Hydroxyapatite injectable hydrogel with nanozyme activity for improved immunoregulation microenvironment and accelerated osteochondral defects repair via mild photothermal therapy

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-08-12 DOI:10.1016/j.bioadv.2025.214462

Chunning Heng , Yizhuang Zhou , Hanwen Luo , Haobo Pan , Xu Cui , Xiaomou Wei , Lingyun Chen , Xiangtao Xie

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引用次数: 0

Abstract

Osteochondral defect repair presents a significant clinical challenge due to the immune microenvironment at the injury site, which impairs osteogenesis. In this study, a Ce/MnHAp was developed by integrating it into an HES hydrogel. This bi-layered hydrogel system comprises an upper cartilage-mimicking layer composed of pure hydrogel and a lower subchondral bone-mimicking layer containing Ce/MnHAp. The HESH hydrogel exhibits dual responsiveness to pH and NIR laser irradiation, enabling spatiotemporally controlled release of the Ce/MnHAp and bioactive ions in response to physiological stimuli during the repair process. Upon release, Ce/MnHAp modulates the local immune micro-environment by ROS, inducing M2 macrophage polarization, restoring immune homeostasis, and improving osteogenic activity. Treatment with the NIR-irradiated HESH hydrogel significantly accelerated osteochondral regeneration over 12 weeks in a rabbit osteochondral defect model. These results highlight this multifunctional hydrogel system's therapeutic potential as an effective osteochondral tissue repair strategy.

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羟基磷灰石注射水凝胶纳米酶活性改善免疫调节微环境和加速骨软骨缺陷修复通过轻度光热疗法

骨软骨缺损修复是一项重大的临床挑战，因为损伤部位的免疫微环境会损害成骨。在本研究中，通过将Ce/MnHAp整合到HES水凝胶中来开发Ce/MnHAp。该双层水凝胶体系包括由纯水凝胶组成的上层软骨模拟层和含有Ce/MnHAp的下层软骨下模拟骨层。HESH水凝胶对pH值和近红外激光照射具有双重响应性，能够在修复过程中响应生理刺激，实现Ce/MnHAp和生物活性离子的时空可控释放。释放后，Ce/MnHAp通过ROS调节局部免疫微环境，诱导M2巨噬细胞极化，恢复免疫稳态，提高成骨活性。在兔骨软骨缺损模型中，nir辐照的HESH水凝胶在12周内显著加速骨软骨再生。这些结果突出了这种多功能水凝胶系统作为一种有效的骨软骨组织修复策略的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!