Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"Editorial special issue - Convergence of biomaterials science and cancer research.","authors":"Anna Taubenberger, Dietmar W Hutmacher, Amaia Cipitria","doi":"10.1016/j.bioadv.2025.214396","DOIUrl":"10.1016/j.bioadv.2025.214396","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":" ","pages":"214396"},"PeriodicalIF":6.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Challenging applicability of ISO 10993-5 for calcium phosphate biomaterials evaluation: Towards more accurate in vitro cytotoxicity assessment\" [Biomater. Adv. 160 (2024) 213866].","authors":"Ilijana Kovrlija, Ksenia Menshikh, Hugo Abreu, Andrea Cochis, Lia Rimondini, Olivier Marsan, Christian Rey, Christèle Combes, Janis Locs, Dagnija Loca","doi":"10.1016/j.bioadv.2025.214386","DOIUrl":"10.1016/j.bioadv.2025.214386","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":" ","pages":"214386"},"PeriodicalIF":6.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Micro/nano-patterns for enhancing differentiation of human neural stem cells and fabrication of nerve conduits via soft lithography and 3D printing\" Biomater. Adv., volume 154 (2023), 213653.","authors":"","doi":"10.1016/j.bioadv.2025.214392","DOIUrl":"https://doi.org/10.1016/j.bioadv.2025.214392","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"177 ","pages":"214392"},"PeriodicalIF":6.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A novel magnesium ion-incorporating dual-crosslinked hydrogel to improve bone scaffold-mediated osteogenesis and angiogenesis\" [Mater. Sci. Eng. C 121 (2021) 111868].","authors":"Xintao Zhang, Pengzhou Huang, Guanwei Jiang, Mengdi Zhang, Fei Yu, Xueping Dong, Liping Wang, Yuhui Chen, Wentao Zhang, Yong Qi, Wenqiang Li, Hui Zeng","doi":"10.1016/j.bioadv.2025.214371","DOIUrl":"10.1016/j.bioadv.2025.214371","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":" ","pages":"214371"},"PeriodicalIF":6.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-vascularized hydrogel co-encapsulating SHEDs and HUVECs for dental pulp regeneration.","authors":"Junyu Liu, Peiwen Li, Yurou Chen, Yukun Shi, Kang Chen, Jiajia Liu, Tingting Yang, Junhao Chen, Zheqi Huang, Xiangyu Wang","doi":"10.1016/j.bioadv.2025.214539","DOIUrl":"https://doi.org/10.1016/j.bioadv.2025.214539","url":null,"abstract":"<p><p>Rapid reconstruction of the dental pulp vascular network is essential for pulp regeneration. While in vitro pre-vascularization enhances vascularization efficiency, current biomaterial carriers are hampered by issues such as low porosity and poor tissue permeability. This study developed a novel functional vascularized hydrogel using 3D bioprinting combined with in vitro pre-vascularization culture. The hydrogel, based on gelatin methacryloyl (GelMA), was loaded with stem cells from human exfoliated deciduous teeth (SHEDs) and human umbilical vein endothelial cells (HUVECs) at varying ratios. Comprehensive characterization of the hydrogel's physical properties was conducted, and its vascular maturity and ability to induce mineralization were evaluated through a series of in vitro and in vivo experiments. The pre-vascularized hydrogel demonstrated compressive mechanical properties akin to natural dental pulp and displayed favorable degradation rates. Co-cultured SHEDs and HUVECs showed higher proliferation rates compared to monocultures. Notably, the S:H = 1:1 group formed microvascular networks exhibiting enhanced maturity and significantly boosted the osteo/odontogenic differentiation potential of SHEDs. Following a 14-day pre-vascularization period, the pre-vascularized GelMA hydrogel, in combination with human root segments (RS), was implanted subcutaneously into nude mice for an 8-week duration. The pre-vascularized hydrogel group demonstrated markedly enhanced microvascular formation and pulp-like tissue regeneration compared to the non-pre-vascularized control group. These findings underscore the potential of this pre-vascularized hydrogel approach as a novel strategy for expeditious vascularization in pulp tissue regeneration engineering, offering significant clinical implications.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"180 ","pages":"214539"},"PeriodicalIF":6.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of crosslinking densities on decanoyl-group modified Alaska pollock gelatin microparticles as tissue-adhesive hemostatic powders","authors":"Hatsune Nishino ,&nbsp;Shima Ito ,&nbsp;Hiyori Komatsu ,&nbsp;Satsuki Minamisakamoto ,&nbsp;Yasuko Kobayashi ,&nbsp;Shiharu Watanabe ,&nbsp;Akihiro Nishiguchi ,&nbsp;Tetsushi Taguchi","doi":"10.1016/j.bioadv.2025.214534","DOIUrl":"10.1016/j.bioadv.2025.214534","url":null,"abstract":"<div><div>Endoscopic submucosal dissection (ESD) is widely utilized as a minimally invasive treatment for early-stage gastrointestinal cancers. However, bleeding after ESD remains a major challenge. This clinical problem necessitates biomaterials with tissue-adhesive and hemostatic properties. Recently, we developed decanoyl group-modified Alaska pollock gelatin microparticles (C10-MPs) as tissue-adhesive hemostatic powders. Dried C10-MPs adhered to and formed colloidal gels on the gastrointestinal tissue surface and demonstrated excellent hemostatic properties. However, the effect of crosslinking density on tissue adhesion and hemostatic properties has not yet been clarified. Herein, we investigated the effect of the crosslinking density on C10-MPs' performance as tissue-adhesive hemostatic powders. C10-MPs with different crosslinking densities were prepared by varying the thermal crosslinking time. All C10-MPs with different crosslinking densities exhibited rapid hydration. Additionally, C10-MPs with higher crosslinking densities exhibited increased adhesion strength and underwater adhesion stability, even in moist environments. Contrastingly, <em>in vitro</em> and <em>in vivo</em> hemostatic evaluation models showed that C10-MPs thermally crosslinked for 5 h (C10 5 h) were the most suitable powder in terms of blood coagulation ability. Thus, C10 5 h has great potential for use in preventing post-ESD bleeding.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"180 ","pages":"Article 214534"},"PeriodicalIF":6.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive in vitro and in vivo assessment of spongin/hydroxyapatite biohybrid scaffolds for bone regeneration","authors":"Demet Çakır ,&nbsp;Tülay Selin Erkut ,&nbsp;Yusuf Irmak ,&nbsp;Mert Çalış ,&nbsp;Elif Yavaş ,&nbsp;Sevil Çaylı ,&nbsp;Menemşe Gümüşderelioğlu","doi":"10.1016/j.bioadv.2025.214532","DOIUrl":"10.1016/j.bioadv.2025.214532","url":null,"abstract":"<div><div>The selection of an appropriate scaffold is vital for successful bone tissue engineering. Biohybrid scaffolds, combining the mechanical tunability of synthetic polymers with the biocompatibility of natural materials, have gained significant attention. In this study, biohybrid scaffolds were developed using spongin isolated from the marine sponge <em>Sarcotragus foetidus</em> (Sf), mimicking natural bone architecture. These scaffolds were functionalized with hydroxyapatite (HAp) and boron-doped HAp (B-HAp) to enhance mechanical and osteoconductive properties. Micro-computed tomography (μCT) revealed interconnected porosity above 70 % in all groups, facilitating nutrient exchange and cell migration. Elemental analysis confirmed the presence of carbon, oxygen, calcium, and phosphorus, essential for bone regeneration. Mechanical testing showed increased Young's modulus values, reaching ∼20 kPa for Sf/HAp and ∼ 22 kPa for Sf/B-HAp, due to the reinforcing coatings. <em>In vitro</em> assays over 21 days showed that the Sf/B-HAp scaffold exhibited the highest mineralization, alkaline phosphatase (ALP) activity, collagen synthesis, and extracellular matrix (ECM) formation, indicating enhanced osteogenic capacity. Additionally, antibacterial tests showed superior activity for the Sf/B-HAp group. <em>In vivo</em> studies conducted using a rat calvarial bone defect model over a 20-week period demonstrated significant bone regeneration across all groups, with the Sf/B-HAp scaffold exhibiting the most pronounced effect. Overall, Sf-based scaffolds supported cell adhesion, proliferation, and differentiation, with the Sf/B-HAp variant offering superior mechanical, osteoconductive, osteoinductive, and antibacterial properties—making it a promising candidate for advanced bone tissue engineering.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"180 ","pages":"Article 214532"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel polyurethane nanofiber scaffold with mechanical adaptability and anti-adhesion properties promotes tendon regeneration.","authors":"Qingxin Yang, Tianxu Di, Guiping Zhang, Xuanran Luo, Yuling Zhu, Yu Wen, Shuang Yang, Maolan Zhang","doi":"10.1016/j.bioadv.2025.214536","DOIUrl":"https://doi.org/10.1016/j.bioadv.2025.214536","url":null,"abstract":"<p><p>The High-quality repair of tendon injuries continues to encounter two significant challenges: promoting tendon regeneration and preventing postoperative adhesion (PA). While traditional surgical methods can partially restore tendon function, issues such as postoperative adhesions and insufficient mechanical properties hinder clinical effectiveness. Recently, electrospun nanofiber membranes (ENMs) have emerged as a promising material for tackling these challenges, owing to their capability to mimic the structure and function of the natural extracellular matrix (ECM). This study presents a novel functionalized polyurethane (PU)-based nanofiber scaffold (NFS) using electrospinning technology, creating a multifunctional therapeutic platform characterized by excellent mechanical properties, bioactivity, and anti-adhesion capabilities. Initially, a new PU material was synthesized, incorporating rigid structures and active reactive sites within its backbone, thereby overcoming the limitations posed by traditional PU's chemical inertness for functional modification. The material's mechanical properties were tailored to match those of natural tendons through optimization of molecular design while preserving reactive sites for additional functionalization. The aligned PU nanofiber membrane fabricated via electrospinning successfully mimicked the topological structure of natural tendon sheaths, exhibiting remarkable degradation properties and biocompatibility. Furthermore, it significantly promoted the expression of tendon-related genes and enhanced the tenogenic differentiation potential of bone marrow-derived mesenchymal stem cells (BM-MSCs). Experimental results from a rat model with infected Achilles tendon defects demonstrated that the optimized PU NFS provided exceptional anti-adhesion effects and facilitated tendon repair. This innovative dynamic repair strategy provides an innovative solution for the clinical repair of tendons and other musculoskeletal tissue injuries.</p>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"180 ","pages":"214536"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered small-diameter vascular graft with tailored degradation profile transform into a living blood vessel after implantation in a murine model","authors":"Do Wan Kim ,&nbsp;Mukhammad Kayumov ,&nbsp;Reverien Habimana ,&nbsp;Jiae Seong ,&nbsp;YeongEun Jo ,&nbsp;Hwa-Jin Cho ,&nbsp;Obiweluozor Francis Onyekachi ,&nbsp;In Seok Jeong","doi":"10.1016/j.bioadv.2025.214533","DOIUrl":"10.1016/j.bioadv.2025.214533","url":null,"abstract":"<div><div>Current vascular replacements available on the market often require frequent interventions. In situ tissue engineering (TE), which utilizes biodegradable grafts that transform into autologous vascular tissue at the implantation site, presents a promising solution to these limitations. In this study, electrospun small-diameter scaffolds (2 mm ø) composed of polycaprolactone (PCL) and polydioxanone (PDO), reinforced with a 3D-printed PCL anti-kinking coil, were implanted in a rat abdominal aortic replacement model. Grafts were explanted after 3 and 12 months, and the results were compared with native rat aortic vessels of similar age. The implanted grafts were evaluated for patency, extracellular matrix (ECM) formation, degradation, and remodeling. At 3 months, the grafts were partially resorbed and replaced by vascular neo-tissue due to the degradation of PDO nanofibers. By 12 months, nearly complete graft resorption was observed, with the newly formed vessel exhibiting structural and functional characteristics similar to the native aorta, including elastin deposition, contractile marker expression, and endothelial lining formation. No cases of dilation, rupture, or aneurysmal formation were observed. Patency of the implanted grafts was confirmed by OCT (≈100 %), comparable to native controls.</div><div>This work employed a small animal model to illustrate the transformation of a synthetic, biodegradable vascular scaffold into a functioning, compliant neo-vessel in a rat aortic replacement.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"180 ","pages":"Article 214533"},"PeriodicalIF":6.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroactive PVTF films functionalized with collagen enhance osteogenic differentiation and bone regeneration","authors":"Haoqing Liu ,&nbsp;Kepeng Hu ,&nbsp;Chengwei Wu ,&nbsp;Weiming Lin ,&nbsp;Wenjian Weng ,&nbsp;Xiaojun Long ,&nbsp;Zhangfa Song ,&nbsp;Kui Cheng","doi":"10.1016/j.bioadv.2025.214530","DOIUrl":"10.1016/j.bioadv.2025.214530","url":null,"abstract":"<div><div>Bone tissue is mainly composed of collagen and hydroxyapatite, and has intrinsic electroactivity. The ability of biomaterials to mimic physiological microenvironmental cues holds significant potential for enhancing therapeutic outcomes by activating the intrinsic repair capabilities of cells and tissues. The microenvironment of bone tissue contains abundant collagen and electrophysiological signals, which play a crucial role in regulating, repairing, and regenerating its daily homeostasis. Creating surface potentials on biomaterials has proven to be an efficient method for promoting osteogenic differentiation. However, how to construct a collagen rich environment with different surface potentials and its biological effects remains unexplored. In this study, a biomimetic electrical microenvironment was created on the surface of the PVTF film through polarization and collagen modification. In this microenvironment, collagen with varying surface potentials can replicate the extracellular microenvironment of natural bone tissue. The biomimetic microenvironment has the potential to enhance the bioactivity of the material, particularly in terms of improving stem cell adhesion, promoting osteogenic differentiation, and accelerating bone regeneration in vivo. Further integrin inhibition assays and PCR analyses revealed that the biomimetic microenvironment promoted osteogenic differentiation by activating integrin α2β1 on the cell surface, which in turn triggered the FAK/ERK signaling pathway and upregulated the expression of osteogenesis-related genes. These findings provide valuable insights into the biological effects of surface potential and biochemical signals on osteogenesis at the material surface and offer a novel surface modification strategy to enhance the therapeutic efficacy of tissue engineering.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214530"},"PeriodicalIF":6.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}