{"title":"Cytotoxic Iridoid Glycosides from the Aerial Parts of Paederia foetida","authors":"Jiang Hu, Guihua Yu, Fengming Xu, Tao Lv, Qiang Li, Feng Gao","doi":"10.1007/s10600-025-04735-x","DOIUrl":null,"url":null,"abstract":"<p>Two previously undescribed iridoid glycosides, 6′-<i>O</i>-trans-caffeoyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-3<i>α</i>- methylthioasperulosid (<b>1</b>) and 6′-<i>O</i>-trans-feruloyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-2′-<i>O</i>-3<i>α</i>-paederosid (<b>2</b>), were isolated from the 90% EtOH extract of the aerial part of <i>Paederia foetida</i> L. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H–<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that <b>2</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM and provided a scientific basis for further processing and utilization of <i>P. foetida</i>.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"676 - 680"},"PeriodicalIF":0.9000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04735-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two previously undescribed iridoid glycosides, 6′-O-trans-caffeoyl-(4S,6R)-3,4-dihydro-3α- methylthioasperulosid (1) and 6′-O-trans-feruloyl-(4S,6R)-3,4-dihydro-2′-O-3α-paederosid (2), were isolated from the 90% EtOH extract of the aerial part of Paederia foetida L. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, and HMBC) NMR spectroscopy, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that 2 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 20.0 μM and provided a scientific basis for further processing and utilization of P. foetida.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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