发布求助
文献互助 智能选刊 最新文献

Chemistry of Natural Compounds最新文献

筛选
英文 中文
Secondary Metabolites of Michelia crassipes 含笑的次生代谢物
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-18 DOI: 10.1007/s10600-026-04908-2
C. Y. Chen, S. T. Huang, W. J. Li, H. T. Li, C. H. Chuang, Y. H. Liu
{"title":"Secondary Metabolites of Michelia crassipes","authors":"C. Y. Chen, S. T. Huang, W. J. Li, H. T. Li, C. H. Chuang, Y. H. Liu","doi":"10.1007/s10600-026-04908-2","DOIUrl":"10.1007/s10600-026-04908-2","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"153 - 156"},"PeriodicalIF":0.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Pyridine of Physalis peruviana 秘鲁Physalis purviana的一个新吡啶
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-18 DOI: 10.1007/s10600-026-04896-3
C. Y. Chen, J. J. Wang, C. L. Kao, S. T. Huang, H. T. Li
{"title":"A New Pyridine of Physalis peruviana","authors":"C. Y. Chen,&nbsp;J. J. Wang,&nbsp;C. L. Kao,&nbsp;S. T. Huang,&nbsp;H. T. Li","doi":"10.1007/s10600-026-04896-3","DOIUrl":"10.1007/s10600-026-04896-3","url":null,"abstract":"<p>A new pyridine, 1-(4-methylpyridin-2-yl)ethyl acetate (<b>1</b>) as well as xanthyletin (<b>2</b>), 7,4′-dimethoxyisoflavone (<b>3</b>), 5-hydroxy-7,4′-dimethoxyisoflavone (<b>4</b>), (+)-lariciresinol (<b>5</b>), (+)-5,5′-dimethoxylariciresinol (<b>6</b>), and (+)-medioresinol (<b>7</b>), were isolated from the roots of <i>Physalis peruviana</i> L. The structure of the new pyridine was elucidated by chemical and physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"90 - 92"},"PeriodicalIF":0.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Benzoxazinoid Alkaloid and Other Constituents from Acanthus ilicifolius var. xiamenensis 厦门棘中一个新的苯并恶嗪类生物碱及其它成分
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04890-9
Xinhua Ma, Nana Yang, Yifan Zhang, Shibiao Feng, Jinhuang Shen, Xiaohui Huang, Yonghong Zhang
{"title":"A New Benzoxazinoid Alkaloid and Other Constituents from Acanthus ilicifolius var. xiamenensis","authors":"Xinhua Ma,&nbsp;Nana Yang,&nbsp;Yifan Zhang,&nbsp;Shibiao Feng,&nbsp;Jinhuang Shen,&nbsp;Xiaohui Huang,&nbsp;Yonghong Zhang","doi":"10.1007/s10600-026-04890-9","DOIUrl":"10.1007/s10600-026-04890-9","url":null,"abstract":"<p>A new benzoxazinoid alkaloid, (2<i>R</i>)-2-<i>O</i>-(2′-methoxy-4′-carboxyphenyl)-2<i>H</i>-1,4-benzoxazin-3(4<i>H</i>)-one (<b>1</b>) was isolated from the extract of the whole plants of <i>Acanthus ilicifolius</i> var. <i>xiamenensis</i>, together with nine known compounds (<b>2</b>–<b>10</b>). The structure elucidations were based on analyses of spectroscopic and mass-spectrometric data, including 1D, 2D NMR, and HR-MS. All compounds were examined for their anti-inflammatory and cytotoxic activities. Compound <b>10</b> exhibited moderate cytotoxicity against the HeLa, HepG2, and KB cancer cell lines with IC<sub>50</sub> values ranging from 14.71 to 31.07 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"71 - 74"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Structure, and Anti-LSD1 Activity of Novel C-16 Triazole-Fused Isosteviol Derivatives 新型C-16三唑-异甜菊醇衍生物的合成、结构及抗lsd1活性
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04883-8
Cong-Jun Liu, Wen-Shuo Jiang, Wei-Wen Huang, Ke-Jia Qiang, Shang-Yu Yang, Li-Na Liu, Wen-Min Zhang, Yu-Ling Li, Yu-Tao Min, Yang Sun, Yu-Fei Wang
{"title":"Synthesis, Structure, and Anti-LSD1 Activity of Novel C-16 Triazole-Fused Isosteviol Derivatives","authors":"Cong-Jun Liu,&nbsp;Wen-Shuo Jiang,&nbsp;Wei-Wen Huang,&nbsp;Ke-Jia Qiang,&nbsp;Shang-Yu Yang,&nbsp;Li-Na Liu,&nbsp;Wen-Min Zhang,&nbsp;Yu-Ling Li,&nbsp;Yu-Tao Min,&nbsp;Yang Sun,&nbsp;Yu-Fei Wang","doi":"10.1007/s10600-026-04883-8","DOIUrl":"10.1007/s10600-026-04883-8","url":null,"abstract":"<p>Eleven novel C-16 triazole-fused isosteviol derivatives <b>6a–6k</b> were synthesized by “Huisgen-click” 1,3-dipolar cycloaddition reaction. The structures of synthesized compounds were characterized by IR, NMR, and HR-MS spectra, respectively. Furthermore, the anti-LSD1 activity of compounds was investigated, after which the results revealed that compound <b>6h</b> exhibited the best inhibitory activity with an IC<sub>50</sub> value of 8.944 ± 1.013 μM. The structure–activity relationships were further analyzed to guide the future design of novel isosteviol derivatives with enhanced LSD1 inhibitory capabilities.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"41 - 46"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic Lanostane Triterpenoids from Ganoderma leucocontextum 从白灵芝中提取的细胞毒性羊毛甾烷类三萜
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04885-6
Jiang Hu, Tao Lv, Qiang Li, Feng Gao
{"title":"Cytotoxic Lanostane Triterpenoids from Ganoderma leucocontextum","authors":"Jiang Hu,&nbsp;Tao Lv,&nbsp;Qiang Li,&nbsp;Feng Gao","doi":"10.1007/s10600-026-04885-6","DOIUrl":"10.1007/s10600-026-04885-6","url":null,"abstract":"<p>A phytochemical investigation of the 80% acetone extract of the fruiting bodies of <i>Ganoderma leucocontextum</i> afforded three new lanostane triterpenoids, 3<i>β</i>-acetyloxy-24,26-dihydroxy-25-methoxy-lanosta-8-en-7,11-dioxo (<b>1</b>), 3<i>β</i>-acetyloxy-11<i>β</i>,26,27-trihydroxylanosta-8,24-dien-7-oxo (<b>2</b>), and 15<i>α</i>-hydroxy-22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3,20-dioxo (<b>3</b>), as well as one known compound lanosta-8-en-7,11-dioxo-3<i>β</i>-acetyloxy-24,25,26-trihydroxy (<b>4</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D NMR spectrometry, HR-ESI-MS. The isolated triterpenoids were tested in vitro for cytotoxic activities against five gastric carcinoma cell lines. As a result, <b>1</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 20 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"51 - 55"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Nor-Diterpenoids from Roots of Perovskia angustifolia 刺叶钙根中新的非二萜类化合物
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04882-9
M. U. Zhuraev, Kh. M. Bobakulov, D. R. Siddikov, O. K. Askarova, E. Kh. Botirov, K. K. Turgunov, B. Tashkhodzhaev
{"title":"New Nor-Diterpenoids from Roots of Perovskia angustifolia","authors":"M. U. Zhuraev,&nbsp;Kh. M. Bobakulov,&nbsp;D. R. Siddikov,&nbsp;O. K. Askarova,&nbsp;E. Kh. Botirov,&nbsp;K. K. Turgunov,&nbsp;B. Tashkhodzhaev","doi":"10.1007/s10600-026-04882-9","DOIUrl":"10.1007/s10600-026-04882-9","url":null,"abstract":"<p>Two new nor-diterpenoids called perangustine (<b>1</b>) and perangustinine (<b>2</b>) were isolated from roots of <i>Perovskia angustifolia</i> (Lamiaceae). The chemical structures of the isolated compounds were proved based on IR, UV, <sup>1</sup>H and <sup>13</sup>C NMR spectral data and COSY, HSQC, and HMBC experiments. The molecular structure of perangustine was established by an X-ray crystal structure analysis.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"36 - 40"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Biological Evaluation of Coumarin Derivatives as Potent TGF-β1 Inhibitors 香豆素衍生物作为TGF-β1有效抑制剂的合成及生物学评价
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04876-7
Kechong Fan, Yang Liu, Yan Tian, Wei Wang, Xue Hu, Luping Wang, Fenglin Zhang
{"title":"Synthesis and Biological Evaluation of Coumarin Derivatives as Potent TGF-β1 Inhibitors","authors":"Kechong Fan,&nbsp;Yang Liu,&nbsp;Yan Tian,&nbsp;Wei Wang,&nbsp;Xue Hu,&nbsp;Luping Wang,&nbsp;Fenglin Zhang","doi":"10.1007/s10600-026-04876-7","DOIUrl":"10.1007/s10600-026-04876-7","url":null,"abstract":"<p>In the current work, we carried out the synthesis and evaluation of coumarin derivatives <b>4a–f</b> (R= hydrogen, fluoro, bromo, methoxy, trifluoromethyl) against their TGF-β1 inhibitory activity. EIA kits were used to detect the in vitro inhibitory activity of human TGF-β1 for <b>4a–f</b> following the manufacturer’s instructions. Among them, compound <b>4f</b> exhibited the strongest activity with an IC<sub>50</sub> value of 6.43 μM, making its potency comparable to the positive control, coumarin (IC<sub>50</sub> = 7.81 μM).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"15 - 18"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Approach to 3-Oxolithocholic Acid α-Acylaminocarboxamides with α-Glucosidase Inhibitory Activity 具有α-葡萄糖苷酶抑制活性的3-氧胆酸α-酰基氨基羧酰胺的研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-17 DOI: 10.1007/s10600-026-04886-5
A. A. Smirnova, E. V. Tretyakova, H. T. T. Nguyen, O. B. Kazakova
{"title":"An Approach to 3-Oxolithocholic Acid α-Acylaminocarboxamides with α-Glucosidase Inhibitory Activity","authors":"A. A. Smirnova,&nbsp;E. V. Tretyakova,&nbsp;H. T. T. Nguyen,&nbsp;O. B. Kazakova","doi":"10.1007/s10600-026-04886-5","DOIUrl":"10.1007/s10600-026-04886-5","url":null,"abstract":"<p>The one-pot synthesis of novel molecular hybrids incorporating pseudopeptide and steroidal moieties is described. For this, an efficient conjugation approach based on the Ugi four-component reaction (Ugi-4CR) was implemented for the ligation of amines or L-aminoacids to 3-oxolithocholic acid. Compounds <b>3</b> and <b>4</b> showed a more pronounced <i>α</i>-glucosidase inhibitory activity than acarbose in vitro with IC<sub>50</sub> values 16.30 and 11.04 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"56 - 60"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triterpenoids and Steroids from Euphorbia antiquorum 大戟中的三萜和类固醇
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-16 DOI: 10.1007/s10600-026-04884-7
Sheng-Dan Mao, Dong-Hao Liu, Wen-Na Li, Ting-Xiang Shi, Yong Zhao
{"title":"Triterpenoids and Steroids from Euphorbia antiquorum","authors":"Sheng-Dan Mao,&nbsp;Dong-Hao Liu,&nbsp;Wen-Na Li,&nbsp;Ting-Xiang Shi,&nbsp;Yong Zhao","doi":"10.1007/s10600-026-04884-7","DOIUrl":"10.1007/s10600-026-04884-7","url":null,"abstract":"<p>One new lupane triterpenoid, antieuphenone (<b>1</b>), along with seven known triterpenoids (<b>2–8</b>) and eleven steroids (<b>9–19</b>) were isolated from the twigs and leaves of <i>Euphorbia antiquorum</i>. Their structures were determined by 1D and 2D NMR data along with HR-ESI-MS. Except for compounds <b>4</b> and <b>8</b>, all others were obtained from this species for the first time as were the steroids.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"47 - 50"},"PeriodicalIF":0.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-02-16
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"6 - 9"},"PeriodicalIF":0.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书