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Phenylpropanoid Glycosides from the Endophytic Fungus Pestalotiopsis uvicola GMH31 内生真菌uvicola拟盘多毛孢GMH31的苯丙苷
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-23 DOI: 10.1007/s10600-025-04732-0
Xiao-Han Li, Xing-Bian Yang, Jun He, Ji-Chuan Kang, Yi-Xin Qian
{"title":"Phenylpropanoid Glycosides from the Endophytic Fungus Pestalotiopsis uvicola GMH31","authors":"Xiao-Han Li,&nbsp;Xing-Bian Yang,&nbsp;Jun He,&nbsp;Ji-Chuan Kang,&nbsp;Yi-Xin Qian","doi":"10.1007/s10600-025-04732-0","DOIUrl":"10.1007/s10600-025-04732-0","url":null,"abstract":"<p>A new phenylpropanoid glycoside, named <i>β</i>-(3,4-dihydroxyphenyl)ethyl-<i>O</i>-α-L-rhamnopyranosyl-(1→3)-<i>β</i>-D-(4-<i>O</i>-caffeoyl)-(6-<i>O</i>-benzoyl)glucopyranoside (<b>1</b>), and three known phenylpropanoid glycosides <b>2–4</b> were isolated from the endophytic fungus <i>Pestalotiopsis uvicola</i> GMH31 for the first time. Their structures were determined by their comprehensive spectral data and reported references.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"663 - 665"},"PeriodicalIF":0.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents from Leaves of Ficus carica and Their Antimicrobial Activity 无花果叶化学成分及其抑菌活性研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-23 DOI: 10.1007/s10600-025-04755-7
D. Chen, Y. Yuan, Z. Li, C. Liu, H. A. Aisa
{"title":"Chemical Constituents from Leaves of Ficus carica and Their Antimicrobial Activity","authors":"D. Chen,&nbsp;Y. Yuan,&nbsp;Z. Li,&nbsp;C. Liu,&nbsp;H. A. Aisa","doi":"10.1007/s10600-025-04755-7","DOIUrl":"10.1007/s10600-025-04755-7","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"770 - 772"},"PeriodicalIF":0.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Dihydrofuran Cembrane-Type Diterpene from Okinawan Soft Coral Sarcophyton sp. 冲绳软珊瑚中新型二氢呋喃膜型二萜。
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04736-w
Karen Takashima, Kazuki Tani, Tsukasa Orita, Kozue Sakao, Takahiro Ishii
{"title":"Novel Dihydrofuran Cembrane-Type Diterpene from Okinawan Soft Coral Sarcophyton sp.","authors":"Karen Takashima,&nbsp;Kazuki Tani,&nbsp;Tsukasa Orita,&nbsp;Kozue Sakao,&nbsp;Takahiro Ishii","doi":"10.1007/s10600-025-04736-w","DOIUrl":"10.1007/s10600-025-04736-w","url":null,"abstract":"<p>Novel dihydrofuran cembrane-type diterpene, 8-<i>epi</i>-8-hydroxyisosarcophytoxid-6-ene (<b>1</b>), along with eight known compounds – 8-hydroxyisosarcophytoxid-6-ene (<b>2</b>), sarcophytonin A (<b>3</b>), isosarcophytoxide (<b>4</b>), (+)-17-hydroxyisosarcophytoxide (<b>5</b>), (2<i>S</i>*,7<i>S</i>*,8<i>S</i>*,11<i>R</i>*,1<i>Z</i>,3<i>E</i>)-7,8:2,16-diepoxycembra-1(15),3,12(20)-trien-11-ol (<b>6</b>), crassmol A (<b>7</b>), (2<i>S</i>,3<i>R</i>,4<i>E</i>,8<i>E</i>)-<i>N</i>-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (<b>8</b>), and sarcomilasterol (<b>9</b>) – were isolated from the soft coral, <i>Sarcophyton</i> sp., collected from the coast of Irijima, Urasoe City, Okinawa Prefecture, Japan. The chemical structures of the isolated compounds were elucidated by the FTIR, NMR, and HR-ESI-MS analyses. The relative stereochemistry of <b>1</b> was determined using NOESY. Compounds <b>1–9</b> were evaluated for their inhibitory effects on HCT116 cell proliferation. All compounds demonstrated antiproliferative activity at 25 μM, with compound <b>9</b> showing the most pronounced effect (IC<sub>50</sub> = 10.55 ± 0.68 μM).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"681 - 685"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two New Antibacterial Benzoazepines from a Cigar-Tobacco-Derived Endophytic Aspergillus fumigatus 从烟曲霉内生真菌中提取的两种新型抗菌苯并氮卓类药物
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04746-8
Yu-Ping Wu, Hua-Yin Liu, Heng Yao, Gao-Kun Zhao, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Ling-Duo Bu, Guang-Hui Kong
{"title":"Two New Antibacterial Benzoazepines from a Cigar-Tobacco-Derived Endophytic Aspergillus fumigatus","authors":"Yu-Ping Wu,&nbsp;Hua-Yin Liu,&nbsp;Heng Yao,&nbsp;Gao-Kun Zhao,&nbsp;Yu-Long Su,&nbsp;Xue-Ru Song,&nbsp;Wei Li,&nbsp;Wei-Guang Wang,&nbsp;Qiu-Fen Hu,&nbsp;Ling-Duo Bu,&nbsp;Guang-Hui Kong","doi":"10.1007/s10600-025-04746-8","DOIUrl":"10.1007/s10600-025-04746-8","url":null,"abstract":"<p>In this study, two new benzoazepines (<b>1</b> and <b>2</b>), together with five known analogs (<b>3–7</b>) were isolated from the cigar-tobacco-derived endophytic Aspergillus fumigatus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. All compounds were evaluated for their antibacterial activities against five nitrosobacteria strains <i>Nitrosomonas communis</i>, <i>Nitrosomonas nitrosa</i>, <i>Nitrosospira multiformis</i>, <i>Nitrobacter winogradskyi</i>, and <i>Nitrospira inopinata</i>. Interestingly, compounds <b>1–7</b> exhibited notable antibacterial activity with bacteriostatic diameters within the range 13.8 ± 1.9–26.3 ± 2.5 mm against five nitrosobacteria strains, and most of the bacteriostatic diameters are higher than that of positive controls. Owing to the nitrosobacteria having the ability to convert nitrogen components into nitrite in tobacco, and then converting to tobacco-specific nitrosamines (TSNAs), the above compounds have the potential to reduce TSNAs in tobacco by inhibiting nitrosobacteria during the fermentation process of tobacco leaves.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"737 - 741"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volatile Constituents and In Vitro Antioxidant Activity of Leaf Essential Oil of Hydrocera triflora 三花水仙叶精油挥发性成分及体外抗氧化活性研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04768-2
Biswabhusan Dash, Prabhat Kumar Das, Soumya Swarup Panda, Omprakash Mohanta, Jasasmita Parida, Ambika Sahoo, Sudipta Jena, Asit Ray, Sanghamitra Nayak, Pratap Chandra Panda
{"title":"Volatile Constituents and In Vitro Antioxidant Activity of Leaf Essential Oil of Hydrocera triflora","authors":"Biswabhusan Dash,&nbsp;Prabhat Kumar Das,&nbsp;Soumya Swarup Panda,&nbsp;Omprakash Mohanta,&nbsp;Jasasmita Parida,&nbsp;Ambika Sahoo,&nbsp;Sudipta Jena,&nbsp;Asit Ray,&nbsp;Sanghamitra Nayak,&nbsp;Pratap Chandra Panda","doi":"10.1007/s10600-025-04768-2","DOIUrl":"10.1007/s10600-025-04768-2","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"812 - 814"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoselective Synthesis of 2-Ester and Dioxolane Derivatives of 20-Hydroxyecdysone and Poststerone 20-羟基蜕皮酮和后睾酮2-酯和二氧烷衍生物的化学选择性合成
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04737-9
R. G. Savchenko, L. V. Parfenova
{"title":"Chemoselective Synthesis of 2-Ester and Dioxolane Derivatives of 20-Hydroxyecdysone and Poststerone","authors":"R. G. Savchenko,&nbsp;L. V. Parfenova","doi":"10.1007/s10600-025-04737-9","DOIUrl":"10.1007/s10600-025-04737-9","url":null,"abstract":"<p>Chemoselective approaches to the synthesis of ester and cyclic acetal derivatives of ecdysteroids with 5-bromovaleric and lipoic acids and aromatic heterocyclic aldehydes were proposed. Chemoselective formation of 2-monoester derivatives (compounds <b>4</b>–<b>7</b>) or dioxolane adducts (compounds <b>8</b>–<b>10</b>) occurred during condensation of an ecdysteroid with an acid or aldehyde. Compound <b>8</b>, which was prepared by acid-catalyzed condensation of 20-hydroxyecdysone with furfuraldehyde, was an analog of the phytoecdysteroid serfurosterone A, which was isolated from the plant Achyranthes bidentata.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"686 - 691"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile and Biological Activity of Essential Oil from Roots of Ferula tenuisecta 藤阿魏根挥发油的特征及生物活性研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04764-6
D. T. Asilbekova, G. Ozek, T. Ozek, Kh. M. Bobakulov, S. A. Sasmakov, A. M. Nigmatullaev
{"title":"Profile and Biological Activity of Essential Oil from Roots of Ferula tenuisecta","authors":"D. T. Asilbekova,&nbsp;G. Ozek,&nbsp;T. Ozek,&nbsp;Kh. M. Bobakulov,&nbsp;S. A. Sasmakov,&nbsp;A. M. Nigmatullaev","doi":"10.1007/s10600-025-04764-6","DOIUrl":"10.1007/s10600-025-04764-6","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"801 - 803"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents of Limonium coralloides and Their Biological Activity 珊瑚酸锂的化学成分及其生物活性
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04763-7
Z. Abuduhelili, J. Li, L. Liu, P. Sukhrobov, H. A. Aisa, J. Y. Zhao
{"title":"Chemical Constituents of Limonium coralloides and Their Biological Activity","authors":"Z. Abuduhelili,&nbsp;J. Li,&nbsp;L. Liu,&nbsp;P. Sukhrobov,&nbsp;H. A. Aisa,&nbsp;J. Y. Zhao","doi":"10.1007/s10600-025-04763-7","DOIUrl":"10.1007/s10600-025-04763-7","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"798 - 800"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive Non-Alkaloidal Chemical Constituents of Daphniphyllum oldhamii 水蚤的非生物碱活性化学成分研究
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04759-3
Qi-Bin Yang, Di-Fang Zhang, Ling Zhang, Lin-Fu Liang
{"title":"Bioactive Non-Alkaloidal Chemical Constituents of Daphniphyllum oldhamii","authors":"Qi-Bin Yang,&nbsp;Di-Fang Zhang,&nbsp;Ling Zhang,&nbsp;Lin-Fu Liang","doi":"10.1007/s10600-025-04759-3","DOIUrl":"10.1007/s10600-025-04759-3","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"785 - 787"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Phenolic Glycosides from Humulus lupulus and Their Inhibitory Activity Against DGKζ 葎草酚类新苷类及其对DGKζ的抑制活性
IF 0.9 4区 化学
Chemistry of Natural Compounds Pub Date : 2025-07-22 DOI: 10.1007/s10600-025-04730-2
Y. Wang, H. A. Aisa, G. Zou, Z. Li
{"title":"New Phenolic Glycosides from Humulus lupulus and Their Inhibitory Activity Against DGKζ","authors":"Y. Wang,&nbsp;H. A. Aisa,&nbsp;G. Zou,&nbsp;Z. Li","doi":"10.1007/s10600-025-04730-2","DOIUrl":"10.1007/s10600-025-04730-2","url":null,"abstract":"<p>The new chromone derivative 1-[(2-methylpropanoyl)chromone]-<i>β</i>-D-glucopyranoside (<b>1</b>) together with eight known compounds (<b>2–9</b>) were isolated from <i>Humulus lupulus</i> (common hops). The structures of the isolated compounds were confirmed by detailed analyses of NMR and HR-ESI-MS data. The glucose fragment in <b>1</b> was determined as the D-glucoside based on GC analysis. Compounds <b>2</b>, <b>4</b>, and <b>5</b> exhibited significant inhibitory activity against diacylglycerol kinase ζ (DGKζ). Compound <b>5</b> demonstrated strong inhibition of DGKζ with an IC<sub>50</sub> value of 1.60 μM. Molecular docking studies gave important information about the role of the galloyl group in DGKζ inhibition.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"653 - 658"},"PeriodicalIF":0.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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