Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"Nanotechnology-driven drug delivery systems for breast cancer: A review","authors":"Tao Wang ,&nbsp;Yuxuan Chen ,&nbsp;Xuyang Zhang ,&nbsp;Yuejie Dou ,&nbsp;Ying Chen ,&nbsp;Maobin Xie ,&nbsp;Antonella Motta ,&nbsp;Zhaozhu Zheng ,&nbsp;Xiaoqin Wang ,&nbsp;Xiaying Kuang ,&nbsp;Zhifen Han ,&nbsp;Gang Li","doi":"10.1016/j.bioadv.2026.214725","DOIUrl":"10.1016/j.bioadv.2026.214725","url":null,"abstract":"<div><div>Breast cancer (BC) remains a global health challenge, with treatment limitations from systemic toxicity, poor drug bioavailability, and multidrug resistance (MDR). Recent advancements in nanotechnology have revolutionized drug delivery systems (DDS), offering targeted, controlled, and synergistic therapeutic strategies. This review explores cutting-edge micro- and nanocarriers, including liposomes (Lips), nanoparticles (NPs), metal-organic frameworks (MOFs), exosomes and nanofibers (NFs)-designed to optimize the delivery of chemotherapeutic agents. Key design parameters are critically analyzed for their roles in optimizing drug encapsulation, tumor specificity, and biocompatibility. We highlight innovations in carrier engineering that enable biological modulation. Furthermore, co-delivery systems combining chemotherapy drugs with siRNA, P-glycoprotein inhibitors, or photothermal agents demonstrate remarkable success in reversing MDR <em>in vitro</em> and <em>in vivo</em>. Despite progress, challenges such as tumor heterogeneity, long-term carrier safety, and cost-effectiveness require further investigation. This review underscores the transformative potential of nanotechnology-driven DDS in precision oncology, paving the way for next-generation therapies to combat breast BC.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214725"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous polydopamine loaded with silver nanoparticles and quercetin for bacterial keratitis treatment through antibacterial and anti-angiogenic mechanisms","authors":"Meiliang Wu ,&nbsp;Rong Liu ,&nbsp;Weijin Nan ,&nbsp;Can Meng ,&nbsp;Wenxin Zhang ,&nbsp;Qingyu Guo ,&nbsp;Hong Wu","doi":"10.1016/j.bioadv.2026.214715","DOIUrl":"10.1016/j.bioadv.2026.214715","url":null,"abstract":"<div><div>Bacterial keratitis (BK) is a serious blinding eye disease, with pathological features mainly including corneal stromal opacity, edema, inflammatory response, and corneal neovascularization (CoNV). Timely intervention and treatment are required in clinical practice. In this study, we successfully prepared mesoporous polydopamine (MPDA) using a soft-template method, and further introduced silver nanoparticles (Ag NPs) and quercetin (Que) onto its surface, resulting in the effective preparation of a Q/AMP nanocomposite with dual functions of anti-angiogenesis and antibacterial activity, which is expected to be applied in the prevention and treatment of BK. The experimental results demonstrated that Q/AMP, based on favorable in vitro and in vivo biocompatibility, effectively inhibited the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as markedly inhibited CoNV in rats. In the in vitro antibacterial experiment, Q/AMP exhibited broad-spectrum and highly efficient antibacterial activity. In the BK animal model, Q/AMP achieved a 97.0% antibacterial rate, higher than Levofloxacin (LVFX) eye drops (77.4%), and Q/AMP showed a greater therapeutic effect, reducing corneal opacity score from 2.5 with LVFX to 0.8 and effectively alleviating ocular symptoms. Therefore, this study presents a promising new strategy for the treatment of infectious keratitis. Q/AMP has demonstrated strong capabilities in antibacterial, anti-angiogenic, and anti-inflammatory aspects, which may attract more attention to the deeper integration of biomaterials and infectious keratitis research.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214715"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superparamagnetic Fe3O4 nanoclusters for cancer therapy and metastasis prevention via synergistic chemotherapy and NETs degradation","authors":"Liqin Xie ,&nbsp;Tianyi Zeng ,&nbsp;Dan Li ,&nbsp;Wenke Chang ,&nbsp;Shenglu Ji ,&nbsp;Zichun Hua","doi":"10.1016/j.bioadv.2026.214709","DOIUrl":"10.1016/j.bioadv.2026.214709","url":null,"abstract":"<div><div>The overexpression of neutrophil extracellular traps (NETs) serves as a critical biomarker and mediator of tumorigenesis and metastasis. By inhibiting their formation or degrading existing structures, therapeutic strategies targeting NETs have shown promising potential in cancer treatment and metastasis prevention. Deoxyribonuclease I (DNase), while effective in NETs degradation, suffers from rapid plasma clearance, necessitating delivery vehicles to prolong its therapeutic activity. In this study, we developed superparamagnetic Fe₃O₄ nanoclusters via a one-step solvothermal method for co-delivery of doxorubicin (DOX) and DNase. The resulting nanoplatform demonstrated: (1) enhanced magnetic retention at tumor sites for improved local drug concentration and targeted delivery, and (2) synergistic therapeutic effects under alternating magnetic field (AMF) exposure, combining magnetic hyperthermia with chemotherapy while simultaneously remodeling the tumor microenvironment through NETs degradation. Comprehensive evaluations revealed that this combined approach significantly enhanced antitumor efficacy compared to monotherapies, with the additional benefit of metastasis prevention through tumor microenvironment modulation. This multifunctional nanoplatform thus represents a promising strategy for synergistic cancer therapy, addressing both primary tumor control and metastatic suppression.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214709"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An injectable dual-drug-loaded hydrogel for the treatment of bacterial endophthalmitis","authors":"Jianzhong He ,&nbsp;Huixiang Ma ,&nbsp;Yan Zhang ,&nbsp;Daokai Huang ,&nbsp;Zhou Zhou ,&nbsp;Meng Cheng ,&nbsp;Lei Wang ,&nbsp;Yinzi Piao ,&nbsp;Xiaojuan Hao","doi":"10.1016/j.bioadv.2026.214704","DOIUrl":"10.1016/j.bioadv.2026.214704","url":null,"abstract":"<div><div>Bacterial endophthalmitis is a severe ocular infection that frequently leads to severe visual impairment or blindness. Current clinical treatments primarily rely on intravitreal antibiotics to eliminate pathogens; however, these often fail to control the excessive inflammatory response that contributes to irreversible retinal tissue damage. We developed an injectable thermosensitive hydrogel that treats bacterial endophthalmitis via a combined antibacterial and anti-inflammatory strategy. The hydrogel is constructed with a chitosan/β-glycerophosphate/gelatin platform co-loaded with moxifloxacin and a curcumin–cyclodextrin inclusion complex. In vitro injectability, rheological, and drug release studies demonstrated that the hydrogel precursor rapidly formed a gel following intravitreal injection and enabled sustained drug release. Rheological and swelling-degradation investigations confirmed its low mechanical modulus, minimal swelling capacity, and optimal biodegradation profile, thereby avoiding potential ocular discomfort during intraocular application. This system enables rapid release of moxifloxacin to eliminate bacteria, followed by sustained release of curcumin to mitigate inflammation and reduce inflammatory-mediated tissue injury. Both in vitro and in vivo evaluations demonstrated that the hydrogel showed a strong antibacterial efficacy against <em>S. aureus</em> and significant anti-inflammatory activity, leading to preserved retinal structure and improved visual function. The hydrogel exhibited excellent injectability, biodegradability, and biocompatibility. These properties support its potential for clinical application by providing sustained release of antibacterial and anti-inflammatory drugs for 14 days. To our knowledge, this also represents a novel application of such a dual-drug delivery strategy, specifically for treating <em>S. aureus</em> endophthalmitis. This approach underscores significant promise for future clinical investigation.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214704"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in functionalized biodegradable biliary stents: From material design to clinical translation","authors":"Shuiguo Tang ,&nbsp;Rongji Ye ,&nbsp;Guanzhi Lai ,&nbsp;Haoqing Xu ,&nbsp;Yu Mao ,&nbsp;Xiangling Wei ,&nbsp;Chengjun Sun ,&nbsp;Wuzheng Xia ,&nbsp;Ming Han ,&nbsp;Luybov Mikhailovna Akhmedova ,&nbsp;Erkin Isakovich Musabaev ,&nbsp;Sunrui Chen ,&nbsp;Shaojun Shi ,&nbsp;Linwei Wu","doi":"10.1016/j.bioadv.2025.214699","DOIUrl":"10.1016/j.bioadv.2025.214699","url":null,"abstract":"<div><div>Biliary stricture, primarily caused by inflammation, hepatobiliary and pancreatic malignancies and other pathological factors, often leads to impaired bile drainage and subsequent poor clinical outcomes. While biliary stent implantation has become a standard palliative and therapeutic intervention, conventional plastic and metal stents are limited by issues such as biofilm formation, epithelial hyperplasia, and the necessity for secondary removal surgery. The emergence of biodegradable stents offers a promising alternative by providing temporary mechanical support and controlled <em>in vivo</em> degradation, thereby eliminating the need for retrieval procedures. However, single-material stents often fail to address the complex and varied clinical demands, particularly in cases involving biliary fibrosis, infection, or malignancy. This review comprehensively summarizes recent advances in functionalized biodegradable biliary stents, referring to additional capabilities beyond their primary mechanical function, with a focus on material innovations and their enhanced functionalities such as anti-fibrotic, anti-tumor, antimicrobial, anti-corrosion, and visualizable properties. We also discuss integrated therapeutic strategies, such as drug-eluting systems and tissue-engineered scaffolds, alongside manufacturing breakthroughs like 3D printing. Furthermore, we also highlight the persistent translational challenges and preclinical limitations of current biodegradable stent technologies, while outlining promising directions for future research to bridge the gap between experimental development and clinical application.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214699"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-enhanced transdermal delivery: Magnolol-borneol nanoparticle hydrogel for topical treatment of diabetic peripheral neuropathy","authors":"Zhengzhou Sha ,&nbsp;Mingqian Hao ,&nbsp;Xi Xue ,&nbsp;Feihong Zhuo ,&nbsp;Xuting Zhou ,&nbsp;Tingmei Lyu ,&nbsp;Yuting Cui ,&nbsp;Yaqin Gao ,&nbsp;Chenqi Zhu ,&nbsp;Baoping Jiang ,&nbsp;Zhipeng Chen ,&nbsp;Liu Xu","doi":"10.1016/j.bioadv.2025.214676","DOIUrl":"10.1016/j.bioadv.2025.214676","url":null,"abstract":"<div><div>Diabetic peripheral neuropathy (DPN) remains a prevalent and challenging complication of diabetes with limited therapeutic options. Magnolol (Mag), a natural multi-target agent, demonstrates significant potential in managing DPN through synergistic anti-inflammatory, antioxidant, and neurorestorative properties. However, its poor oral bioavailability and limited skin penetration hinder clinical application. To address these challenges, we developed a novel topical nanogel system for enhanced transdermal delivery of Mag. Borneol (Bor), a potent penetration enhancer, was co-assembled with Mag via antisolvent precipitation to form self-assembled nanoparticles (Mag-Bor NPs), which were further encapsulated into a carbomer hydrogel matrix to construct the Mag-Bor nanogel (Mag-Bor NPs Gel). The resulting formulation exhibited markedly improved skin permeability and sustained drug retention. Upon topical administration, Mag-Bor NPs Gel effectively alleviated neuropathic impairments in DPN rats through a “transdermal enhancement – anti-inflammatory – nerve repair” mechanism. This therapeutic strategy comprehensively improved key pathological indicators, including plantar thermal, mechanical pain sensitivity, motor nerve conduction velocity (MNCV), intraepidermal nerve fiber density (IENFD), sciatic nerve myelin structure, and inflammation levels in dorsal root ganglia (DRG). This study is the first to report a nanogel system combining efficient transdermal delivery and neurorestorative functions, offering a novel and promising strategy for topical DPN treatment.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214676"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme-triggered peptide assembly boosts dental stem cell osteogenic differentiation by enhancing osteogenic pentapeptide accumulation","authors":"Zhe Yu ,&nbsp;Xiaoying Liu ,&nbsp;Yao Du ,&nbsp;Haiqin Huang ,&nbsp;Lihui Zhang ,&nbsp;Juanjuan Zhang ,&nbsp;Yan Sun ,&nbsp;Zhitao Wang ,&nbsp;Jingkun Bai","doi":"10.1016/j.bioadv.2025.214670","DOIUrl":"10.1016/j.bioadv.2025.214670","url":null,"abstract":"<div><div>Tooth regeneration and bone tissue repair represent significant challenges in oral surgery, and osteogenic differentiation is crucial with respect to dental implant osseointegration and bone healing. Studies have reported that osteogenic growth pentapeptide (OGP5) promotes the differentiation of bone marrow mesenchymal stem cells into osteoblasts. Owing to their easy availability and multipotent differentiation capabilities, human dental pulp stem cells (hDPSCs) are promising in the context of regenerative medicine and dental therapeutics. However, research on the effects of OGP5 on the differentiation of hDPSCs remains insufficient, and the short half-life and poor targeting of functional small-molecule peptides limit its application. Our findings indicate that OGP5 facilitates the differentiation of hDPSCs into osteoblasts. To increase the efficiency with which OGP5 can induce the osteogenic differentiation of hDPSCs, an amphiphilic peptide (Pep1) with alkaline phosphatase (ALP)-responsive properties was designed and synthesized. The encapsulation of OGP5 led to the self-assembly of OGP5/Pep1 into spherical nanoparticles, which transformed into nanofibers upon ALP induction. Importantly, Pep1 significantly enhanced the accumulation of OGP5 in hDPSCs, thereby promoting the differentiation of hDPSCs into osteoblasts, thus providing a new perspective that can facilitate the development of bone repair and regenerative medicine.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214670"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermosensitive nanogel-based oxaliplatin delivery system for synergistic intratumoral radiofrequency chemotherapy","authors":"Ling Li ,&nbsp;Anna Liu ,&nbsp;Cai Wang ,&nbsp;Ling Zhang ,&nbsp;Houqiang Yu ,&nbsp;Han Li ,&nbsp;Hongfu Zhou","doi":"10.1016/j.bioadv.2026.214726","DOIUrl":"10.1016/j.bioadv.2026.214726","url":null,"abstract":"<div><div>To achieve sustained release and prolonged tumor retention of oxaliplatin (OXA), a thermosensitive OXA-loaded poly(N-isopropyl acrylamide-<em>co</em>-acrylic acid) nanogel (PAAs) was developed via a synergistic mixing-stirring method. The formulation, consisting of 0.8 mg/mL OXA thoroughly dispersed in 8% poly(N-isopropyl acrylamide-<em>co</em>-acrylic acid) nanogel (PNAs), exhibited favorable radiofrequency responsiveness, thermosensitivity, and controlled-release properties, enabling continuous OXA release for up to five days. The sol–gel phase transition behavior of the thermosensitive PAAs nanogel was characterized using the vial-inversion method and rheological analysis. Platinum content analysis revealed enhanced tumor retention of the PAAs nanogel compared with free OXA, as evidenced by significantly higher platinum levels in tumors treated with the nanogel formulation. In vivo antitumor efficacy evaluation demonstrated that a single administration of the PAAs nanogel resulted in sustained tumor regression, reducing the relative tumor volume to 0.81 ± 0.06 times the initial volume within 14 days. In contrast, treatment with an equivalent dose of free OXA, PNAs alone, or normal saline led to rapid tumor progression, with tumor volumes increasing to 3.22 ± 0.65, 7.01 ± 0.47, and 10.07 ± 1.57 times the initial volume, respectively. Preliminary biocompatibility assessment indicated that the incorporation of OXA into PNAs within the nanogel significantly alleviated the toxic side effects associated with free OXA. These findings underscore the considerable potential of the PAAs nanogel as a versatile strategy to enhance the antitumor efficacy of platinum-based drugs while mitigating their systemic toxicity and size-related limitations. This system therefore represents a promising candidate for further development as a novel nanomedicine for localized chemotherapy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214726"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed carbonate apatite scaffolds inspired by cuttlebone biomechanics and blood flow dynamics for layer-by-layer collapse and spatial bone formation","authors":"Ahmad Nazir Taleb Alashkar ,&nbsp;Koichiro Hayashi ,&nbsp;Kunio Ishikawa","doi":"10.1016/j.bioadv.2026.214710","DOIUrl":"10.1016/j.bioadv.2026.214710","url":null,"abstract":"<div><div>In bone tissue engineering, scaffolds are required to resist mechanical impact and promote bone regeneration, both are highly dependent on the structure of the scaffolds. In this study, we aimed to develop scaffolds inspired by the uniquely layered and curved structure of cuttlebone, which underlies its distinctive biomechanical behavior, and it is hypothesized to promote favorable blood flow dynamics. The scaffolds were composed of carbonate apatite, bone mineral analog, and designed with three structures: one with straight interlayer walls (SW) and two with curved walls (CW). In the CW designs, the bottom curvature amplitude was fixed at 0.3 mm, while the top was 0.6 mm (CW-2) or 0.9 mm (CW-3). Upon compression, CW-3 scaffolds exhibited a distinct layer-by-layer collapse pattern, whereas SW and CW-2 scaffolds collapsed as a whole. Computational fluid dynamics revealed that SW scaffolds had uniformly fast blood flow throughout their channels. Compared to SW, CW scaffolds showed reduced flow velocities across their channels, with markedly slower flow near the concave regions of their curved walls. These flow dynamics affected the distribution of wall shear stress (WSS); CW scaffolds showed a higher proportion of WSS values favorable for cell adhesion and proliferation than SW. At both 4 and 12 weeks post-surgery, the in vivo bone formation in the CW scaffold groups was significantly greater than that observed in the SW scaffold and sham groups. This study elucidates CW-3 structure offers both mechanical resilience and enhanced bone formation, representing a significant advancement in the field of bone tissue engineering.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214710"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paotianxiong polysaccharides as a stabilizer for protein nanoparticles and construction of an enhanced gastric acid-responsive hydrogel for delivery of fisetin to alleviate alcoholic gastric injury","authors":"Qiao Ren ,&nbsp;Jiaxin Jiang ,&nbsp;Chenghao He ,&nbsp;Jiayizhuo Liu ,&nbsp;Jingcheng Jiang ,&nbsp;Shuguang Hou ,&nbsp;Qinwan Huang","doi":"10.1016/j.bioadv.2025.214702","DOIUrl":"10.1016/j.bioadv.2025.214702","url":null,"abstract":"<div><div>Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding. To address fisetin's (FIT) limitations in ameliorating alcohol-induced gastric injury while resolving stability issues of pH-driven albumin nanoparticles and oral protein-based drug delivery carriers, this study innovatively employed Paotianxiong polysaccharides (PP) as a stabilizer for protein nanoparticles and constructed an enhanced gastric acid-responsive hydrogel for delivery of FIT to alleviate alcohol-induced gastric injury. Through a green strategy (pH-driven method), albumin-PP composite nanoparticles were fabricated to improve FIT's solubility, stability, and bioavailability. The nanoparticles exhibit a uniform particle size and excellent dispersibility. In different pH acidic environments and ionic concentrations, the addition of PP significantly boosts the nanoparticles' stability. To further enhance gastric retention and sustained drug-release properties, an acid-responsive hydrogel was designed using SA and Ca²⁺, and carboxymethyl chitosan and PP were introduced to optimize the hydrogel's toughness, bioadhesion, and biocompatibility. This gastric-retentive delivery system formed by incorporating drug-loaded composite nanoparticles into the hydrogel shows a denser network structure, excellent mechanical properties, bioadhesion, sustained-release and gastric-retentive properties. In vivo studies demonstrate that the drugs delivered by this system exhibit superior distribution characteristics in the stomach and liver. They can effectively alleviate alcohol-induced gastric injury by accelerating hepatic ethanol metabolism, regulating oxidative stress and inflammatory responses in gastric tissues, and inhibiting pyroptosis. Finally, this delivery system is composed of biomaterials, conferring excellent safety. This delivery system provides new strategies for improving the stability of protein nanoparticles and ameliorating alcohol-induced gastric injury, respectively.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214702"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}