Materials Science & Engineering C-Materials for Biological Applications最新文献

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Mechanism of selenium-doped black phosphorus nanosheets wrapped with biomimetic tumor cell membrane for prostate cancer immunotherapy 仿生肿瘤细胞膜包裹硒掺杂黑磷纳米片用于前列腺癌免疫治疗的机理
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-05-06 DOI: 10.1016/j.bioadv.2025.214339
Xingjian Yan , Han Dong , Liyin Gao , Mengqi Liu , Chunxi Wang
{"title":"Mechanism of selenium-doped black phosphorus nanosheets wrapped with biomimetic tumor cell membrane for prostate cancer immunotherapy","authors":"Xingjian Yan ,&nbsp;Han Dong ,&nbsp;Liyin Gao ,&nbsp;Mengqi Liu ,&nbsp;Chunxi Wang","doi":"10.1016/j.bioadv.2025.214339","DOIUrl":"10.1016/j.bioadv.2025.214339","url":null,"abstract":"<div><div>Prostate cancer (PCa) is commonly considered a “cold tumor” due to its immunosuppressive microenvironment. Cold tumors are typically identified by the absence of T-cell infiltration within the tumor, while other immune populations and myeloid cells can be observed in these tumors. To achieve light-heat combined immunotherapy checkpoint inhibitor treatment for castration-resistant prostate cancer, we aimed to transforming “cold tumors” into “hot tumors”. We designed and synthesized a two-dimensional material, selenium-doped black phosphorus (BP), to enhance the photothermal conversion efficiency, and formed Se@BPNSs by liquid-phase exfoliation. To address the issue of enhanced permeability and retention effect, and to achieve efficient targeting, we coated the Se@BPNSs with RM-1 cell membrane derived from mouse prostate cancer cells. By injecting a certain dose of Se@BPNSs into the tumor and irradiating with a 808 nm laser, the Se@BPNSs converted light energy into heat to kill tumor cells at high temperatures while releasing antigens captured by dendritic cells. In addition, we combined the immunotherapy checkpoint inhibitor anti-PD1 to enhance the immune response and promote immune cell infiltration. The successful preparation of Se@BPNSs was verified through material characterization, cell-level and animal-level experiments, and the antitumor effect was meanwhile verified, which further provided guidance for prostate cancer treatment by photothermal synergistic immunotherapy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"176 ","pages":"Article 214339"},"PeriodicalIF":5.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matrix-bound nanovesicles recapitulate tissue-specific angiogenic properties of parent extracellular matrix with distinct miRNA profiles 基质结合的纳米囊泡具有不同miRNA谱的亲本细胞外基质的组织特异性血管生成特性
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-05-06 DOI: 10.1016/j.bioadv.2025.214338
Hee-Woong Yun , Mijin Kim , Dong Il Shin , Hyeon Jae Kwon , In-Su Park , Do Young Park , Byoung-Hyun Min
{"title":"Matrix-bound nanovesicles recapitulate tissue-specific angiogenic properties of parent extracellular matrix with distinct miRNA profiles","authors":"Hee-Woong Yun ,&nbsp;Mijin Kim ,&nbsp;Dong Il Shin ,&nbsp;Hyeon Jae Kwon ,&nbsp;In-Su Park ,&nbsp;Do Young Park ,&nbsp;Byoung-Hyun Min","doi":"10.1016/j.bioadv.2025.214338","DOIUrl":"10.1016/j.bioadv.2025.214338","url":null,"abstract":"<div><div>Decellularized extracellular matrix (dECM) exhibits tissue-specific pro- or anti-angiogenic effects. Previous studies have demonstrated that matrix-bound nanovesicles (MBVs) act as key bioactive components of dECM, replicating various biological functions such as anti-inflammatory and immunomodulatory effects. Building on this evidence, this study hypothesized that MBVs derived from cartilage and small intestinal submucosa (SIS) modulate angiogenesis through the selective packaging of miRNAs. Cartilage-derived MBVs (cMBVs) and SIS-derived MBVs (sMBVs) were isolated, characterized, and analyzed for their miRNA profiles using RNA sequencing and RT-qPCR validation. The interactions between MBVs and human umbilical vein endothelial cells (HUVECs) were assessed by examining proliferation, adhesion, migration, and tube formation in comparison to the parent ECM. Angiogenic modulation was further evaluated using a mouse Matrigel plug assay and a rabbit corneal neovascularization (NV) model. Our results demonstrated that anti-angiogenic miRNAs (e.g., miR-140-3p, miR-455-5p, and miR-148a-5p) were predominant in cMBVs, suppressing endothelial cell activity and angiogenesis, while pro-angiogenic miRNAs (e.g., miR-143-3p, miR-181a, and miR-21-5p) were prevalent in sMBVs, enhancing vessel formation. In vivo, cMBVs significantly inhibited vascular invasion and neovessel formation, whereas sMBVs promoted angiogenesis in both models. These findings confirm that MBVs reflect the tissue-specific angiogenic regulatory functions of their parent ECM, and highlight their potential as therapeutic tools for targeted modulation of angiogenesis in regenerative medicine and tissue engineering.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214338"},"PeriodicalIF":5.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of multifunctional nanozymes with amplified immunogenic death effect as a long-term anti-tumor nanoplatform 具有扩增免疫原性死亡效应的多功能纳米酶作为长期抗肿瘤纳米平台的构建
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-05-06 DOI: 10.1016/j.bioadv.2025.214336
Kexin Luo , Sasha You , Jingyu Chen , Wang Ye , Jian Tian , Xiyue Feng , Yingxi Wang , Ling Li , Xiaolan Yu
{"title":"Construction of multifunctional nanozymes with amplified immunogenic death effect as a long-term anti-tumor nanoplatform","authors":"Kexin Luo ,&nbsp;Sasha You ,&nbsp;Jingyu Chen ,&nbsp;Wang Ye ,&nbsp;Jian Tian ,&nbsp;Xiyue Feng ,&nbsp;Yingxi Wang ,&nbsp;Ling Li ,&nbsp;Xiaolan Yu","doi":"10.1016/j.bioadv.2025.214336","DOIUrl":"10.1016/j.bioadv.2025.214336","url":null,"abstract":"<div><div>Stimulating the immunogenic cell death (ICD) effect is a method of tumor treatment through activating immunity. While conventional approaches including chemotherapy, photothermal therapy (PTT), and chemodynamic therapy (CDT), demonstrate partial ICD induction capabilities, their efficacy in eliciting systemic immune responses remains constrained by the immunosuppressive tumor microenvironment. Herein, a trimetallic nanozyme (Mn/Fe-MIL-101/CuS/DOX@FA) was engineered through the integration of Mn-doped Fe-MOFs, CuS, doxorubicin (DOX, 35.08 mg/g), and folic acid (FA). The design leverages the synergistic effects of Mn(II), Fe(III), and Cu(II), combined with the photothermal performance of CuS, which collectively enhance glutathione peroxidase (GPx)-like and peroxidase (POD)-like activities. This catalytic cascade depletes glutathione and boosts hydroxyl radicals via Fenton-like reactions, thereby disrupting redox balance to amplify chemodynamic therapy. CuS-mediated photothermal effects coupled with pH/GSH-responsive DOX release further augment ICD, effectively reversing immunosuppression. In vivo evaluations demonstrated 57 % inhibition of the primary tumor and 66.7 % inhibition of the distant tumor, confirming its efficacy in tumor treatment and prevention of recurrence/metastasis. Besides, magnetic resonance imaging experiments showed the T<sub>1</sub>/T<sub>2</sub> dual-mode imaging performance. Thereby, a long-term anti-tumor nanoplatform is constructed through dual-mode imaging-guided multimodal therapy, which integrates tumor diagnosis, treatment, and prevention of recurrence and metastasis.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214336"},"PeriodicalIF":5.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial membrane-anchored lipopeptide/MXene nanoplatform for tri-modal therapy toward bacteria-infected diabetic wound 细菌膜锚定脂肽/MXene纳米平台三段式治疗细菌感染的糖尿病伤口
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-05-01 DOI: 10.1016/j.bioadv.2025.214324
Ding-Yi Zhang , Meng-Xi Wang , Chuang Cai , Wei-Wei Cheng , Yin-Jia Cheng , Wen-Long Liu , Rong Huang , Ai-Qing Zhang , Si-Yong Qin
{"title":"Bacterial membrane-anchored lipopeptide/MXene nanoplatform for tri-modal therapy toward bacteria-infected diabetic wound","authors":"Ding-Yi Zhang ,&nbsp;Meng-Xi Wang ,&nbsp;Chuang Cai ,&nbsp;Wei-Wei Cheng ,&nbsp;Yin-Jia Cheng ,&nbsp;Wen-Long Liu ,&nbsp;Rong Huang ,&nbsp;Ai-Qing Zhang ,&nbsp;Si-Yong Qin","doi":"10.1016/j.bioadv.2025.214324","DOIUrl":"10.1016/j.bioadv.2025.214324","url":null,"abstract":"<div><div>Diabetic wound healing is extremely difficult, originating from the aspects of bacterial infection, continuous inflammation, hypoxia and excessive reactive oxygen species (ROS), etc. Consequently, multifunctional nanoplatforms capable of highly eliminating bacteria, scavenging ROS and promoting angiogenesis possess a promising prospect. This work reports our fabrication of lipopeptide/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanohybrid to cure bacteria-infected diabetic wounds. Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> nanosheet has been employed to disrupt the bacterial membrane through both the physical puncture mediated by direct contact and mild-temperature photothermal therapy (PTT) due to its excellent photothermal conversion efficiency. Moreover, it exhibits the capacities of ROS scavenging and pro-angiogenesis during the diabetic wound healing process. Positively charged lipopeptide integration on 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene improves the contact of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> nanosheet with negative bacterial membrane for membrane-anchoring. More importantly, drug-free lipopeptide shows antibacterial capacity, which compensates the decline in therapeutic efficacy of mild-temperature PTT because of its inferior heat intensity. The cooperation between 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene and therapeutic lipopeptide allows for the effective cure on bacteria-infected diabetic wound.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214324"},"PeriodicalIF":5.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tannylated lipid nanoparticles for prolonged circulation and PET imaging-guided cancer therapy 单宁化脂质纳米颗粒用于延长循环和PET成像引导的癌症治疗
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-30 DOI: 10.1016/j.bioadv.2025.214325
Yeli Fan , Wujun Miao , Rusong Yan , Changyuan Li , Xinyu Wang
{"title":"Tannylated lipid nanoparticles for prolonged circulation and PET imaging-guided cancer therapy","authors":"Yeli Fan ,&nbsp;Wujun Miao ,&nbsp;Rusong Yan ,&nbsp;Changyuan Li ,&nbsp;Xinyu Wang","doi":"10.1016/j.bioadv.2025.214325","DOIUrl":"10.1016/j.bioadv.2025.214325","url":null,"abstract":"<div><div>Tannic acid-based nanoplatforms represent a promising approach to overcome current challenges in anticancer drug delivery by enhancing therapeutic efficacy, reducing systemic toxicity, and improving tumor targeting. In this study, we developed a novel nanoparticle system—tannic acid-condensed lipid nanoparticles (TLNPs) through the self-assembly of tannic acid (TA), DSPE-PEG2k, and doxorubicin (DOX). The resulting nanoparticles DOX@TLNPs exhibited a uniform size, satisfactory encapsulation efficiency, excellent stability, and sustained drug release properties. In vitro evaluations demonstrated efficient cellular uptake and comparable cytotoxic activity to free DOX against multiple breast cancer cell lines (SKBR3, MCF-7). In vivo evaluation involved positron emission tomography (PET) imaging of <sup>89</sup>Zr-labeled DOX@TLNPs administered to SKBR3 tumor-bearing mice. The nanoparticles showed prolonged circulation and enhanced tumor accumulation, evidenced by a significantly higher area under the curve compared to free DOX, likely due to the enhanced permeability and retention effect. Furthermore, antitumor studies revealed that DOX@TLNPs markedly inhibited tumor growth, improved survival rates, and induced increased apoptosis alongside reduced proliferation within tumor tissues, without eliciting significant histopathological changes in major organs. These findings highlight the significant potential of TA-condensed TLNPs as a safe, robust, and effective nanomedicine platform for targeted cancer treatment.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214325"},"PeriodicalIF":5.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mineralized extracellular matrix composite scaffold incorporated with salvianolic acid A enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration 掺入丹酚酸A的矿化细胞外基质复合支架增强骨髓间充质干细胞成骨,促进颅骨骨再生
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-29 DOI: 10.1016/j.bioadv.2025.214327
Jiayu Chen , Qing Liu , Jiayang Wan , Qihua Cao , Zili Guo , Kaijia Tang , Xin Chen , Qilei Lou , Xiaodong Xu , Yong Fu , Xiaoqiang Jin , Songying Zhang , Xiaohua Yu , Chang Li
{"title":"Mineralized extracellular matrix composite scaffold incorporated with salvianolic acid A enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration","authors":"Jiayu Chen ,&nbsp;Qing Liu ,&nbsp;Jiayang Wan ,&nbsp;Qihua Cao ,&nbsp;Zili Guo ,&nbsp;Kaijia Tang ,&nbsp;Xin Chen ,&nbsp;Qilei Lou ,&nbsp;Xiaodong Xu ,&nbsp;Yong Fu ,&nbsp;Xiaoqiang Jin ,&nbsp;Songying Zhang ,&nbsp;Xiaohua Yu ,&nbsp;Chang Li","doi":"10.1016/j.bioadv.2025.214327","DOIUrl":"10.1016/j.bioadv.2025.214327","url":null,"abstract":"<div><div>Natural products, especially phenolic components isolated from Traditional Chinese Medicine (TCM), were reported to exhibit significant osteogenic potential in treating bone defects. However, low bioavailability, short half-life, and high clearance rate in the body hindered their practical applications in many cases. To develop delivery technologies for a bioactive phenolic acid from <em>Salvia miltiorrhiza</em> (<em>Danshen</em>), salvianolic acid A (SAA), a sustained release system based on biocompatible extracellular matrix (ECM) meticulously modified with a Hydroxyapatite (HAP) mineralized coating was established. The SAA construction of such delivery system not only addressed the low bioavailability of TCM formulation for SAA by local sustained release of this molecule, but also remarkably promoted its bone healing outcomes by synergizing with calcium and phosphate ion release during SAA release period. This approach collectively had a synergistic effect of osteogenesis with SAA, thereby significantly enhanced the efficacy of SAA in promoting bone formation. The <em>in vitro</em> experimental results indicated that the SAA@MECM exhibited good biocompatibility and significantly enhances angiogenesis and osteogenic differentiation. By day 14, compared to the MECM group, the gene expression levels of Col<img>I, ALP, Runx-2, and OCN in the SAA-H group increased by 1.8, 1.5, 1.5, and 2.0 times, respectively. This demonstrates the potential role of SAA in promoting the activity and differentiation of osteoblasts, highlighting its potential applications in bone tissue engineering. Leveraging such favorable feature of this system, SAA-loaded MECM demonstrated extraordinary bone healing capability in a rat calvarial defect model by showing successful bridging of the defects and large amount of new bone formation. Histological analysis further confirmed its outstanding osteogenic potential, while the dense distribution of micro vessels in the newly formed bone revealed the scaffold's remarkable potential in enhancing vascularization. This study might offer an innovative delivery strategy for enhancing the efficacy of natural phenolic acids through biomaterials.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214327"},"PeriodicalIF":5.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive manufacturing of 316 L stainless steel orthopedic implant with improved in vitro hemocompatibility and hydrophilicity for osteoinduction in Wistar rat model 316l不锈钢体外血液相容性及亲水性改良骨植入物增材制造Wistar大鼠骨诱导模型
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-29 DOI: 10.1016/j.bioadv.2025.214322
Suvranshu Pattanayak , Priyanka Dash , Sanghamitra Satpathi , Ananda Kumar Sahoo , Nihar Ranjan Das , Bismita Nayak , Susanta Kumar Sahoo
{"title":"Additive manufacturing of 316 L stainless steel orthopedic implant with improved in vitro hemocompatibility and hydrophilicity for osteoinduction in Wistar rat model","authors":"Suvranshu Pattanayak ,&nbsp;Priyanka Dash ,&nbsp;Sanghamitra Satpathi ,&nbsp;Ananda Kumar Sahoo ,&nbsp;Nihar Ranjan Das ,&nbsp;Bismita Nayak ,&nbsp;Susanta Kumar Sahoo","doi":"10.1016/j.bioadv.2025.214322","DOIUrl":"10.1016/j.bioadv.2025.214322","url":null,"abstract":"<div><div>Long-term implantation is still challenging for 316 L stainless steel (SS) due to low hydrophilicity and borderline corrosion, which further advances a coating to induce osteoinduction and prevent metallic ions leaching. Here, arc-based direct energy deposition technology is introduced to fabricate 316 L SS <em>via</em> additive manufacturing (AM). The AM 316 L SS are subjected to metallurgical, mechanical, chemical, <em>in vitro</em> and <em>in vivo</em> analyses for their possible orthopedic applications. Compared to commercially available 316 L SS implant, the AM implants encompass γ-austenite phases with δ-ferrite structures that induce pinning dislocations, improve resistance to crack propagation and enhance mechanical performances. The evolution of δ-ferrite structures with higher inter-layer dwell times promotes Cr and Mo content, improving passive layer thickness and thereby enhancing the corrosion resistance, which prevents the release of toxic ions into the bloodstream and cellular metabolism. Additionally, improved BCI with less adherence and activation of platelets on the AM deposits indicates uninterrupted blood flow along the site of implantation and improved thrombo-resistance. The reduction in contact angle (highly hydrophilic) promotes the adsorption of body fluid and proteinaceous materials that boost the adhesion, proliferation, and cytoplasmic extension of cells (from <em>in vitro</em>), marrow spaces, collagen fibers, and tissue adherences (from <em>in vivo</em>). The AM implants do not show any acute toxicity in blood profiles and vital organs (liver and kidney) after long-term implantation in Wistar rats. These peculiarities highlight the hemocompatibility and osteointegration capabilities of AM implants with a faster bone regeneration rate.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214322"},"PeriodicalIF":5.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence tool for prediction of ECM mimics hydrogel formulations via click chemistry 用于预测ECM的人工智能工具通过点击化学模拟水凝胶配方
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-28 DOI: 10.1016/j.bioadv.2025.214323
Francesca Cadamuro , Marco Piazzoni , Elia Gamba , Beatrice Sonzogni , Fabio Previdi , Francesco Nicotra , Antonio Ferramosca , Laura Russo
{"title":"Artificial Intelligence tool for prediction of ECM mimics hydrogel formulations via click chemistry","authors":"Francesca Cadamuro ,&nbsp;Marco Piazzoni ,&nbsp;Elia Gamba ,&nbsp;Beatrice Sonzogni ,&nbsp;Fabio Previdi ,&nbsp;Francesco Nicotra ,&nbsp;Antonio Ferramosca ,&nbsp;Laura Russo","doi":"10.1016/j.bioadv.2025.214323","DOIUrl":"10.1016/j.bioadv.2025.214323","url":null,"abstract":"<div><div>A user-friendly machine learning (ML) predictive tool is reported for designing extracellular matrix (ECM)-mimetic hydrogels with tailored rheological properties. Developed for regenerative medicine and 3D bioprinting, the model leverages click chemistry crosslinking to fine-tune the mechanical behaviour of gelatin- and hyaluronic acid-based hydrogels. Using both experimental rheological data and synthetic datasets, our supervised ML approach accurately predicts hydrogel compositions, significantly reducing the cost and time associated with trial-and-error approach. Despite advancements in the field, existing models remain limited in their ability to mimic the ECM due to the use of non-natural polymers, reliance on a single type of biologically active macromolecule, and physical crosslinking reactions with limited tuneability. Additionally, their lack of generalizability confines them to specific formulations and demands extensive experimental data for training. This predictive platform represents a major advancement in biomaterial design, improving reproducibility, scalability, and efficiency. By integrating rational design, it accelerates tissue engineering research and expands access to customized ECM-mimetic hydrogels with tailored viscoelastic properties for biomedical applications, enabling both experts and non-experts in materials design.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214323"},"PeriodicalIF":5.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis 功能纳米材料在牙周炎治疗中的应用进展
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-27 DOI: 10.1016/j.bioadv.2025.214326
Ziyi Xu , Yue Wang , Shuoshun Li , Yuanhong Li , Lili Chang , Yang Yao , Qiang Peng
{"title":"Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis","authors":"Ziyi Xu ,&nbsp;Yue Wang ,&nbsp;Shuoshun Li ,&nbsp;Yuanhong Li ,&nbsp;Lili Chang ,&nbsp;Yang Yao ,&nbsp;Qiang Peng","doi":"10.1016/j.bioadv.2025.214326","DOIUrl":"10.1016/j.bioadv.2025.214326","url":null,"abstract":"<div><div>Periodontitis is a common chronic inflammatory disease primarily caused by pathogenic microorganisms in the oral cavity. Without appropriate treatments, it may lead to the gradual destruction of the supporting tissues of the teeth. While current treatments can alleviate symptoms, they still have limitations, particularly in eliminating pathogenic bacteria, promoting periodontal tissue regeneration, and avoiding antibiotic resistance. In recent years, functional nanomaterials have shown great potential in the treatment of periodontitis due to their unique physicochemical and biological properties. This review summarizes various functionalization strategies of nanomaterials and explores their potential applications in periodontitis treatment, including metal-based nanoparticles, carbon nanomaterials, polymeric nanoparticles, and exosomes. The mechanisms and advances in antibacterial effects, immune regulation, reactive oxygen species (ROS) scavenging, and bone tissue regeneration are discussed in detail. In addition, the challenges and future directions of applying nanomaterials in periodontitis therapy are also discussed.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"175 ","pages":"Article 214326"},"PeriodicalIF":5.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-aspect ratio titanium nanopillars modulate macrophage responses 高纵横比钛纳米柱调节巨噬细胞反应
IF 5.5 2区 医学
Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-23 DOI: 10.1016/j.bioadv.2025.214321
Benedictus I.M. Eijkel , Khashayar Modaresifar , Eszter Mádai , Mahya Ganjian , Peyman Taheri , Iulian Apachitei , Lidy E. Fratila-Apachitei
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