Li-Ying Yang, Yi Li, Gui-Feng Li, Gui-Juan Zhao, Pei-Song Yang
{"title":"烟草内生真菌 Aspergillus puniceus 中的吡咯异喹啉及其生物活性","authors":"Li-Ying Yang, Yi Li, Gui-Feng Li, Gui-Juan Zhao, Pei-Song Yang","doi":"10.1007/s10600-025-04644-z","DOIUrl":null,"url":null,"abstract":"<p>Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinolin-7-ol (<b>1</b>) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinoline (<b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the <i>Nicotiana tabacum</i>-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds <b>1</b> and <b>2</b> exhibited potential anti-SARS-CoV-2 activity with IC<sub>50</sub> of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds <b>1</b> and <b>2</b> showed obvious anti-<i>Gibberella cichoracearum</i> (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"346 - 350"},"PeriodicalIF":0.8000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pyrroloisoquinolines from Nicotiana tabacum Derived Endophytic Fungus Aspergillus puniceus and its Bioactivity\",\"authors\":\"Li-Ying Yang, Yi Li, Gui-Feng Li, Gui-Juan Zhao, Pei-Song Yang\",\"doi\":\"10.1007/s10600-025-04644-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinolin-7-ol (<b>1</b>) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinoline (<b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the <i>Nicotiana tabacum</i>-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds <b>1</b> and <b>2</b> exhibited potential anti-SARS-CoV-2 activity with IC<sub>50</sub> of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds <b>1</b> and <b>2</b> showed obvious anti-<i>Gibberella cichoracearum</i> (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.</p>\",\"PeriodicalId\":514,\"journal\":{\"name\":\"Chemistry of Natural Compounds\",\"volume\":\"61 2\",\"pages\":\"346 - 350\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry of Natural Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10600-025-04644-z\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04644-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Pyrroloisoquinolines from Nicotiana tabacum Derived Endophytic Fungus Aspergillus puniceus and its Bioactivity
Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinolin-7-ol (1) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline (2), together with five known pyrroloisoquinolines (3–7) were isolated from the Nicotiana tabacum-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds 1 and 2 exhibited potential anti-SARS-CoV-2 activity with IC50 of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds 1 and 2 showed obvious anti-Gibberella cichoracearum (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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