Guang-Hui Kong, Hua-Yin Liu, Guang-Hai Zhang, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Yu-Ping Wu, Ling-Duo Bu
{"title":"雪茄烟草内生真菌曲霉的抗菌吡咯喹啉类","authors":"Guang-Hui Kong, Hua-Yin Liu, Guang-Hai Zhang, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Yu-Ping Wu, Ling-Duo Bu","doi":"10.1007/s10600-025-04750-y","DOIUrl":null,"url":null,"abstract":"<p>In this study, two new pyrroloisoquinolines, cigarpyrro A and B (<b>1</b> and <b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the cigar-tobacco-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were evaluated for their antibacterial activities against five pathogenic strains (<i>Staphylococcus aureus</i> (SEA), <i>Escherichia coli</i> (EPEC), <i>Streptococcus pyogenes</i> (GAS), <i>Bacillus subtilis</i> (QST713), and <i>Proteus</i> spp.). Interestingly, compounds <b>1</b> and <b>2</b> exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds <b>1</b> and <b>2</b> used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"731 - 736"},"PeriodicalIF":0.9000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antibacterial Pyrroloquinolines from Cigar-Tobacco-Derived Endophytic Fungus Aspergillus puniceus\",\"authors\":\"Guang-Hui Kong, Hua-Yin Liu, Guang-Hai Zhang, Yu-Long Su, Xue-Ru Song, Wei Li, Wei-Guang Wang, Qiu-Fen Hu, Yu-Ping Wu, Ling-Duo Bu\",\"doi\":\"10.1007/s10600-025-04750-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this study, two new pyrroloisoquinolines, cigarpyrro A and B (<b>1</b> and <b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the cigar-tobacco-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were evaluated for their antibacterial activities against five pathogenic strains (<i>Staphylococcus aureus</i> (SEA), <i>Escherichia coli</i> (EPEC), <i>Streptococcus pyogenes</i> (GAS), <i>Bacillus subtilis</i> (QST713), and <i>Proteus</i> spp.). Interestingly, compounds <b>1</b> and <b>2</b> exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds <b>1</b> and <b>2</b> used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.</p>\",\"PeriodicalId\":514,\"journal\":{\"name\":\"Chemistry of Natural Compounds\",\"volume\":\"61 4\",\"pages\":\"731 - 736\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry of Natural Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10600-025-04750-y\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04750-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Antibacterial Pyrroloquinolines from Cigar-Tobacco-Derived Endophytic Fungus Aspergillus puniceus
In this study, two new pyrroloisoquinolines, cigarpyrro A and B (1 and 2), together with five known pyrroloisoquinolines (3–7) were isolated from the cigar-tobacco-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds 1 and 2 used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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