Xiao-Yan Duan, Dong-Bao Hu, Hataichanok Pandith, Terd Disayathanoowat, Xue Bai, Jun Yang, Ji-Feng Luo, Angkhana Inta, Yue-Hu Wang
{"title":"Chemical Constituents and Antimicrobial Properties of the Nonresinous Heartwood of Aquilaria sinensis","authors":"Xiao-Yan Duan, Dong-Bao Hu, Hataichanok Pandith, Terd Disayathanoowat, Xue Bai, Jun Yang, Ji-Feng Luo, Angkhana Inta, Yue-Hu Wang","doi":"10.1007/s10600-025-04571-z","DOIUrl":"10.1007/s10600-025-04571-z","url":null,"abstract":"<p>Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (<i>R</i>)-2-(1-hydroxy-2- phenylethyl)chromone (<b>1</b>), and one new resorcylic acid lactone, (<i>S</i>)-de-O-methylhispidulactone A (<b>2</b>), were isolated from the nonresinous heartwood of <i>Aqualaria sinensis</i> (Lour.) Spreng. Among these compounds, (<i>S</i>)-de-<i>O</i>-methylhispidulactone A (<b>2</b>), 2-(2-phenylethyl)chromone (<b>4</b>), 2-[2-(4-hydroxyphenyl)ethyl]chromone (<b>7</b>), 6-methoxy-2-(2-phenylethyl)chromone (<b>8</b>), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (<b>9</b>), 2-[2-(3-methoxyphenyl)ethyl]chromone (<b>10</b>), 6,7-dimethoxy-2-(2-phenylethyl)chromone (<b>11</b>), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (<b>13</b>), (+)-(<i>R</i>)-de-<i>O</i>-methyllasiodiplodin (<b>14</b>), lasiodiplodin (<b>15</b>), and (3<i>R</i>)-(–)-melliein (<b>20</b>) exhibited antifungal activity against <i>Epidermophyton floccosum</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum gypseum</i>, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (<i>R</i>)-2-(2-hydroxy-2-phenylethyl)chromone (<b>3b</b>), <b>7</b>, <b>8</b>, <b>9</b>, <b>14, 15</b>, 5-hydroxy-7,3′,4′- trimethoxyflavone (<b>17</b>), and velutin (<b>18</b>) demonstrated antibacterial effects against <i>Staphylococcus aureus</i>, with MIC values ranging from 20.2 to 96.0 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"42 - 51"},"PeriodicalIF":0.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Y. Chen, M. J. Cheng, C. M. Liu, S. T. Huang, W. J. Li, H. T. Li
{"title":"Lignans of Cinnamomum tenuifolium and Coix lachrymal-jobi","authors":"C. Y. Chen, M. J. Cheng, C. M. Liu, S. T. Huang, W. J. Li, H. T. Li","doi":"10.1007/s10600-025-04567-9","DOIUrl":"10.1007/s10600-025-04567-9","url":null,"abstract":"<p>Two new lignans, named (7′<i>R</i>)-7′-hydroxy-5′-methoxylariciresinol (<b>1</b>) and (7′<i>S</i>)-7′-hydroxy-5′- methoxylariciresinol (<b>2</b>) were isolated from the stems of <i>Cinnamomum tenuifolium</i> (<i>Lauraceae</i>) and the roots of Coix lacryma-jobi L., along with five known compounds, (+)-syringaresinol (<b>3</b>), (+)-medioresinol (<b>4</b>), (+)-pinoresinol (<b>5</b>), (+)-lariciresinol (<b>6</b>), and (+)-5,5′-dimethoxylariciresinol (<b>7</b>). The structure of the new lignan was elucidated by spectroscopic and physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"22 - 26"},"PeriodicalIF":0.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. M. Tsyrlina, T. M. Gabbasov, A. N. Lobov, M. S. Yunusov
{"title":"Adamantyl-Containing Derivatives of Lappaconitine","authors":"E. M. Tsyrlina, T. M. Gabbasov, A. N. Lobov, M. S. Yunusov","doi":"10.1007/s10600-025-04587-5","DOIUrl":"10.1007/s10600-025-04587-5","url":null,"abstract":"<p>Adamantyl-containing derivatives of lappaconitine were prepared via reactions of <i>N</i>-20-norlappaconitine, <i>N</i>-deacetyllappaconitine, and their derivatives with 1-adamantylisocyanate and 1-adamantylisothiocyanate.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"119 - 126"},"PeriodicalIF":0.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinqian Yu, Xiao Wang, E. Kh. Botirov, Hongjing Dong, S. D. Gusakova, Wei Liu
{"title":"Chemical Constituents from Achyranthes bidentata and Their Antihyperuricemic Acid Activities","authors":"Jinqian Yu, Xiao Wang, E. Kh. Botirov, Hongjing Dong, S. D. Gusakova, Wei Liu","doi":"10.1007/s10600-025-04572-y","DOIUrl":"10.1007/s10600-025-04572-y","url":null,"abstract":"<p>One new coumaronochromone named 5,7,2′-trihydroxy-6-methoxycoumaronochromone (<b>1</b>), and six known compounds named benzyl-<i>O</i>-<i>α</i>-L-rhamnopyranosyl-(1→6)-<i>β</i>-D-glucopyranoside (<b>2</b>), chikusetsusaponin V (<b>3</b>), crotonine (<b>4</b>), ayamenin A (<b>5</b>), achyranthoside A (<b>6</b>), 5-hydroxypyridine-2-carboxylic acid methyl ester (<b>7</b>), were obtained from <i>Achyranthes bidentata</i>. The antihyperuricemic acid activities of these isolated compounds (<b>1–7</b>) were assayed by an HK-2 cell model induced by adenosine combined with xanthine oxidase. The contents of uric acid produced by the HK-2 cell model were determined by HPLC analysis. As the results show, compound <b>3</b> was the most effective and was almost in line with the positive drug of febuxostat, whereas compounds <b>1</b>, <b>4</b>, <b>5</b>, and <b>6</b> showed moderate antihyperuricemic acid activities at a concentration of 50.0 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"52 - 55"},"PeriodicalIF":0.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Y. Chen, M. J. Cheng, C. M. Liu, W. J. Li, H. T. Li
{"title":"A New Furan of Synsepalum dulcificum","authors":"C. Y. Chen, M. J. Cheng, C. M. Liu, W. J. Li, H. T. Li","doi":"10.1007/s10600-025-04580-y","DOIUrl":"10.1007/s10600-025-04580-y","url":null,"abstract":"<p>A new 2,3-dihydrofuran, synsedulcifuran (<b>1</b>) was isolated from the fruits of <i>Synsepalum dulcificum</i> (Schumach. & Thonn.) Daniell (Sapotaceae). The structure of the new 2,3-dihydrofuran was elucidated by chemical and physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"83 - 85"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemical Composition of Artemisia vachanica Growing in Tajikistan","authors":"P. Sukhrobov, J. Li, S. Numonov, H. A. Aisa","doi":"10.1007/s10600-025-04600-x","DOIUrl":"10.1007/s10600-025-04600-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"169 - 171"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. B. A. Soares, A. M. S. Almeida, M. M. Moraes, C. A. G. Camara, J. Evencio-Neto
{"title":"Chemical Composition and Antioxidant Activity of Essential Oil from Maytenus rigida","authors":"E. B. A. Soares, A. M. S. Almeida, M. M. Moraes, C. A. G. Camara, J. Evencio-Neto","doi":"10.1007/s10600-025-04601-w","DOIUrl":"10.1007/s10600-025-04601-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"172 - 174"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Acetylated Flavone O-Sophorosides from Carduus nutans ssp. leiophyllus","authors":"D. N. Olennikov","doi":"10.1007/s10600-025-04574-w","DOIUrl":"10.1007/s10600-025-04574-w","url":null,"abstract":"<p>Apigenin 7-<i>O</i>-sophoroside, chrysoeriol 7-<i>O</i>-sophoroside, and four new flavonoids <b>1–4</b> were observed in leaves of <i>Carduus nutans</i> ssp. <i>leiophyllus</i> (Petrovic) Stoj. & Stef. (syn. <i>C. thoermeri</i> Weinm.). The structures of the new compounds were determined using UV and NMR spectroscopy and mass spectrometry as luteolin 7-<i>O</i>-[2′′-<i>O</i>-(4′′′-<i>O</i>-acetyl)-<i>β</i>-D-glucopyranosyl]-<i>β</i>-D-glucopyranoside (carduleioside A, <b>1</b>), chrysoeriol 7-<i>O</i>-[2′′-<i>O</i>-(4′′′-<i>O</i>-acetyl)-<i>β</i>-D-glucopyranosyl]-<i>β</i>-D-glucopyranoside (carduleioside B, <b>2</b>), apigenin 7-<i>O</i>-[2′′-<i>O</i>-(2′′′-<i>O</i>-acetyl)-<i>β</i>-D-glucopyranosyl]-<i>β</i>-D-glucopyranoside (carduleioside C, <b>3</b>), and apigenin 7-<i>O</i>-[2′′-<i>O</i>-(6′′′-<i>O</i>-acetyl)-<i>β</i>-D-glucopyranosyl]-<i>β</i>-D-glucopyranoside (carduleioside D, <b>4</b>). Compounds <b>1</b> and <b>2</b> inhibited the activity of monoamine oxidases A and B.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"59 - 62"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Y. Chen, C. M. Liu, M. J. Cheng, H. C. Yeh, W. J. Li, H. T. Li
{"title":"Secondary Metabolites of Ficus religiosa","authors":"C. Y. Chen, C. M. Liu, M. J. Cheng, H. C. Yeh, W. J. Li, H. T. Li","doi":"10.1007/s10600-025-04576-8","DOIUrl":"10.1007/s10600-025-04576-8","url":null,"abstract":"<p>One previously undescribed flavone analogue, 5,4′-dihydroxy-7,6-(2′′,3′′-furano)flavone (<b>14</b>), together with 13 known ones, were isolated from the unripe fruits of <i>Ficus religiosa</i> L. (Moraceae). The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with data from the literature.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"68 - 71"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}