节瘤属和Cymathaere褐藻岩藻蛋白的结构特征及其对SK-MEL-5黑色素瘤细胞集落形成的代谢导向作用

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-07-19 DOI:10.1007/s10600-025-04723-1

N. M. Shevchenko, V. V. Surits, R. V. Usoltseva, A. S. Silchenko, A. O. Zueva, R. A. Shkrabov, O. S. Malyarenko, S. P. Ermakova

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引用次数: 0

摘要

研究了5种褐藻中9个褐藻糖聚糖组分的组成，分别为：双歧节藻的AbF、库利纳沙的AkF1和AkF2、纤维Cymathaere的CfF1和CfF2、日本锦鲤的CjF1和CjF2、三叶锦鲤的CtF1和CtF2。AbF、AkF2、CfF2、CjF2和CtF2的主链由1,3结合α-L-聚焦构建。所研究的多糖在浓度高达400 μg/mL时无毒，对SK-MEL-5黑色素瘤细胞集落形成的抑制活性较弱，与2-脱氧-d -葡萄糖联合抑制活性明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural Characteristics of Fucoidans from Brown Algae of the Genera Arthrothamnus and Cymathaere and their Metabolically Oriented Action on Colony Formation of SK-MEL-5 Melanoma Cells

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Structural Characteristics of Fucoidans from Brown Algae of the Genera Arthrothamnus and Cymathaere and their Metabolically Oriented Action on Colony Formation of SK-MEL-5 Melanoma Cells

The compositions of nine fucoidan fractions from five species of brown alga, i.e., AbF from Arthrothamnus bifidus, AkF1 and AkF2 from A. kurilensis, CfF1 and CfF2 from Cymathaere fibrosa, CjF1 and CjF2 from C. japonica, and CtF1 and CtF2 from C. triplicata were studied. The main chains of AbF, AkF2, CfF2, CjF2, and CtF2 were constructed from 1,3-bound α-L-fucose. The studied polysaccharides were nontoxic at concentrations up to 400 μg/mL and exhibited weak inhibitory activity and pronounced inhibitory activity in combination with 2-deoxy-D-glucose on colony formation of SK-MEL-5 melanoma cells.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.