具有α-葡萄糖苷酶抑制活性的巨地甲苷类

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI:10.1007/s10600-025-04734-y

Zi-Han Wang, Hong-Juan Zhou, Meng-Ya Yang, Jian-Hua Shao, Chun-Chao Zhao

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引用次数: 0

摘要

从紫荚豆荚果实的甲醇提取物中分离出了一种新的巨加藤甲苷(1)、viburcoside A和四种已知的类似物（2-5）。通过广泛的波谱分析（NMR和HR-ESI-MS）、DP4+ NMR和ECD计算以及酶解对化合物1的绝对构型进行了鉴定。体外实验结果表明，与阳性对照阿卡波糖（IC50 = 18.84 μM）相比，viburcoside A(1)对α-葡萄糖苷酶具有抑制作用，IC50值为16.03 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Megastigmane Glycosides with α-Glucosidase Inhibitory Activity from Viburnum urceolatum Fruits

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Megastigmane Glycosides with α-Glucosidase Inhibitory Activity from Viburnum urceolatum Fruits

A new megastigmane glycoside (1), viburcoside A, and four known analogs (2–5) were isolated from the methanol extract of Viburnum urceolatum fruits. The structure, including the absolute configuration of compound 1, was elucidated by extensive spectroscopic analysis (NMR and HR-ESI-MS), DP4+ NMR and ECD calculations, and enzyme hydrolysis. In the in vitro assay, viburcoside A (1) exhibited the potential inhibition of α-glucosidase with the IC₅₀ value of 16.03 μM, compared with the positive control acarbose (IC₅₀ = 18.84 μM).

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.