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Phytochemical and Biological Screening of Prunus rechingeri 桃李的植物化学和生物学筛选
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04648-9
M. S. Ali, S. Shezadi, M. Latif, M. Yousuf, M. I. Malik, R. B. Tareen
{"title":"Phytochemical and Biological Screening of Prunus rechingeri","authors":"M. S. Ali, S. Shezadi, M. Latif, M. Yousuf, M. I. Malik, R. B. Tareen","doi":"10.1007/s10600-025-04648-9","DOIUrl":"10.1007/s10600-025-04648-9","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"364 - 366"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Alkenyl Derivative from the Fruits of Choerospondias axillaris 一种新的烯基衍生物，来自斧头苣苔的果实
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04628-z
Shuang-Shuang Chen, Hui-Yang Cao, Hong-Qiao Dai, Lin Hu, Jun-Lin Yin, Wen-Ting Li, Meng-Yuan Jiang
{"title":"A New Alkenyl Derivative from the Fruits of Choerospondias axillaris","authors":"Shuang-Shuang Chen,&nbsp;Hui-Yang Cao,&nbsp;Hong-Qiao Dai,&nbsp;Lin Hu,&nbsp;Jun-Lin Yin,&nbsp;Wen-Ting Li,&nbsp;Meng-Yuan Jiang","doi":"10.1007/s10600-025-04628-z","DOIUrl":"10.1007/s10600-025-04628-z","url":null,"abstract":"<p>Phytochemical investigation of the fruits of <i>Choerospondias axillaris</i> afforded a new alkenyl derivative, choerosponol M (<b>1</b>), and three known metabolites choerosponol A (<b>2</b>), poupartone A (<b>3</b>), and 5-hydroxymethyl-2-furancarboxaldehyde (<b>4</b>). The absolute configuration of <b>1</b> was elucidated by comparing experimental and calculated ECD data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"274 - 277"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical Evaluation, In Silico Binding Affinity, and In Vitro Antibacterial Activity of Volatile Oil from Leaves of Bambusa polymorpha 簕杜鹃叶挥发油的植物化学评价、硅结合亲和力和体外抗菌活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04622-5
Alekhya Sarkar, Sudhan Debnath, Debanjan Sen, Bipul Das Chowdhury, Rajat Ghosh, Bimal Debnath
{"title":"Phytochemical Evaluation, In Silico Binding Affinity, and In Vitro Antibacterial Activity of Volatile Oil from Leaves of Bambusa polymorpha","authors":"Alekhya Sarkar,&nbsp;Sudhan Debnath,&nbsp;Debanjan Sen,&nbsp;Bipul Das Chowdhury,&nbsp;Rajat Ghosh,&nbsp;Bimal Debnath","doi":"10.1007/s10600-025-04622-5","DOIUrl":"10.1007/s10600-025-04622-5","url":null,"abstract":"<p>Bamboo shoots are a popular vegetable in the ethnic population of NE India. The study’s main objective is to identify the compounds available in the volatile oil of <i>Bambusa polymorpha</i>, to determine their binding affinity against different bacterial target proteins and in vitro antibacterial activity against bacterial strains with which compounds exhibit significant binding affinity. In light of this, the current study is designed to conduct GC-MS analysis to identify the compounds in the volatile oil fraction of <i>B. polymorpha</i>. Molecular docking studies of identified molecules were conducted against target proteins of <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and the New Delhi Metallo(NDM)-beta-lactamase. The molecular docking and molecular dynamic (MD) simulation revealed that compounds BP_13 and BP_15 exhibited good binding affinity towards the target of DHFR of <i>S. aureus</i>. BP_13, BP_15, and trimethoprim (co-ligand) binding affinity with DHFR were –8.7, –10.0, and –7.5 kcal/mol, respectively. The <i>in vitro</i> activity of the extract against <i>S. aureus</i> was evaluated, and the MIC value was 250 μg/mL. The predicted ADME parameters of BP_13 and BP_15 are within the permissible range, and these compounds may be developed into more potential antibacterial agents.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"243 - 250"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Caffeoyl Glycosides from the Roots of Picrorhiza scrophulariiflora 来自山苍子根部的新咖啡酰苷
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04625-2
Tong-Fei Zhu, Zhi-Hui Yan, Qian Tang
{"title":"New Caffeoyl Glycosides from the Roots of Picrorhiza scrophulariiflora","authors":"Tong-Fei Zhu,&nbsp;Zhi-Hui Yan,&nbsp;Qian Tang","doi":"10.1007/s10600-025-04625-2","DOIUrl":"10.1007/s10600-025-04625-2","url":null,"abstract":"<p>From the underground parts of <i>Picrorhiza scrophulariiflora</i>, scrocaffeside D (<b>1</b>), methyl-4-O-<i>β</i>-Dglucopyranosyl-5-methoxy ferulic acid (<b>2</b>), phenethyl-<i>β</i>-D-glucopyranoside (<b>3</b>), veratric acid (<b>4</b>), were isolated. Scrocaffeside D (<b>1</b>) was a new one, and other known compounds were also isolated from the plants of Picrorhiza Royle for the first time. Their structures were elucidated on the basis of chemical and spectroscopic evidence and comparisons with the literature data of related compounds.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"262 - 264"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavonoids from Herb of Ononis pusilla 黄酮类化合物的研究
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04649-8
S. V. Kovalev, N. N. Deviatkina, A. S. Smirnov, V. N. Kovalev, V. P. Khilya
{"title":"Flavonoids from Herb of Ononis pusilla","authors":"S. V. Kovalev,&nbsp;N. N. Deviatkina,&nbsp;A. S. Smirnov,&nbsp;V. N. Kovalev,&nbsp;V. P. Khilya","doi":"10.1007/s10600-025-04649-8","DOIUrl":"10.1007/s10600-025-04649-8","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"367 - 368"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Novel Curcumin Derivatives as Potential Anti-Lung Cancer Agents by Inhibiting Cell Proliferation and Migration 新的姜黄素衍生物通过抑制细胞增殖和迁移作为潜在的抗肺癌药物
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04623-4
Weiya Cao, Pan Yu, Qiaoping Wu, Na Che, Siyuan Liu, Nan Yin, Shuhui Feng
{"title":"Discovery of Novel Curcumin Derivatives as Potential Anti-Lung Cancer Agents by Inhibiting Cell Proliferation and Migration","authors":"Weiya Cao,&nbsp;Pan Yu,&nbsp;Qiaoping Wu,&nbsp;Na Che,&nbsp;Siyuan Liu,&nbsp;Nan Yin,&nbsp;Shuhui Feng","doi":"10.1007/s10600-025-04623-4","DOIUrl":"10.1007/s10600-025-04623-4","url":null,"abstract":"<p>The antitumor activity and the underlying mechanism of six novel curcumin derivatives (<b>F1–F6</b>) were evaluated in lung cancer cells. <b>F5</b> was found to be the most potent derivative (IC<sub>50</sub> = 13.67 μM) compared to curcumin (IC<sub>50</sub> = 40.93 μM), with significant differences via MTT assay. A series of pharmacological experiments, including clone formation, wound healing, and transwell assay, reveal that <b>F5</b> can inhibit lung cell proliferation and migration. Western blot and molecular docking studies demonstrate that the potential mechanism may relate to the regulation of the AKT/ERK/MMP9 signaling pathway. Therefore, curcumin derivative <b>F5</b> can potentially be used for treating lung cancer.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"251 - 256"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites of Ficus benjamina 榕树次生代谢产物
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04654-x
C. Y. Chen, C. M. Liu, H. C. Yeh, W. J. Li, H. T. Li
{"title":"Secondary Metabolites of Ficus benjamina","authors":"C. Y. Chen,&nbsp;C. M. Liu,&nbsp;H. C. Yeh,&nbsp;W. J. Li,&nbsp;H. T. Li","doi":"10.1007/s10600-025-04654-x","DOIUrl":"10.1007/s10600-025-04654-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"381 - 382"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Flavonol Glycosides from the Genus Dryas 树属黄酮醇新苷类
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04621-6
D. N. Olennikov, N. I. Kashchenko, V. M. Shishmarev
{"title":"New Flavonol Glycosides from the Genus Dryas","authors":"D. N. Olennikov,&nbsp;N. I. Kashchenko,&nbsp;V. M. Shishmarev","doi":"10.1007/s10600-025-04621-6","DOIUrl":"10.1007/s10600-025-04621-6","url":null,"abstract":"<p>Studies of three species of <i>Dryas</i> (<i>D. sumneviczii</i> Serg., <i>D. octopetala</i> L., <i>D. oxyodonta</i> Juz., Rosaceae), growing in Baikal District led to the isolation of 19 flavonoids, including seven new flavonol glycosides. UV and NMR spectroscopic and mass spectrometric data characterized the new flavonoids as 8-methoxykaempferol 3-<i>O</i>-<i>α</i>-L-arabinopyranoside (dryadoside A, <b>1</b>), 8-methoxykaempferol 3-<i>O</i>-<i>α</i>-Larabinofuranoside (dryadoside B, <b>2</b>), 8-methoxyquercetin 3-<i>O</i>-<i>α</i>-L-arabinopyranoside (dryadoside C, <b>3</b>), 8-methoxykaempferol 3-<i>O</i>-(6′′-<i>O</i>-caffeyl)-<i>β</i>-D-galactopyranoside (dryadoside D, <b>5</b>), 8-methoxykaempferol 3-<i>O</i>-(2′′-<i>O</i>-caffeyl)-<i>α</i>-L-arabinofuranoside (dryadoside E, <b>6</b>), 8-methoxyquercetin 3-<i>O</i>-(6′′-<i>O</i>-caffeyl)-<i>β</i>-Dgalactopyranoside (dryadoside F, <b>7</b>), and 8-methoxyquercetin 3-<i>O</i>-(2′′-<i>O</i>-caffeyl)-<i>α</i>-L-arabinofuranoside (dryadoside G, <b>8</b>). Compounds <b>5–8</b> inhibited the activity of human pancreatic lipase.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"237 - 242"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites from the Soil-Derived Fungus Trichoderma sp. BCRC-18F0056 土源真菌木霉sp. BCRC-18F0056的代谢物
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04629-y
Ming-Jen Cheng, Hsia-Wei Liu, Jyh-Yih Leu, Ming-Der Wu, Chang-Yu Chang, Kai-Chun Hung, Chung-Yi Chen, Jih-Jung Chen, Chih-Zen Chang, Hsien-Ting Pan
{"title":"Metabolites from the Soil-Derived Fungus Trichoderma sp. BCRC-18F0056","authors":"Ming-Jen Cheng,&nbsp;Hsia-Wei Liu,&nbsp;Jyh-Yih Leu,&nbsp;Ming-Der Wu,&nbsp;Chang-Yu Chang,&nbsp;Kai-Chun Hung,&nbsp;Chung-Yi Chen,&nbsp;Jih-Jung Chen,&nbsp;Chih-Zen Chang,&nbsp;Hsien-Ting Pan","doi":"10.1007/s10600-025-04629-y","DOIUrl":"10.1007/s10600-025-04629-y","url":null,"abstract":"<p>One previously undescribed phenol analog, 18F0056 (<b>1</b>), together with two known ones, indole-3-carboxylic acid (<b>2</b>), ergosterol peroxide (<b>3</b>) were isolated from the mycelial EtOAc extracts of soil-derived fungus <i>Trichoderma</i> sp. BCRC-18F0056. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"278 - 280"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrroloisoquinolines from Nicotiana tabacum Derived Endophytic Fungus Aspergillus puniceus and its Bioactivity 烟草内生真菌 Aspergillus puniceus 中的吡咯异喹啉及其生物活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04644-z
Li-Ying Yang, Yi Li, Gui-Feng Li, Gui-Juan Zhao, Pei-Song Yang
{"title":"Pyrroloisoquinolines from Nicotiana tabacum Derived Endophytic Fungus Aspergillus puniceus and its Bioactivity","authors":"Li-Ying Yang,&nbsp;Yi Li,&nbsp;Gui-Feng Li,&nbsp;Gui-Juan Zhao,&nbsp;Pei-Song Yang","doi":"10.1007/s10600-025-04644-z","DOIUrl":"10.1007/s10600-025-04644-z","url":null,"abstract":"<p>Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinolin-7-ol (<b>1</b>) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinoline (<b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the <i>Nicotiana tabacum</i>-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds <b>1</b> and <b>2</b> exhibited potential anti-SARS-CoV-2 activity with IC<sub>50</sub> of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds <b>1</b> and <b>2</b> showed obvious anti-<i>Gibberella cichoracearum</i> (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"346 - 350"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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