Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"Corrigendum to \"Synthesis of fluorescent molybdenum nanoclusters at ambient temperature and their application in biological imaging\" [Mater. Sci. Eng. C 99 (2019) 9287].","authors":"Amit Kumar Sharma, Sunil Pandey, Nallin Sharma, Hui-Fen Wu","doi":"10.1016/j.bioadv.2026.215109","DOIUrl":"10.1016/j.bioadv.2026.215109","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":" ","pages":"215109"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Macromolecular modulation of a 3D hydrogel construct differentially regulates human stem cell tissue-to-tissue interface\" [Biomater. Adv. 133 (2022) 112611].","authors":"Diana R Pereira, Joana Silva-Correia, Joaquim M Oliveira, Rui L Reis, Abhay Pandit","doi":"10.1016/j.bioadv.2026.215108","DOIUrl":"10.1016/j.bioadv.2026.215108","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":" ","pages":"215108"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical bone scaffolds with integrated trabecular topology and lacuno-canalicular connectivity modulate fluid dynamics and support osteogenic culture.","authors":"Sara Sebastiani, Giuliana Tromba, Valentina Rafaela Herrera Millar, Laura Maria Vergani, Federica Buccino","doi":"10.1016/j.bioadv.2026.215160","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215160","url":null,"abstract":"<p><p>The hierarchical structure of bone governs both mechanical behavior and mechanobiological signaling, yet most Bone Tissue Engineering (BTE) scaffolds reproduce only meso-scale porosity while neglecting the Lacuno-Canalicular Network (LCN), a key regulator of interstitial fluid flow. Here, we present a multi-scale bio-inspired scaffold integrating synchrotron μ-CT-derived trabecular architecture with a computationally engineered LCN-like micro-porosity. Two micro-network topologies, Regular and Canalicular-like, were fabricated via two-photon polymerization using IP-VISIO, here applied for the first time in a BTE context. Computational fluid dynamics revealed topology-dependent transport behavior: the Canalicular-like architecture exhibited >40% higher permeability and more homogeneous wall shear stress distributions within osteogenic-relevant ranges compared to the Regular design. Human bone marrow-derived mesenchymal stromal cells were cultured onto scaffolds under static conditions, showing cell attachment, osteogenic gene expression, and mineralized matrix deposition in both designs, assessed by SEM, RT-qPCR and Alizarin Red S staining. Synchrotron μ-CT showed mineral deposition throughout both trabecular regions and the engineered micro-network, with a more uniform spatial distribution in the Canalicular-like scaffold. Overall, this work proposes a multi-scale design framework and identifies LCN-inspired micro-architecture as a promising design variable for hierarchical bone scaffolds, influencing predicted fluid-dynamic behavior and supporting osteogenic culture.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215160"},"PeriodicalIF":6.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfonation modification of REDV peptides for directing cardiovascular cell fates.","authors":"Zhe Fang, Shuaiwei Xu, Fan Li, Siyu Liu, Huimin Duan, Yanchao Wang, Hao Sun, Jingan Li, Shaokang Guan","doi":"10.1016/j.bioadv.2026.215157","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215157","url":null,"abstract":"<p><p>The Arginine-Glutamic acid-Aspartic acid-Valine (Arg-Glu-Asp-Val, REDV) peptide selectively binds endothelial cells but exhibits limited multifunctional bioactivity for cardiovascular applications. Sulfonation has been reported to confer multi-cellular regulatory functions to various biomolecules. In this study, sulfonated REDV peptides (S-REDV) with sulfur contents of 3.56 ± 0.10, 4.20 ± 0.23, 5.39 ± 0.13, and 5.98 ± 0.08 at.% were prepared by controlling the reaction time. Comprehensive cytocompatibility evaluations revealed that a moderate sulfonation degree (S-REDV-3) significantly enhanced human umbilical vein endothelial cell (HUVEC) proliferation, nitric oxide (NO) release and migration. Moreover, it restrained excessive smooth muscle cell (SMC) proliferation, preserved the contractile phenotype of SMCs, and drove macrophage polarization toward an anti-inflammatory phenotype. In contrast, excessive sulfonation resulted in structural degradation and compromised bioactivity. These results indicate that appropriately sulfonated REDV, particularly S-REDV-3, may serve as a promising bioactive peptide for surface functionalization of cardiovascular biomaterials.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215157"},"PeriodicalIF":6.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic engineering of polymer-based drug delivery systems: From particle synthesis to organ-on-a-chip validation and application.","authors":"Andrey N Kuskov, Ekaterina N Krasnoselskaya, Albina R Khanova, Sergey N Filatov","doi":"10.1016/j.bioadv.2026.215141","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215141","url":null,"abstract":"<p><p>The convergence of microfluidic engineering and organ-on-a-chip (OoC) technology is redefining the development and preclinical validation of polymer-based drug delivery systems and biomedical preparations. This review presents a bidirectional framework: first, how microfluidics enables precision synthesis of polymer particles with controlled size, morphology and multifunctionality; second, how OoC platforms serve as physiologically relevant testbeds to evaluate these particles under dynamic, human-mimetic conditions. We examine droplet microfluidics principles for generating monodisperse polymer particles (spheres, Janus, core-shell, porous architectures) from natural and synthetic polymers. These particles are explored as functional additives within OoC systems, as embedded sensors for real-time oxygen/pH monitoring, as controlled-release depots for localized growth factor delivery and as building blocks (microscaffolds, bioinks, spheroid templates) for constructing three-dimensional tissue microenvironments. Conversely, we critically analyze how OoC platforms, including vascularized tumor models, liver-kidney multi-organ chips and blood-brain barrier systems, enable more physiologically relevant assessment of micro- and nanoparticle transport, extravasation, toxicity, immunogenicity and metabolism under fluidic shear and multi-cellular complexity, which are capabilities inaccessible to static cultures. Current challenges (scalability, GMP compliance, standardization, regulatory context-of-use) and emerging opportunities (smart responsive particles, personalized screening using patient-derived organoids, AI-driven automation and closed-loop optimization) are critically discussed. This review demonstrates that microfluidic particle engineering and OoC technology together form an iterative framework for advancing next-generation biomaterials and supporting their preclinical-to-clinical development pathway.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215141"},"PeriodicalIF":6.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional DNA hydrogel for radiation-induced skin injury repair.","authors":"Xiandong Lin, Feng Zhao, Chuanmei Zheng, Dan Hu, Xin Lan, Wenbo Han, Jinrong Liao, Jiuyue Liu, Zaisheng Ye, Xian Chen","doi":"10.1016/j.bioadv.2026.215137","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215137","url":null,"abstract":"<p><p>Radiation-induced skin injury (RISI) is one of the major complications of tumor radiotherapy, and remains clinically unaddressed due to insufficient wound healing and high infection risks. To address this clinical challenge, this study developed a novel multifunctional composite material based on a DNA hydrogel. This material innovatively integrates polydopamine-modified graphene oxide (PDA@GO) and fibroblast growth factor 2 (FGF2) into a DNA hydrogel matrix, achieving integrated therapeutic effects in radioprotection and tissue repair. Specifically, PDA@GO, with its excellent free radical scavenging ability, effectively eliminates excessive reactive oxygen species (ROS) in the wound microenvironment. Meanwhile, the unique three-dimensional porous network structure of the DNA hydrogel acts as an ideal sustained-release carrier for FGF2, significantly enhancing its bioavailability. Both in vitro and in vivo experiments demonstrated that this composite material demonstrates excellent biocompatibility, anti-inflammatory properties, and radioprotective performance. Compared with similar radioprotective agents and conventional clinical treatments, the FGF2-PDA@GO/DG hydrogel showed significant advantages in promoting wound healing and alleviating radiation-caused damage. These results support an encouraging biomaterial-based strategy for treating radiation-induced skin injury.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215137"},"PeriodicalIF":6.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tannic acid-derived nanocarbon promotes angiogenesis by restoring the paracrine activity of senescent BMSCs through the Lama2/integrin α3β1/PI3K/AKT axis.","authors":"Qinying Wang, Bichong Luo, Yongbin Duan, Longquan Shao","doi":"10.1016/j.bioadv.2026.215140","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215140","url":null,"abstract":"<p><p>Impaired angiogenesis is a major cause of delayed healing in age-related bone defects, and dysfunction of the pro-angiogenic paracrine activity of senescent bone marrow mesenchymal stem cells (BMSCs) contributes substantially to this vascular deficiency. Here, we synthesised a tannic acid-derived nanocarbon (TANC) and investigated whether it could promote angiogenesis by restoring the pro-angiogenic paracrine function of senescent BMSCs. In an aged rat calvarial defect model treated with locally implanted TANC-loaded GelMA hydrogels, TANC significantly increased blood perfusion, CD31-positive vessel density, and VEGF expression. In vitro, conditioned medium from TANC-treated senescent BMSCs markedly enhanced endothelial proliferation, migration, tube formation, and angiogenesis-related marker expression, whereas direct TANC treatment showed little effect. Transcriptomic screening and functional validation identified Lama2 as a key paracrine mediator regulated by TANC. Lama2 knockdown in vitro and Lama2 neutralisation in vivo both markedly attenuated the pro-angiogenic effect. Mechanistically, Lama2 preferentially interacted with integrin α3β1 on endothelial cells and activated downstream PI3K/AKT signalling. Collectively, these findings show that TANC restores the pro-angiogenic paracrine function of senescent BMSCs through the Lama2/integrin α3β1/PI3K/AKT axis and represents a promising biomaterial-based strategy for age-related bone defects with impaired vascularisation.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215140"},"PeriodicalIF":6.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental biomaterials-on-chip: A scoping review of dynamic material-tissue-biofilm models.","authors":"Rene Garcia-Contreras, Febe Carolina Vazquez-Vazquez","doi":"10.1016/j.bioadv.2026.215136","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215136","url":null,"abstract":"<p><p>The preclinical evaluation of dental biomaterials remains largely dependent on static in vitro assays that provide limited insight into dynamic material-tissue-biofilm interactions. Microfluidic lab-on-a-chip (LoC) and organ-on-a-chip (OoC) platforms can reproduce selected features of the oral microenvironment, including controlled transport, tissue barriers, three-dimensional cellular organization, microbial challenge, and time-resolved monitoring. This scoping review with structured narrative synthesis mapped peer-reviewed dental and oral microfluidic studies published through July 27, 2026. An initial search of PubMed/MEDLINE, Scopus, Web of Science Core Collection, ScienceDirect, Embase, and IEEE Xplore was supplemented by an updated focused search, Google Scholar, and backward and forward citation tracking. Of 114 records identified, 82 remained after duplicate removal, 46 full-text reports were assessed, and 28 sources were included: 21 original experimental studies and seven dental/oral reviews. Original platforms comprised tooth and dentin-pulp models, oral mucosa and gingival barriers, periodontal and bone-vascular interfaces, dental pulp angiogenesis systems, peri-implant models, and dynamic host-microbe platforms. These systems enabled trans-barrier exposure, controlled flow and shear, long-term barrier monitoring, biomaterial cytotoxicity testing, inflammatory modeling, biofilm challenge, and regenerative assessment. Nevertheless, fluidic parameters, adsorption, oxygenation, comparator assays, and interlaboratory reproducibility were inconsistently reported. None of the included original dental studies used artificial intelligence for externally validated predictive inference. A conceptual Modular Dental Microfluidic Ecosystem Platform is presented as an evidence-informed future framework. Current dental chips should therefore be regarded as complementary mechanistic and qualification tools rather than replacements for standardized testing.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215136"},"PeriodicalIF":6.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency-tuned microcurrent stimulation directs ADSC spheroid chondrogenesis through Ca²⁺-calcineurin-NFAT signaling.","authors":"Zhenying Chen, Zhao An, Axiu Zheng, Yong Xu, Yingran Shen, Jun Lu","doi":"10.1016/j.bioadv.2026.215139","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215139","url":null,"abstract":"<p><p>Adipose-derived stem cells (ADSCs) are promising for cartilage regeneration, but efficient, safe strategies to enhance chondrogenesis remain limited. This study examined frequency-dependent effects of microcurrent stimulation (MS) on rabbit ADSCs cultured as monolayers and three-dimensional spheroids. Cells were exposed to 0 Hz, 10 Hz, 100 Hz, 1 kHz, 10 kHz, or 60 kHz MS for 20 min daily. Chondrogenesis, extracellular matrix deposition, spheroid morphology, mechanical properties, inflammatory/catabolic responses, apoptosis, and Ca²⁺-calcineurin-NFAT signaling were evaluated. Among tested frequencies, 1 kHz MS most effectively enhanced chondrogenic differentiation, increasing SOX9, COL2A1, ACAN, and COMP expression and promoting collagen II and glycosaminoglycan deposition. It also improved spheroid morphology and mechanical properties while suppressing fibrocartilaginous, hypertrophic, inflammatory, and catabolic markers. MS did not alter medium pH, temperature, or reactive oxygen species levels and did not impair viability or increase apoptosis. Mechanistically, 1 kHz MS promoted Ca²⁺ influx, NFAT nuclear translocation, and NFATc1 expression; inhibition of L-type Ca²⁺ channels, intracellular Ca²⁺, or calcineurin attenuated this response. These findings identify frequency-tuned MS as a noninvasive strategy for promoting ADSC chondrogenesis and cartilage-like matrix formation.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215139"},"PeriodicalIF":6.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-responsive Ag/CuO@PDA nanowire platform for photothermal-amplified chemodynamic/ion-synergistic antibacterial therapy and infected wound healing.","authors":"Silu Sun, Yujiang Liu, Yuhui Shi, Yiting Liu, Hailiang Pei, Di Huang, Zhiyuan Feng","doi":"10.1016/j.bioadv.2026.215134","DOIUrl":"https://doi.org/10.1016/j.bioadv.2026.215134","url":null,"abstract":"<p><p>Biofilm-associated wound infections and antimicrobial resistance urgently require non-antibiotic therapies that integrate efficient antibacterial activity with tissue repair. Herein, we developed a sandwich-like trilayer Ag/CuO@PDA nanoplatform composed of one-dimensional CuO nanowires, Ag nanoparticles, and a polydopamine (PDA) photothermal shell. Under 980 nm near-infrared (NIR) irradiation, PDA-mediated local heating enhanced CuO-driven reactive oxygen species (ROS) generation and significantly promoted Ag⁺/Cu²⁺ release, as verified by ICP-MS analysis. Ag/CuO@PDA combined with NIR showed potent broad-spectrum antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA)and Escherichia coli (E. coli) and effectively disrupted mature biofilms by damaging bacterial membranes, increasing membrane permeability, and inducing intracellular component leakage. Meanwhile, the nanoplatform exhibited favorable cytocompatibility and supported wound-healing-related cellular behaviors, including cell migration and endothelial tube formation. In an Staphylococcus aureus (S. aureus) -infected wound model, Ag/CuO@PDA + NIR markedly reduced bacterial burden, alleviated inflammation, promoted collagen deposition and angiogenesis, and accelerated wound closure without obvious systemic toxicity. Overall, this trilayer nanoplatform integrates photothermal conversion, ROS generation, and metal ion-mediated antibacterial action, offering a promising non-antibiotic strategy for treating biofilm-associated infected wounds while promoting tissue repair.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"190 ","pages":"215134"},"PeriodicalIF":6.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}