Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"A novel antimicrobial peptide AH-12 attenuates mitochondrial response to inflammatory stimuli and prevents periodontitis via antibacterial and anti-inflammatory effects","authors":"Yuanchen Wang ,&nbsp;Shuting Zhang ,&nbsp;Jinrong Sun ,&nbsp;Qian Zhang ,&nbsp;Xi Zhang","doi":"10.1016/j.bioadv.2026.214711","DOIUrl":"10.1016/j.bioadv.2026.214711","url":null,"abstract":"<div><div>Antibiotic-assisted periodontal therapy remains a primary clinical strategy, yet the rising prevalence of bacterial resistance severely compromises its therapeutic efficacy. To address this challenge, antimicrobial peptides (AMPs) have emerged as promising alternatives owing to their distinct antibacterial mechanisms. Here, we developed a novel antimicrobial peptide, AH-12, by systematically optimizing P-113—the minimal inhibitory fragment of human salivary Histatin 5—through N-terminal modification, amidation, and acetylation. <em>In vitro</em> evaluations demonstrated potent inhibitory effects of AH-12 against key oral pathogens (<em>Fusobacterium nucleatum</em>, <em>Porphyromonas gingivalis</em>, and <em>Streptococcus gordonii</em>), achieved via bacterial membrane lysis and suppression of FadA adhesin secretion in <em>F. nucleatum</em>. Beyond its antibacterial properties, AH-12 targeted inflammatory regulation by modulating mitochondrial function. Mitochondria, as early responders to inflammation, drive inflammatory cascades via Ca²⁺-dependent signaling. Remarkably, AH-12 stabilized mitochondrial Ca²⁺ levels, thereby attenuating mitochondrial reactive oxygen species (mtROS) overproduction and mitochondrial DNA (mtDNA) release, which collectively contributed to its robust anti-inflammatory effects. In order to minimize the loss of medication during administration and to better fit the shape of the periodontal pockets, a GelMA hydrogel (GelMA@AH-12) was engineered for controlled release applications. <em>In vivo</em> studies validated the outstanding efficacy of GelMA@AH-12, highlighting AH-12 as a transformative candidate for periodontitis treatment.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214711"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoplatform for renal ischemia-reperfusion injury repair: Modulating macrophage polarization, oxidative stress, and mitophagy","authors":"Mu He ,&nbsp;Ting Liu ,&nbsp;Hongchao Zhao ,&nbsp;Tianran Zheng ,&nbsp;Maonan Chen ,&nbsp;Hengcheng Zhu ,&nbsp;Kang Yang","doi":"10.1016/j.bioadv.2025.214697","DOIUrl":"10.1016/j.bioadv.2025.214697","url":null,"abstract":"<div><div>Acute kidney injury (AKI) is a common clinical condition characterized by high morbidity and mortality rates, with a notable lack of effective therapeutic drugs. Complex pathological processes—such as oxidative stress overload, aberrant macrophage polarization, mitochondrial dysfunction, and renal tubular epithelial cell apoptosis—contribute to the current absence of effective clinical treatments for AKI. Although mesoporous cerium dioxide nanospheres have been widely applied in various diseases due to their remarkable ROS-scavenging and drug-loading capabilities, their poor targeting ability limits their use in ischemia-reperfusion injury models. To address this, we developed a multifunctional nanoplatform RGD-CeO₂@Que. based on mesoporous hollow cerium dioxide (AhCeO₂). This system achieves targeted accumulation in injured kidneys by binding to integrin αvβ3 receptors, which are overexpressed under oxidative stress. Through the Nrf2/HO-1/GPX4/SOD1 pathway, it alleviates oxidative stress and reduces apoptosis. Moreover, the platform is loaded with the bioactive molecule quercetin to promote mitophagy in renal tubular epithelial cells (HK−2). In vivo studies demonstrated that RGD-CeO₂@Que. improves renal function, ameliorates pathological damage, and reduces inflammatory infiltration in AKI mice. In summary, this integrated nanoplatform combines multiple restorative mechanisms, offering a novel and targeted therapeutic strategy for AKI induced by renal ischemia-reperfusion injury.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214697"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amine functionalized TiO2 doped mesoporous bioactive glass coated curcumin infused 3d printed poly (L-lactic acid): A promising multifunctional scaffold with enhanced osteogenesis and tumour relapse inhibition characteristics","authors":"Shubham Pant ,&nbsp;Sravanthi Loganathan ,&nbsp;Ravi Babu Valapa","doi":"10.1016/j.bioadv.2026.214705","DOIUrl":"10.1016/j.bioadv.2026.214705","url":null,"abstract":"<div><div>The two main clinical problems with post-operative metastatic bone disease are high death rate and a notable local recurrence rate. When diseased bone sections are removed from patients, they suffer from significant bone defects that cannot be repaired on their own, and therefore require a support mechanism via the incorporation of scaffolds. In such cases, multifunctional scaffolds are deemed to be an appropriate option with promising potential as bone substitutes and limit the recurrence of post-operative tumour cells. This can be achieved via constructing a multi-functional scaffold incorporated with therapeutic compounds that helps in the prevention of tumour recurrence and improved surface characteristics for achieving enhanced osteogenesis. In the current work, a multi-functional scaffold is constructed via coating of amine functionalized Titanium dioxide (TiO₂) doped mesoporous bioactive glass (MBG) on 3D printed curcumin infused PLA support. The influence of curcumin incorporation towards inhibiting the growth of osteosarcoma cells and surface coating for enhanced osteogenesis of adipose-derived mesenchymal stem cells (AD-MSCs) is investigated. In this study, MBG is doped with TiO₂ and surface grafted with amine groups to facilitate coating on 3D printed PLA and curcumin infused PLA surface via EDC-NHS carbodiimide chemistry. As revealed by FESEM analysis, the bioactive coating was observed to induce <em>in-vitro</em> bioactivity on day 1 of SBF treatment. Most importantly, the release of curcumin shows antibacterial activity against gram-positive (∼90 %) and gram-negative bacterial strain (∼85 %) as well as cytotoxicity towards osteosarcoma cells lines (∼ 90 % cell apoptosis observed after 14 days of culture). The TiO₂ doped MBG promotes osteogenic differentiation, observed with a significant increase in calcium mineralization (<em>p</em> &lt; 0.0001) and Alkaline phosphatase activity (<em>p</em> &lt; 0.0001) compared to PLA scaffolds via mild release of reactive oxygen species, which facilitates production of antioxidant proteins and ultimately promotes upregulation of early and late osteogenic markers.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214705"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfated poly(aspartic acid) coatings as next-generation biomimetic interfaces for blood-contacting devices","authors":"Cuong Hung Luu ,&nbsp;Akriti Nepal ,&nbsp;Nam-Trung Nguyen ,&nbsp;Hang Thu Ta","doi":"10.1016/j.bioadv.2026.214723","DOIUrl":"10.1016/j.bioadv.2026.214723","url":null,"abstract":"<div><div>The increasing reliance on blood-contacting medical devices underscores the need for materials that minimise thrombosis and inflammation. Devices such as stents and dialysis membranes often face complications related to clot formation and microbial colonisation. To address these challenges, this study explored the development of sulfated poly(aspartic acid) (sPASP) coatings aimed at improving haemocompatibility and reducing infection risk. PASP, a biodegradable, biocompatible polymer, and calcium chelator, served as the base material, with sulfation introduced to enhance its antithrombotic, antibacterial, and anti-inflammatory properties. Sulfate groups mimic natural anticoagulants such as heparin, potentially promoting antithrombin activity and inhibiting clot development. The coatings were fabricated <em>via</em> a simplified one-pot process on polydopamine-modified substrates. The degree of sulfation was systematically varied from 10% to 80% to optimise the material's performance and thoroughly evaluated across multiple dimensions of blood compatibility. Assessments included surface physicochemical properties, protein adsorption, platelet adhesion, antithrombotic efficacy, cellular compatibility, and antibacterial activity, under static and dynamic conditions. Notably, sPASP with a sulfation degree of 40% exhibited the most favourable blood compatibility, demonstrating strong potential compared to heparin-mimicking polysaccharide coatings. In addition, the material exhibited excellent <em>in vivo</em> biocompatibility in implantation models, further underscoring its promise as a high-performance, multifunctional biomimetic interface for blood-contacting biomedical applications.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214723"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel polymeric hydrogel of Periplaneta americana polysaccharide loaded with kaempferol-chitosan microspheres, which possesses antibacterial, hemostatic, antioxidant and wound healing promoting activities","authors":"Yiting Yang ,&nbsp;Hanwen Hu ,&nbsp;Xinxin Zhang ,&nbsp;Seiichi Tokula ,&nbsp;Manting Zhao ,&nbsp;Ling He ,&nbsp;Hujing Zhang ,&nbsp;Qiao Liu ,&nbsp;Qiang Fu ,&nbsp;Qin Song","doi":"10.1016/j.bioadv.2026.214722","DOIUrl":"10.1016/j.bioadv.2026.214722","url":null,"abstract":"<div><div><em>Periplaneta americana</em>, as a traditional Chinese medicine, is widely used in wound repair. We isolated and purified a heteropolysaccharide PAP55–1-2 (8.13 kDa) from <em>Periplaneta americana</em> medicinal materials, which is mainly composed of <em>N</em>-acetylgalactosamine, galactose, glucose and mannose, etc. Among them, the content of <em>N</em>-acetylgalactosamine is relatively high, with a large number of <em>N</em>-acetyl groups. Through the study of structure-activity relationship, it was found that the <em>N</em>-acetyl groups play an important role in the process of wound healing. Therefore, PAP55–1-2 was reacted with N, N′‑carbonyldiimidazole (CDI) in DMSO at 50 °C for 3 h, and then ethylenediamine was added and reacted for 48 h. By using this mild method, the amino-modified <em>Periplaneta americana</em> polysaccharide (PAP-AM) was prepared while retaining the <em>N</em>-acetyl groups and their activity, and then reacted with aldehyde-modified chondroitin sulfate (Chs-CHO) to prepare a hydrogel. The cross-linking mechanism is attributed to the Schiff base reaction between amino and aldehyde groups. Subsequently, we prepared kaempferol (Kae)-chitosan (CS) microspheres with a diameter of 89.01 μm by a modified emulsification method, and then embedded them into high-dose PAP-AM hydrogel (PH-C) to produce a composite scaffold. The composite hydrogel Kae-CS@PH-C has good biodegradability, injectability, adhesion, self-healing and mechanical properties. In addition, it can accelerate the wound healing process in mice through antibacterial, hemostatic, antioxidant and immunomodulatory activities. These experiments indicate that the composite hydrogel has potential for biological applications.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214722"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printing of Y-27632 enhanced elastic hydrogel conduits for peripheral nerve repair","authors":"Wenbi Wu ,&nbsp;Haofan Liu ,&nbsp;Jiamei Zhang ,&nbsp;Yinchu Dong ,&nbsp;Min Peng ,&nbsp;Qi Zhu ,&nbsp;Yi Zhang ,&nbsp;Wei Zhao ,&nbsp;Li Zhang ,&nbsp;Ya Ren ,&nbsp;Jinlu Liu ,&nbsp;Boya Li ,&nbsp;Wentao Li ,&nbsp;Yu Hu ,&nbsp;Jingzhu Duan ,&nbsp;Maling Gou","doi":"10.1016/j.bioadv.2025.214679","DOIUrl":"10.1016/j.bioadv.2025.214679","url":null,"abstract":"<div><div>Nerve guide conduits provide an advanced tool for peripheral nerve repair, but their efficacy remains limited due to suboptimal axon regeneration. Y-27632, a ROCK inhibitor, has the potential to promote axon regeneration and functional restoration. Here, we show a Y-27632 enhanced elastic hydrogel conduit for effective nerve repair. The conduit comprised of gelatin methacryloyl (GelMA)/silk fibroin methacryloyl (SF-MA) hydrogels with Y-27632 loaded poly(lactic-co-glycolic acid) (PLGA)/polyvinyl alcohol (PVA) nanoparticles, is rapidly fabricated by a continuous 3D printing process. The drug Y-27632 can be sustainedly released from the conduits to promote neurite elongation. Meanwhile, the bioactive gelatin/fibroin hydrogels can facilitate Schwann cell adhesion, proliferation, and migration. Moreover, the elastic hydrogel conduit can be surgically sutured with nerve stumps to bridge nerve defects. At 16 weeks post-surgery, this conduit efficiently promotes axon regeneration and remyelination, facilitates muscle re-innervation, and enhances functional recovery in a 12 mm nerve defect model. These findings implicate that elastic hydrogel conduits with Y-27632 release would provide a promising therapeutic strategy for long-gap peripheral nerve defects.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214679"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering of green sterilization technology to obtain biocompatible aerogels: Supercritical CO2 versus ethylene oxide and gamma radiation","authors":"María Carracedo-Pérez ,&nbsp;Antonella Caterina Boccia ,&nbsp;Inés Ardao ,&nbsp;Cláudia P. Passos ,&nbsp;Víctor Santos-Rosales ,&nbsp;Beatriz Santos ,&nbsp;Fabio Bernardo ,&nbsp;María Blanco-Vales ,&nbsp;Beatriz Magariños ,&nbsp;Carlos A. García-González","doi":"10.1016/j.bioadv.2025.214698","DOIUrl":"10.1016/j.bioadv.2025.214698","url":null,"abstract":"<div><div>The growing relevance of aerogels in biomedicine demands the choice of compatible sterilization techniques with these materials. Conventional methods, such as ethylene oxide (EO) and gamma radiation (γ-rays) sterilization, have significant drawbacks while facing important environmental restrictions. In this study, supercritical CO₂ (scCO₂) sterilization is tested for polysaccharide (starch and alginate) aerogels as an eco-friendly alternative to conventional procedures. Three post-processing treatments under different CO₂ exposure regimes (static, dynamic and combined) and in the presence of H₂O₂ as additive were developed and assessed to reach sterility assurance levels (SAL) below 10⁻⁶. After sterilization, a vacuum treatment was implemented to ensure a low residual presence of H₂O₂ in the aerogels so that the material biocompatibility was not compromised according to <em>in vitro</em> cell tests with fibroblasts. The residual adsorbed H₂O₂ was quantified for the first time in aerogels by nuclear magnetic resonance spectroscopy. The effects of the supercritical sterilization treatments on the textural and chemical properties of the aerogels were evaluated and compared to those treated with EO and γ-rays. Results highlight the unique efficiency of scCO₂ sterilization as a post-processing method that preserves the aerogel structure while offering an eco-sustainable potential for producing sterile and biocompatible materials.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214698"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable silk fibroin hydrogel encapsulating pH-Responsive ZnS nanoparticles for synergistic redox modulation and diabetic wound healing","authors":"Xi Cheng ,&nbsp;Yuchong Wang ,&nbsp;Jiao Qian ,&nbsp;Rong Bai","doi":"10.1016/j.bioadv.2025.214674","DOIUrl":"10.1016/j.bioadv.2025.214674","url":null,"abstract":"<div><div>Chronic diabetic wounds remain a major clinical challenge due to excessive reactive oxygen species (ROS), persistent inflammation, and impaired cellular function. Current wound dressings offer limited capacity to simultaneously regulate redox imbalance and support tissue regeneration, highlighting the necessity for adaptive, intelligent, and multifunctional platforms for regenerative therapy. Herein, we developed an injectable hydrogel system composed of methacrylated silk fibroin (SilMA) and aqueous-phase, pH-sensitive zinc sulfide nanoparticles (ZnS NPs). Spherical ZnS NPs were synthesized <em>via</em> a green aqueous-phase hydrothermal method, offering stable colloidal properties and controlled release of therapeutic H₂S and Zn²⁺ under different pH conditions. Upon UV crosslinking, SilMA formed a porous, shear-thinning hydrogel (SF hydrogel) that facilitates <em>in situ</em> application and localized drug delivery. ZnS NPs were loaded into SF hydrogels and the resulting SF/ZnS hydrogel exhibited suitable mechanical strength, swelling and biodegradability for wound healing application. <em>In vitro</em> studies demonstrated the ZnS NPs' potent ROS-scavenging capacity and cytocompatibility, while the SF/ZnS hydrogel effectively restored fibroblasts and endothelial cells' function under oxidative stress and promoted macrophage polarization toward a reparative M2 phenotype. In a streptozotocin-induced diabetic mouse model, SF/ZnS hydrogel significantly accelerated wound closure, enhanced re-epithelialisation and collagen remodelling, and promoted neovascularization, while mitigating chronic inflammation. The SF/ZnS hydrogel developed in this study presents a promising therapeutic platform for chronic diabetic wounds, integrating redox regulation, immunomodulation, and regenerative enhancement within a single injectable system.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214674"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostic platforms for skin tissue engineering: Bridging healing and real-time monitoring","authors":"Lidia Maeso ,&nbsp;Mohammadsadegh Nadimifar ,&nbsp;Saptarshi Biswas ,&nbsp;Shounak Roy ,&nbsp;Akhilesh K. Gaharwar ,&nbsp;Alireza Dolatshahi-Pirouz ,&nbsp;Gorka Orive","doi":"10.1016/j.bioadv.2026.214724","DOIUrl":"10.1016/j.bioadv.2026.214724","url":null,"abstract":"<div><div>Chronic wounds are a major healthcare challenge, contributing to significant morbidity and reduced quality of life while imposing a substantial economic burden on healthcare systems. Traditional wound care approaches often fail to provide real-time feedback on treatment efficacy, limiting the ability to adapt therapeutic strategies dynamically. Theranostic platforms, which can integrate both diagnostic and therapeutic functionalities, have emerged as a promising solution to bridge this gap. These advanced systems enable continuous monitoring of key wound parameters, such as temperature, pH, oxygen levels, glucose, and reactive oxygen species (ROS), while simultaneously delivering targeted therapies, including drug release, gene and cell therapies, immunomodulation, and photothermal or photodynamic treatments. By incorporating both healing and monitoring capabilities into acellular scaffolds, hydrogel-based matrices, self-healing hydrogels, and 3D-bioprinted skin substitutes, researchers aim to optimize therapeutic efficacy and improve clinical outcomes. This review explores the different platforms available for skin tissue engineering that serve as the foundation for theranostic systems, alongside the most relevant diagnostic and therapeutic strategies for enhanced wound healing, and discusses future directions and challenges in this evolving field.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214724"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-dried and imprinted collagen scaffolds in tendon engineering","authors":"Ignacio Sallent ,&nbsp;Lefki Chaniotaki ,&nbsp;Dimitrios I. Zeugolis","doi":"10.1016/j.bioadv.2025.214681","DOIUrl":"10.1016/j.bioadv.2025.214681","url":null,"abstract":"<div><div>Collagen type I, as the main component of tendons, is an attractive biomaterial for the development of scaffolds for tendon repair and regeneration. Herein, we review advancements in freeze-drying and soft lithography scaffold fabrication procedures that permit the manufacturing of collagen scaffolds with precise architectural features. We also provide an overview of collagen crosslinking strategies that allow for the development of scaffolds with appropriate stiffness and cytocompatibility. In addition, we appraise the contribution of freeze-dried and imprinted collagen scaffolds in tendon engineering.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214681"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}