Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-Inflammatory Agents

Abstract

A novel class of isoaurone analogs was designed, synthesized, and investigated in vivo for their anti-inammatory activity using a xylene-induced ear edema model. Isoaurones 8a–e exhibited anti-inflammatory activity at a dose of 100 mg/kg with inhibition rates ranging from 21.75% to 34.46%. 3-(4-(3-((5-(3-Chlorophenyl)-4H-1,2,4-triazol-3-yl)thio)propoxy)benzylidene)-6-methoxybenzofuran-2(3H)-one (8e) showed the most potent growth inhibitory effects (34.46%), indicated by the slightly higher inhibitory effects of celecoxib (31.92%).