Yuan-Dong Li, Jian Mei, Yan-Qing Duan, Jin Wang, Jian-Duo Zhang, Jin Li, Heng Wu, Qiu-Fen Hu, Ju-Xing Jiang, Hua-Yin Liu
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Two New Antibacterial Naphtho[2,3-b]Furans from the Dry Distillation Products of Tobacco Stem Bark
In this study, two new naphtho[2,3-b]furans (1 and 2), together with five known naphthalene analogues (3–7), were isolated from the dry distillation products of tobacco stem bark. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter in the range of 17.0 ± 1.6–25.8 ± 2.5 mm against the above strains, while most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for 1 and 2 used as an antiseptic agent were also evaluated, indicating that they have potential value for use as an antiseptic agent for cigarette tipping paper.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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