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Cucurbitane Triterpenoids from the Whole Herb of Chrysosplenium carnosum 金合春全草中的葫芦烷三萜
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04636-z
Gang Ren, Fei Yang, Wei Jiang, Haofen Wu, Yunlong Chen, Aihong Liu, Wenyan Li
{"title":"Cucurbitane Triterpenoids from the Whole Herb of Chrysosplenium carnosum","authors":"Gang Ren,&nbsp;Fei Yang,&nbsp;Wei Jiang,&nbsp;Haofen Wu,&nbsp;Yunlong Chen,&nbsp;Aihong Liu,&nbsp;Wenyan Li","doi":"10.1007/s10600-025-04636-z","DOIUrl":"10.1007/s10600-025-04636-z","url":null,"abstract":"<p><i>Chrysosplenium carnosum</i>, an original plant used in traditional Tibetan medicine known as “Yajima”, was subjected to phytochemical study. This led to the isolation of a new hexanor-cucurbitane triterpenoid, namely chrycarnin A (<b>1</b>), along with three previously known structurally related analogs (<b>2–4</b>). Their structures were determined by spectroscopic methods, including 1D and 2D NMR, UV, IR, ECD, and HR-ESI-MS, and comparison of the spectroscopic data with those reported in the literature.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"310 - 313"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volatile Components and Cholinesterase Inhibitory Activity of Mesua daphnifolia from Malaysia 马来西亚鹅掌楸的挥发性成分和胆碱酯酶抑制活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04659-6
Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Nurunajah Ab Ghani, Shamsul Khamis, Mohd Afiq Aizat Juhari, Arwa R. Althaher
{"title":"Volatile Components and Cholinesterase Inhibitory Activity of Mesua daphnifolia from Malaysia","authors":"Wan Mohd Nuzul Hakimi Wan Salleh,&nbsp;Abubakar Siddiq Salihu,&nbsp;Nurunajah Ab Ghani,&nbsp;Shamsul Khamis,&nbsp;Mohd Afiq Aizat Juhari,&nbsp;Arwa R. Althaher","doi":"10.1007/s10600-025-04659-6","DOIUrl":"10.1007/s10600-025-04659-6","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"394 - 395"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformation of 5α-Pregnenolone Into Some Hydrazones: Synthesis and Biological Activity 5α-孕烯醇酮向某些腙的转化：合成及其生物活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04634-1
N. Sh. Nadaraia, N. N. Barbakadze, T. B. Kvaratskhelia, M. L. Kakhabrishvili, J. Legault, K. G. Mulkidzhanyan, V. D. Mshvildadze
{"title":"Transformation of 5α-Pregnenolone Into Some Hydrazones: Synthesis and Biological Activity","authors":"N. Sh. Nadaraia,&nbsp;N. N. Barbakadze,&nbsp;T. B. Kvaratskhelia,&nbsp;M. L. Kakhabrishvili,&nbsp;J. Legault,&nbsp;K. G. Mulkidzhanyan,&nbsp;V. D. Mshvildadze","doi":"10.1007/s10600-025-04634-1","DOIUrl":"10.1007/s10600-025-04634-1","url":null,"abstract":"<p>Three series of <i>N</i>-containing 5<i>α</i>-steroids were synthesized during a search for biologically active steroids from pregn-16-en-3<i>β</i>-ol-20-one. The structures of the synthesized compounds were proved using <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectra. Studies of the <i>in vitro</i> cytotoxic, anti-inflammatory, and antioxidant activity of 14 synthesized steroids identified four compounds with pronounced anti-inflammatory activity and one with cytotoxic activity against colorectal adenocarcinoma cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"300 - 305"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential Oil Composition and Antioxidant Activity of Inula grandiflora from North-West Himalayas 西北喜马拉雅地区大花菊精油成分及抗氧化活性研究
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04661-y
Saroj Kumar Pradhan, Vivek Sharma
{"title":"Essential Oil Composition and Antioxidant Activity of Inula grandiflora from North-West Himalayas","authors":"Saroj Kumar Pradhan,&nbsp;Vivek Sharma","doi":"10.1007/s10600-025-04661-y","DOIUrl":"10.1007/s10600-025-04661-y","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"398 - 400"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Furan-Containing Pyrrolo[2,1-a]Isoquinoline Derivatives Based on Phosphoranylidenesucciminide 磷酰亚胺基含呋喃吡咯[2,1-a]异喹啉衍生物的合成
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04642-1
G. F. Sakhautdinova, I. M. Sakhautdinov, A. G. Mustafin
{"title":"Synthesis of Furan-Containing Pyrrolo[2,1-a]Isoquinoline Derivatives Based on Phosphoranylidenesucciminide","authors":"G. F. Sakhautdinova,&nbsp;I. M. Sakhautdinov,&nbsp;A. G. Mustafin","doi":"10.1007/s10600-025-04642-1","DOIUrl":"10.1007/s10600-025-04642-1","url":null,"abstract":"<p>A synthetic method for new furan-containing tetrahydropyrroloisoquinolinone derivatives based on the use of <i>N</i>-homoveratrylsuccinimide phosphorane and furfurol derivatives is reported for the first time.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"335 - 338"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Compounds of Gelsemium elegans and their Anti-Cancer Activity 线虫的化学成分及其抗癌活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04645-y
Lu-Yi Zhao, Yang Hong, Chao-Qun Wang, Xiang-Wei Zheng, Xin Fang, Shuang Liang
{"title":"Chemical Compounds of Gelsemium elegans and their Anti-Cancer Activity","authors":"Lu-Yi Zhao,&nbsp;Yang Hong,&nbsp;Chao-Qun Wang,&nbsp;Xiang-Wei Zheng,&nbsp;Xin Fang,&nbsp;Shuang Liang","doi":"10.1007/s10600-025-04645-y","DOIUrl":"10.1007/s10600-025-04645-y","url":null,"abstract":"<p>Thirty-three compounds were isolated from <i>Gelsemium elegans.</i> Among them, compound <b>16</b> was a new natural product and its absolute configuration was elucidated by spectral analysis and an esterification reaction. Compounds <b>14</b>, <b>17</b>, <b>24</b>, <b>25</b>, <b>26</b>, <b>29</b>, <b>30</b>, and <b>32</b> were isolated from this plant for the first time. Compounds <b>1–23</b> were screened for their <i>in vitro</i> inhibitory activities against the human breast cancer cell line MCF-7 and mouse hepatocellular carcinoma cell line Hepa 1-6. The results showed <b>1</b>, <b>13</b>, <b>14</b> and the total alkaloids had different inhibitory activities against the cancer cell lines previously mentioned.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"351 - 355"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Inflammatory and Antioxidant Constituents from Cuscuta japonica var. formosana 台湾菟丝子抗炎及抗氧化成分研究
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04639-w
Li-Chai Chen, Chien-Ming Huang, Zih-Rong Chen, Chia-Ching Liaw, Ming-Jen Cheng, Jen-Wen Hsiao, Jih-Jung Chen
{"title":"Anti-Inflammatory and Antioxidant Constituents from Cuscuta japonica var. formosana","authors":"Li-Chai Chen,&nbsp;Chien-Ming Huang,&nbsp;Zih-Rong Chen,&nbsp;Chia-Ching Liaw,&nbsp;Ming-Jen Cheng,&nbsp;Jen-Wen Hsiao,&nbsp;Jih-Jung Chen","doi":"10.1007/s10600-025-04639-w","DOIUrl":"10.1007/s10600-025-04639-w","url":null,"abstract":"<p>A new amide derivative, cuscujaponamide (<b>1</b>), has been isolated from the aerial parts of <i>Cuscuta japonica</i> var. <i>formosana</i>, together with eight known compounds, kaempferol (<b>2</b>), quercetin (<b>3</b>), astragalin (<b>4</b>), hyperoside (<b>5</b>), (+)-pinoresinol (<b>6</b>), (+)-sesamin (<b>7</b>), caffeic acid (<b>8</b>), and <i>p</i>-coumaric acid (<b>9</b>). The structure of the new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolates, cuscujaponamide (<b>1</b>), kaempferol (<b>2</b>), hyperoside (<b>5</b>), and (+)-pinoresinol (<b>6</b>) showed potent inhibition with IC<sub>50</sub> values of 16.03 ±1.46, 18.52 ± 1.70, 18.17 ± 1.64, and 15.90 ± 2.04 μM, respectively, against LPS-induced NO generation. In addition, compounds <b>1</b>, <b>2</b>, <b>3</b>, and <b>5</b> also showed potent DPPH radicals scavenging activities with IC<sub>50</sub> values of 17.29 ± 1.63, 19.02 ± 2.14, 15.62 ±1.42, and 13.25 ±1.45 μM, respectively.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"322 - 326"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites and Cytotoxic Activity of Endophytic Fungus of Aspergillus terreus from Plantago asiatica 车前草土曲霉内生真菌次生代谢物及细胞毒活性研究
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI: 10.1007/s10600-025-04655-w
Jinlong Pu, Jian Lu, Rui Dong, Lingling Li, Taofeng Zhang, Shuhong Yang, Xiuying Pu, Aimei Yang
{"title":"Secondary Metabolites and Cytotoxic Activity of Endophytic Fungus of Aspergillus terreus from Plantago asiatica","authors":"Jinlong Pu,&nbsp;Jian Lu,&nbsp;Rui Dong,&nbsp;Lingling Li,&nbsp;Taofeng Zhang,&nbsp;Shuhong Yang,&nbsp;Xiuying Pu,&nbsp;Aimei Yang","doi":"10.1007/s10600-025-04655-w","DOIUrl":"10.1007/s10600-025-04655-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"383 - 385"},"PeriodicalIF":0.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition and Antioxidant Activity of the Leaf Essential Oil of Cratoxylum formosum from Malaysia 马来西亚 Cratoxylum formosum 叶精油的化学成分和抗氧化活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04660-z
Wen-Nee Tan, Effa Nadiah Mohd Ali Hanafiah, Juzaili Azizi, Arif Fadlan, Woei-Yenn Tong, Chean-Ring Leong, Nuniek Herdyastuti
{"title":"Chemical Composition and Antioxidant Activity of the Leaf Essential Oil of Cratoxylum formosum from Malaysia","authors":"Wen-Nee Tan,&nbsp;Effa Nadiah Mohd Ali Hanafiah,&nbsp;Juzaili Azizi,&nbsp;Arif Fadlan,&nbsp;Woei-Yenn Tong,&nbsp;Chean-Ring Leong,&nbsp;Nuniek Herdyastuti","doi":"10.1007/s10600-025-04660-z","DOIUrl":"10.1007/s10600-025-04660-z","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"396 - 397"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Pyridine Alkaloids from Portulaca oleracea and their Anti-Inflammatory and Antioxidant Activities 马齿苋中两种吡啶类生物碱及其抗炎和抗氧化活性
IF 0.8 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI: 10.1007/s10600-025-04646-x
Xiaoqian Zhang, Shuangshuo Liu, Wenjuan Wei, Jing Liu, Pengyan Liu, Ying Yang, Xixiang Ying
{"title":"Two Pyridine Alkaloids from Portulaca oleracea and their Anti-Inflammatory and Antioxidant Activities","authors":"Xiaoqian Zhang,&nbsp;Shuangshuo Liu,&nbsp;Wenjuan Wei,&nbsp;Jing Liu,&nbsp;Pengyan Liu,&nbsp;Ying Yang,&nbsp;Xixiang Ying","doi":"10.1007/s10600-025-04646-x","DOIUrl":"10.1007/s10600-025-04646-x","url":null,"abstract":"<p>Two pyridine alkaloids, 5-ethoxypyridin-2-ol, named olerapyridineol (<b>1</b>) and methyl 5-hydroxynicotinate (<b>2</b>), were obtained from the <i>Portulaca oleracea</i> L., from which compound <b>1</b> was the new compound and compound <b>2</b> was isolated from <i>P. oleracea</i> for the first time. The structure of compound <b>1</b> was identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR. Compounds <b>1–2</b> presented antioxidant activities with IC<sub>50</sub> values of 42.625 ± 0.37, 37.423 ± 0.43 μM. In addition, the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages of compounds <b>1–2</b> were also investigated.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"356 - 359"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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