Materials Science & Engineering C-Materials for Biological Applications最新文献

{"title":"Design, fabrication, and evaluation of antimicrobial sponge-hydrogel bilayer microneedles: An integrated system for transdermal insulin delivery and glucose sensing","authors":"Xinyi Zhang ,&nbsp;Huishan Zheng ,&nbsp;Yuelian Zhang ,&nbsp;Xue Yang ,&nbsp;Nan Jin ,&nbsp;Qiulong Zhang ,&nbsp;Jianmin Chen","doi":"10.1016/j.bioadv.2025.214693","DOIUrl":"10.1016/j.bioadv.2025.214693","url":null,"abstract":"<div><div>Diabetes mellitus is a chronic metabolic disorder that requires long-term management, as persistent hyperglycemia may lead to severe complications, thereby making real-time glucose monitoring and precise control essential. Traditional subcutaneous insulin injections are inconvenient, exhibit poor patient compliance and dosing accuracy, and do not provide real-time feedback, thereby hindering personalized therapy. Microneedles (MNs) offers a minimally invasive, user-friendly, and self-administered alternative; however, existing MN systems still exhibit low drug-loading capacity, insufficient controlled-release performance, a lack of glucose-monitoring capability, and inherent infection risks, which limit their application in long-term diabetes management. To address these limitations, we developed a novel antimicrobial sponge–hydrogel bilayer MNs system (ASMNs@PVA/SA-INS) that integrates insulin delivery, glucose sensing, and antimicrobial protection. The system comprises a polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel layer for controlled insulin release and a sponge MN base functionalized silver nanoparticles to provide antibacterial activity. Experiments results demonstrated that over 83 % of insulin was released within 24 h, effectively controlling blood glucose for more than 8 h. Additionally, the system responded to glucose level changes within 10 min through a visible color change, indicating real-time sensing capability. This platform offers a promising strategy for intelligent and individualized diabetes management.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214693"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ engineering of a covalent organic framework-based biomimetic nanoplatform for multi-target therapy of Alzheimer’s disease","authors":"Yujiao Yan ,&nbsp;Yutong Chen ,&nbsp;Fengmei Yang ,&nbsp;Ruixin Zhao ,&nbsp;Die Tian ,&nbsp;Liran Deng ,&nbsp;Meng Xie","doi":"10.1016/j.bioadv.2026.214728","DOIUrl":"10.1016/j.bioadv.2026.214728","url":null,"abstract":"<div><div>To address the complex pathology of Alzheimer’s disease (AD), including abnormal amyloid-β (Aβ) aggregation, metal ion homeostasis disruption and oxidative stress, we developed an integrated multifunctional nanoplatform. This platform leveraged a covalent organic framework (TD-COF) with intrinsic capabilities for Cu²⁺ chelation and Aβ inhibition as the carrier. Through <em>in</em>-<em>situ</em> engineering, ultrafine palladium nanoparticles (PdNPs) were anchored to construct a stable, functionally integrated core (Pd-COF). However, due to limitations of nanomaterials such as short half-life and poor brain targeting, we further employed red blood cell (RBC) membrane for biomimetic modification, yielding the final platform Pd-COF-RBC. <em>In vitro</em> experiments demonstrated that Pd-COF-RBC concurrently achieved Cu²⁺ chelation, Aβ fibrillation inhibition and reactive oxygen species (ROS) scavenging. Notably, the design of Pd-COF also regulated the size and dispersibility of PdNPs, enhancing catalase-like (CAT) activity by 34.7%. In Aβ-induced cellular models, the material effectively alleviated oxidative stress and mitochondrial dysfunction, increasing cell survival by over 78.4%. Further experiments confirmed that Pd-COF-RBC modified with RBC membrane possessed good biocompatibility, long circulation property and brain accumulation capacity. Based on these findings, we evaluated its therapeutic potential in the transgenic AD <em>C. elegans</em> model. The results demonstrated the motor and cognitive functions of the worms were markedly restored, with the average paralysis time prolonged by approximately 37.3% and the chemotactic index recovering to near wild-type levels. Thus, the study has promise for providing experimental evidence for multi-target intervention against the complex pathological network of AD <em>via</em> an integrated strategy of <em>in situ</em> engineering and biomimetic modification.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214728"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLP 3D-printed biomimetic periodontium composite with xenogenic treated dentin matrix modulates periodontal regeneration and inflammatory response","authors":"Xiaoyu Hu ,&nbsp;Tao Qiu ,&nbsp;Yuxuan Xiao ,&nbsp;Yun Wang ,&nbsp;Weihua Guo ,&nbsp;Yu Chen","doi":"10.1016/j.bioadv.2025.214668","DOIUrl":"10.1016/j.bioadv.2025.214668","url":null,"abstract":"<div><div>Xenogeneic treated dentin matrix (xTDM) roots serve as a promising donor source for tooth replantation. Nevertheless, the regeneration of the alveolar bone–periodontal ligament (PDL)–cementum complex persists as a challenging task owing to tissue heterogeneity, limited vascularization, and immune-associated complications. In this study, a biomimetic tubular periodontium was fabricated through digital light processing (DLP)-based 3D bioprinting around columnar xTDM roots. The bio-ink was composed of silk fibroin methacrylate (SilMA), dental follicle stem cells (DFCs), and transforming growth factor-β1 (TGF-β1). In a rat subcutaneous model, the DLP Bioprinting Periodontium (DLBPB) enhanced the formation of Sharpey's fiber-like bundles with aligned orientation surrounding the xTDM. To address immune rejection, local FTY720 administration down-regulated TNF-α and IL-1β expression and induced macrophage polarization from the M1 toward the M2 phenotype. Co-delivery of TGF-β1 and FTY720 exerted synergistic immunomodulatory effects. RNA sequencing revealed downregulation of Card9 and inhibition of NF-κB signaling, thereby reducing inflammatory mediator expression. This study proposes a modular strategy that integrates biomimetic scaffold design, stem-cell-based biofabrication, and localized immunomodulation to promote functional periodontal regeneration around xTDM. Therapeutic efficacy was verified in a Beagle dog orthotopic tooth replantation model, suggesting the translational potential of DLPBP for clinical functional tooth restoration.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214668"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic modulation of inflammation and angiogenesis by a polyphenol-functionalized MOF nanozyme for enhancing wound closure","authors":"Beibei Han ,&nbsp;Yidan Xia ,&nbsp;Kai Liu ,&nbsp;Ruichu Li ,&nbsp;Jiangbo Shao ,&nbsp;Mengke Wang ,&nbsp;Shun Wang ,&nbsp;Bin Liu","doi":"10.1016/j.bioadv.2026.214707","DOIUrl":"10.1016/j.bioadv.2026.214707","url":null,"abstract":"<div><div>Persistent inflammation, excessive oxidative stress, and impaired angiogenesis are persistent challenges that adversely affect skin wound healing, which are particularly prominent in diabetic wounds and often lead to hindered repair processes. Bioactive materials with integrated anti-inflammatory, reactive oxygen species (ROS) scavenging, and angiogenesis-promoting functions are emerging as novel therapeutic strategies for enhancing wound healing. Therefore, we pioneered the development of a tannic acid -functionalized cerium-based metal-organic framework (CeMT) with multi-enzyme mimetic activities. Experiments <em>in vitro</em> and <em>in vivo</em> confirm CeMT's good biocompatibility. By mimicking the activities of superoxide dismutase and catalase, CeMT efficiently catalyzes the decomposition of ROS through a cascade reaction to generate oxygen, thereby eliminating excess ROS, alleviating hypoxia in the wound area, and reducing inflammatory responses. Furthermore, CeMT promotes macrophage polarization, angiogenesis, and collagen deposition, which accelerates the skin wound healing process. Proteomic analysis further indicated that CeMT inhibits the formation of neutrophil extracellular traps and remodels the inflammatory microenvironment of the wound. The proposed CeMT-based approach represents a safe, efficient, and clinically promising nanotherapeutic strategy for the treatment of large-scale acute and healing-impaired wounds, such as diabetic wounds.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214707"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric nanocomposite patch for self-powered bioelectrical stimulation for cardiac tissue engineering","authors":"Hyunjin Kim ,&nbsp;Kannan Badri Narayanan ,&nbsp;Vineet Kumar ,&nbsp;Sung Soo Han ,&nbsp;Rakesh Bhaskar","doi":"10.1016/j.bioadv.2026.214717","DOIUrl":"10.1016/j.bioadv.2026.214717","url":null,"abstract":"<div><div>Cardiovascular diseases remain the leading cause of mortality worldwide, and myocardial infarction results in irreversible loss of functional myocardium with limited regenerative treatment options. Here, we report a self-responsive piezoelectric elastomeric patch designed for cardiac tissue engineering (CTE) by integrating dual nanofillers (TiC and MoS₂; 2 phr each) into a polydimethylsiloxane (PDMS) matrix and following a PLA/PDMS electrospun nanofiber coating as a temporary biointerface to promote early cell attachment. Composite patches (PDMS, PDMS+TiC, PDMS+MoS₂, and Hybrid) were fabricated by casting/curing and coated at a semi-cured stage to enable physical interlocking of the fiber layer. The materials were characterized by SEM, FTIR, XRD, XPS, wettability measurements, compressive testing, and TGA/DTGA. Electromechanical performance was assessed by cyclic compression (30% strain), and biological performance was evaluated using NIH3T3 fibroblasts (MTT, Live/Dead, and intracellular ROS assays) and H9c2 cardiomyoblasts on fiber-coated configurations under low-intensity agitation. The Hybrid patch exhibited balanced mechanical reinforcement and reproducible voltage generation (typically ±20–30 mV) under cyclic loading. All formulations maintained cytocompatibility, while the Hybrid group reduced intracellular ROS compared with single-filler composites and supported improved cell adhesion/spreading when combined with the nanofiber interface. These findings demonstrate a mechanically robust, electrically responsive, and cytocompatible PDMS-based hybrid scaffold with a degradable fibrous bio-interface, providing a foundation for self-powered, mechanically interactive cardiac patch platforms.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214717"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular uptake of anisotropic microparticles in 2D and 3D culture systems","authors":"Navneet Kaur ,&nbsp;Annie Scutte ,&nbsp;Mary Jean Savitsky ,&nbsp;Qi Wang ,&nbsp;Pitchaimari Gnanasekar ,&nbsp;Hannah Matos Pimentel ,&nbsp;Dazhi Yang ,&nbsp;Jamel Ali","doi":"10.1016/j.bioadv.2025.214692","DOIUrl":"10.1016/j.bioadv.2025.214692","url":null,"abstract":"<div><div>Three-dimensional (3D) cell culture models offer a more physiologically relevant alternative to traditional two-dimensional (2D) cultures by better replicating <em>in vivo</em> microenvironments, including extracellular matrix interactions, cell-cell contacts, and nutrient gradients. While nanoparticle uptake in 3D cultures has been extensively characterized, microparticle internalization remains less explored. Here we evaluate cellular uptake of monodisperse anisotropic hematite microparticles of varying geometry (cubic, ellipsoidal, and rod-shaped), synthesized <em>via</em> a sol-gel method, in both 2D and 3D cultured normal and cancer cell lines. Using a combination of microscopy and spectroscopy, we reveal shape-dependent uptake patterns, with rod-shaped microparticles exhibiting significantly enhanced internalization, particularly within 3D cancer spheroids. Confocal <em>Z</em>-stack imaging further demonstrated deeper penetration of rod-shaped particles into spheroid cores compared to other shapes, underscoring the influence of particle aspect ratio and cellular microenvironment on uptake efficiency. Cytotoxicity assays highlight differential responses in 2D <em>versus</em> 3D cultures, emphasizing the importance of 3D models for evaluating therapeutic platforms. These findings advance the understanding of microparticle behavior in complex tissue-like environments, supporting their potential for improved drug delivery, tissue engineering, and regenerative medicine applications.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214692"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement in fabricating precision hemostats using nanocomposites and polymeric systems: From biofunctionality to clinical translation","authors":"Ankit Majie,&nbsp;Santanu Ghosh,&nbsp;Bapi Gorain","doi":"10.1016/j.bioadv.2025.214683","DOIUrl":"10.1016/j.bioadv.2025.214683","url":null,"abstract":"<div><div>The ever-increasing challenge of tackling traumatic injuries urges newer hemostatic technologies with rapid hemorrhagic control and improved wound healing to overcome the limitations of conventional gauze and dressings, used for emergency trauma control. With this aim, the current review focuses on nanocomposites, biopolymeric, and synthetic systems, as well as their complex combinations that incorporate different bioactive nanomaterials into either naturally derived or synthetic polymeric matrices. These nanoscale particles are providing an increased surface area for their bioactivity and improved drug-loading capacity. Additionally, advanced polymeric materials, such as hydrogels, gauzes, microspheres, nanofibers, sponges, and foams, are currently loaded with these nanoparticles to enhance their properties, including improved swellability, porosity, and adsorption. These advanced formulations primarily restrict blood flow by providing a physical barrier, followed by the absorption of platelets and RBCs onto their structural scaffold due to the modulation of their surface charge, imparted by various functional groups. Furthermore, highly porous matrices are known to absorb fluid and concentrate blood cells at the wound surface, inducing the formation of a firm and stable blood clot. Consequently, the nanoparticles released from the polymeric matrices induce several molecular effects to accelerate wound closure.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214683"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of N-substituted phenothiazine styrene monomers for amphiphilic fluorescence nanoparticles: structure-fluorescence relationship, from AIE to ACQ effect and drugs delivery systems","authors":"Zengfang Huang ,&nbsp;Xiaotong Zhang ,&nbsp;Jinwen Tan ,&nbsp;Siying Yang ,&nbsp;Yikai Lin ,&nbsp;Jinwen Yan ,&nbsp;Jinying Yuan ,&nbsp;Lei Tao ,&nbsp;Mei Tian ,&nbsp;Yen Wei","doi":"10.1016/j.bioadv.2025.214684","DOIUrl":"10.1016/j.bioadv.2025.214684","url":null,"abstract":"<div><div>Phenothiazines are highly active and attracting significant attention in various fields including biology and medicine, etc. Herein, several styryl phenothiazine derivatives including VPPA, VPBM, 3PVP and 4PVP were successfully synthesized, and their relationship of functional groups and photophysical properties was investigated in detail. Among them, VPPA demonstrated twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) properties, while 4PVP with phenothiazine-pyridine structure demonstrated aggregation-caused quenching (ACQ) effect and obvious pH sensitivity for targeting potential in various pH environments. In order to explore AIE and ACQ effects, a series of fluorescence performances, molecular electrostatic potential (ESP), stacking models, and quantization calculations were conducted. Subsequently, 3PVP, 4PVP and VPPA were copolymerized by RAFT polymerization with PEGMA for their potential in intracellular imaging and drugs delivery, and the obtained copolymers self-assembled in aqueous solution into fluorescent nanoparticles with about 150 nm with low toxicity and good biocompatibility. Drugs delivery systems of VA-PTX FONs and 4VP-PTX FONs with the anti-tumors drug paclitaxel (PTX) could successfully release PTX with high toxicity to the A549 cells, which respectively decreased the cells viability to 31.84 % and 26.90 %, showing high cells inhibition ratio. The as-prepared drug-delivery nanoparticles have perspective potential in visualizing, bioimaging, medical diagnostics, and drugs track.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214684"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional POSS-based nanoparticles functionalized with silver, SPIONs, and rhamnolipid for antibacterial applications","authors":"Güneş Kibar ,&nbsp;Melisa Kafali ,&nbsp;Olgu Cagan Ozonuk ,&nbsp;Merve Oztas ,&nbsp;Berk Usta ,&nbsp;Batur Ercan","doi":"10.1016/j.bioadv.2025.214678","DOIUrl":"10.1016/j.bioadv.2025.214678","url":null,"abstract":"<div><div>Nano-engineered materials, particularly those featuring bio-based surface modifications, are emerging as effective tools in combating bacterial infections. In this study, polyhedral oligomeric silsesquioxane (POSS) nanoparticles were functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and the biosurfactant rhamnolipid (RL)—either individually or in combination—to evaluate their antibacterial and antibiofilm activities against <em>Staphylococcus aureus</em> (<em>S. aureus</em>) and <em>Pseudomonas aeruginosa</em> (<em>P. aeruginosa</em>). The modified nanoparticles exhibited sizes ranging from 127 to 227 nm and demonstrated superparamagnetic behavior, offering potential for magnetic targeting. Among the various formulations, the RL-coated, silver- and SPION-decorated POSS nanoparticles (RSMP) exhibited the highest antibacterial efficacy, reducing <em>S. aureus</em> and <em>P. aeruginosa</em> colony growth by approximately 90 % and 66 %, respectively, at a concentration of 0.01 g/L. RSMP nanoparticles also showed strong biofilm inhibition and had the lowest MIC₅₀ values. Notably, these nanoparticles supported the proliferation of human osteoblasts at concentrations up to 0.05 g/L, indicating favorable cytocompatibility. Overall, RSMP nanoparticles present a promising platform for magnetically targetable antibacterial agents, with potential applications in biomedical fields, particularly for managing orthopedic infections.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214678"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric micelles for encapsulation of plant-derived bioactives: a decade of advances in antimicrobial, antitumor, and antioxidant applications","authors":"Astrid Corrales ,&nbsp;James Villar ,&nbsp;Ana Lívia de Carvalho Bovolato ,&nbsp;Alberto Gomes Tavares Júnior ,&nbsp;Rita de Cássia Lacerda Brambilla Rodrigues ,&nbsp;Marlus Chorilli ,&nbsp;Daniele Ribeiro de Araujo ,&nbsp;André Moreni Lopes","doi":"10.1016/j.bioadv.2026.214713","DOIUrl":"10.1016/j.bioadv.2026.214713","url":null,"abstract":"<div><div>This 10-year review provides a comprehensive overview of advances in the use of polymeric micelles (PMs) for the encapsulation of bioactive compounds derived from renewable green sources. PMs have emerged as highly versatile nanocarriers that capable of enhancing the solubility, stability, and bioavailability of poorly water-soluble compounds while enabling controlled and targeted release. Across the literature, PM formulations typically exhibit nanoscale sizes ranging from ∼10 to 200 nm, low polydispersity indices (generally &lt;0.300), and high encapsulation efficiencies, commonly ranging from ∼70 to &gt;95%. By protecting plant-derived bioactives from degradation and enabling sustained release profiles over hours to days, PMs significantly improve antimicrobial, antitumor, and antioxidant performance, frequently reducing effective concentrations compared to free compounds. The incorporation of green-source biomolecules adds further value through their natural origin, biocompatibility, low toxicity, and alignment with sustainability-driven pharmaceutical development. This review critically analyzes the physicochemical parameters governing PM performance, including particle size, surface charge, encapsulation efficiency, and release kinetics, and correlates these features with biological activity and therapeutic outcomes. Special emphasis is placed on key formulation strategies reported over the past decade, highlighting PMs as a rapidly evolving and high-performance platform for the development of safer, more efficient, and innovative nanomedicine.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"182 ","pages":"Article 214713"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}