Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"Preparation of baicalin nano prodrug and its effect on inhibiting metastasis of triple-negative breast cancer","authors":"Meng Lan ,&nbsp;Fansu Meng ,&nbsp;Lanwen Gao ,&nbsp;Anil K. Giri ,&nbsp;Makiya Nishikawa ,&nbsp;Kosuke Kusamori ,&nbsp;Jaiwoo Lee ,&nbsp;Mulazim Hussain Asim ,&nbsp;Shumaila Arshad ,&nbsp;Honghui Gu ,&nbsp;Qi Li ,&nbsp;Lina Yang ,&nbsp;Zhong Chen ,&nbsp;Zhenjiang Yang ,&nbsp;Jiajia Qin ,&nbsp;Yu Cai","doi":"10.1016/j.bioadv.2025.214464","DOIUrl":"10.1016/j.bioadv.2025.214464","url":null,"abstract":"<div><h3>Background</h3><div>Triple-negative breast cancer (TNBC) faces great challenges in clinical treatment, owing to the lack of specific therapeutic targets and easy metastasis. The natural component baicalin can effectively inhibit the growth and metastasis of TNBC; however, it has some limitations, such as poor targeting and side effects. Nano targeted delivery systems can improve drug efficacy by enhancing drug accumulation and controlling drug release.</div></div><div><h3>Objective</h3><div>Trop-2 transmembrane glycoprotein expression is high in TNBC cells, suggesting that it can serve as a specific active targeting molecular-modified nano drug delivery system for TNBC to overcome non-specific distribution. Based on the characteristics of high-concentration glutathione in the tumor microenvironment, redox-sensitive nano-prodrugs (Trop2-BA-ss-PPEP) have been designed to achieve intelligent slow control and release of drugs.</div></div><div><h3>Methods</h3><div>The chemical structure of the Trop2-BA-ss-PPEP, and its stability, reductive response to drug release behavior, and targeting ability in vitro were characterized. Cell experiments and a transplanted tumor model verified the anti-tumor effect and biosafety.</div></div><div><h3>Results</h3><div>Trop2-BA-ss-PPEP was stable in a physiological environment and rapidly released the drug under reducing conditions. The experiments showed that Trop2-BA-ss-PPEP significantly promoted cellular uptake, and drug accumulation and maintenance time at the tumor site were increased. It enhanced the inhibitory effect on metastasis in vivo and in vitro, and no obvious toxicity or side effects were observed.</div></div><div><h3>Conclusion</h3><div>Trop2-BA-ss-PPEP was successfully constructed. The targeting ability, microenvironment responsiveness, and anti-tumor metastatic effects of Trop2-BA-ss-PPEP provide a new strategy for TNBC therapy, which has good application and transformation potential.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214464"},"PeriodicalIF":6.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple porphyrin nanoparticles for combined photo-immunotherapy of colorectal cancer","authors":"Haojie Sun ,&nbsp;Zhuang Fan ,&nbsp;Qing Pei ,&nbsp;Zhigang Xie ,&nbsp;Tao Zhang ,&nbsp;Chong Ma","doi":"10.1016/j.bioadv.2025.214466","DOIUrl":"10.1016/j.bioadv.2025.214466","url":null,"abstract":"<div><div>Immune checkpoint inhibitors targeting PD-1 have shown improved survival rates in colorectal cancer patients. Poor clinical response rate due to the low intratumoral infiltration of T lymphocytes limited their further clinical application. Herein, we designed mono-hydroxyphenyl porphyrin (TPP-OH) for synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)-immunotherapy against colorectal cancer. TPP-OH can assemble into stable nanoparticles (TPP-OH NPs) with the help of DSPE-PEG_2K. The as-prepared TPP-OH NPs exhibit excellent photothermal and photodynamic performance upon light irradiation. After systemic injection, TPP-OH NPs can locate at tumor site, and produce robust singlet oxygen (¹O₂) and local hyperthermia, which not only synergistically induces cell death through PDT and PTT effect, but also produces ICD effect to trigger antitumor immune response, thus synergizing with anti-PD-1 to achieve primary tumor control while suppressing metastatic progression. This study provides theoretical guidance for enhancing colorectal cancer treatment through the integration of phototherapy and immunotherapy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214466"},"PeriodicalIF":6.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel-based drug delivery system designed for chemotherapy-induced alopecia","authors":"Romila Manchanda ,&nbsp;Alireza Aminoroaya ,&nbsp;Brett Volmert ,&nbsp;Jacob J. Haffner ,&nbsp;Patrick Vaughan ,&nbsp;Connor Grady ,&nbsp;Tian Autumn Qiu ,&nbsp;Bryan Ronain Smith","doi":"10.1016/j.bioadv.2025.214452","DOIUrl":"10.1016/j.bioadv.2025.214452","url":null,"abstract":"<div><div>Chemotherapy-induced alopecia (CIA) is a common side effect of many chemotherapeutic anticancer treatments. The only CIA treatment used clinically is a hypothermic cap over the scalp which works through cutaneous vasoconstriction. However, these caps are expensive, often extremely painful, logistically challenging and bulky, and may produce heterogeneous results. In this study, we developed a new bioengineered hydrogel to treat hair follicles during chemotherapy. We physically and chemically characterized Lidocaine (LID) and adrenalone (ADR)-loaded hydrogels and then assessed them using various methods including electron microscopy, rheology, and optical analyses. These studies quantitatively demonstrated desirable hydrogel porosity, rheology/viscosity, thickness, and swelling behavior for topical application. In vitro release studies revealed a biphasic drug release pattern wherein the primary release phase length depended on hydrogel thickness. In vivo murine experiments indicated no ADR and only small amounts of released LID entered blood vessels after topical application based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses, matching the matrix-assisted laser desorption/ionization (MALDI) MS imaging results on drug penetration in skin tissues. Upon hydrogel application, Flemish giant rabbit skin showed significant blood vessel constriction, the primary mechanism-of-action to reduce CIA, suggesting that our hydrogels are likely to be efficacious in avoiding CIA. LID and ADR hydrogels reduced blood vessel diameters by ~39 % and 21 %, respectively. This study thus demonstrates the potential to alleviate CIA using clinically translatable hydrogels.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214452"},"PeriodicalIF":6.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the anti-tumor effect of gambogic acid loaded macrophage membranes nanoparticles combined with radiotherapy and anti-PD-1mAb in the colorectal cancer with liver metastasis model","authors":"Xin Zhang ,&nbsp;Li Li ,&nbsp;Haiqing Niu ,&nbsp;Zixin Liang ,&nbsp;Liuqi Sang ,&nbsp;Ning Wang ,&nbsp;Fengli Huang ,&nbsp;Xingzhi Han ,&nbsp;Zhihao Liu ,&nbsp;Xiao Shi ,&nbsp;Qun Zhang ,&nbsp;Jing Hu ,&nbsp;Xiaoping Qian","doi":"10.1016/j.bioadv.2025.214463","DOIUrl":"10.1016/j.bioadv.2025.214463","url":null,"abstract":"<div><h3>Background</h3><div>The prognosis of patients with colorectal liver metastasis (CRLM) is poor. The 5-year survival rate of those who cannot be treated by surgery is less than 5 %, thus, the management of patients with CRLM remains a significant challenge. Based on the anti-tumor activity of traditional Chinese medicine monomer and the local immune activation caused by low dose radiotherapy combined with immune checkpoint inhibitors, we jointly applied it to explore the tumor inhibitory effect and the change of local immune microenvironment in liver metastasis model.</div></div><div><h3>Methods</h3><div>We engineered biomimetic nanoparticles through macrophage membrane encapsulation of gambogic acid (GA)-loaded PLGA cores, employing a double emulsion-solvent evaporation method to fabricate M-PLGA@GA nanoparticles. In tumor-bearing mice with surgically induced colorectal liver metastasis via hemisplenectomy, therapeutic efficacy was evaluated through intratumoral administration of M-PLGA@GA combined with triple-modality therapy: low-dose radiotherapy (LDRT; 5 Gy), anti-programmed cell death protein 1 monoclonal antibody (anti-PD-1 mAb; 200 μg), and nanoparticle delivery. This combinatorial approach leveraged spatial-temporal control of tumor microenvironment modulation.</div></div><div><h3>Results</h3><div>The nanoparticles augmented the targeted delivery ability of drugs to tumor cells and in vivo circulation duration, coupled with improved aqueous solubility of the encapsulated therapeutic agent, all while preserving its therapeutic potency. The radiotherapy notably augments the population of Dendritic cells (DCs) and bolsters the presentation of antigens to the tumor cells. Moreover, the administration of GA induces modifications in the tumor's immune microenvironment and escalates the fraction of CD8+ T cells. Within the context of the mouse CRLM model, the amalgamation of M-PLGA@GA with low-dose radiotherapy and immunotherapy markedly attenuates the pace of tumor proliferation and extends the survival of mice.</div></div><div><h3>Conclusions</h3><div>Our findings propose that a novel therapeutic regimen combining radiotherapy, immunotherapy, and Nanoparticle gambogic acid can effectively impede tumor progression in the mouse model of CRLM. Therefore, our study provides novel insights into the role of combined antitumor therapy on innate and adaptive antitumor immunity modulation for CRLM.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214463"},"PeriodicalIF":6.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxyapatite injectable hydrogel with nanozyme activity for improved immunoregulation microenvironment and accelerated osteochondral defects repair via mild photothermal therapy","authors":"Chunning Heng ,&nbsp;Yizhuang Zhou ,&nbsp;Hanwen Luo ,&nbsp;Haobo Pan ,&nbsp;Xu Cui ,&nbsp;Xiaomou Wei ,&nbsp;Lingyun Chen ,&nbsp;Xiangtao Xie","doi":"10.1016/j.bioadv.2025.214462","DOIUrl":"10.1016/j.bioadv.2025.214462","url":null,"abstract":"<div><div>Osteochondral defect repair presents a significant clinical challenge due to the immune microenvironment at the injury site, which impairs osteogenesis. In this study, a Ce/MnHAp was developed by integrating it into an HES hydrogel. This bi-layered hydrogel system comprises an upper cartilage-mimicking layer composed of pure hydrogel and a lower subchondral bone-mimicking layer containing Ce/MnHAp. The HESH hydrogel exhibits dual responsiveness to pH and NIR laser irradiation, enabling spatiotemporally controlled release of the Ce/MnHAp and bioactive ions in response to physiological stimuli during the repair process. Upon release, Ce/MnHAp modulates the local immune micro-environment by ROS, inducing M2 macrophage polarization, restoring immune homeostasis, and improving osteogenic activity. Treatment with the NIR-irradiated HESH hydrogel significantly accelerated osteochondral regeneration over 12 weeks in a rabbit osteochondral defect model. These results highlight this multifunctional hydrogel system's therapeutic potential as an effective osteochondral tissue repair strategy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214462"},"PeriodicalIF":6.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-modal imaging hyaluronic acid micelle for enhanced mild photothermal therapy of triple-negative breast cancer","authors":"Mengjie Ma ,&nbsp;Shaowei Bo ,&nbsp;Xi Xu ,&nbsp;Kunlin Ye ,&nbsp;Le Bai ,&nbsp;Dong Zhang ,&nbsp;Jifeng Chen ,&nbsp;Zeyu Xiao ,&nbsp;Liangping Luo ,&nbsp;Changzheng Shi","doi":"10.1016/j.bioadv.2025.214460","DOIUrl":"10.1016/j.bioadv.2025.214460","url":null,"abstract":"<div><div>Mild photothermal therapy (PTT) for cancer treatment has gained significant attention due to its selective targeting of cancer cells and the mildness of the treatment. However, its efficacy is limited by tumor heterogeneity and the resistance of cancer cells to treatment. The self-renewal capacity of therapy-resistant cancer stem cells (CSCs) and the activation of epithelial-mesenchymal transition (EMT) in cancer cells largely contribute to the recurrence and metastasis of residual tumors. In this study, we developed a self-assembling micelle (HA-ADH@IR808) with CD44-targeting capabilities, designed to enhance the performance of mild PTT in the treatment of triple-negative breast cancer (TNBC). The hydrazide group within the HA-ADH@IR808 micelles generates a strong chemical exchange saturation transfer (CEST) signal at 4.4 ppm and 5.4 ppm, enabling precise intratumoral mapping of the photosensitizer. Multi-modal imaging enhances the efficacy of mild PTT by enabling accurate localization of the photosensitizer and real-time monitoring of treatment temperature, thereby minimizing side effects. In vivo experiments revealed that CD44-targeted mild PTT significantly inhibits cancer cell proliferation, suggesting that the selective ablation of CD44⁺ cells—predominantly CSCs—results in reduced tumor growth and metastatic potential. In addition, our study found that low-temperature photothermal treatment induced the degradation of collagen I in the tumor extracellular matrix (ECM), which subsequently led to a reduction in the expression of proteins associated with the EMT pathway. Overall, this study provides new insights into the design of mild photothermal therapeutic micelles, as well as advancements in in vivo visualization and treatment monitoring.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214460"},"PeriodicalIF":6.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Degradable UV-crosslinked hydrogel for the controlled release of triclosan with reduced cytotoxicity” [Mater. Sci. Eng. C, 67 (2016), 151–158]","authors":"Yunfeng Hu ,&nbsp;Guangli Ren ,&nbsp;Liehua Deng ,&nbsp;Jinglin Zhang ,&nbsp;Huidi Liu ,&nbsp;Shansong Mu ,&nbsp;Ting Wu","doi":"10.1016/j.bioadv.2025.214450","DOIUrl":"10.1016/j.bioadv.2025.214450","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214450"},"PeriodicalIF":6.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic continuum robot-mediated intracranial delivery of peptide nanophotosensitizers for glioblastoma photodynamic therapy","authors":"Junfeng Wu ,&nbsp;Na Li ,&nbsp;Tianyang Ma ,&nbsp;Daojing Lin ,&nbsp;Junjian Zhou ,&nbsp;Yingqiu Song ,&nbsp;Wen Cheng ,&nbsp;Anhua Wu ,&nbsp;Niandong Jiao","doi":"10.1016/j.bioadv.2025.214458","DOIUrl":"10.1016/j.bioadv.2025.214458","url":null,"abstract":"<div><div>Effective treatment of glioblastoma (GBM) remains a significant clinical challenge. Although photodynamic therapy (PDT) is a promising anticancer treatment method, its clinical application in GBM is limited by poor light penetration through the skull and insufficient drug delivery across the blood–brain barrier (BBB). Here, an innovative magnetic continuum robot (MCR)-mediated intracranial PDT strategy is proposed. The MCR enters the cranial cavity via an Ommaya device, enabling direct delivery of photodynamic nanoparticles (PNPs) to the tumor region and localized laser irradiation through an integrated optical fibre. PNPs, self-assembled from an aromatic short peptide and a porphyrin derivative, were employed owing to their favorable biocompatibility and photosensitivity. To ensure precise navigation within the brain, a closed-loop control system was developed, leveraging the MCR's active deflection capabilities under an electromagnetic driving system. In vitro studies confirmed that this PDT approach effectively induced GBM cell apoptosis, while in vivo experiments demonstrated efficient intratumoral accumulation of PNPs and significant tumor suppression. This strategy bypasses the BBB and enables site-specific light activation, thereby enhancing PDT efficacy. Overall, this robot-guided therapeutic platform represents a promising advance for precision PDT in GBM treatment.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214458"},"PeriodicalIF":6.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biocompatibility of a novel polyether ether ketone (PEEK) stoma device with human epidermal keratinocytes","authors":"Aaron Palmer ,&nbsp;Racheal Wadlow ,&nbsp;Anna Chruscik ,&nbsp;Mathilde Maybery ,&nbsp;Paulomi Burey ,&nbsp;Eliza Whiteside ,&nbsp;Nikita Walz","doi":"10.1016/j.bioadv.2025.214459","DOIUrl":"10.1016/j.bioadv.2025.214459","url":null,"abstract":"<div><div>Surgical stomas are essential interventions for many medical conditions, however, can create physical complications, such as peristomal skin irritation. Medical stoma devices (MSD) are a potential treatment to mitigate such complications. Polyether ether ketone (PEEK) is a promising material for implantable MSD due to its established biocompatibility within orthodontic and orthopaedic applications. However, its cytocompatibility with human epidermal keratinocytes has not been evaluated according to ISO 10993-5:2009 guidelines. This study aimed to assess the biocompatibility of a novel PEEK MSD with human keratinocytes (HaCaT cells). Cells were cultured on discs of PEEK, surface-modified PEEK (m-PEEK), and polylactic acid (PLA). Surface topography was investigated <em>via</em> SEM to assess surface roughness (S_a, S_z), and water contact angle (WCA). m-PEEK demonstrated increased S_a and WCA compared to PLA and unmodified PEEK. Cell proliferation and viability were evaluated using CyQUANT™ and AlamarBlue™ assays and no significant differences were observed among PLA, PEEK, and m-PEEK. Cell adhesion was assessed using an adhesion assay, with m-PEEK demonstrating significantly higher cell adhesion than PLA (<em>p</em> &lt; 0.05), with cell attachment confirmed <em>via</em> SEM imaging. Cytokine analysis of supernatants using Luminex Immunoassay revealed two (IL-1α and IL-6) of six cytokines outlined in the ISO 10993-20:2006 guidelines were elevated in the presence of PEEK at 72 h. These findings suggest that PEEK is non-cytotoxic and biocompatible with human keratinocytes. Further studies are warranted to assess PEEK's compatibility with colonic cells, 3D skin models, and <em>in vivo</em> systems (including for chronic inflammatory responses) for MSD applications.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214459"},"PeriodicalIF":6.0,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral petal honeycomb metamaterial structures: Biomimetic design and application in vascular stents","authors":"Junhua Zhang ,&nbsp;Wen Geng ,&nbsp;Minghui Yao","doi":"10.1016/j.bioadv.2025.214453","DOIUrl":"10.1016/j.bioadv.2025.214453","url":null,"abstract":"<div><div>Auxetic structure has a very good application prospect in biomedical engineering as implant and stent design, but this scenario faces the difficulty of synergistic optimization of multiple performance indexes. This paper aims to break through this dilemma through innovative design concepts and methods. The study integrates bio-morphology and engineering biomimicry to design a chiral petal-type honeycomb structure by extracting the cross symmetry of cruciferous plant petals and the mechanical properties of wind turbine blades. The whole process framework of “bio-morphological feature extraction-parametric modeling -- multi-objective optimization -- application” is constructed. The neural network model is used to carry out multi-objective prediction, parameter sensitivity analysis, and structure optimization with the help of differential evolutionary algorithm. It is found that the designed structure greatly improves the adjustable range of negative Poisson's ratio, and at the same time, a smaller value of the chiral parameter <span><math><msub><mi>la</mi><mn>4</mn></msub></math></span> can make the structure improve the load carrying capacity in the elastic phase. Simulation of the balloon-expandable stent-vessel coupling process shows that the chiral petal-type cellular stent has outstanding advantages in reducing the stenosis rate maintaining the structural stability and dispersing the stress in the vessel wall among the three cellular structures. This study provides innovative technological solutions for medical device design, and is expected to promote the translation of metamaterial honeycomb structures from theoretical research to practical applications in the field of biomedical engineering, pointing out the direction of focusing on the optimization of key parameters and expanding the clinical applications for subsequent studies.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"178 ","pages":"Article 214453"},"PeriodicalIF":6.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}