乌拉尔金丝桃中具有细胞毒性的聚丙烯酰化酰基间苯三酚

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-24 DOI:10.1007/s10600-025-04630-5

Jiang Hu, Fengming Xu, Guihua Yu, Tao Lv, Qiang Li, Nianhua Jin, Hongzhou Jin

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引用次数: 0

摘要

对乌拉尔金丝桃（Hypericum uralum）全株植物进行化学研究，得到了两个先前未被描述的多环聚戊烯基化衍生物，高尿酸啉A和B（1和2）。新化合物的结构通过1D和2D （1H-1H COSY、HMQC和HMBC）核磁共振波谱以及高分辨率质谱分析得到。分离的化合物在体外对三种人类肿瘤细胞系进行了细胞毒活性测试。结果表明，化合物2对3种肿瘤细胞系（MGC-803、BGC-823和SGC-7901）的IC50值分别为14.6±3.3、17.5±4.1和15.7±3.9 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cytotoxic Polyprenylated Acylphloroglucinols from Hypericum uralum

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Cytotoxic Polyprenylated Acylphloroglucinols from Hypericum uralum

A chemical investigation on the whole plant of Hypericum uralum afforded two previously undescribed polycyclic polyprenylated derivatives, hyperuralines A and B (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (¹H–¹H COSY, HMQC, and HMBC) NMR spectroscopy, together with high-resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against three human tumour cell lines. As a result, compound 2 exhibited modest cytotoxic potential against the three tested tumour cell lines (MGC-803, BGC-823, and SGC-7901) with IC₅₀ values of 14.6 ± 3.3, 17.5 ± 4.1, 15.7 ± 3.9 μM, respectively.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.