A New Secondary Metabolite with Cytotoxicity from Formosa Tithonia diversifolia

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-09-19 DOI:10.1007/s10600-025-04789-x

Rou-Yi Fang, Mei-Chin Lu, Chi-I Chang, Jue-Liang Hsu, Chih-I Liu, Huey-Jen Su, Yun-Sheng Lin

引用次数: 0

Abstract

A new germacrane sesquiterpene, tagitinin J (1), along with five previously reported known sesquiterpenes (2–6), and two caffeoylquinic acid derivatives (7 and 8) were isolated from the branches and leaves of Tithonia diversifolia (Hemsl.) A. Gray. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. In addition, the in vitro cytotoxic activities of those compounds were evaluated against DLD-1, MOLT-4, LNCaP, and PC3 human tumor cell lines.

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一种具有细胞毒性的新次生代谢物

从山楂（Tithonia difolia, Hemsl）的枝叶中分离得到了一种新的山楂属倍半萜类化合物tagitinin J(1)，以及5种已知的倍半萜类化合物（2-6）和2种咖啡酰奎宁酸衍生物（7和8）。答:灰色。这些结构是通过广泛的光谱分析和与相关已知化合物的光谱数据比较确定的。此外，我们还研究了这些化合物对人肿瘤DLD-1、MOLT-4、LNCaP和PC3细胞的体外细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.