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A New Acetophenone and Antiproliferative Constituents from the Roots of Melicope pteleifolia 一种新的苯乙酮及其抗增殖活性成分的研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-25 DOI: 10.1007/s10600-026-04990-6
Xin-Rui Liao, Feng Wu, Yan-Chao Yang, Gao-Rong Zhang, Wen-Zhe Ma, Lai-You Wang, Wen-Jian Lan
{"title":"A New Acetophenone and Antiproliferative Constituents from the Roots of Melicope pteleifolia","authors":"Xin-Rui Liao,&nbsp;Feng Wu,&nbsp;Yan-Chao Yang,&nbsp;Gao-Rong Zhang,&nbsp;Wen-Zhe Ma,&nbsp;Lai-You Wang,&nbsp;Wen-Jian Lan","doi":"10.1007/s10600-026-04990-6","DOIUrl":"10.1007/s10600-026-04990-6","url":null,"abstract":"<p>A new acetophenone (<b>1</b>) and 14 known compounds (<b>2–15</b>) were isolated from the roots of <i>Melicope pteleifolia</i>. Their structures were elucidated by means of comprehensive spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, as well as though comparison with published data. All isolated compounds were assessed for their in vitro cytotoxicity against human cancer cell lines using the SRB method. Among them, compound <b>13</b>, one of the flavonoids, exhibited the strongest cytotoxic activity, with an IC<sub>50</sub> value of 14.79 μM. Further investigation revealed that compound <b>13</b> could induce HCT116 cell apoptosis by suppressing the cleavage of Cleaved Caspase-3 and Cleaved PARP.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"483 - 488"},"PeriodicalIF":1.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Azaphilones from the Endophytic Fungus Penicillium viticola and their Antifungal Activity 葡萄内生真菌青霉中的氮化霉素及其抗真菌活性
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05017-w
Wei-Lin Xu, Xing Tian, Shi-Yi Shi, Meng Yuan, Zhi-Yong Guo, Xue-Qing Zhang
{"title":"Azaphilones from the Endophytic Fungus Penicillium viticola and their Antifungal Activity","authors":"Wei-Lin Xu,&nbsp;Xing Tian,&nbsp;Shi-Yi Shi,&nbsp;Meng Yuan,&nbsp;Zhi-Yong Guo,&nbsp;Xue-Qing Zhang","doi":"10.1007/s10600-026-05017-w","DOIUrl":"10.1007/s10600-026-05017-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"600 - 603"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aromatic Compounds from Euphorbia esula 大戟属植物的芳香化合物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05016-x
D. F. Yan, M. M. Zhang, Y. Q. Song, L. Liu, N. Begmatov, O. T. Turginov, B. Zhao, G. A. Zou
{"title":"Aromatic Compounds from Euphorbia esula","authors":"D. F. Yan,&nbsp;M. M. Zhang,&nbsp;Y. Q. Song,&nbsp;L. Liu,&nbsp;N. Begmatov,&nbsp;O. T. Turginov,&nbsp;B. Zhao,&nbsp;G. A. Zou","doi":"10.1007/s10600-026-05016-x","DOIUrl":"10.1007/s10600-026-05016-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"597 - 599"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Davallia mariesii 马丽花次生代谢物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05015-y
C. Y. Chen, M. J. Cheng, C. M. Liu, S. T. Huang, W. J. Li, H. T. Li
{"title":"Secondary Metabolites of Davallia mariesii","authors":"C. Y. Chen,&nbsp;M. J. Cheng,&nbsp;C. M. Liu,&nbsp;S. T. Huang,&nbsp;W. J. Li,&nbsp;H. T. Li","doi":"10.1007/s10600-026-05015-y","DOIUrl":"10.1007/s10600-026-05015-y","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"593 - 596"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition of Potentilla kleiniana 蕨麻的化学成分
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05018-9
Li Jiang, Qian-Lian Yin, Qian-Qian Jin, Wen-Shuang Tang, Yang Wang, Shi-Hai Zhang, Xue Ma, Yong-Jun Li
{"title":"Chemical Composition of Potentilla kleiniana","authors":"Li Jiang,&nbsp;Qian-Lian Yin,&nbsp;Qian-Qian Jin,&nbsp;Wen-Shuang Tang,&nbsp;Yang Wang,&nbsp;Shi-Hai Zhang,&nbsp;Xue Ma,&nbsp;Yong-Jun Li","doi":"10.1007/s10600-026-05018-9","DOIUrl":"10.1007/s10600-026-05018-9","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"604 - 606"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Inflammatory and Antioxidant Constituents from Polygonum multiflorum 何首乌抗炎、抗氧化成分研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-04992-4
Li-Chai Chen, Chien-Ming Huang, Zih-Rong Chen, Chia-Ching Liaw, Ming-Jen Cheng, Jen-Wen Hsiao, Jih-Jung Chen
{"title":"Anti-Inflammatory and Antioxidant Constituents from Polygonum multiflorum","authors":"Li-Chai Chen,&nbsp;Chien-Ming Huang,&nbsp;Zih-Rong Chen,&nbsp;Chia-Ching Liaw,&nbsp;Ming-Jen Cheng,&nbsp;Jen-Wen Hsiao,&nbsp;Jih-Jung Chen","doi":"10.1007/s10600-026-04992-4","DOIUrl":"10.1007/s10600-026-04992-4","url":null,"abstract":"<p>A new resveratrol derivative, <i>trans</i>-resveratrol-4′-<i>O</i>-gallate (<b>1</b>), has been isolated from the leaves of <i>Polygonum multiflorum</i>, together with eight known compounds, resveratrol (<b>2</b>), 2,3,5,4′-tetrahydroxystilbene-2-<i>O-β</i>-D-glucoside (<b>3</b>), emodin (<b>4</b>), chrysophanol (<b>5</b>), tricin (<b>6</b>), apigenin (<b>7</b>), gallic acid (<b>8</b>), and methyl gallate (<b>9</b>). The structure of the new compound <b>1</b> was determined using spectroscopic and MS analyses. Among the isolates, <i>trans</i>-resveratrol-4′-O-gallate (<b>1</b>), resveratrol (<b>2</b>), emodin (<b>4</b>), and apigenin (<b>7</b>) showed potent inhibition with IC<sub>50</sub> values of 8.27 ± 0.54, 12.74 ± 1.28, 13.02 ± 0.52, and 11.75 ± 1.07 μM, respectively, against LPS-induced nitric oxide generation. In addition, compounds <b>1</b>, <b>2</b>, <b>8</b>, and <b>9</b> also showed potent DPPH radical scavenging activities, with IC<sub>50</sub> values of 7.28 ± 0.57, 13.48 ± 1.25, 15.17 ± 1.36, and 35.06 ± 2.69 μM, respectively.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"492 - 496"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Passiflora edulis 西番莲次生代谢产物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05014-z
H. T. Li, M. J. Cheng, M. H. Ke, H. L. Huang, T. H. Chen, H. M. Wu, S. T. Huang, W. J. Li, C. Y. Chen
{"title":"Secondary Metabolites of Passiflora edulis","authors":"H. T. Li,&nbsp;M. J. Cheng,&nbsp;M. H. Ke,&nbsp;H. L. Huang,&nbsp;T. H. Chen,&nbsp;H. M. Wu,&nbsp;S. T. Huang,&nbsp;W. J. Li,&nbsp;C. Y. Chen","doi":"10.1007/s10600-026-05014-z","DOIUrl":"10.1007/s10600-026-05014-z","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"589 - 592"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two New Anti-TMV Furo[3,2-c]quinolines from the Fermentation Products of an Endophytic Aspergillus versicolor 内生杂色曲霉发酵产物中两种新的抗tmv呋喃[3,2-c]喹啉
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05013-0
Wu-Xia Xi, Xin-Yao Huang, Li-Ying Yang, Jian-Rong Chu, Long-Hui Ren, Lin Yang, Yu-Ping Wu, Wei-Guang Wang, Guang-Hui Kong, Qiu-Fen Hu, Gao-Kun Zhao
{"title":"Two New Anti-TMV Furo[3,2-c]quinolines from the Fermentation Products of an Endophytic Aspergillus versicolor","authors":"Wu-Xia Xi,&nbsp;Xin-Yao Huang,&nbsp;Li-Ying Yang,&nbsp;Jian-Rong Chu,&nbsp;Long-Hui Ren,&nbsp;Lin Yang,&nbsp;Yu-Ping Wu,&nbsp;Wei-Guang Wang,&nbsp;Guang-Hui Kong,&nbsp;Qiu-Fen Hu,&nbsp;Gao-Kun Zhao","doi":"10.1007/s10600-026-05013-0","DOIUrl":"10.1007/s10600-026-05013-0","url":null,"abstract":"<p>Two new furo[3,2-c]quinoline derivatives, 8-isopropyl-7-methoxy-3-methylfuro[3,2-c]quinoline (<b>1</b>) and 8-isopropyl-6-methoxy-3-methylfuro[3,2-c]quinoline (<b>2</b>), together with five known analogs (<b>3–7</b>) were isolated from the fermentation products of an endophytic fungus <i>Aspergillus versicolor</i>, which originated from cigar tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their antitobacco mosaic virus (anti-TMV) activity. The results revealed that compounds <b>1</b> and <b>2</b> exhibited potential anti-TMV activity, with inhibition rates of 36.5 ± 3.6 and 32.8% ± 3.4, respectively, at a concentration of 50 μg/mL. These rates are close to that of a positive control.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"584 - 588"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromones from the Stem Bark of Cassia alata and Their Anti-TMV Activities 决明子茎皮色素及其抗tmv活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-04985-3
Hua-Ying Liu, Gao-Kun Zhao, Heng Yao, Guang-Hai Zhang, Guang-Hui Kong, Qiu-Fen Hu, Wei-Guang Wang, Shi-Ping Zhou, Yu-Ping Wu
{"title":"Chromones from the Stem Bark of Cassia alata and Their Anti-TMV Activities","authors":"Hua-Ying Liu,&nbsp;Gao-Kun Zhao,&nbsp;Heng Yao,&nbsp;Guang-Hai Zhang,&nbsp;Guang-Hui Kong,&nbsp;Qiu-Fen Hu,&nbsp;Wei-Guang Wang,&nbsp;Shi-Ping Zhou,&nbsp;Yu-Ping Wu","doi":"10.1007/s10600-026-04985-3","DOIUrl":"10.1007/s10600-026-04985-3","url":null,"abstract":"<p>The <i>Cassia</i> genus (Leguminosae) has attracted a lot of attention as a prolific source of chromones with diverse structures and biological properties. The aim of this study was to screen the antiviral activities of chromones from <i>Cassia alata</i>. The extract of stem bark of this plant was separated using silica gel, MCI, ODS C<sub>18</sub>, and Sephadex LH-20 column chromatography, as well as semipreparative HPLC. As a result, two new chromones (<b>1</b> and <b>2</b>), together with five known analogs (<b>3–7</b>) were isolated. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Interestingly, the anti-tobacco mosaic virus (TMV) test revealed that compounds <b>1</b> and <b>2</b> showed notable anti-TMV activity with inhibition rates of 40.2 ± 2.9% and 46.5 ± 3.1%, respectively. These rates are close to that of the positive control.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"458 - 462"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New PTP1B Inhibitory Metabolite from the Endophytic Fungus Aspergillus fumigatus J2-22-1 内生真菌烟曲霉J2-22-1中新的PTP1B抑制代谢物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-23 DOI: 10.1007/s10600-026-05012-1
Jintao Wang, Meng Ren, Liyue Su, Li Zhang, Tianxiang Zhang, Jun Zhang, Sijun Dong, Dan Ma, Du-Qiang Luo
{"title":"New PTP1B Inhibitory Metabolite from the Endophytic Fungus Aspergillus fumigatus J2-22-1","authors":"Jintao Wang,&nbsp;Meng Ren,&nbsp;Liyue Su,&nbsp;Li Zhang,&nbsp;Tianxiang Zhang,&nbsp;Jun Zhang,&nbsp;Sijun Dong,&nbsp;Dan Ma,&nbsp;Du-Qiang Luo","doi":"10.1007/s10600-026-05012-1","DOIUrl":"10.1007/s10600-026-05012-1","url":null,"abstract":"<p>Two new compounds (<b>1</b> and <b>2</b>) and six known compounds (<b>3–8</b>) were isolated from the endophytic fungus <i>Aspergillus fumigatus</i> J2-22-1, and their structures were elucidated through comprehensive NMR spectroscopy and HR-ESI-MS analyses. All compounds were evaluated for PTP1B inhibitory activity. Notably, compound <b>1</b> demonstrated significant inhibition with an IC<sub>50</sub> value of 7.36 μM, demonstrating comparable potency with the positive control Na<sub>3</sub>VO<sub>4</sub>. These findings underscore the potential of fungal metabolites as promising sources for developing novel PTP1B inhibitors.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"579 - 583"},"PeriodicalIF":1.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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