Structurally Diverse Flavonolignans with Hepatoprotective Activities from the Fruits of Hippophae rhamnoides

Abstract

A novel flavonolignan, named 3,3′,4′,5-tetrahydroxy-3′′′,5′′′-dimethoxy-9′,9′′′dihydroxymethyl-4- hydroxyphenyl-4′′′-hydroxy-3′′′,5′′′-dimethoxyphenylflavonolignan (1), together with five known flavonolignan derivatives (2–6) were isolated from Hippophae rhamnoides L. for the first time. Their structures were determined by extensive and comprehensive IR, UV, NMR, MS spectra, as well as reported references. Compounds 1–6 were evaluated for their hepatoprotective activities on APAP-treated HepG2 cells. As a result, compounds 1 and 2 exhibited moderate hepatoprotective activities.