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Isolation and Antibacterial Activity of Nodosuxanthone from Calophyllum nodosum 块茎甘蓝中结核杉酮的分离及抑菌活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-04989-z
Yiizamy Suffian, Vivien Yi Mian Jong, Mas Atikah Lizazman, Ainaa Nadiah Abd Halim, Mohamad Izwan Ismail, Choy Ker Woon, Enis Nadia Md Yusof, Leong Sze Wei, Nor Hisam Zamakshshari
{"title":"Isolation and Antibacterial Activity of Nodosuxanthone from Calophyllum nodosum","authors":"Yiizamy Suffian,&nbsp;Vivien Yi Mian Jong,&nbsp;Mas Atikah Lizazman,&nbsp;Ainaa Nadiah Abd Halim,&nbsp;Mohamad Izwan Ismail,&nbsp;Choy Ker Woon,&nbsp;Enis Nadia Md Yusof,&nbsp;Leong Sze Wei,&nbsp;Nor Hisam Zamakshshari","doi":"10.1007/s10600-026-04989-z","DOIUrl":"10.1007/s10600-026-04989-z","url":null,"abstract":"<p>A new xanthone derivative, nodosuxanthone (<b>1</b>), along with six known compounds <b>2–7</b>, were isolated from <i>Calophyllum nodosum</i> to our knowledge for the first time. Their structures were elucidated using various spectroscopic techniques, UV, MS, IR, and 1D and 2D NMR, and confirmed by comparison with the literature data. Compounds <b>1–7</b> were evaluated for their antibacterial activities on five different bacterial strains of <i>Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa,</i> and <i>Escherichia coli</i> by adapting the well-diffusion method. Among them, the hexane extract, compounds <b>4</b>, <b>5</b>, and <b>7</b>, demonstrated notable antibacterial and bactericidal effects.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"476 - 482"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Cinnamomum kanehirai 肉桂次生代谢产物的研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-04991-5
C. Y. Chen, M. J. Cheng, S. T. Huang, H. T. Li, S. L. Liu
{"title":"Secondary Metabolites of Cinnamomum kanehirai","authors":"C. Y. Chen,&nbsp;M. J. Cheng,&nbsp;S. T. Huang,&nbsp;H. T. Li,&nbsp;S. L. Liu","doi":"10.1007/s10600-026-04991-5","DOIUrl":"10.1007/s10600-026-04991-5","url":null,"abstract":"<p>A new cyclohexa-1,3-dien-1-ol, cinnakanehirainol (2,4,6,6-tetra-methylcyclohexa-1,3-dien-1-ol) (<b>1</b>) as well as eight known compounds were isolated from the roots of <i>Cinnamomum kanehirai</i> Hayata (Lauraceae). The structure of the new constituent was essentially elucidated by spectral evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"489 - 491"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Hexanor-Cucurbitane Triterpenoid from the Whole Herb of Chrysosplenium carnosum 金合欢全草中一个新的己-葫芦烷三萜
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05000-5
Jing Wu, Lina Fu, Yong Lou, Wei Jiang, Aihong Liu, Gang Ren
{"title":"A New Hexanor-Cucurbitane Triterpenoid from the Whole Herb of Chrysosplenium carnosum","authors":"Jing Wu,&nbsp;Lina Fu,&nbsp;Yong Lou,&nbsp;Wei Jiang,&nbsp;Aihong Liu,&nbsp;Gang Ren","doi":"10.1007/s10600-026-05000-5","DOIUrl":"10.1007/s10600-026-05000-5","url":null,"abstract":"<p>Phytochemical investigation on <i>Chrysosplenium carnosum</i> Hook. f. &amp; Thomson, the source plant of Tibetan medicine “Yajima,” resulted in the isolation and characterization of a new hexanor-cucurbitane triterpenoid, namely 3-<i>epi</i>-hexanorcucurbitacin F (<b>1</b>), along with 20 known compounds (<b>2–21</b>). Their structures were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR, UV, IR, and HR-ESI-MS, and comparison of the spectroscopic data with those reported in the literature.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"528 - 531"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Embelin Derivatives with Their Biological Activities 新的内皮素衍生物及其生物活性
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05006-z
Thi-Kim-Dung Le, Tran-Ngoc-Tu-Trinh Cao, Thi-Bich-Ngan Nguyen, Quach-Mai-Anh Nguyen, Ngoc-Phuong-Nhi Ho, Minh-Truong-Tho Ho, Chuong Hoang Nguyen, Duc-Dung Pham, Thuc-Huy Duong, Ngoc-Hong Nguyen, Jirapast Sichaem
{"title":"New Embelin Derivatives with Their Biological Activities","authors":"Thi-Kim-Dung Le,&nbsp;Tran-Ngoc-Tu-Trinh Cao,&nbsp;Thi-Bich-Ngan Nguyen,&nbsp;Quach-Mai-Anh Nguyen,&nbsp;Ngoc-Phuong-Nhi Ho,&nbsp;Minh-Truong-Tho Ho,&nbsp;Chuong Hoang Nguyen,&nbsp;Duc-Dung Pham,&nbsp;Thuc-Huy Duong,&nbsp;Ngoc-Hong Nguyen,&nbsp;Jirapast Sichaem","doi":"10.1007/s10600-026-05006-z","DOIUrl":"10.1007/s10600-026-05006-z","url":null,"abstract":"<p>Eight synthetic derivatives of embelin (<b>1a–1f</b> and <b>2a</b> and <b>2b</b>) were synthesized to investigate their <i>α</i>-glucosidase inhibitory activity and antibacterial activity against two bacterial strains, <i>Aeromonas hydrophila</i> and <i>Acinetobacter baumannii</i>. Four of these compounds (<b>1a</b>, <b>1d</b>, <b>2a</b>, and <b>2b</b>) were to our knowledge previously unreported. In terms of <i>α</i>-glucosidase inhibition, compounds <b>2a</b> and <b>2b</b> exhibited the most potent activity, with IC<sub>50</sub> values of 15.2 and 15.1 μM, respectively, surpassing the positive control agent (acarbose, IC<sub>50</sub> 332.5 ± 5.0 μM). Both compounds, <b>2a</b> and <b>2b</b>, showed moderate inhibition against A. hydrophila, with inhibition zones of 15 and 16 mm, respectively. Only compound <b>2a</b> exhibited an inhibition zone of 16 mm against A. baumannii. The other derivatives (<b>1a–1f</b>) showed no activity in either of the tested assays.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"554 - 557"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites from the Soil-Derived Fungus Trichoderma yilanense 18F0052 土源真菌伊兰木霉18F0052的代谢物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-04999-x
Huei-Mei Chen, Ming-Jen Cheng, Hsia-Wei Liu, Jyh-Yih Leu, Ming-Der Wu, Yu-Hui We, Jih-Jung Chen, Wen-Ru Chou, Nanthaphong Khamthong
{"title":"Metabolites from the Soil-Derived Fungus Trichoderma yilanense 18F0052","authors":"Huei-Mei Chen,&nbsp;Ming-Jen Cheng,&nbsp;Hsia-Wei Liu,&nbsp;Jyh-Yih Leu,&nbsp;Ming-Der Wu,&nbsp;Yu-Hui We,&nbsp;Jih-Jung Chen,&nbsp;Wen-Ru Chou,&nbsp;Nanthaphong Khamthong","doi":"10.1007/s10600-026-04999-x","DOIUrl":"10.1007/s10600-026-04999-x","url":null,"abstract":"<p>One previously undescribed sesquiterpenoid analog, trichoderyilanin (<b>1</b>), together with two known ones, 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (<b>2</b>) and 5-hydroxy-2-hydroxymethyl-3-methyl-7-methoxychromone (<b>3</b>), were isolated from the EtOAc extracts of the soil-derived fungus <i>Trichoderma yilanense</i> 18F0052. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"524 - 527"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phyllocladane Diterpenoids from the Bark of Cryptomeria japonica 柳杉树皮中的叶绿烷二萜
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05001-4
Chi-I Chang, Cheng-Chi Chen, Yueh-Hsiung Kuo
{"title":"Phyllocladane Diterpenoids from the Bark of Cryptomeria japonica","authors":"Chi-I Chang,&nbsp;Cheng-Chi Chen,&nbsp;Yueh-Hsiung Kuo","doi":"10.1007/s10600-026-05001-4","DOIUrl":"10.1007/s10600-026-05001-4","url":null,"abstract":"<p>A new phyllocladane-type diterpenoid, 3-oxophyllocladane-16α,18-diol (<b>1</b>) and one known phyllocladane-type diterpenoid, 3-oxophyllocladan-16α-ol (<b>2</b>) were isolated from the bark of <i>Cryptomeria japonica</i>. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR (<sup>1</sup>H, <sup>13</sup>C, COSY, HMQC, HMBC, and NOESY) and HR-EI-MS and comparison of NMR data with those of known analogs.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"532 - 535"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Dihydroflavonol Glycoside from Euonymus glaber 一种新的卫矛二氢黄酮醇苷类化合物
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-04987-1
Ying Liu, Na Zhao, Rui Zhan, Hui-Mei Pu
{"title":"A New Dihydroflavonol Glycoside from Euonymus glaber","authors":"Ying Liu,&nbsp;Na Zhao,&nbsp;Rui Zhan,&nbsp;Hui-Mei Pu","doi":"10.1007/s10600-026-04987-1","DOIUrl":"10.1007/s10600-026-04987-1","url":null,"abstract":"<p>A new dihydroflavonol glycoside, pinobanksin-7-<i>O-β</i>-D-glucopyranoside (<b>1</b>), and 13 known flavonoids (<b>2–14</b>) were isolated from the ethanol extract of <i>Euonymus glaber</i> Roxb. The structure was established by spectroscopic analyses, including 1D and 2D NMR (<sup>1</sup>H, <sup>13</sup>C, COSY, HMBC, and HSQC), UV, and HR-ESI-MS.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"468 - 471"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Improved Total Synthesis of Kukoamine B Dihydrobromide 二氢溴化Kukoamine B的改进全合成
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05007-y
Lijuan Zhai, Lili He, Jingwen Ji, Yuanyu Gao, Rui Jiang, Pengjuan Zhou, Dong Tang, Jian Sun
{"title":"An Improved Total Synthesis of Kukoamine B Dihydrobromide","authors":"Lijuan Zhai,&nbsp;Lili He,&nbsp;Jingwen Ji,&nbsp;Yuanyu Gao,&nbsp;Rui Jiang,&nbsp;Pengjuan Zhou,&nbsp;Dong Tang,&nbsp;Jian Sun","doi":"10.1007/s10600-026-05007-y","DOIUrl":"10.1007/s10600-026-05007-y","url":null,"abstract":"<p>Kukoamine B is a naturally occurring spermine alkaloid and possesses a variety of pharmacological significance, especially for the treatment of patients with sepsis, and as an antidiabetic agent. We synthesized kukoamine B dihydrobromide in 29.3% overall yield over eight steps. The synthetic scheme avoids harsh reaction conditions, improves the yield of each step, needs minimal chromatographic purification, and uses readily available and cheaper reagents.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"558 - 562"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Isopimarane Diterpene Glycoside from Endophytic Fungus Xylaria sp. ZY-13 内生真菌Xylaria sp. ZY-13中一个新的异吡马烷二萜苷
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05002-3
Wang Shou-dong, Zhang Ming-yue, Song Yong-qi, Chen Xiao-hui, Liu Bao-guang, Feng Yu-xiao, Shi Jia-qi, Feng Shu-ying, Guo Tao
{"title":"A New Isopimarane Diterpene Glycoside from Endophytic Fungus Xylaria sp. ZY-13","authors":"Wang Shou-dong,&nbsp;Zhang Ming-yue,&nbsp;Song Yong-qi,&nbsp;Chen Xiao-hui,&nbsp;Liu Bao-guang,&nbsp;Feng Yu-xiao,&nbsp;Shi Jia-qi,&nbsp;Feng Shu-ying,&nbsp;Guo Tao","doi":"10.1007/s10600-026-05002-3","DOIUrl":"10.1007/s10600-026-05002-3","url":null,"abstract":"<p>One new isopimarane diterpene glycoside, xylariside D (<b>1</b>), and five known analogs (<b>2–6</b>) were identified from the secondary metabolites of the plant-derived endophytic fungus <i>Xylaria</i> sp. ZY-13. The chemical structure of compound <b>1</b> was elucidated using 1D and 2D NMR, HR-ESI-MS, ECD spectral analysis, and other spectroscopic methods. These compounds exhibit intriguing structures characterized by diterpenes linked to sugar groups. Additionally, the anti-inflammatory activities of all compounds were evaluated. The results indicate that only compounds <b>5</b> and <b>6</b> exhibit weak anti-inflammatory activities.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"536 - 540"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triterpenoids from Potentilla nivea and Their Anti-Inflammatory Activities 芜菁中的三萜及其抗炎活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-18 DOI: 10.1007/s10600-026-05003-2
Qiang Wu, Xun Yan, En Yuan, Jing Wu, Ling-Yun Zhong, Yan-Ping Gao
{"title":"Triterpenoids from Potentilla nivea and Their Anti-Inflammatory Activities","authors":"Qiang Wu,&nbsp;Xun Yan,&nbsp;En Yuan,&nbsp;Jing Wu,&nbsp;Ling-Yun Zhong,&nbsp;Yan-Ping Gao","doi":"10.1007/s10600-026-05003-2","DOIUrl":"10.1007/s10600-026-05003-2","url":null,"abstract":"<p>A new 20,28-epoxyursan triterpenoid (<b>1</b>), together with four known triterpenoids (<b>2–5</b>) were isolated from the ethanolic extract of the whole plants of <i>Potentilla nivea</i>. Their structures were elucidated on the basis of extensive spectroscopic and MS data analyses and comparing data reported. Among the isolates, compounds <b>1</b> and <b>5</b> showed potent inhibition with IC<sub>50</sub> values of 21.89 ± 0.40 and 27.99 ± 0.41 μM, respectively, against LPS-induced NO generation.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"541 - 544"},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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