Seong Su Hong, Jung A Lee, Ju-Hyoung Park, Suon Sovann, Kry Masphal, Jae Shin Kang, Jaeho Lee, Woo Young Bang, Chun Whan Choi, Eun-Kyoung Ahn, Joa Sub Oh
{"title":"Halimane Diterpenoids and Phenolic Metabolites from the Stems of Croton poilanei","authors":"Seong Su Hong, Jung A Lee, Ju-Hyoung Park, Suon Sovann, Kry Masphal, Jae Shin Kang, Jaeho Lee, Woo Young Bang, Chun Whan Choi, Eun-Kyoung Ahn, Joa Sub Oh","doi":"10.1007/s10600-026-05078-x","DOIUrl":"10.1007/s10600-026-05078-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"836 - 839"},"PeriodicalIF":1.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Turdu, A. Wali, Y. H. Gao, R. Kelaimu, X. M. Zhao, A. Yili
{"title":"Isolation and Purification of Immunomodulating Protein from Ovis Aries Small Intestine","authors":"G. Turdu, A. Wali, Y. H. Gao, R. Kelaimu, X. M. Zhao, A. Yili","doi":"10.1007/s10600-026-05061-6","DOIUrl":"10.1007/s10600-026-05061-6","url":null,"abstract":"<p>A protein (F1-a) was isolated and purified from sheep small intestine using column chromatography over Sephadex G-25, DEAE-650M, and HW-55F. The protein content was 55.28%; yield, 50.42%; approximate molecular mass, 66 kDa. The amino-acid composition of purified F1-a was determined by HPLC. Its main component was identified by liquid-chromatography–tandem mass-spectrometry (LC-MS/MS). Also, purified F1-a exhibited immunological activity because it was observed to cause a dose-dependent increase in secretion of nitric oxide (NO), tumor necrosis factor <i>α</i> (TNF-<i>α</i>), and interleukin-6 (IL-6) in unactivated RAW264.7 cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"778 - 782"},"PeriodicalIF":1.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. N. Olennikov, N. I. Kashchenko, N. K. Chirikova
{"title":"New Flavonoids from Rhododendron adamsii. I. Myricetin Glycosides","authors":"D. N. Olennikov, N. I. Kashchenko, N. K. Chirikova","doi":"10.1007/s10600-026-05043-8","DOIUrl":"10.1007/s10600-026-05043-8","url":null,"abstract":"<p>Runners of <i>Rhododendron adamsii</i> Rehder (Ericaceae) afforded 18 flavonoids, among which were glycosides of myricetin, quercetin, dihydromyricetin, and dihydroquercetin, including the two new compounds <b>1</b> and <b>2</b>. The new flavonoids were myricetin 3-O-<i>β</i>-D-glucuronopyranoside-3′-O-<i>β</i>-D-glucopyranoside (adamsoside I, <b>1</b>) and myricetin 3-O-<i>β</i>-D-(6′′-O-galloyl)-glucopyranoside-3′-O-<i>β</i>-D-glucopyranoside (adamsoside II, <b>2</b>). Compounds <b>1</b> and <b>2</b> possessed antiradical activity.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"682 - 686"},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syarifah Nadhirah Wan Idrus, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Nur Nabilah Mohd Zaini, Faezatul Alwani Mohd Rahim, Nurunajah Ab Ghani, Farkhod Eshboev
{"title":"Chemical Constituents from Piper frustratum and Acetylcholinesterase Inhibitory Activity","authors":"Syarifah Nadhirah Wan Idrus, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Nur Nabilah Mohd Zaini, Faezatul Alwani Mohd Rahim, Nurunajah Ab Ghani, Farkhod Eshboev","doi":"10.1007/s10600-026-05063-4","DOIUrl":"10.1007/s10600-026-05063-4","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"788 - 791"},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolation and Biological Activity of Malformins and Other Cyclodipeptides from Endophytic Aspergillus niger and Aspergillus fumigatus of Eucommia ulmoides","authors":"Hongchi Zhang, Rui Liu","doi":"10.1007/s10600-026-05081-2","DOIUrl":"10.1007/s10600-026-05081-2","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"847 - 851"},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structurally Diverse 12-Methylene Biflavononid Derivatives from Citrus medica var. sarcodactylis and Their Hepatoprotective Activities","authors":"Wen-Min Liu, Xu-Tao Wu, Rong-Rui Wei, Qin-Ge Ma","doi":"10.1007/s10600-026-05041-w","DOIUrl":"10.1007/s10600-026-05041-w","url":null,"abstract":"<p>A new 12-methylene biflavonoid, named 3′′,3′′′-dimethoxy-4′′/4′′′-dihydroxy-11/11′-dicarboxydibenzofuran-12-methylene biflavonoid (<b>1</b>), and two known 12-methylene biflavonoid derivatives (<b>2</b> and <b>3</b>) were isolated from <i>Citrus medica</i> L. var. <i>sarcodactylis</i> Swingle to our knowledge for the first time. Their structures were elucidated by extensive spectral data and related references. Among them, compound <b>1</b> (10 μM) exhibited moderate hepatoprotective activities with cell-survival rates of 69.68 ± 0.93%.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"672 - 676"},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. V. Nemtarev, M. E. Shemakhina, A. D. Voloshina, A. P. Lyubina, R. R. Faizullin, V. F. Mironov
{"title":"Synthesis and Properties of Phosphorus-Containing β-Ionone Derivatives","authors":"A. V. Nemtarev, M. E. Shemakhina, A. D. Voloshina, A. P. Lyubina, R. R. Faizullin, V. F. Mironov","doi":"10.1007/s10600-026-05037-6","DOIUrl":"10.1007/s10600-026-05037-6","url":null,"abstract":"<p>Experimental data for the reactions of natural<i> β</i>-ionone with phosphorus-containing regents, i.e., methyl dichlorophosphite and P–H-phosphonium salts were presented. The reaction of <i>β</i>-ionone with methyl dichlorophosphite formed 1,2-oxaphospholene with an unsaturated cyclic moiety in the 3-position. Hydrolysis of the obtained 1,2-oxaphospholene opened the oxaphospholene ring to give 1-cycloalkyl-3-oxobutylphosphonic acid. The P–H-phosphonium salts (using triarylphosphonium triflates as examples) were shown to add ionone to the multiple bond in the<i> β</i>-position to the carbonyl group to form 1-cycloalkyl-3-oxobutylphosphonium salts that demonstrated high cytotoxicity against human cancer cell lines with IC<sub>50</sub> 1.1–32.4 μM and antibacterial activity against Gram-positive bacteria.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 4","pages":"652 - 659"},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}