Gao
{"title":"Cytotoxic Iridoid Glycosides from the Aerial Parts of Paederia foetida","authors":"Jiang Hu,&nbsp;Guihua Yu,&nbsp;Fengming Xu,&nbsp;Tao Lv,&nbsp;Qiang Li,&nbsp;Feng Gao","doi":"10.1007/s10600-025-04735-x","DOIUrl":"10.1007/s10600-025-04735-x","url":null,"abstract":"<p>Two previously undescribed iridoid glycosides, 6′-<i>O</i>-trans-caffeoyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-3<i>α</i>- methylthioasperulosid (<b>1</b>) and 6′-<i>O</i>-trans-feruloyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-2′-<i>O</i>-3<i>α</i>-paederosid (<b>2</b>), were isolated from the 90% EtOH extract of the aerial part of <i>Paederia foetida</i> L. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H–<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that <b>2</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM and provided a scientific basis for further processing and utilization of <i>P. foetida</i>.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"676 - 680"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-Inflammatory Agents 异aurone衍生物抗炎药物的合成及生物学评价
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04728-w
Fei Yu, Zhe Liu, Yuan Song, Jinfeng Zhang, Yongsheng Bi, Dianzhuo Jiang
{"title":"Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-Inflammatory Agents","authors":"Fei Yu,&nbsp;Zhe Liu,&nbsp;Yuan Song,&nbsp;Jinfeng Zhang,&nbsp;Yongsheng Bi,&nbsp;Dianzhuo Jiang","doi":"10.1007/s10600-025-04728-w","DOIUrl":"10.1007/s10600-025-04728-w","url":null,"abstract":"<p>A novel class of isoaurone analogs was designed, synthesized, and investigated <i>in vivo</i> for their anti-inammatory activity using a xylene-induced ear edema model. Isoaurones <b>8a–e</b> exhibited anti-inflammatory activity at a dose of 100 mg/kg with inhibition rates ranging from 21.75% to 34.46%. 3-(4-(3-((5-(3-Chlorophenyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)propoxy)benzylidene)-6-methoxybenzofuran-2(3<i>H</i>)-one (<b>8e</b>) showed the most potent growth inhibitory effects (34.46%), indicated by the slightly higher inhibitory effects of celecoxib (31.92%).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"643 - 647"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Characteristics of Fucoidans from Brown Algae of the Genera Arthrothamnus and Cymathaere and their Metabolically Oriented Action on Colony Formation of SK-MEL-5 Melanoma Cells 节瘤属和Cymathaere褐藻岩藻蛋白的结构特征及其对SK-MEL-5黑色素瘤细胞集落形成的代谢导向作用
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04723-1
N. M. Shevchenko, V. V. Surits, R. V. Usoltseva, A. S. Silchenko, A. O. Zueva, R. A. Shkrabov, O. S. Malyarenko, S. P. Ermakova
{"title":"Structural Characteristics of Fucoidans from Brown Algae of the Genera Arthrothamnus and Cymathaere and their Metabolically Oriented Action on Colony Formation of SK-MEL-5 Melanoma Cells","authors":"N. M. Shevchenko,&nbsp;V. V. Surits,&nbsp;R. V. Usoltseva,&nbsp;A. S. Silchenko,&nbsp;A. O. Zueva,&nbsp;R. A. Shkrabov,&nbsp;O. S. Malyarenko,&nbsp;S. P. Ermakova","doi":"10.1007/s10600-025-04723-1","DOIUrl":"10.1007/s10600-025-04723-1","url":null,"abstract":"<p>The compositions of nine fucoidan fractions from five species of brown alga, i.e., AbF from <i>Arthrothamnus bifidus</i>, AkF1 and AkF2 from <i>A. kurilensis</i>, CfF1 and CfF2 from <i>Cymathaere fibrosa</i>, CjF1 and CjF2 from <i>C. japonica</i>, and CtF1 and CtF2 from <i>C. triplicata</i> were studied. The main chains of AbF, AkF2, CfF2, CjF2, and CtF2 were constructed from 1,3-bound <i>α</i>-L-fucose. The studied polysaccharides were nontoxic at concentrations up to 400 μg/mL and exhibited weak inhibitory activity and pronounced inhibitory activity in combination with 2-deoxy-D-glucose on colony formation of SK-MEL-5 melanoma cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"626 - 631"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Dihydrofurochromones from Saposhnikovia divaricata 新二氢呋喃胺类化合物的研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI: 10.1007/s10600-025-04726-y
D. N. Olennikov, T. M. Shishmareva, V. M. Shishmarev
{"title":"New Dihydrofurochromones from Saposhnikovia divaricata","authors":"D. N. Olennikov,&nbsp;T. M. Shishmareva,&nbsp;V. M. Shishmarev","doi":"10.1007/s10600-025-04726-y","DOIUrl":"10.1007/s10600-025-04726-y","url":null,"abstract":"<p>The herb of <i>Saposhnikovia divaricata</i> (Turcz.) Schischk. (Apiaceae) growing in Baikal District contained 15 compounds, among which were known dihydrofurochromones (<b>3</b>–<b>6</b>), flavonol <i>O</i>-glycosides (<b>7</b>–<b>12</b>), caffeoylquinic acids (<b>13</b>–<b>15</b>), and new chromones <b>1</b> and <b>2</b>. The new compounds were cimifugin 4′-O-(6′′-O-<i>β</i>-D-apiofuranosyl)-<i>β</i>-D-glucopyranoside (divarichromone A, <b>1</b>) and cimifugin 4′-O-(6′′-O-malonyl)-<i>β</i>-D-glucopyranoside (divarichromone B, <b>2</b>) according to UV, NMR, and mass spectral data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"639 - 642"},"PeriodicalIF":0.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites from Zingiber zerumbet with Antioxidant Activity 生姜代谢产物的抗氧化活性研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-05-21 DOI: 10.1007/s10600-025-04688-1
C. Y. Chen, C. L. Kao, H. T. Li, S. T. Huang, W. J. Li
{"title":"Metabolites from Zingiber zerumbet with Antioxidant Activity","authors":"C. Y. Chen,&nbsp;C. L. Kao,&nbsp;H. T. Li,&nbsp;S. T. Huang,&nbsp;W. J. Li","doi":"10.1007/s10600-025-04688-1","DOIUrl":"10.1007/s10600-025-04688-1","url":null,"abstract":"<p>A new pyridine, 4-(1′-hydroxy-2′-methylpropyl)pyridine-2-carboxylic acid (<b>16</b>), along with fifteen known compounds including α-humulene (<b>1</b>), zerumbone (<b>2</b>), zerumbone epoxide (<b>3</b>), <i>β</i>-sitosterone (<b>4</b>), <i>β</i>-sitosterol (<b>5</b>), kaempferol-3-O-(3′′,4′′-O-diacetyl)rhamnoside (<b>6</b>), kaempferol-3-O-(4′′-O-acetyl)rhamnoside, kaempferol-3,4′-O-dimethylether (<b>8</b>), ferulic acid (<b>9</b>), vanillic acid (<b>10</b>), methyl indole-3-carboxylate (<b>11</b>), indole-3-carbaldehyde (<b>12</b>), indole-3-carboxylic acid (<b>13</b>), pyridine-2-carboxylic acid (picolinic acid) (<b>14</b>), and 3-methylpyridine-2-carboxylic acid (3-methylpicolinic acid) (<b>15</b>) were isolated from the rhizomes of <i>Zingiber zerumbet</i> (L.) Sm. (Zingiberaceae). The structure of the new pyridine was elucidated by physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 3","pages":"511 - 515"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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