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Bioactivity Biphenyls from Sun-Cured Tobacco-Derived Endophytic Fungus Aspergillus fumigatus 烤烟内生真菌烟曲霉的生物活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-04994-2
Jing Li, Zhi-Hua Huang, Shu-Hao Xu, Yong Xu, Chao Min, Biao Li, Zheng-Nan Jia, Jin Wang, Jue-Ting Liu, Yi-Shan Duan, Wen-Bing Zhou
{"title":"Bioactivity Biphenyls from Sun-Cured Tobacco-Derived Endophytic Fungus Aspergillus fumigatus","authors":"Jing Li,&nbsp;Zhi-Hua Huang,&nbsp;Shu-Hao Xu,&nbsp;Yong Xu,&nbsp;Chao Min,&nbsp;Biao Li,&nbsp;Zheng-Nan Jia,&nbsp;Jin Wang,&nbsp;Jue-Ting Liu,&nbsp;Yi-Shan Duan,&nbsp;Wen-Bing Zhou","doi":"10.1007/s10600-026-04994-2","DOIUrl":"10.1007/s10600-026-04994-2","url":null,"abstract":"<p>Two new biphenyls, 3,4′ ,5-trimethoxy-3′-(4-methylfuran-2-yl)-[1,1′-biphenyl]-4-ol (<b>1</b>) and 3′-(4-(hydroxymethyl)furan-2-yl)-3,4′,5-trimethoxy-[1,1′-biphenyl]-4-ol (<b>2</b>), along with five known ones (<b>3–7</b>) were isolated from the fermentation products of a sun-cured tobacco-derived endophytic fungus <i>Aspergillus fumigatus</i>. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their antifungal activity against Golovinomyces cichoracearum (the main pathogenic sources of tobacco powdery mildew disease). Compounds <b>1</b> and <b>2</b> showed potential anti-<i>G</i>. cichoracearum activity with inhibition rates of 76.8% ± 4.8, and 85.6% ± 4.6, respectively, compared with the negative control. These rates are close to that of the positive control (with an inhibition rate of 88.4% ± 5.5).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"502 - 506"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Antibacterial Sesquiterpene Alkaloid from the Cigar-Tobacco-Derived Aspergillus ustus 从雪茄烟草曲霉中提取的新型抗菌倍半萜生物碱
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-05011-2
Heng Yao, Wen-Bing Zhou, Jing Li, Zhi-Hua Huang, Gao-Kun Zhao, Yong Xu, Yu-Long Su, Guang-Hai Zhang, Guang-Hui Kong, Yu-Ping Wu, Jin Wang
{"title":"A New Antibacterial Sesquiterpene Alkaloid from the Cigar-Tobacco-Derived Aspergillus ustus","authors":"Heng Yao,&nbsp;Wen-Bing Zhou,&nbsp;Jing Li,&nbsp;Zhi-Hua Huang,&nbsp;Gao-Kun Zhao,&nbsp;Yong Xu,&nbsp;Yu-Long Su,&nbsp;Guang-Hai Zhang,&nbsp;Guang-Hui Kong,&nbsp;Yu-Ping Wu,&nbsp;Jin Wang","doi":"10.1007/s10600-026-05011-2","DOIUrl":"10.1007/s10600-026-05011-2","url":null,"abstract":"<p>A new unusual sesquiterpene alkaloid (<b>1</b>), as well as four known sesquiterpenes (<b>2–5</b>) were isolated from the fermentation broth of the cigar tobacco-derived <i>Aspergillus ustus</i>. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound <b>1</b> was tested for its antibacterial activity against five pathogenic strains (<i>Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Bacillus subtilis,</i> and <i>Proteus</i> spp.). The results revealed that compound <b>1</b> showed high antibacterial activity with bacteriostatic diameter within the range 19.2 ± 1.4~24.8 ± 1.6 mm, and most of the bacteriostatic diameters of compound <b>1</b> are higher than that of the positive control. This compound has the potential to be used as a natural preservative.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"575 - 578"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two New Alkaloids of Capsicum annuum var. fasciculatum 辣椒的两种新生物碱
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-05009-w
C. Y. Chen, C. L. Kao, M. Y. Chen, C. E. Kuo, H. T. Li, S. T. Huang, M. J. Cheng
{"title":"Two New Alkaloids of Capsicum annuum var. fasciculatum","authors":"C. Y. Chen,&nbsp;C. L. Kao,&nbsp;M. Y. Chen,&nbsp;C. E. Kuo,&nbsp;H. T. Li,&nbsp;S. T. Huang,&nbsp;M. J. Cheng","doi":"10.1007/s10600-026-05009-w","DOIUrl":"10.1007/s10600-026-05009-w","url":null,"abstract":"<p>Two new alkaloids, 2-(2′,4′-dimethylpyridin-1′-ium-1′-yl)-3-phenylpropanoate (<b>1</b>) and 2-(2′,4′-dimethylpyridin-1′-ium-1′-yl)-3-(4″-hydroxyphenyl)propanoate (<b>2</b>), along with six known compounds (<b>3–8</b>), were isolated from the roots of <i>Capsicum annuum</i> L. var. <i>fasciculatum</i> (Sturt.) Irish (Solanaceae). The structures of these two new alkaloids were elucidated by physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"567 - 570"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial Napthalene Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii 内生真菌福氏磷藻发酵产物中抗菌萘衍生物的研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-04977-3
Gao-Kun Zhao, Wen-Bing Zhou, Heng Yao, Yu-Long Su, Guang-Hai Zhang, Yu-Ping Wu, Wei-Guang Wang, Guang-Hui Kong, Zhi-Hua Huang
{"title":"Antibacterial Napthalene Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii","authors":"Gao-Kun Zhao,&nbsp;Wen-Bing Zhou,&nbsp;Heng Yao,&nbsp;Yu-Long Su,&nbsp;Guang-Hai Zhang,&nbsp;Yu-Ping Wu,&nbsp;Wei-Guang Wang,&nbsp;Guang-Hui Kong,&nbsp;Zhi-Hua Huang","doi":"10.1007/s10600-026-04977-3","DOIUrl":"10.1007/s10600-026-04977-3","url":null,"abstract":"<p>Two new naphthalene derivatives, 1-acetyl-5-isopropyl-2,7-dimethoxynaphthalene (<b>1</b>) and 1-acetyl-5-isopropyl-2,8-dimethoxynaphthalene (<b>2</b>), together with five known analogs (<b>3–7</b>) were isolated from the fermentation products of an endophytic fungus <i>Phomopsis fukushii</i> originating from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their anti-methicillin-resistant <i>Staphylococcus aureus</i> (anti-MRSA) activity. The results showed that compounds <b>1</b> and <b>2</b> showed weak inhibition with IZD of 9.4 ± 1.6 and 10.6 ± 1.8 mm, respectively.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"425 - 429"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stilbene Dimers from Ampelopsis brevipedunculata var. hancei and Their Angiotensin-Converting Enzyme Inhibitory Activities 短柄葡萄二苯乙烯二聚体及其抑制血管紧张素转换酶活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-04978-2
Wen-Chi Hou, Chiung-Lin Liu, Yeh-Lin Lu, Chung-Yi Chen, Chien-Hsing Lee, Jue-Liang Hsu, Chi-I Chang
{"title":"Stilbene Dimers from Ampelopsis brevipedunculata var. hancei and Their Angiotensin-Converting Enzyme Inhibitory Activities","authors":"Wen-Chi Hou,&nbsp;Chiung-Lin Liu,&nbsp;Yeh-Lin Lu,&nbsp;Chung-Yi Chen,&nbsp;Chien-Hsing Lee,&nbsp;Jue-Liang Hsu,&nbsp;Chi-I Chang","doi":"10.1007/s10600-026-04978-2","DOIUrl":"10.1007/s10600-026-04978-2","url":null,"abstract":"<p><i>A</i> new dimeric stilbene, ampelopsinol A (<b>1</b>), and one known dimeric stilbene, vitisinol A (<b>2</b>), were isolated from the methyl alcohol extract of stems of <i>Ampelopsis brevipedunculata</i> var. <i>hancei</i>. The structure of the new compound was determined based on comprehensive spectroscopic analyses, including 1D and 2D NMR and HR-FAB-MS, as well as by comparison of its NMR data with those of related known analogs. Among these isolates, compound <b>1</b> exhibited significant ACE inhibitory activity, with an IC<sub>50</sub> value of 7.29 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"430 - 433"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents of Crithmum maritimum 海苔的化学成分
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-20 DOI: 10.1007/s10600-026-05010-3
C. Y. Chen, M. Y. Chen, S. T. Huang, M. J. Cheng
{"title":"Chemical Constituents of Crithmum maritimum","authors":"C. Y. Chen,&nbsp;M. Y. Chen,&nbsp;S. T. Huang,&nbsp;M. J. Cheng","doi":"10.1007/s10600-026-05010-3","DOIUrl":"10.1007/s10600-026-05010-3","url":null,"abstract":"<p>A new pyridinium-type compound, named 2-(2′,4′-dimethylpyridin-1′-ium-1′-yl)propanoate (<b>1</b>), as well as glutamate (<b>2</b>), glutamine (<b>3</b>), glutamic acid (<b>4</b>), diacetone alcohol (<b>5</b>), aesculetin (<b>6</b>), and caffeic acid (<b>7</b>), were isolated from the MeOH extract of the roots of <i>Crithmum maritimum</i> L. The structure of the new benzenoid was elucidated by chemical and physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"571 - 574"},"PeriodicalIF":1.1,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structurally Diverse Phenylpropanoid Glycosides with Anti-Rheumatoid Arthritis Activities from Vicatia thibetica 具有抗类风湿关节炎活性的结构多样的苯丙苷
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-19 DOI: 10.1007/s10600-026-04993-3
Jia-Zeng Guo, Qin-Ge Ma, Rong-Rui Wei
{"title":"Structurally Diverse Phenylpropanoid Glycosides with Anti-Rheumatoid Arthritis Activities from Vicatia thibetica","authors":"Jia-Zeng Guo,&nbsp;Qin-Ge Ma,&nbsp;Rong-Rui Wei","doi":"10.1007/s10600-026-04993-3","DOIUrl":"10.1007/s10600-026-04993-3","url":null,"abstract":"<p>A new phenylpropanoid glycoside, named (7<i>E</i>)-1′-phenylethanol-6′-(3,5-dimethoxy-4-hydroxycinnamic acid) 3′′ ,4′′ -(11′′-carbonylfuran)-8′′ /11′′ -O-<i>β</i>-D-diglucopyranosylphenylpropanoid (<b>1</b>), and seven known phenylpropanoid glycosides (<b>2–8</b>) were isolated from <i>Vicatia thibetica</i> H. Boissieu for the first time. Their structures were elucidated by extensive spectroscopic methods (NMR, MS, UV, IR) and comparison with literature data. The anti-rheumatoid arthritis activities of these phenylpropanoid glycosides (<b>1–8</b>) were evaluated on a TNF-α induced MH7A human rheumatoid fibroblast-like synoviocyte model. Among them, compounds <b>1</b> and <b>2</b> exhibited important anti-rheumatoid arthritis activities.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"497 - 501"},"PeriodicalIF":1.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the Chemical Profile and Bioactivity of Diospyros confertiflora Essential Oil 黄花薯蓣精油的化学成分及生物活性研究
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-19 DOI: 10.1007/s10600-026-05021-0
Syarifah Nadhirah Wan Idrus, Faezatul Alwani Mohd Rahim, Nur Nabilah Mohd Zaini, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Nurunajah Ab Ghani, Bachir Benarba
{"title":"Insights into the Chemical Profile and Bioactivity of Diospyros confertiflora Essential Oil","authors":"Syarifah Nadhirah Wan Idrus,&nbsp;Faezatul Alwani Mohd Rahim,&nbsp;Nur Nabilah Mohd Zaini,&nbsp;Wan Mohd Nuzul Hakimi Wan Salleh,&nbsp;Abubakar Siddiq Salihu,&nbsp;Nurunajah Ab Ghani,&nbsp;Bachir Benarba","doi":"10.1007/s10600-026-05021-0","DOIUrl":"10.1007/s10600-026-05021-0","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"612 - 614"},"PeriodicalIF":1.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antifungal Activity of Chromones from a Cigar Tobacco-Derived Fungus Penicillium sclerotiorum 雪茄烟草源真菌菌核青霉色素的抗真菌活性
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-19 DOI: 10.1007/s10600-026-04984-4
Si-Si Lin, Dan He, Jian-Xiong Zhao, Bin Yang, Yi-Wen Zhang, Ben-Hui Li, Hong-Hui Yang, Yong-Jun Zhang, Jin Wang, Qiu-Fen Hu, Jin Li, Hou-Fa Zhou
{"title":"Antifungal Activity of Chromones from a Cigar Tobacco-Derived Fungus Penicillium sclerotiorum","authors":"Si-Si Lin,&nbsp;Dan He,&nbsp;Jian-Xiong Zhao,&nbsp;Bin Yang,&nbsp;Yi-Wen Zhang,&nbsp;Ben-Hui Li,&nbsp;Hong-Hui Yang,&nbsp;Yong-Jun Zhang,&nbsp;Jin Wang,&nbsp;Qiu-Fen Hu,&nbsp;Jin Li,&nbsp;Hou-Fa Zhou","doi":"10.1007/s10600-026-04984-4","DOIUrl":"10.1007/s10600-026-04984-4","url":null,"abstract":"<p>With the aims of screening more antifungal metabolites, in this study, two new chromones (<b>1</b> and <b>2</b>), together with six known (<b>3–8</b>) analogs, were isolated from the cigar tobacco-derived endophytic fungi <i>Penicillium sclerotiorum</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The antifungal activity was tested for compounds <b>1–8</b> against Golovinomyces cichoracearum (the main pathogen of tobacco powdery mildew). The results revealed that compounds <b>1–8</b> demonstrated obvious anti-<i>G. cichoracearum</i> activity with inhibition rates within the range of 42.9% ± 4.4 to 65.2% ± 4.2 compared with the negative control. However, these rates are lower than that of the positive control (with an inhibition rate of 91.4% ± 4.9).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"452 - 457"},"PeriodicalIF":1.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Aliphatic Lactone of Oryza sativa 水稻中一个新的脂肪族内酯
IF 1.1 4区 化学
Chemistry of Natural Compounds Pub Date : 2026-06-19 DOI: 10.1007/s10600-026-04979-1
C. Y. Chen, C. L. Kao, S. T. Huang, H. T. Li
{"title":"A New Aliphatic Lactone of Oryza sativa","authors":"C. Y. Chen,&nbsp;C. L. Kao,&nbsp;S. T. Huang,&nbsp;H. T. Li","doi":"10.1007/s10600-026-04979-1","DOIUrl":"10.1007/s10600-026-04979-1","url":null,"abstract":"<p>A new aliphatic lactone, 2-heneicos-(<i>Z</i>)-3-en-1,5-olide (<b>1</b>), along with six known compounds (<b>2–7</b>), were isolated from the roots of rice (<i>Oryza sativa</i> L.) (Gramineae). The structure of these two new aliphatic lactones was elucidated by physical evidence.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 3","pages":"434 - 436"},"PeriodicalIF":1.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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